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Today: 26 January 2021, Tuesday.

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#1

 

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Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line anti-PD-1 monotherapy vs. BRAF/MEK inhibitors in advanced BRAFV600-mutant melanoma patients. We selected patients diagnosed between 2014 and 2017 with advanced melanoma and a known BRAFV600-mutation treated with first-line BRAF/MEK inhibitors or anti-PD-1 antibodies, registered in the Dutch Melanoma Treatment Registry. Patients were matched based on their propensity scores using the nearest neighbour and the optimal matching method. Between 2014 and 2017, a total of 330 and 254 advanced melanoma patients received BRAF/MEK inhibitors and anti-PD-1 monotherapy as first-line systemic therapy. In the matched cohort, patients receiving anti-PD-1 antibodies as a first-line treatment had a higher median and 2-year overall survival compared to patients treated with first-line BRAF/MEK inhibitors, 42.3 months (95% CI: 37.3-NE) vs. 19.8 months (95% CI: 16.7–24.3) and 85.4% (95% CI: 58.1–73.6) vs. 41.7% (95% CI: 34.2–51.0). Our data suggest that in the matched BRAFV600-mutant advanced melanoma patients, anti-PD-1 monotherapy is the preferred first-line treatment in patients with relatively favourable patient and tumour characteristics.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#2

 

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Ubiquitylation is a critical post-translational modification that controls a wide variety of processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different cellular functions and control the stability, activity, interaction properties, and localization of many different proteins. Recent work has highlighted a role for branched ubiquitin chains in the regulation of cell signaling and protein degradation pathways. Similar to their unbranched counterparts, branched ubiquitin chains are remarkably diverse in terms of their chemical linkages, structures, and the biological information they transmit. In this review, we discuss emerging themes related to the architecture, synthesis, and functions of branched ubiquitin chains. We also describe methodologies that have recently been developed to identify and decode the functions of these branched polymers.

#Theoretical sciences
Field # Theoretical sciences
Updated 26 January 2021

#3

 

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Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10–18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10–8). The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#4

 

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Republic Day Parade 2021 will be livestreamed at 9.00 am on Tuesday, January 26 on the YouTube channel of the Press Information Bureau (PIB) and DD National. The Republic Day 2021 livestream can also be accessed via the Republic Day Parade 2021 Android app that can be downloaded from the Google Play store. You can also watch the Republic Day Parade live telecast via a DTH connection such as Airtel, Dish TV, and Tata Sky.

#Entertainments
Field # Entertainments
Updated 26 January 2021

#5

 

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A single kilogram of this new aerogel can generate enough drinking water to meet a household's daily needs

#Materials
Field # Materials
Updated 26 January 2021

#6

 

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Exploiting nonlinear characteristics in micro/nanosystems has been a subject of increasing interest in the last decade. Among others, vigorous intermodal coupling through internal resonance (IR) has drawn much attention because it can suggest new strategies to steer energy within a micro/nanomechanical resonator. However, a challenge in utilizing IR in practical applications is imposing the required frequency commensurability between vibrational modes of a nonlinear micro/nanoresonator. Here, we experimentally and analytically investigate the 1:2 and 2:1 IR in a clamped–clamped beam resonator to provide insights into the detailed mechanism of IR. It is demonstrated that the intermodal coupling between the second and third flexural modes in an asymmetric structure (e.g., nonprismatic beam) provides an optimal condition to easily implement a strong IR with high energy transfer to the internally resonated mode. In this case, the quadratic coupling between these flexural modes, originating from the stretching effect, is the dominant nonlinear mechanism over other types of geometric nonlinearity. The design strategies proposed in this paper can be integrated into a typical micro/nanoelectromechanical system (M/NEMS) via a simple modification of the geometric parameters of resonators, and thus, we expect this study to stimulate further research and boost paradigm-shifting applications exploring the various benefits of IR in micro/nanosystems. Achieving strong ‘internal resonance’ within a simple nanoelectromechanical resonator opens doors to further research and practical applications. Hanna Cho, and a team from The Ohio State University and Michigan State University, United States, describe in their new paper how internal resonance (IR) offers a “unique pathway” to steer vibrational energy, with applications in signal detection and simultaneous physical property sensing. Robust achievement of IR has proved challenging, with the property first realized in the early 2010s. The team now describe the robust generation of IR by a “relatively simple” nanoelectromechanical resonator, and the design parameters that can be manipulated to alter resonance behaviors. The team hope that their blueprints can act as a stepping stone for deeper investigation into the exploitation of IR for various applications.

#Environment & Nature
Field # Environment & Nature
Updated 26 January 2021

#7

 

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Conquistadors murdered hundreds of Acolhua people, a sister culture of the Aztecs, after members of a Spanish caravan in Mexico were captured, sacrificed and eaten.

#Archaeology & History
Field # Archaeology & History
Updated 26 January 2021

#8

 

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A veteran rocket from billionaire entrepreneur Elon Musk’s SpaceX aerospace company launched 143 spacecraft into space on Sunday, a new record for the most spaceships deployed on a single mission, according to the company.

#Astronautics
Field # Astronautics
Updated 26 January 2021

#9

 

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“Social robots like me can take care of the sick or elderly,” Sophia says as she conducts a tour of her lab in Hong Kong. “I can help communicate, give therapy and provide social stimulation, even in difficult situations.”

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 26 January 2021

#10

 

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Italian consumer association Altroconsumo said it had told Apple it has launched a class action against the US tech giant for the practice of planned obsolescence.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#11

 

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For non-English users, using Google Maps could be frustrating. For starters, understanding that “एनआईटी from the acronym NIT is pronounced “en-aye-tee”, not as the English word “nit”.

#Software;#Maps
Field # Software
Updated 26 January 2021

#12

 

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Facebook Inc said it would provide academic researchers information on how political ads were targeted in the lead-up to the presidential election in the United States last year.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 26 January 2021

#13

 

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Padget Electronics, a subsidiary of Dixon Technologies, on Monday entered into a partnership to manufacture Nokia smartphones in India for HMD Global.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#14

 

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Union Budget 2021 will be like none other, Finance Minister Nirmala Sitharaman has promised. What does that mean for startups? A look at some of their budget expectations.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 26 January 2021

#15

 

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TBD

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 26 January 2021

#16

 

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The Ministry of Electronics and Information Technology has allegedly responded to PUBG Corporation in a notice.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#17

 

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The Indian variant of the Poco M3 could come with similar specs and features as the global variant.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 26 January 2021

#18

 

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In a major breach in security, users’ data of over 500 million Facebook users are being sold using a Telegram bot.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#19

 

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Apart from the bug fixes and optimisations, the new update also comes with the latest Google Security patch.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#20

 

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The OnePlus 9 Pro is tipped to come with a Snapdragon 888 chipset and a 4,500mAh battery with 65W fast charging.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#21

 

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FAU-G is short for Fearless and United Guards, the storyline of which is based on the Galwan Valley clash between India and China.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#22

 

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Apple is likely to equip the new iPhone models with sensor-shift optical image stabilisation which can bring their camera stabilisation very close to DSLRs.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#23

 

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If you have been planning to buy one of the newer iPhone models, this is probably the best time with Maple Online store offering great deals and discounts on all variants.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#24

 

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TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 26 January 2021

#25

 

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Great Fairy Fountains in The Legend of Zelda: Breath of the Wild let you upgrade your armor. Here's where to find every fairy fountain in Breath of the Wild.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#26

 

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You'll have to travel deep into Hyrule Castle to find Link's iconic shield. This guide will walk you through a few ways to find the most durable shield in BOTW.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#27

 

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For as long as video games have existed, there have been cheat codes. Here are some of the most famous cheat codes from historical games and a few modern ones.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#28

 

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Whether you're a seasoned Keyblade master or a new adventurer, we have some essential tips and tricks to help you on your journey through Kingdom Hearts 3.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#29

 

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TBD

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#30

 

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The $249 Polk Audio React soundbar can deliver virtual 5.1 surround sound on its own, or you can expand it with wireless speakers and a wireless subwoofer.

#Hardware & Devices;#Artificial intelligence
Field # Hardware & Devices
Updated 26 January 2021

#31

 

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A new Lego line made with Universal Music scans bricks to create AR music videos in your home.

#Entertainments;#Music
Field # Entertainments
Updated 26 January 2021

#32

 

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Compensatory mechanisms, such as a decrease in thoracic spine kyphosis and posterior tilting or rotation of the pelvis, aim to achieve optimal alignment of the spine. However, the effect of muscle strength on these compensatory mechanisms has not been elucidated. This study aimed to investigate the impact of back muscle and lower extremity strength on compensatory mechanisms in elderly people. Overall, 409 community-dwelling elderly participants (164 men, 245 women) were included. Age, disc degeneration, and 2 or more vertebral fractures showed a significant increase of risk for sagittal vertical axis (SVA) deterioration. Conversely, stronger back, hip flexor, and knee extensor muscles reduced the risk for SVA deterioration. To investigate the association of each muscle’s strength with compensatory mechanisms, 162 subjects with pelvic incidence-lumbar lordosis > 10° were selected. The linear regression model for thoracic kyphosis demonstrated a negative correlation with back muscle strength and positive correlation with vertebral fracture. The regression analysis for pelvic tilt demonstrated a positive correlation with knee extensor strength. Back, hip flexor, and knee extensor muscle strength were associated with sagittal spinal alignment. Back muscle strength was important for the decrease in thoracic kyphosis, and knee extensor strength was associated with pelvic tilt.

#Social & Corporation affairs;#Security;#Privacy
Field # Social & Corporation affairs
Updated 26 January 2021

#33

 

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Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#34

 

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Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeutic alternative. However, knowledge about how probiotics influence brain metabolite changes during HE is missing. In the present study, we combined the advantages of ultra-high field in vivo 1H MRS with behavioural tests to analyse whether a long-term treatment with a multistrain probiotic mixture (VIVOMIXX) in a rat model of type C HE had a positive effect on behaviour and neurometabolic changes. We showed that the prophylactic administration of this probiotic formulation led to an increase in gut Bifidobacteria and attenuated changes in locomotor activity and neurometabolic profile in a rat model of type C HE. Both the performance in behavioural tests and the neurometabolic profile of BDL + probiotic rats were improved compared to the BDL group at week 8 post-BDL. They displayed a significantly lesser increase in brain Gln, a milder decrease in brain mIns and a smaller decrease in neurotransmitter Glu than untreated animals. The clinical implications of these findings are potentially far-reaching given that probiotics are generally safe and well-tolerated by patients.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#35

 

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Wolfram syndrome (WS) is a monogenic progressive neurodegenerative disease and is characterized by various neurological symptoms, such as optic nerve atrophy, loss of vision, cognitive decline, memory impairment, and learning difficulties. GLP1 receptor agonist liraglutide and BDNF mimetic 7,8-dihydroxyflavone (7,8-DHF) have had protective effect to visual pathway and to learning and memory in different rat models of neurodegenerative disorders. Although synergistic co-treatment effect has not been reported before and therefore the aim of the current study was to investigate liraglutide, 7,8-DHF and most importantly for the first time their co-treatment effect on degenerative processes in WS rat model. We took 9 months old WS rats and their wild-type (WT) control animals and treated them daily with liraglutide, 7,8-DHF or with the combination of liraglutide and 7,8-DHF up to the age of 12.5 months (n = 47, 5–8 per group). We found that liraglutide, 7,8-DHF and their co-treatment all prevented lateral ventricle enlargement, improved learning in Morris Water maze, reduced neuronal inflammation, delayed the progression of optic nerve atrophy, had remyelinating effect on optic nerve and thereby improved visual acuity in WS rats compared to WT controls. Thus, the use of the liraglutide, 7,8-DHF and their co-treatment could potentially be used as a therapeutic intervention to induce neuroprotection or even neuronal regeneration.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#36

 

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Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p < 0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.2 ± 7.1 vs. 29.4 ± 9.7 units/L, p < 0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by 31phosphorus- and 1proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.

#Energy
Field # Energy
Updated 26 January 2021

#37

 

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Tinnitus is the chronic perception of a phantom sound with different levels of related distress. Past research has elucidated interactions of tinnitus distress with audiological, affective and further clinical variables. The influence of tinnitus distress on cognition is underinvestigated. Our study aims at investigating specific influences of tinnitus distress and further associated predictors on cognition in a cohort of n = 146 out-ward clinical tinnitus patients. Age, educational level, hearing loss, Tinnitus Questionnaire (TQ) score, tinnitus duration, speech in noise (SIN), stress, anxiety and depression, and psychological well-being were included as predictors of a machine learning regression approach (elastic net) in three models with scores of a multiple choice vocabulary test (MWT-B), or two trail-making tests (TMT-A and TMT-B), as dependent variables. TQ scores predicted lower MWT-B scores and higher TMT-B test completion time. Stress, emotional, and psychological variables were not found to be relevant predictors in all models with the exception of small positive influences of SIN and depression on TMT-B. Effect sizes were small to medium for all models and predictors. Results are indicative of specific influence of tinnitus distress on cognitive performance, especially on general or crystallized intelligence and executive functions. More research is needed at the delicate intersection of tinnitus distress and cognitive skills needed in daily functioning.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#38

 

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#Theoretical sciences
Field # Theoretical sciences
Updated 26 January 2021

#39

 

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Molecular biologists rely on the use of fluorescent probes to take measurements of their model systems. These fluorophores fall into various classes (e.g. fluorescent dyes, fluorescent proteins, etc.), but they all share some general properties (such as excitation and emission spectra, brightness) and require similar equipment for data acquisition. Selecting an ideal set of fluorophores for a particular measurement technology or vice versa is a multidimensional problem that is difficult to solve with ad hoc methods due to the enormous solution space of possible fluorophore panels. Choosing sub-optimal fluorophore panels can result in unreliable or erroneous measurements of biochemical properties in model systems. Here, we describe a set of algorithms, implemented in an open-source software tool, for solving these problems efficiently to arrive at fluorophore panels optimized for maximal signal and minimal bleed-through. Vaidyanathan et al. present a heuristic algorithm for the selection of fluorescent reporters in the context of single-cell analysis. They present a tool to enable biologists to design multi-colour fluorophore panels based on specific equipment’s configurations. The authors demonstrate the efficacy of their algorithm by comparing computational predictions with experimental observations.

#Hardware & Devices;#Gadgets
Field # Hardware & Devices
Updated 26 January 2021

#40

 

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Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins. PTMs contribute to regulation of protein function and thereby greatly increase the functional diversity of the proteome. In the heart, a few well-studied PTMs, such as phosphorylation and glycosylation, are known to play essential roles for cardiac function. Yet, only a fraction of the ~ 300 known PTMs have been studied in a cardiac context. Here we investigated the proteome-wide map of PTMs present in human hearts by utilizing high-resolution mass spectrometry measurements and a suite of PTM identification algorithms. Our approach led to identification of more than 150 different PTMs across three of the chambers in human hearts. This finding underscores that decoration of cardiac proteins by PTMs is much more diverse than hitherto appreciated and provides insights in cardiac protein PTMs not yet studied. The results presented serve as a catalogue of which PTMs are present in human hearts and outlines the particular protein and the specific amino acid modified, and thereby provides a detail-rich resource for exploring protein modifications in human hearts beyond the most studied PTMs.

#Theoretical sciences
Field # Theoretical sciences
Updated 26 January 2021

#41

 

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In vitro neuronal models are essential for studying neurological physiology, disease mechanisms and potential treatments. Most in vitro models lack controlled vasculature, despite its necessity in brain physiology and disease. Organ-on-chip models offer microfluidic culture systems with dedicated micro-compartments for neurons and vascular cells. Such multi-cell type organs-on-chips can emulate neurovascular unit (NVU) physiology, however there is a lack of systematic data on how individual cell types are affected by culturing on microfluidic systems versus conventional culture plates. This information can provide perspective on initial findings of studies using organs-on-chip models, and further optimizes these models in terms of cellular maturity and neurovascular physiology. Here, we analysed the transcriptomic profiles of co-cultures of human induced pluripotent stem cell (hiPSC)-derived neurons and rat astrocytes, as well as one-day monocultures of human endothelial cells, cultured on microfluidic chips. For each cell type, large gene expression changes were observed when cultured on microfluidic chips compared to conventional culture plates. Endothelial cells showed decreased cell division, neurons and astrocytes exhibited increased cell adhesion, and neurons showed increased maturity when cultured on a microfluidic chip. Our results demonstrate that culturing NVU cell types on microfluidic chips changes their gene expression profiles, presumably due to distinct surface-to-volume ratios and substrate materials. These findings inform further NVU organ-on-chip model optimization and support their future application in disease studies and drug testing.

#Hardware & Devices
Field # Hardware & Devices
Updated 26 January 2021

#42

 

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Kuschelorhynchus macadamiae is a major pest of macadamias in Australia, causing yield losses of up to 15%. Our previous studies have shown the weevil is susceptible to Beauveria bassiana and Metarhizium anisopliae. The aim of this study was to investigate horizontal transmission of both fungal species to healthy weevils from both infected adults and weevil cadavers. In a confined environment the mortality of healthy adults caused by the transmission of conidia from live fungus-infected adults was < 50%. Under similar experimental conditions, the mortality of healthy adults reached 100% when exposed to conidiated cadavers. However, when conidiated cadavers were used in more spacious environments (insect cages), the mortality of adults was < 80%. Using scanning electron microscopy, it was observed that all healthy adults had conidia attached to all external parts of the body. This suggests that although the conidia were readily transferred to the adults, the lower mortality in the larger insect cages could be the result of an unfavourable environmental factor such as low humidity. The presence of conidia attached to all the adults indicated that they did not show any discriminatory behaviour such as avoidance of conidiated cadavers infected by these two fungal species. The results from this study show that there is potential for enhanced control of adult K. macadamiae via transmission from either fungus-infected adults or conidiated cadavers and this could strengthen sustainable pest management in macadamias.

#Theoretical sciences
Field # Theoretical sciences
Updated 26 January 2021

#43

 

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Recent studies have found that the core–shell structured metal nanoparticles and porous carbon nanofibers (PCNF) are combined into a microwave absorbing material through electrospinning, which exhibits excellent microwave absorption performance. In this study, the core–shell structure Co nanoparticles prepared by the self-developed HEIBE process (production rate of > 50 g/h) were combined with porous carbon fibers, and their absorbing properties were greatly improved. The morphology of Co/PCNF demonstrated that CoNPs are randomly dispersed in the porous carbon nanofibers and carbon nanofiber form complex conductive network which enhances the dielectric loss of the materials. Meanwhile, the Co/PCNF has a low graphitization and shows a significant improvement in permittivity due to the combination of CoNPs and high conductivity of carbon material. The maximum reflection loss (RL) of Co/PCNF reaches − 63.69 dB at 5.28 GHz with a thickness of 5.21 mm and the absorption bandwidth (RL ≤  − 10.0 dB) is 12.92 GHz. In terms of 5.60 mm and 6.61 mm absorber, there are two absorption peaks of − 47.64 dB and − 48.30 dB appear around 12.50 GHz and 14.10 GHz, respectively. The results presented in this paper may pave a way for promising applications of lightweight and high-efficiency microwave absorbing materials (MAMs).

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 26 January 2021

#44

 

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The quantum secure multiparty computation is one of the important properties of secure quantum communication. In this paper, we propose a quantum secure multiparty summation (QSMS) protocol based on (t, n) threshold approach, which can be used in many complex quantum operations. To make this protocol secure and realistic, we combine both the classical and quantum phenomena. The existing protocols have some security and efficiency issues because they use (n, n) threshold approach, where all the honest players need to perform the quantum multiparty summation protocol. We however use a (t, n) threshold approach, where only t honest players need to compute the quantum summation protocol. Compared to other protocols our proposed protocol is more cost-effective, realistic, and secure. We also simulate it using the IBM corporation’s online quantum computer, or quantum experience.

#Hardware & Devices
Field # Hardware & Devices
Updated 26 January 2021

#45

 

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As silver nanowires (Ag NWs) are usually manufactured by chemical synthesis, a patterning process is needed to use them as functional devices. Pulsed laser ablation is a promising Ag NW patterning process because it is a simple and inexpensive procedure. However, this process has a disadvantage in that target materials are wasted owing to the subtractive nature of the process involving the removal of unnecessary materials, and large quantities of raw materials are required. In this study, we report a minimum-waste laser patterning process utilizing silver nanoparticle (Ag NP) debris obtained through laser ablation of Ag NWs in liquid media. Since the generated Ag NPs can be used for several applications, wastage of Ag NWs, which is inevitable in conventional laser patterning processes, is dramatically reduced. In addition, electrophoretic deposition of the recycled Ag NPs onto non-ablated Ag NWs allows easy fabrication of junction-enhanced Ag NWs from the deposited Ag NPs. The unique advantage of this method lies in using recycled Ag NPs as building materials, eliminating the additional cost of junction welding Ag NWs. These fabricated Ag NW substrates could be utilized as transparent heaters and stretchable TCEs, thereby validating the effectiveness of the proposed process.

#Hardware & Devices;#Laser
Field # Hardware & Devices
Updated 26 January 2021

#46

 

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When magnetic properties are analysed in a transmission electron microscope using the technique of electron magnetic circular dichroism (EMCD), one of the critical parameters is the sample orientation. Since small orientation changes can have a strong impact on the measurement of the EMCD signal and such measurements need two separate measurements of conjugate EELS spectra, it is experimentally non-trivial to measure the EMCD signal as a function of sample orientation. Here, we have developed a methodology to simultaneously map the quantitative EMCD signals and the local orientation of the crystal. We analyse, both experimentally and by simulations, how the measured magnetic signals evolve with a change in the crystal tilt. Based on this analysis, we establish an accurate relationship between the crystal orientations and the EMCD signals. Our results demonstrate that a small variation in crystal tilt can significantly alter the strength of the EMCD signal. From an optimisation of the crystal orientation, we obtain quantitative EMCD measurements.

#Theoretical sciences
Field # Theoretical sciences
Updated 26 January 2021

#47

 

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Laser-driven proton acceleration is a growing field of interest in the high-power laser community. One of the big challenges related to the most routinely used laser-driven ion acceleration mechanism, Target-Normal Sheath Acceleration (TNSA), is to enhance the laser-to-proton energy transfer such as to maximize the proton kinetic energy and number. A way to achieve this is using nanostructured target surfaces in the laser-matter interaction. In this paper, we show that nanowire structures can increase the maximum proton energy by a factor of two, triple the proton temperature and boost the proton numbers, in a campaign performed on the ultra-high contrast 10 TW laser at the Lund Laser Center (LLC). The optimal nanowire length, generating maximum proton energies around 6 MeV, is around 1–2  $$upmu$$ m. This nanowire length is sufficient to form well-defined highly-absorptive NW forests and short enough to minimize the energy loss of hot electrons going through the target bulk. Results are further supported by Particle-In-Cell simulations. Systematically analyzing nanowire length, diameter and gap size, we examine the underlying physical mechanisms that are provoking the enhancement of the longitudinal accelerating electric field. The parameter scan analysis shows that optimizing the spatial gap between the nanowires leads to larger enhancement than by the nanowire diameter and length, through increased electron heating.

#Hardware & Devices;#Laser
Field # Hardware & Devices
Updated 26 January 2021

#48

 

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Name
Description
The set of known stable phases of water may not be complete, and some of the phase boundaries between them are fuzzy. Starting from liquid water and a comprehensive set of 50 ice structures, we compute the phase diagram at three hybrid density-functional-theory levels of approximation, accounting for thermal and nuclear fluctuations as well as proton disorder. Such calculations are only made tractable because we combine machine-learning methods and advanced free-energy techniques. The computed phase diagram is in qualitative agreement with experiment, particularly at pressures ≲ 8000 bar, and the discrepancy in chemical potential is comparable with the subtle uncertainties introduced by proton disorder and the spread between the three hybrid functionals. None of the hypothetical ice phases considered is thermodynamically stable in our calculations, suggesting the completeness of the experimental water phase diagram in the region considered. Our work demonstrates the feasibility of predicting the phase diagram of a polymorphic system from first principles and provides a thermodynamic way of testing the limits of quantum-mechanical calculations. Complex interatomic interactions and diverse structures make computing the phase diagram of water very challenging. Here, a combination of machine learning and advanced free-energy methods at three levels of hybrid DFT enables the prediction of the phase diagram in close agreement with experiment.

#Hardware & Devices
Field # Hardware & Devices
Updated 26 January 2021

#49

 

View it
Name
Description
TBD

#Archaeology & History
Field # Archaeology & History
Updated 26 January 2021

#50

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 26 January 2021

#51

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#52

 

View it
Name
Description
Invite-only audio social network Clubhouse is readying to let in the masses with the help of a fresh funding round reported to value it at nearly a billion dollars.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 26 January 2021

#53

 

View it
Name
Description
WATCH LIVE: Samsung announce major mobile phone developments

#Gadgets
Field # Gadgets
Updated 26 January 2021

#54

 

View it
Name
Description
TBD

#Gadgets
Field # Gadgets
Updated 26 January 2021

#55

 

View it
Name
Description
TBD

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 26 January 2021

#56

 

View it
Name
Description
Amazon's iOS app has a new icon, and it's a bit more colorful than the last one.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 26 January 2021

#57

 

View it
Name
Description
It appears the UK's B.1.1.7 coronavirus variant is slightly more deadly and more transmissible than other variants, but improved treatments may limit the risk of death if you are infected

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#58

 

View it
Name
Description
The new FAU-G, aka Fearless and United Guards, game is now available on Google Play as a free download. Users can go to the Google Play store on their Android smartphones and download FAU-G. The game is compatible with handsets running Android 8 and above.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#59

 

View it
Name
Description
It’s been few days since the Samsung Galaxy S21 series was launched in India. The hype has settled and it’s time to take a closer look at what’s on offer and whether you should spend on it or not.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#60

 

View it
Name
Description
FAU-G review: After a lot of ‘halla’, multiple trailers and long wait, FAU-G or Fearless and United Guards is now available for download via Google Play Store.

#Entertainments;#Games
Field # Entertainments
Updated 26 January 2021

#61

 

View it
Name
Description
The phone's Snapdragon 870 SoC could be paired with 8GB of LPDDR5 RAM and up to 256GB of UFS 3.1 storage.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#62

 

View it
Name
Description
There is a strong chance that Clubhouse turns out to be the next big smartphone app. The audio-based social networking platform has seen immense growth in last few months and is becoming increasingly popular among users.

#Software
Field # Software
Updated 26 January 2021

#63

 

View it
Name
Description
Facebook landed in a soup recently when a security researcher unearthed that the phone numbers of Facebook users are being sold using a Telegram bot

#Gadgets
Field # Gadgets
Updated 26 January 2021

#64

 

View it
Name
Description
Along with discounts on some of the popular smartphones, Flipkart is offering bank offers and exchange offers to further sweeten the deals.

#Gadgets
Field # Gadgets
Updated 26 January 2021

#65

 

View it
Name
Description
Google said it's working with authoritative sources including government agencies and retail pharmacies for the information.

#Medicine & Human body
Field # Medicine & Human body
Updated 26 January 2021

#66

 

View it
Name
Description
Priced at an aggressive Rs 54,999, the Mi QLED TV 4K attempts to take on offerings from OnePlus and TCL. But is it worth your money?

#Entertainments
Field # Entertainments
Updated 26 January 2021

#67

 

View it
Name
Description
Researchers think dogs were first domesticated in Siberia, and humans took them along as they migrated.

#Archaeology & History
Field # Archaeology & History
Updated 26 January 2021

#68

 

View it
Name
Description
TBD

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 26 January 2021

#69

 

View it
Name
Description
EdgeQ reveals its new "base-station-on-a-chip" that combines 5G and AI functions to replace multiple hardware components, including Intel CPUs and FPGAs.

#Hardware & Devices
Field # Hardware & Devices
Updated 26 January 2021

#70

 

View it
Name
Description
OnePlus 9 Pro and OnePlus 9 could both have 120Hz refresh rate, as per a tipster. OnePlus 9 Pro could feature a 6.8-inch Quad HD+ curved display, while OnePlus 9 may have a 6.55-inch full-HD+ flat display. The phones, rumoured to launch in March, are tipped to weigh less than 200 grams.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#71

 

View it
Name
Description
Apple has cautioned users that implanted pacemakers, defibrillators and other medical implants might contain sensors that respond to magnets in iPhones and MagSafe accessories. Users are advised to keep their iPhones and MagSafe accessories a safe distance away (more than 6 inches/ 15 cm apart or more than 12 inches/ 30 cm apart if wirelessly charging). &ldquo;But consult with your physician and your device manufacturer for specific guidelines,&rdquo; says the support page.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#72

 

View it
Name
Description
Google CEO Sundar Pichai has announced via a blog post that the company&rsquo;s offices in the US will be used as COVID-19 vaccination centres. Google has also pledged $150 million (roughly Rs. 1,090 crores) for programmes to promote vaccine education.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#73

 

View it
Name
Description
Google and other tech behemoths will have to eventually pay for using media content, Australia has said. Responding to the Internet giant&rsquo;s threat to disable its search engine in the country if it&rsquo;s forced to pay local publishers for news, Australia&rsquo;s Treasurer Josh Frydenberg said that paying for new was &ldquo;inevitable&rdquo;.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#74

 

View it
Name
Description
MIUI 12 boasts a ton of new improvements, but it still features pesky ads in its interface. Here&rsquo;s how you can remove them.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#75

 

View it
Name
Description
A new Star Wars: Knights of the Old Republic game is reportedly in development, but not at BioWare or Electronic Arts. Reports note that Star Wars fans will &ldquo;never guess&rdquo; which studio is behind it.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#76

 

View it
Name
Description
Razer&rsquo;s latest gaming mouse has 16 programmable buttons and a right-handed ergonomic design. The Razer Naga X gaming mouse is designed for massively multiplayer online (MMO) gamers. It is priced at $79.99 (roughly Rs. 5,800) and is available for purchase from Razer&rsquo;s website. The gaming mouse features the Razer Chroma RGB lighting.

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#77

 

View it
Name
Description
Netflix is rolling out a significant update that promises to improve sound quality on Android devices running version 9 and above. The xHE-AAC codec is said to offer studio-quality audio, better reliability on mobile data, and more.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#78

 

View it
Name
Description
OnePlus Buds Z Steven Harrington Edition truly wireless (TWS) earbuds have been launched in India as a limited edition of the regular OnePlus Buds Z. The new earbuds come in a two-tone purple and mint colour option.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#79

 

View it
Name
Description
The main YouTube site can now be installed as a Progressive Web App (PWA) for quicker access. Google had recently announced that it was bringing Stadia to iOS as a PWA. After the PWA is installed, the users get a large red play logo in the app launcher to open YouTube in a window that doesn&rsquo;t have the address bar among other user interface elements.

#Software
Field # Software
Updated 25 January 2021

#80

 

View it
Name
Description
Microsoft has added the capability to drag and drop files from Outlook to Teams. With this feature, users can move attachments between the two apps easily. Until now, users had to first drag the files onto a location like the desktop, and drag them from there to the files tab in Teams.

#Software;#Social & Corporation affairs
Field # Software
Updated 25 January 2021

#81

 

View it
Name
Description
Elon Musk&rsquo;s SpaceX set a new record on Sunday for the most spaceships deployed on a single mission with the launch of 143 spacecraft into space via its Falcon 9 reusable rocket.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#82

 

View it
Name
Description
Tesla has filed a case against a former employee, Alex Khatilov, who the company says stole 26,000 confidential files within three days of being hired, according to a court filing.

#Vehicles & Special machines
Field # Vehicles & Special machines
Updated 25 January 2021

#83

 

View it
Name
Description
Xiaomi might expand its Note line up next month with the launch of the Redmi Note 10 in India. The smartphone has been teased for the very first time by company’s general manager Lu Weibing through a Weibo post.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#84

 

View it
Name
Description
The Redmi K40 series is set for launch next month. Here's what we know about it so far.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#85

 

View it
Name
Description
Realme C20 comes as the company's first entry-level smartphone of the year 2021.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#86

 

View it
Name
Description
Realme is working on the successor of the Buds Q that impressed me last year.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#87

 

View it
Name
Description
Oppo has launched a new smartphone in China called the A55 5G that is powered by a MediaTek Dimensity 700 processor.

#Energy
Field # Energy
Updated 25 January 2021

#88

 

View it
Name
Description
The OnePlus Buds Z Steven Harrington Edition brings the same hardware as the OnePlus Buds Z truly wireless (TWS) earbuds.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#89

 

View it
Name
Description
HMD Global may be close to launching the Nokia 1.4, Nokia 6.4, and Nokia 7.4 as early as February this year.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#90

 

View it
Name
Description
It is finally out that Nikon Z7 mirrorless camera uses Sony-made sensor. The code name of the image sensor is Sony IMX309BQJ.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#91

 

View it
Name
Description
Canon will soon release a firmware update for Canon EOS R5 with two major improvements including C-Log 3 support and 1080p video capture at up to 120FPS.

#Software;#Security
Field # Software
Updated 25 January 2021

#92

 

View it
Name
Description
BSNL has extended the availability of its Rs 699 prepaid plan in the Kerala circle as part of its Republic Day offer. The plan is ideal for customers looking for unlimited calling benefits and long validity.

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 25 January 2021

#93

 

View it
Name
Description
The core OnePlus 9 series phone are tipped to come with the Snapdragon 888 SoC under the hood.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#94

 

View it
Name
Description
The iPhone 13 lineup is expected to see a couple of major improvements in design, display, cameras, authentication and more. Read this story to find out everything we know so far about the upcoming iPhone 13 lineup.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#95

 

View it
Name
Description
FAU-G is said to be based on real-world scenarios and has already been confirmed that the game's first level is based on Galwan Valley.

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#96

 

View it
Name
Description
Coronavirus can infect a wide range of species including cats, dogs, mink and other domesticated species, experts said.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#97

 

View it
Name
Description
The technology could be used for the treatment of brain, head, and neck cancers.

#Hardware & Devices;#Laser
Field # Hardware & Devices
Updated 25 January 2021

#98

 

View it
Name
Description
It’s vital to keep your blood pressure healthy. This is how I keep an eye on mine.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#99

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#100

 

View it
Name
Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#101

 

View it
Name
Description
Five cybersecurity vendors disclosed in recent weeks that hackers have attacked their internal systems, compromised their certificates, or attempted to access their email accounts. Here’s a rundown of what happened when.

#Software;#Security
Field # Software
Updated 25 January 2021

#102

 

View it
Name
Description
New IBM SVP Bob Lord says the company is upping its partner game as it sharpens its focus on Red Hat OpenShift as the standard for hybrid cloud and AI.

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#103

 

View it
Name
Description
Robin.io is beefing up its channel program to better serve Kubernetes and cloud-native application solution providers.

#Social & Corporation affairs;#Vehicles & Special machines
Field # Social & Corporation affairs
Updated 25 January 2021

#104

 

View it
Name
Description
SonicWall’s 21,000 channel partners had a very long weekend after the company admitted a sophisticated cyberattack against its internal systems had revealed zero-day product vulnerabilities.

#Software;#Security
Field # Software
Updated 25 January 2021

#105

 

View it
Name
Description
Here is a look at why IBM CEO Arvind Krishna has named IBM Senior Vice President Bob Lord as the new head of worldwide ecosystems and blockchain.

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#106

 

View it
Name
Description
Here's a look at why Hewlett Packard Enterprise has snatched away a channel veteran from HP to oversee its worldwide distribution business.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#107

 

View it
Name
Description
It was said that all he touched turned to gold. But destiny eventually caught up with the legendary King Midas, and a long-lost chronicle of his ancient downfall appears to have literally surfaced in Turkey.

#Archaeology & History
Field # Archaeology & History
Updated 25 January 2021

#108

 

View it
Name
Description
Moncef Slaoui candidly discusses Trump, the shortcomings of the COVID-19 vaccine rollout, and the joy of getting his first dose

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#109

 

View it
Name
Description
Researchers combine ancient DNA from people and dogs to spell out story of dog domestication

#Archaeology & History
Field # Archaeology & History
Updated 25 January 2021

#110

 

View it
Name
Description
On Sunday (Jan. 24), SpaceX launched the Transporter-1 mission with an incredible 143 satellites. Not everyone is celebrating, though.  ...

#Astronautics
Field # Astronautics
Updated 25 January 2021

#111

 

View it
Name
Description
TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#112

 

View it
Name
Description
The Iranian government is shutting down some 1,6000 cryptocurrency mining operations after several major power outages sweeped the country.

#Software;#Finance
Field # Software
Updated 25 January 2021

#113

 

View it
Name
Description
Valve CEO Gabe Newell says his company is working on a brain-computer interface (BCI) headset that can make video games more immersive than ever.

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#114

 

View it
Name
Description
The Apple Watch series has a new chip for faster processing and even more health and fitness monitoring.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#115

 

View it
Name
Description
The mouse species survived a devastating volcano eruption in the Philippines.

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#116

 

View it
Name
Description
Keep the beer cold and the dips hot with these handy game-day gadgets.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#117

 

View it
Name
Description
In response to iPhone 12 fears, Apple updates support hub with revised guidance.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#118

 

View it
Name
Description
Dolly Parton, Shawn Mendes, and more lend their voices to the first episodes.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#119

 

View it
Name
Description
After testing to 628mph in 2019, the car now needs its rocket engine integrated.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#120

 

View it
Name
Description
It's unclear whether AT&T will maintain operational control of DirecTV.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#121

 

View it
Name
Description
Over 20 years later, "Cloud in a dress" isn't just treated as a joke.

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#122

 

View it
Name
Description
This article presents a retrospective descriptive analysis about female-to-male (FtM) gender-affirmation nongenital surgical procedures involving the gynecological team at the CIDIGeM (Centro Interdipartimentale Disturbi di Identità di Genere Molinette) Center in Turin. From 2004 to 2019, seventy FtM transsexual patients underwent hysteroannessiectomy: the chosen surgical technique involved a Total Laparoscopic Hysterectomy. The patients presented a median age of 30.5 years (range 21–53). No patients presented intraoperative complications, the median of surgery time was 80 min (range 40–150) and the hospital stay median was 5 days (range: 2–25). Histopathological examinations were negative for cancer in all patients except for one unknown case of grade 3 cervical intraepithelial neoplasia. Total Laparoscopic Hysterectomy is confirmed to be the method of choice in the group of FtM transsexuals: this approach has several advantages over abdominal hysterectomy, including more rapid recovery, fewer wound or abdominal wall infections; moreover, it has enabled us to preserve the vital structures needed for reconstruction of external genitalia. Cancer risk is still considered an area of priority in transgender research; thus, we underline the importance of performing a histopathological examination of the surgical specimen.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#123

 

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Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#124

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#125

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#126

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#127

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#128

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#129

 

View it
Name
Description
TBD

#Energy
Field # Energy
Updated 25 January 2021

#130

 

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Name
Description
Our bodies send out hosts of signals—chemicals, electrical pulses, mechanical shifts—that can provide a wealth of information about our health.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#131

 

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Name
Description
Scientists excavating a new species of dinosaur in Argentina have reported that the specimen might be the largest that ever ...

#Archaeology & History
Field # Archaeology & History
Updated 25 January 2021

#132

 

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Name
Description
A chilling episode of the Twilight Zone that first aired 60 years ago focused on a young boy (played by Bill Mumy) who frustrated his parents by insisting he speaks to his grandmother daily on the toy phone she had given ...

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 25 January 2021

#133

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#134

 

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Name
Description
Apple is warning owners of the iPhone 12 and any MagSafe charging accessories to keep the gadgets at a "safe distance" from medical devices.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#135

 

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Name
Description
TBD

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 25 January 2021

#136

 

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Name
Description
Airlines could save fuel and reduce emissions on transatlantic flights by hitching a better ride on the jet stream, new research has shown.

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#137

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#138

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#139

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#140

 

View it
Name
Description
TBD

#Software;#Security
Field # Software
Updated 25 January 2021

#141

 

View it
Name
Description
Steve Jurczyk was catapulted from third-in-line to acting leader of NASA when Biden took office. Here's some of what we know about him and his leadership.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#142

 

View it
Name
Description
In Birdwatch, a new pilot program, Twitter users can apply to add contextual notes to tweets that seem misleading.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#143

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#144

 

View it
Name
Description
Apple's new Time to Walk feature on Fitness+ automatically downloads episodes to your Apple Watch. Here's how to turn off the setting.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#145

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#146

 

View it
Name
Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#147

 

View it
Name
Description
Overprovisioning and leaving cloud resources on are two enormous sources of wasted spend. Wasted spend drags down IT budgets –…...

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#148

 

View it
Name
Description
Once championed as the future of how we would control all kinds of Samsung hardware, the Bixby virtual assistant has steadily been silenced over the past years.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#149

 

View it
Name
Description
If you have a pacemaker or some other medical device fitted, and also own an iPhone 12 and/or any MagSafe accessories, then you need to exercise some caution.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#150

 

View it
Name
Description
Our review of Dell’s OptiPlex 7780 All-In-One finds strong performance and terrific display quality, along with some helpful collaboration features.

#Software
Field # Software
Updated 25 January 2021

#151

 

View it
Name
Description
Big data database and analysis system developer Ocient raises $40 million.

#Software
Field # Software
Updated 25 January 2021

#152

 

View it
Name
Description
Notebooks from Alienware, Asus, Dell, HP, MSI and Razer are on sale.

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#153

 

View it
Name
Description
If you're planning to upgrade your TV for Super Bowl LV, Walmart is selling this 65-inch TCL QLED TV at $423 off and this 55-inch Samsung QLED TV at $302 off.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#154

 

View it
Name
Description
SN9 is on deck to boldly follow in the footsteps of SN8, which bravely sacrificed itself in the name of iteration.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#155

 

View it
Name
Description
New displays will consume 16% less power, the electronics giant says.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#156

 

View it
Name
Description
A veteran rocket from billionaire entrepreneur Elon Musk’s SpaceX aerospace company launched 143 spacecraft into space on Sunday, a new record.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#157

 

View it
Name
Description
Support for other Wacom products is in the works, too.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#158

 

View it
Name
Description
WHO scientists are in China to investigate where the coronavirus came from and how it spilled into humans. The trip is the focus of intense political scrutiny.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#159

 

View it
Name
Description
The five nonprofits share names with either the Oath Keepers and the Three Percent movement.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#160

 

View it
Name
Description
Moderna is tweaking its coronavirus vaccine to make it more effective against emerging variants of the virus, the company announced Monday.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#161

 

View it
Name
Description
Like Parler, Telegram is facing allegations of being used to encourage racism and violence.

#Software
Field # Software
Updated 25 January 2021

#162

 

View it
Name
Description
Archaeologists have discovered traces of a 200-year-old wooden fort in southeastern Alaska built by Indigenous people to resist an invasion by Imperial Russia.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#163

 

View it
Name
Description
This AI robot dog not only climbs stairs but also interacts socially with its human owners.

#Artificial intelligence
Field # Artificial intelligence
Updated 25 January 2021

#164

 

View it
Name
Description
Can you smell what Peacock is cooking?

#Entertainments
Field # Entertainments
Updated 25 January 2021

#165

 

View it
Name
Description
Live TV streaming services like AT&T TV, Hulu Live and YouTube TV offer ABC, ESPN, TNT, NBA TV and more. So which one is the best for basketball fans?

#Entertainments
Field # Entertainments
Updated 25 January 2021

#166

 

View it
Name
Description
The move follows employees unionizing in the US.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#167

 

View it
Name
Description
Over four and a half years, a home security technician gave himself access to more than 200 ADT Pulse accounts in order to spy on female customers.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#168

 

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Description
Vaccine site listings will show access requirements and appointment info.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#169

 

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Biden admin officials work to manage expectations on topsy-turvy vaccine rollout.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#170

 

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The graves may belong to people who worshipped the pharaoh Teti, buried nearby.

#Archaeology & History
Field # Archaeology & History
Updated 25 January 2021

#171

 

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The Sondors Metacycle will have a range of 80 miles and a top speed of 85mph.

#Materials
Field # Materials
Updated 25 January 2021

#172

 

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Since the end of World War II, the US and allies have tried to network-enable war.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#173

 

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"Remember when Bob got hacked by Russian malware [and] ran naked through forests?"

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#174

 

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It's only been about six weeks since SN8 flew.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#175

 

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Head-down bed rest (HDBR) has previously been shown to alter cerebrovascular and autonomic control. Previous work found that sustained HDBR (≥ 20 days) attenuates the hypercapnic ventilatory response (HCVR); however, little is known about shorter-term effects of HDBR nor the influence of HDBR on the hypoxic ventilatory response (HVR). We investigated the effect of 4-h HDBR on HCVR and HVR and hypothesized attenuated ventilatory responses due to greater carotid and brain blood flow. Cardiorespiratory responses of young men (n = 11) and women (n = 3) to 5% CO2 or 10% O2 before and after 4-h HDBR were examined. HDBR resulted in lower HR, lower cardiac output index, lower common carotid artery flow, higher SpO2, and higher pulse wave velocity. After HDBR, tidal volume and ventilation responses to 5% CO2 were enhanced (all P < 0.05), yet no other changes in cardiorespiratory variables were evident. There was no influence of HDBR on the cardiorespiratory responses to hypoxia (all P > 0.05). Short-duration HDBR does not alter the HVR, yet enhances the HCVR, which we hypothesize is a consequence of cephalic CO2 accumulation from cerebral congestion.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#176

 

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Because the liver plays a major role in metabolic homeostasis and secretion of clotting factors and inflammatory innate immune proteins, there is interest in understanding the mechanisms of hepatic cell activation under hyperglycaemia and whether this can be attenuated pharmacologically. We have previously shown that hyperglycaemia stimulates major changes in chromatin organization and metabolism in hepatocytes, and that the histone deacetylase inhibitor valproic acid (VPA) is able to reverse some of these metabolic changes. In this study, we have used RNA-sequencing (RNA-seq) to investigate how VPA influences gene expression in hepatocytes. Interesting, we observed that VPA attenuates hyperglycaemia-induced activation of complement and coagulation cascade genes. We also observe that many of the gene activation events coincide with changes to histone acetylation at the promoter of these genes indicating that epigenetic regulation is involved in VPA action.

#Sport & Camping
Field # Sport & Camping
Updated 25 January 2021

#177

 

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TBD

#Construction;#Agriculture & Gardening;#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#178

 

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Retinoic acid and retinoid acid receptor (RA-RAR) signaling exhibits suppressive functions in the progression of hepatocellular carcinoma (HCC) through multiple mechanisms. However, whether RA-RAR signaling induces autophagy that contributes its anti-tumor activity in HCC remains elusive. In the current study, the effects of RA-RAR pathway on autophagy were investigated in two HCC cell lines: alpha-fetoprotein (AFP) positive PLC/PRF/5 and AFP negative HLE cells. Cell autophagy was analyzed with western blot for detection of LC3 conversion and p62/SQSTM1 degradation while autophagy flux was assayed using the mRFP-GFP-LC3 reporter. Cell apoptosis and viability were analyzed by caspase-3 activity, TdT-mediated dUTP nick end labeling (TUNEL) assay, and Cell Counting Kit (CCK)-8, respectively. Chromatin immunoprecipitation (ChIP) was employed to detect the binding of RAR onto the promoter of autophagy-relevant 7 (ATG7), and co-immunoprecipitation (CoIP) was used to analyze the interaction of AFP and RAR. The results showed that ATRA dosage and time-dependently induced high levels of cell autophagy in both the PLC/PRF/5 and HLE cells, which was accompanied with up-regulation of ATG7. ChIP assay showed that RAR was able to bind to its responsive elements on ATG7 promoter. Impairment of ATG7 induction or blockade of autophagy with chloroquine aggravated ATRA induced apoptosis of HCC cells. Furthermore, intracellular AFP was able to complex with RAR in PLC/PRF/5 cells. Knockdown of AFP in PLC/PRF/5 cells augmented the up-regulation of ATG7 by ATRA while overexpression of AFP in HLE cells attenuated ATRA induced ATG7 expression and autophagy. Thus, ATRA induced ATG7 and autophagy participated in its cytotoxicity on HCC cells and AFP interfere with the induction of ATG7 and autophagy through forming complex with RAR.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#179

 

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Behavioural interventions tailored to psychological characteristics of an individual can effectively achieve risk-reducing behaviour. The impact of tailored interventions on population-level chlamydia prevalence is unknown. We aimed to assess the impact on overall chlamydia prevalence five years after the introduction of an intervention aimed at increasing self-efficacy, social norms, attitudes and intentions towards condom use (i.e., condom intervention), and an intervention aimed at increasing health goals and decreasing impulsiveness (i.e., impulsiveness intervention). A pair model, informed by longitudinal psychological and behavioural data of young heterosexuals visiting sexual health centers, with susceptible-infected-susceptible structure was developed. The intervention effect was defined as an increased proportion of each subgroup moving to the desired subgroup (i.e., lower risk subgroup). Interventions tailored to subgroup-specific characteristics, assuming differential intervention effects in each subgroup, more effectively reduced overall chlamydia prevalence compared to non-tailored interventions. The most effective intervention was the tailored condom intervention, which was assumed to result in a relative reduction in chlamydia prevalence of 18% versus 12% in the non-tailored scenario. Thus, it is important to assess multiple psychological and behavioural characteristics of individuals. Tailored interventions may be more successful in achieving risk-reducing behaviour, and consequently, reduce chlamydia prevalence more effectively.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#180

 

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Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target for muscle disease therapy because of its role as a negative regulator of muscle growth and strength. Here, we describe a novel antibody therapeutic approach that maximizes the potential of myostatin-targeted therapy. We generated an antibody, GYM329, that specifically binds the latent form of myostatin and inhibits its activation. Additionally, via “sweeping antibody technology”, GYM329 reduces or “sweeps” myostatin in the muscle and plasma. Compared with conventional anti-myostatin agents, GYM329 and its surrogate antibody exhibit superior muscle strength-improvement effects in three different mouse disease models. We also demonstrate that the superior efficacy of GYM329 is due to its myostatin specificity and sweeping capability. Furthermore, we show that a GYM329 surrogate increases muscle mass in normal cynomolgus monkeys without any obvious toxicity. Our findings indicate the potential of GYM329 to improve muscle strength in patients with muscular disorders.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#181

 

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Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology is not fully understood and for which no effective treatment is available. Recently, research has focused on the dysbiosis of gut microbiome in UC. However, the results so far remain inconsistent and insufficient to understand the microbial component in UC pathogenesis. In this study, we determine specific changes in the gut microbial profile in Polish UC patients compared to healthy subjects for the first time. Using 16S rRNA gene-based analysis we have described the intestinal microbial community in a group of 20 individuals (10 UC patients and 10 controls). Our results after multiple hypothesis testing correction demonstrated substantially lower gut microbiome diversity in UC cases compared to the controls and considerable differences at the phylum level, as well as among 13 bacterial families and 20 bacterial genera (p < 0.05). UC samples were more abundant in Proteobacteria (8.42%), Actinobacteria (6.89%) and Candidate Division TM7 (2.88%) than those of healthy volunteers (2.57%, 2.29% and 0.012%, respectively). On the other hand, Bacteroidetes and Verrucomicrobia were presented at a lower level in UC relative to the controls (14% and 0% vs 27.97% and 4.47%, respectively). In conclusion, our results show a reduced gut microbial diversity in Polish UC patients, a reduction of taxa with an anti-inflammatory impact and an increased abundance of potentially pathogenic bacteria.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#182

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#183

 

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The effect of altitude on the risk of sudden infant death syndrome (SIDS) has been reported previously, but with conflicting findings. We aimed to examine whether the risk of sudden unexpected infant death (SUID) varies with altitude in the United States. Data from the Centers for Disease Control and Prevention (CDC)’s Cohort Linked Birth/Infant Death Data Set for births between 2005 and 2010 were examined. County of birth was used to estimate altitude. Logistic regression and Generalized Additive Model (GAM) were used, adjusting for year, mother’s race, Hispanic origin, marital status, age, education and smoking, father’s age and race, number of prenatal visits, plurality, live birth order, and infant’s sex, birthweight and gestation. There were 25,305,778 live births over the 6-year study period. The total number of deaths from SUID in this period were 23,673 (rate = 0.94/1000 live births). In the logistic regression model there was a small, but statistically significant, increased risk of SUID associated with birth at > 8000 feet compared with < 6000 feet (aOR = 1.93; 95% CI 1.00–3.71). The GAM showed a similar increased risk over 8000 feet, but this was not statistically significant. Only 9245 (0.037%) of mothers gave birth at > 8000 feet during the study period and 10 deaths (0.042%) were attributed to SUID. The number of SUID deaths at this altitude in the United States is very small (10 deaths in 6 years).

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#184

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#185

 

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In the era where antibiotic resistance is considered one of the major worldwide concerns, bacteriophages have emerged as a promising therapeutic approach to deal with this problem. Genetically engineered bacteriophages can enable enhanced anti-bacterial functionalities, but require cloning additional genes into the phage genomes, which might be challenging due to the DNA encapsulation capacity of a phage. To tackle this issue, we designed and assembled for the first time synthetic phages with smaller genomes by knocking out up to 48% of the genes encoding hypothetical proteins from the genome of the newly isolated Pseudomonas aeruginosa phage vB_PaeP_PE3. The antibacterial efficacy of the wild-type and the synthetic phages was assessed in vitro as well as in vivo using a Galleria mellonella infection model. Overall, both in vitro and in vivo studies revealed that the knock-outs made in phage genome do not impair the antibacterial properties of the synthetic phages, indicating that this could be a good strategy to clear space from phage genomes in order to enable the introduction of other genes of interest that can potentiate the future treatment of P. aeruginosa infections.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#186

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#187

 

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In response to the drawbacks of autograft donor-site morbidity and bone morphogenetic protein type 2 (BMP2) carcinogenesis and ectopic bone formation, there has been an increased research focus towards developing alternatives capable of achieving spatial control over bone formation. Here we show for the first time both osteogenic differentiation and mineralization (from solution or mediated by cells) occurring within predetermined microscopic patterns. Our results revealed that both PEGylated BMP2 and nacre proteins induced stem cell osteodifferentiation in microscopic patterns when these proteins were covalently bonded in patterns onto polyethylene glycol diacrylate (PEGDA) hydrogel substrates; however, only nacre proteins induced mineralization localized to the micropatterns. These findings have broad implications on the design and development of orthopedic biomaterials and drug delivery.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#188

 

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Neutrophilic Fe(II) oxidizing bacteria like Mariprofundus ferrooxydans are obligate chemolithoautotrophic bacteria that play an important role in the biogeochemical cycling of iron and other elements in multiple environments. These bacteria generally exhibit a singular metabolic mode of growth which prohibits comparative “omics” studies. Furthermore, these bacteria are considered non-amenable to classical genetic methods due to low cell densities, the inability to form colonies on solid medium, and production of copious amounts of insoluble iron oxyhydroxides as their metabolic byproduct. Consequently, the molecular and biochemical understanding of these bacteria remains speculative despite the availability of substantial genomic information. Here we develop the first genetic system in neutrophilic Fe(II) oxidizing bacterium and use it to engineer lithoheterotrophy in M. ferrooxydans, a metabolism that has been speculated but not experimentally validated. This synthetic biology approach could be extended to gain physiological understanding and domesticate other bacteria that grow using a single metabolic mode.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#189

 

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This paper describes a new method for direct measurement and evaluation of the inhomogeneous electrostatic vector field with translational symmetry in electro-optic materials exhibiting the Pockels effect. It is based on the evaluation of maximum transmittance of low intensity light passing through a sample under a voltage bias. Here, the sample is located between rotating crossed polarizers, and camera images are obtained at each point to determine the electric field. The evaluation procedure is demonstrated using data acquired on a CdZnTeSe quasi-hemispheric semiconductor gamma-ray detector. In addition to CdTe-related compounds, the method can be used for various other materials showing $$overline{4}3m$$ symmetry such as GaAs, CdTe, GaP, 3C-SiC, and ZnS. Furthermore, it can be generalized to other crystalline materials showing the Pockels effect. The method can be used to probe the space charge and the electric field in several kinds of electronic components and devices, as well as provide useful data on the role of defects, contact configurations and other surface and bulk inhomogeneities in the material that can affect the distribution of the internal electric field.

#Materials
Field # Materials
Updated 25 January 2021

#190

 

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We analyze data from Twitter to uncover early-warning signals of COVID-19 outbreaks in Europe in the winter season 2019–2020, before the first public announcements of local sources of infection were made. We show evidence that unexpected levels of concerns about cases of pneumonia were raised across a number of European countries. Whistleblowing came primarily from the geographical regions that eventually turned out to be the key breeding grounds for infections. These findings point to the urgency of setting up an integrated digital surveillance system in which social media can help geo-localize chains of contagion that would otherwise proliferate almost completely undetected.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#191

 

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Smart and e-textiles have nowadays an important increasing place in the garment industry. The rise of embedded telecommunications, especially smartphones in our pocket, enables us to provide a power source and a wireless link for smart textiles. The main issue is to develop garments able to receive power from smartphones and communicate with them without flexibility and comfort constraints bound to embedded solid-state electronic components. Consequently, this article aims to develop a fully textile NFC combiner to transfer data and power between a smartphone and sensors without any electronic components. It precisely describes textile NFC multiple combiners composed of textile NFC antennas linked by two-wire transmission lines. Also, theoretical analysis, simulations, and experiments have been conducted to adapt the resonant frequency of such structures to the NFC technology (13.56 MHz). Finally, our article generalizes textile NFC combiner resonant frequency equations for multiple combiners with any number of antennas.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#192

 

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Electrostatics of depolarization field Ed in relation to the polarization is studied. In particular, the value of permittivity for Ed (εd) in prototypical situations of ferroelectrics, including Mehta formula, is examined by ab initio calculations. By using spontaneous polarization PS corresponding to accurate experiment ones, we show εd = 1, which suggests that the results of εd ≫ 1 indicate hidden mechanisms; εd = 1 suggests that the effect of Ed is significant to induce intriguing important phenomena overlooked by εd ≫ 1. A bridge between εd = 1 and εd ≫ 1, i.e. the consistency of εd = 1 with conventional results is presented. The exact electrostatic equality of head-to-head–tail-to-tail domains to free-standing ferroelectrics is deduced. Hence, most stoichiometric clean freestanding monodomain ferroelectrics and head-to-head–tail-to-tail domains are shown unstable regardless of size, unless partially metallic. This verifies the previous results in a transparent manner. This conclusion is shown consistent with a recent hyperferroelectric LiBeSb and “freestanding” monolayer ferroelectrics, of which origin is suggested to be adsorbates. In addition, this restriction is suggested to break in externally strained ultrathin ferroelectrics. The macroscopic formulas of Ed are found valid down to a several unit-cells, when electronic and atomic-scale surface effects are unimportant and accurate PS is used.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#193

 

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The latency of the auditory steady-state response (ASSR) may provide valuable information regarding the integrity of the auditory system, as it could potentially reveal the presence of multiple intracerebral sources. To estimate multiple latencies from high-order ASSRs, we propose a novel two-stage procedure that consists of a nonparametric estimation method, called apparent latency from phase coherence (ALPC), followed by a heuristic sequential forward selection algorithm (SFS). Compared with existing methods, ALPC-SFS requires few prior assumptions, and is straightforward to implement for higher-order nonlinear responses to multi-cosine sound complexes with their initial phases set to zero. It systematically evaluates the nonlinear components of the ASSRs by estimating multiple latencies, automatically identifies involved ASSR components, and reports a latency consistency index. To verify the proposed method, we performed simulations for several scenarios: two nonlinear subsystems with different or overlapping outputs. We compared the results from our method with predictions from existing, parametric methods. We also recorded the EEG from ten normal-hearing adults by bilaterally presenting superimposed tones with four frequencies that evoke a unique set of ASSRs. From these ASSRs, two major latencies were found to be stable across subjects on repeated measurement days. The two latencies are dominated by low-frequency (LF) (near 40 Hz, at around 41–52 ms) and high-frequency (HF) (> 80 Hz, at around 21–27 ms) ASSR components. The frontal-central brain region showed longer latencies on LF components, but shorter latencies on HF components, when compared with temporal-lobe regions. In conclusion, the proposed nonparametric ALPC-SFS method, applied to zero-phase, multi-cosine sound complexes is more suitable for evaluating embedded nonlinear systems underlying ASSRs than existing methods. It may therefore be a promising objective measure for hearing performance and auditory cortex (dys)function.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#194

 

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Rawanbuki, a variety of Japanese butterbur (Petasites japonicus subsp. giganteus), grow naturally along the Rawan River, Hokkaido, northern Japan. Most plants reach 2–3 m in height and 10 cm in diameter in 2 months and are much larger than those grown along other rivers. We examined the hypothesis that nutrients exported from upland streams enhance the growth of the Rawanbuki. Nutrient concentrations, including nitrogen, phosphorus, and base cations, in the Rawan River were much higher than those in rivers of adjacent watersheds. High nutrient concentrations and moisture contents were found in soil along the Rawan River and a significant relationship was found between physicochemical soil conditions and aboveground biomass of butterburs. This indicates that extremely large Rawanbuki plants could be caused by these high nutrient concentrations and moisture contents in the soils. A manipulation experiment showed that fertilization simulated the growth environment along the Rawan River and enhanced the stem height and stem diameter of butterburs. This study concluded that the extremely large butterburs are caused by a large amount of nutrients exported from upland areas. These results are the first demonstration of the role of stream water nutrients in enlarging agricultural crops.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#195

 

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Multidrug-resistant bacteria are a growing global concern, and with increasingly prevalent resistance to last line antibiotics such as colistin, it is imperative that alternative treatment options are identified. Herein we investigated the mechanism of action of a novel antimicrobial peptide (CDP-B11) and its effectiveness against multidrug-resistant bacteria including Escherichia coli #0346, which harbors multiple antibiotic-resistance genes, including mobilized colistin resistance gene (mcr-1). Bacterial membrane potential and membrane integrity assays, measured by flow cytometry, were used to test membrane disruption. Bacterial growth inhibition assays and time to kill assays measured the effectiveness of CDP-B11 alone and in combination with colistin against E. coli #0346 and other bacteria. Hemolysis assays were used to quantify the hemolytic effects of CDP-B11 alone and in combination with colistin. Findings show CDP-B11 disrupts the outer membrane of E. coli #0346. CDP-B11 with colistin inhibits the growth of E. coli #0346 at ≥ 10× lower colistin concentrations compared to colistin alone in Mueller–Hinton media and M9 media. Growth is significantly inhibited in other clinically relevant strains, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. In rich media and minimal media, the drug combination kills bacteria at a lower colistin concentration (1.25 μg/mL) compared to colistin alone (2.5 μg/mL). In minimal media, the combination is bactericidal with killing accelerated by up to 2 h compared to colistin alone. Importantly, no significant red blood hemolysis is evident for CDP-B11 alone or in combination with colistin. The characteristics of CDP-B11 presented here indicate that it can be used as a potential monotherapy or as combination therapy with colistin for the treatment of multidrug-resistant infections, including colistin-resistant infections.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#196

 

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Biohybrids composed of microorganisms and nanoparticles have emerged as potential systems for bioenergy and high-value compound production from CO2 and light energy, yet the cellular and metabolic processes within the biological component of this system are still elusive. Here we dissect the biohybrid composed of the anaerobic acetogenic bacterium Moorella thermoacetica and cadmium sulphide nanoparticles (CdS) in terms of physiology, metabolism, enzymatics and transcriptomic profiling. Our analyses show that while the organism does not grow on l-cysteine, it is metabolized to acetate in the biohybrid system and this metabolism is independent of CdS or light. CdS cells have higher metabolic activity, despite an inhibitory effect of Cd2+ on key enzymes, because of an intracellular storage compound linked to arginine metabolism. We identify different routes how cysteine and its oxidized form can be innately metabolized by the model acetogen and what intracellular mechanisms are triggered by cysteine, cadmium or blue light.

#Energy
Field # Energy
Updated 25 January 2021

#197

 

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Bloom Syndrome (BS; OMIM #210900; ORPHA #125) is a rare genetic disorder that is associated with growth deficits, compromised immune system, insulin resistance, genome instability and extraordinary predisposition to cancer. Most efforts thus far have focused on understanding the role of the Bloom syndrome DNA helicase BLM as a recombination factor in maintaining genome stability and suppressing cancer. Here, we observed increased levels of reactive oxygen species (ROS) and DNA base damage in BLM-deficient cells, as well as oxidative-stress-dependent reduction in DNA replication speed. BLM-deficient cells exhibited increased mitochondrial mass, upregulation of mitochondrial transcription factor A (TFAM), higher ATP levels and increased respiratory reserve capacity. Cyclin B1, which acts in complex with cyclin-dependent kinase CDK1 to regulate mitotic entry and associated mitochondrial fission by phosphorylating mitochondrial fission protein Drp1, fails to be fully degraded in BLM-deficient cells and shows unscheduled expression in G1 phase cells. This failure to degrade cyclin B1 is accompanied by increased levels and persistent activation of Drp1 throughout mitosis and into G1 phase as well as mitochondrial fragmentation. This study identifies mitochondria-associated abnormalities in Bloom syndrome patient-derived and BLM-knockout cells and we discuss how these abnormalities may contribute to Bloom syndrome.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#198

 

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Understanding fluid flow in shale rocks is critical for the recovery of unconventional energy resources. Despite the extensive research conducted on water and oil flow in shales, significant uncertainties and discrepancies remain in reported experimental data. The most noted being that while oil spreads more than water on shale surfaces in an inviscid medium, its uptake by shale pores is much less than water during capillary flow. This leads to misjudgement of wettability and the underlying physical phenomena. In this study, therefore, we performed a combined experimental and digital rock investigation on an organic-rich shale including contact angle and spontaneous imbibition, X-ray and neutron computed tomography, and small angle X-ray scattering tests to study the potential physical processes. We also used non-equilibrium thermodynamics to theoretically derive constitutive equations to support our experimental observations. The results of this study indicate that the pre-existing fractures (first continuum) imbibe more oil than water consistent with contact angle measurements. The overall imbibition is, however, higher for water than oil due to greater water diffusion into the shale matrix (second continuum). It is shown that more water uptake into shale is controlled by pore size and accessibility in addition to capillary or osmotic forces i.e. configurational diffusion of water versus oil molecules. While the inorganic pores seem more oil-wet in an inviscid medium, they easily allow passage of water molecules compared to oil due to the incredibly small size of water molecules that can pass through such micro-pores. Contrarily, these strongly oil-wet pores possessing strong capillarity are restricted to imbibe oil simply due to its large molecular size and physical inaccessibility to the micro-pores. These results provide new insights into the previously unexplained discrepancy regarding water and oil uptake capacity of shales.

#Energy
Field # Energy
Updated 25 January 2021

#199

 

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The AlcR fungal protein responds to ethanol and binds to the fungal pAlcA promoter in its presence. This system was transferred to plants over twenty years ago and was claimed to function in the same manner in plants. However, never has the control experiment with plants containing the AlcR gene alone, with no downstream inducible construct, been made. In this paper, I conduct several experiments with this control, growing p35:AlcR plants in the presence or absence of ethanol. I found that when these plants were grown in the presence of ethanol, growth in several tissues and several stages of growth was retarded. This demonstrates that this system is not suitable for use in the plant sciences, and casts doubt on the conclusions of papers that have published phenotypes using this system.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#200

 

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While a detailed knowledge of the hierarchical structure and morphology of the extracellular matrix is considered crucial for understanding the physiological and mechanical properties of bone and cartilage, the orientation of collagen fibres and carbonated hydroxyapatite (HA) crystallites remains a debated topic. Conventional microscopy techniques for orientational imaging require destructive sample sectioning, which both precludes further studies of the intact sample and potentially changes the microstructure. In this work, we use X-ray diffraction tensor tomography to image non-destructively in 3D the HA orientation in a medial femoral condyle of a piglet. By exploiting the anisotropic HA diffraction signal, 3D maps showing systematic local variations of the HA crystallite orientation in the growing subchondral bone and in the adjacent mineralized growth cartilage are obtained. Orientation maps of HA crystallites over a large field of view (~ 3 × 3 × 3 mm3) close to the ossification (bone-growth) front are compared with high-resolution X-ray propagation phase-contrast computed tomography images. The HA crystallites are found to predominantly orient with their crystallite c-axis directed towards the ossification front. Distinct patterns of HA preferred orientation are found in the vicinity of cartilage canals protruding from the subchondral bone. The demonstrated ability of retrieving 3D orientation maps of bone-cartilage structures is expected to give a better understanding of the physiological properties of bones, including their propensity for bone-cartilage diseases.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#201

 

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A novel species of the family Alepocephalidae (slickheads), Narcetes shonanmaruae, is described based on four specimens collected at depths greater than 2171 m in Suruga Bay, Japan. Compared to other alepocephalids, this species is colossal (reaching ca. 140 cm in total length and 25 kg in body weight) and possesses a unique combination of morphological characters comprising anal fin entirely behind the dorsal fin, multiserial teeth on jaws, more scale rows than congeners, precaudal vertebrae less than 30, seven branchiostegal rays, two epurals, and head smaller than those of relatives. Mitogenomic analyses also support the novelty of this large deep-sea slickhead. Although most slickheads are benthopelagic or mesopelagic feeders of gelatinous zooplankton, behavioural observations and dietary analyses indicate that the new species is piscivorous. In addition, a stable nitrogen isotope analysis of specific amino acids showed that N. shonanmaruae occupies one of the highest trophic positions reported from marine environments to date. Video footage recorded using a baited camera deployed at a depth of 2572 m in Suruga Bay revealed the active swimming behaviour of this slickhead. The scavenging ability and broad gape of N. shonanmaruae might be correlated with its colossal body size and relatively high trophic position.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#202

 

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Persistent HPV infection associated with immune modulation may result in high-grade squamous intraepithelial lesions (CIN)2/3. Currently, there is little information on the cervicovaginal microbiome, local cytokine levels and HPV infection related to CIN. Follow-up of patients after local surgery provides an opportunity to monitor changes in the cervicovaginal environment. Accordingly, we undertook this longitudinal retrospective study to determine associations between HPV genotypes, cervicovaginal microbiome and local cytokine profiles in 41 Japanese patients with CIN. Cervicovaginal microbiota were identified using universal 16S rRNA gene (rDNA) bacterial primers for the V3/4 region by PCR of genomic DNA, followed by MiSeq sequencing. We found that Atopobium vaginae was significantly decreased (p < 0.047), whereas A. ureaplasma (p < 0.022) increased after surgery. Cytokine levels in cervical mucus were measured by multiplexed bead-based immunoassays, revealing that IL-1β (p < 0.006), TNF-α (p < 0.004), MIP-1α (p < 0.045) and eotaxin (p < 0.003) were significantly decreased after surgery. Notably, the level of eotaxin decreased in parallel with HPV clearance after surgery (p < 0.028). Thus, local surgery affected the cervicovaginal microbiome, status of HPV infection and immune response. Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia may be important for understanding the pathogenesis of CIN in future.

#Medicine & Human body;#Theoretical sciences
Field # Medicine & Human body
Updated 25 January 2021

#203

 

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Name
Description
Singular blockade of C5a in experimental models of sepsis is known to confer protection by rescuing lethality and decreasing pro-inflammatory responses. However, the role of inhibiting C5a has not been evaluated in the context of sterile systemic inflammatory responses, like polytrauma and hemorrhagic shock (PT + HS). In our presented study, a novel and highly specific C5a L-aptamer, NoxD21, was used to block C5a activity in an experimental murine model of PT + HS. The aim of the study was to assess early modulation of inflammatory responses and lung damage 4 h after PT + HS induction. NoxD21-treated PT + HS mice displayed greater polymorphonuclear cell recruitment in the lung, increased pro-inflammatory cytokine levels in the bronchoalveolar lavage fluids (BALF) and reduced myeloperoxidase levels within the lung tissue. An in vitro model of the alveolar-capillary barrier was established to confirm these in vivo observations. Treatment with a polytrauma cocktail induced barrier damage only after 16 h, and NoxD21 treatment in vitro did not rescue this effect. Furthermore, to test the exact role of both the cognate receptors of C5a (C5aR1 and C5aR2), experimental PT + HS was induced in C5aR1 knockout (C5aR1 KO) and C5aR2 KO mice. Following 4 h of PT + HS, C5aR2 KO mice had significantly reduced IL-6 and IL-17 levels in the BALF without significant lung damage, and both, C5aR1 KO and C5aR2 KO PT + HS animals displayed reduced MPO levels within the lungs. In conclusion, the C5aR2 could be a putative driver of early local inflammatory responses in the lung after PT + HS.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#204

 

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Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates innate immune responses triggered by LPS. Recent studies indicated a positive correlation of circulating LBP level with chronic low-grade inflammation, a condition present in many non-communicable diseases. We determined the association of serum LBP concentration with allergic sensitization in a general pediatric population. Serum LBP was measured in a sample of children (n = 356; mean age = 9.6 ± 0.2 years) in this population-based cross-sectional study. Skin prick tests (SPTs) were performed to assess allergic sensitization to 22 common inhalant and food allergens. One hundred and seven children (30.1%) were nonsensitized, 160 (44.9%) were monosensitized, and 89 (25.0%) were polysensitized. Children who were mono- or polysensitized had a significantly higher median serum LBP level (25.5 ng/mL, inter-quartile range [IQR] 20.3–30.7) than those who were nonsensitized (20.3 ng/mL, IQR = 14.81–25.8, P < 0.0001). Multivariate logistic regression analysis with adjustment for confounders indicated that serum LBP level was positively associated with allergic sensitization overall (adjusted odds ratio [aOR] 1.041; 95% CI 1.007–1.076, P = 0.016), with sensitization to food allergens in particular (aOR 1.080, 95% CI 1.029–1.133, P = 0.002), but not with sensitization to aeroallergens (aOR 1.010, 95% CI 0.982–1.040, P = 0.467). LBP level was not associated with allergic diseases after adjustment. We suggest the possibility of sensitization to food allergens may be related to gut-derived low-grade inflammation, and large sized longitudinal investigations are needed to elucidate the relationship.

#Food
Field # Food
Updated 25 January 2021

#205

 

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Description
Sony's WH-1000XM4 are widely considered to be the best noise-canceling headphones you can buy. These alternatives are almost as good, but they cost way less.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#206

 

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The coronavirus disease (COVID-19) outbreak has killed over a million people since its emergence in late 2019. However, there has been substantial variability in the policies and intensity of diagnostic efforts between countries. In this paper, we quantitatively evaluate the association between national contact tracing policies and case fatality rates of COVID-19 in 138 countries. Our regression analyses indicate that countries that implement comprehensive contact tracing have significantly lower case fatality rates. This association of contact tracing policy and case fatality rates is robust in our longitudinal regression models, even after controlling for the number of tests conducted and non-pharmaceutical control measures adopted by governments. Our results suggest that comprehensive contact tracing is instrumental not only to curtailing transmission but also to reducing case fatality rates. Contact tracing achieves the early detection and isolation of secondary cases which are particularly important given that the peak in infectiousness occurs during the presymptomatic phase. The early detection achieved by contact tracing accelerates the rate at which infected individuals receive medical care they need to maximize their chance of recovery. In addition, the combination of reduced transmission and more rapid recovery diminishes the burden on the healthcare system which in turn ensures that the resources remain available for individuals who do become infected.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#207

 

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Description
The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understanding of T. bryosalmonae-host interactions, we have used a two-host parasite transcriptome sequencing approach in generating two parasite transcriptome assemblies; the first derived from parasite spore sacs isolated from infected bryozoans and the second from infected fish kidney tissues. This approach was adopted to minimize host contamination in the absence of a complete T. bryosalmonae genome. Parasite contigs common to both infected hosts (the intersect transcriptome; 7362 contigs) were typically AT-rich (60–75% AT). 5432 contigs within the intersect were annotated. 1930 unannotated contigs encoded for unknown transcripts. We have focused on transcripts encoding proteins involved in; nutrient acquisition, host–parasite interactions, development, cell-to-cell communication and proteins of unknown function, establishing their potential importance in each host by RT-qPCR. Host-specific expression profiles were evident, particularly in transcripts encoding proteases and proteins involved in lipid metabolism, cell adhesion, and development. We confirm for the first time the presence of homeobox proteins and a frizzled homologue in myxozoan parasites. The novel insights into myxozoan biology that this study reveals will help to focus research in developing future disease control strategies.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#208

 

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Description
The Hippo signaling pathway is a key regulator of tissue development and regeneration. Activation of the Hippo pathway leads to nuclear translocation of the YAP1 transcriptional coactivator, resulting in changes in gene expression and cell cycle entry. Recent studies have demonstrated the nuclear translocation of YAP1 during the development of the sensory organs of the inner ear, but the possible role of YAP1 in sensory regeneration of the inner ear is unclear. The present study characterized the cellular localization of YAP1 in the utricles of mice and chicks, both under normal conditions and after HC injury. During neonatal development, YAP1 expression was observed in the cytoplasm of supporting cells, and was transiently expressed in the cytoplasm of some differentiating hair cells. We also observed temporary nuclear translocation of YAP1 in supporting cells of the mouse utricle after short periods in organotypic culture. However, little or no nuclear translocation of YAP1 was observed in the utricles of neonatal or mature mice after ototoxic injury. In contrast, substantial YAP1 nuclear translocation was observed in the chicken utricle after streptomycin treatment in vitro and in vivo. Together, these data suggest that differences in YAP1 signaling may partially account for the differing regenerative abilities of the avian vs. mammalian inner ear.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#209

 

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Description
Wearable electronic devices, which allow physiological signals to be continuously monitored, can be used in the early detection of asymptomatic and pre-symptomatic cases of COVID-19.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#210

 

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#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#211

 

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Description


#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#212

 

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Description
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are leading causes of sudden death and heart failure in young, otherwise healthy, individuals. We conducted genome-wide association studies and multi-trait analyses in HCM (1,733 cases), DCM (5,521 cases) and nine left ventricular (LV) traits (19,260 UK Biobank participants with structurally normal hearts). We identified 16 loci associated with HCM, 13 with DCM and 23 with LV traits. We show strong genetic correlations between LV traits and cardiomyopathies, with opposing effects in HCM and DCM. Two-sample Mendelian randomization supports a causal association linking increased LV contractility with HCM risk. A polygenic risk score explains a significant portion of phenotypic variability in carriers of HCM-causing rare variants. Our findings thus provide evidence that polygenic risk score may account for variability in Mendelian diseases. More broadly, we provide insights into how genetic pathways may lead to distinct disorders through opposing genetic effects. Genome-wide analyses identify multiple loci associated with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and left ventricular (LV) traits. Cardiomyopathies exhibit strong genetic correlations with LV traits, with opposing effects in HCM and DCM.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#213

 

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This study reports the development of a CRISPR –Cas9 therapeutic to target herpes simplex virus 1 and treat herpetic stromal keratitis in mice.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#214

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#215

 

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Description
Therapeutic approaches to the treatment of type 2 diabetes mellitus that are designed to increase insulin secretion either directly target β-cells or indirectly target gastrointestinal enteroendocrine cells (EECs), which release hormones that modulate insulin secretion (for example, incretins). Given that β-cells and EECs both express a large array of G protein-coupled receptors (GPCRs) that modulate insulin secretion, considerable research and development efforts have been undertaken to design therapeutic drugs targeting these GPCRs. Among them are GPCRs specific for free fatty acid ligands (lipid GPCRs), including free fatty acid receptor 1 (FFA1, otherwise known as GPR40), FFA2 (GPR43), FFA3 (GPR41) and FFA4 (GPR120), as well as the lipid metabolite binding glucose-dependent insulinotropic receptor (GPR119). These lipid GPCRs have demonstrated important roles in the control of islet and gut hormone secretion. Advances in lipid GPCR pharmacology have led to the identification of a number of synthetic agonists that exert beneficial effects on glucose homeostasis in preclinical studies. Yet, translation of these promising results to the clinic has so far been disappointing. In this Review, we present the physiological roles, pharmacology and clinical studies of these lipid receptors and discuss the challenges associated with their clinical development for the treatment of type 2 diabetes mellitus. This Review summarizes the physiological functions, pharmacology and clinical studies of G protein-coupled receptors that are specific for lipid metabolite ligands. The challenges associated with the clinical development of therapeutics for type 2 diabetes mellitus that target these G protein-coupled receptors are also discussed.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#216

 

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#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#217

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#218

 

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Description
Pilot double-blinded randomized controlled trial. To investigate the additive effect of recombinant human erythropoietin (rhEPO) on functional outcome and disability in patients with traumatic cervical spinal cord injury (TCSCI). University-affiliated hospital in Mashhad, Iran. Patients with acute TCSCI admitted within 8 h after injury were randomly assigned to receive only methylprednisolone (M group) or rhEPO 500 IU/mL plus methylprednisolone (M + E group). All the patients underwent surgery within the next several days. Neurological function was assessed on admission, and at 6th and 12th months after the injury according to the sphincter function and American spinal cord injury association (ASIA) scale. Overall, 54 patients (mean age: 39.7 ± 13.3 years) including 46 (85%) males were studied in two groups of 27. The likelihood of developing adverse neurological outcomes (ASIA impairment score of A compared to D or E) was not significantly different between the groups after 6 (OR = 0.39, 95% CI = 0.03–4.80, P = 0.46) and 12 months (OR = 0.83, 95% CI = 0.11–6.11, P = 0.86). The groups also showed no significant difference in 1-year mortality (OR = 0.83, 95% CI = 0.25–2.74, P = 0.76). It is not clear whether combination therapy with erythropoietin compared to methylprednisolone alone improves neurological functions of patients with TCSCI. Our study provides interim data to guide future larger definitive trials.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#219

 

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Racial and ethnic inequities in leadership achievement, compensation, scholarly productivity, and grant funding exists among physicians. This study explores whether similar inequities exist among neonatologists within the United States. A voluntary anonymous survey was distributed to members of the American Academy of Pediatrics Section on Neonatal–Perinatal Medicine with 560 respondents. Logistic regression and ordinary least squares were used to assess whether racial and ethnic identity is associated with clinical time, leadership, compensation, publication, grant funding, or academic rank. As compared to non-Hispanic White neonatologists, statistical differences were found for underrepresented minorities in medicine in: regions of the country where they worked, total cash compensation received, being awarded an NIH grant, and location of graduate medical education. Fewer differences were found for Asian neonatologists and included location of graduate medicine education. Racial and ethnic identity remains a significant independent factor influencing professional achievement and compensation.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 25 January 2021

#220

 

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Description
We present a nuclei isolation protocol for genomic and epigenomic interrogation of multiple cell type populations in the human and rodent brain. The nuclei isolation protocol allows cell type-specific profiling of neurons, microglia, oligodendrocytes, and astrocytes, being compatible with fresh and frozen samples obtained from either resected or postmortem brain tissue. This 2-day procedure consists of tissue homogenization with fixation, nuclei extraction, and antibody staining followed by fluorescence-activated nuclei sorting (FANS) and does not require specialized skillsets. Cell type-specific nuclei populations can be used for downstream omic-scale sequencing applications with an emphasis on epigenomic interrogation such as histone modifications, transcription factor binding, chromatin accessibility, and chromosome architecture. The nuclei isolation protocol enables translational examination of archived healthy and diseased brain specimens through utilization of existing medical biorepositories. This protocol describes procedures for isolation of nuclei of multiple cell populations (neurons, microglia, oligodendrocytes, and astrocytes) from resected or postmortem brain tissue that are compatible with downstream epigenomic or transcriptomic profiling.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#221

 

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Description
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells. Most EV studies have been performed by using cell lines or body fluids, but the number of studies on tissue-derived EVs is still limited. Here, we present a protocol to isolate up to six different EV subpopulations directly from tissues. The approach includes enzymatic treatment of dissociated tissues followed by differential ultracentrifugation and density separation. The isolated EV subpopulations are characterized by electron microscopy and RNA profiling. In addition, their protein cargo can be determined with mass spectrometry, western blot and ExoView. Tissue-EV isolation can be performed in 22 h, but a simplified version can be completed in 8 h. Most experiments with the protocol have used human melanoma metastases, but the protocol can be applied to other cancer and non-cancer tissues. The procedure can be adopted by researchers experienced with cell culture and EV isolation. This protocol describes how to isolate up to six different subpopulations of extracellular vesicles (EVs) from tissues. The procedure includes detailed instructions for EV characterization using electron microscopy, RNA and protein analysis.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#222

 

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Description


#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#223

 

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Description


#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#224

 

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Description
An investigation of the molecular processes of mitochondrial reprogramming and metabolic stress in antigen-experienced T cells within tumor microenvironments reveals mechanisms responsible for T cell exhaustion and dysfunction and facilitates the development of new strategies for tumor immunotherapy.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#225

 

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Description
This study shows that plant root barrier function and the root microbiota coordinate to maintain plant nutrient homeostasis.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#226

 

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Description
This study provides structural insights into how the rotavirus spike protein VP4 undergoes a conformational change to initiate host membrane disruption during infection.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#227

 

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Description


#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#228

 

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Description
For our 2021 technology of the year, we explore the impact of the coronavirus pandemic on digital technology.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#229

 

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Description
Intrinsically stretchable electronics can form intimate interfaces with the human body, creating devices that could be used to monitor physiological signals without constraining movement. However, mechanical strain invariably leads to the degradation of the electronic properties of the devices. Here we show that strain-insensitive intrinsically stretchable transistor arrays can be created using an all-elastomer strain engineering approach, in which the patterned elastomer layers with tunable stiffnesses are incorporated into the transistor structure. By varying the cross-linking density of the elastomers, areas of increased local stiffness are introduced, reducing strain on the active regions of the devices. This approach can be readily incorporated into existing fabrication processes, and we use it to create arrays with a device density of 340 transistors cm–2 and a strain insensitivity of less than 5% performance variation when stretched to 100% strain. We also show that it can be used to fabricate strain-insensitive circuit elements, including NOR gates, ring oscillators and high-gain amplifiers for the stable monitoring of electrophysiological signals. An all-elastomer strain engineering approach, which uses patterned elastomer layers with tunable stiffnesses, can be used to create intrinsically stretchable transistor arrays with a device density of 340 transistors cm–2 and strain insensitivity of less than 5% performance variation when stretched to 100% strain.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#230

 

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Description
Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#231

 

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Description
Among the many reasons a signal may deviate from perfect periodicity, quantum-limited jitter is arguably the most fundamental. A clever experiment has now stripped away technical noise to unveil quantum-limited jitter of ultrafast soliton frequency combs.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#232

 

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Extreme-ultraviolet (XUV) sources including high-harmonic generation (HHG), free-electron lasers (FELs), soft-X-ray lasers and laser-driven plasmas are widely used for applications ranging from femtochemistry and attosecond science to coherent diffractive imaging and EUV (or XUV) lithography. The bandwidth of the XUV light emitted by these sources reflects the XUV generation process used. Whereas light from soft-X-ray lasers1 and seeded XUV FELs2 typically has a relatively narrow bandwidth, plasma sources and HHG sources often emit broadband XUV pulses3. Since these characteristic properties of a given source impose limitations on applications, techniques enabling modification of the bandwidth are highly desirable. Here we introduce a concept for efficient spectral compression by four-wave mixing (FWM), exploiting a phase-matching scheme based on closely-spaced resonances. We demonstrate the compression of broadband radiation in the 145–130 nm wavelength range into a narrow-bandwidth XUV pulse at 100.3 nm wavelength in the presence of a broadband near-infrared (NIR) pulse in a krypton gas jet. Our concept provides new possibilities for tailoring the spectral bandwidth of XUV beams. Through a dense krypton gas jet in the presence of a broadband near-infrared pulse, spectral compression of broadband XUV radiation between 145 and 130 nm wavelengths into a narrow-bandwidth XUV pulse at 100.3 nm wavelength by four-wave mixing is demonstrated.

#Theoretical sciences
Field # Theoretical sciences
Updated 25 January 2021

#233

 

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Description
The nonlinear Hall effect (NLHE), the phenomenon in which a transverse voltage can be produced without a magnetic field, provides a potential alternative for rectification or frequency doubling1,2. However, the low-temperature detection of the NLHE limits its applications3,4. Here, we report the room-temperature NLHE in a type-II Weyl semimetal TaIrTe4, which hosts a robust NLHE due to broken inversion symmetry and large band overlapping at the Fermi level. We also observe a temperature-induced sign inversion of the NLHE in TaIrTe4. Our theoretical calculations suggest that the observed sign inversion is a result of a temperature-induced shift in the chemical potential, indicating a direct correlation of the NLHE with the electronic structure at the Fermi surface. Finally, on the basis of the observed room-temperature NLHE in TaIrTe4 we demonstrate the wireless radiofrequency (RF) rectification with zero external bias and magnetic field. This work opens a door to realizing room-temperature applications based on the NLHE in Weyl semimetals. Broken inversion symmetry in a type-II Weyl semimetal TaIrTe4 enables observation of the room-temperature nonlinear Hall effect as well as wireless radiofrequency rectification.

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#234

 

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Description
Ferroelectricity in bulk crystals of hafnium oxide demonstrates that these properties are not limited to films prepared by thin-film deposition techniques.

#Energy
Field # Energy
Updated 25 January 2021

#235

 

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Description
Closed-loop recycling offers the opportunity to mitigate plastic waste through reversible polymer construction and deconstruction. Although examples of chemical recycling of polymers are known, few have been applied to materials derived from abundant commodity olefinic monomers, which are the building blocks of ubiquitous plastic resins. Here we describe a [2+2] cycloaddition/oligomerization of 1,3-butadiene to yield a previously unrealized telechelic microstructure of (1,n′-divinyl)oligocyclobutane. This material is thermally stable, has stereoregular segments arising from chain-end control, and exhibits high crystallinity even at low molecular weight. Exposure of the oligocyclobutane to vacuum in the presence of the pyridine(diimine) iron precatalyst used to synthesize it resulted in deoligomerization to generate pristine butadiene, demonstrating a rare example of closed-loop chemical recycling of an oligomeric material derived from a commodity hydrocarbon feedstock. Iron-catalysed [2+2] cycloaddition/oligomerization of neat butadiene affords (1,n′-divinyl)oligocyclobutane—a telechelic, crystalline material consisting of 1,3-enchained cyclobutyl units. This oligocyclobutane can be chemically recycled to pure butadiene using the same iron catalyst employed in its synthesis, demonstrating design principles for next-generation plastic materials that can be returned to pristine monomer.

#Chemicals
Field # Chemicals
Updated 25 January 2021

#236

 

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The recent discoveries of strikingly large zero-field Hall and Nernst effects in antiferromagnets Mn3X (X = Sn, Ge) have brought the study of magnetic topological states to the forefront of condensed matter research and technological innovation. These effects are considered fingerprints of Weyl nodes residing near the Fermi energy, promoting Mn3X (X = Sn, Ge) as a fascinating platform to explore the elusive magnetic Weyl fermions. In this review, we provide recent updates on the insights drawn from experimental and theoretical studies of Mn3X (X = Sn, Ge) by combining previous reports with our new, comprehensive set of transport measurements of high-quality Mn3Sn and Mn3Ge single crystals. In particular, we report magnetotransport signatures specific to chiral anomalies in Mn3Ge and planar Hall effect in Mn3Sn, which have not yet been found in earlier studies. The results summarized here indicate the essential role of magnetic Weyl fermions in producing the large transverse responses in the absence of magnetization. The large anomalous Hall (AHE) and anomalous Nernst effects (ANE) in antiferromagnets Mn3Sn/Mn3Ge are considered fingerprints of Weyl nodes residing near the Fermi energy. Here, the authors review the results from previous studies combining with new transport measurements on Mn3Sn/Mn3Ge single crystals, suggesting the essential role of magnetic Weyl fermions in explaining the AHE and ANE.

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#237

 

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Description
Binary metal oxides are attractive anode materials for lithium-ion batteries. Despite sustained effort into nanomaterials synthesis and understanding the initial discharge mechanism, the fundamental chemistry underpinning the charge and subsequent cycles—thus the reversible capacity—remains poorly understood. Here, we use in operando X-ray pair distribution function analysis combining with our recently developed analytical approach employing Metropolis Monte Carlo simulations and non-negative matrix factorisation to study the charge reaction thermodynamics of a series of Fe- and Mn-oxides. As opposed to the commonly believed conversion chemistry forming rocksalt FeO and MnO, we reveal the two oxide series topotactically transform into non-native body-centred cubic FeO and zincblende MnO via displacement-like reactions whose kinetics are governed by the mobility differences between displaced species. These renewed mechanistic insights suggest avenues for the future design of metal oxide materials as well as new material synthesis routes using electrochemically-assisted methods. The charging of Fe and Mn oxide anodes in lithium-ion batteries are believed to form rocksalt phases via reconstructive conversion reactions. Here, the authors show that MxOy (M = Fe, Mn) transform into non-native body-centred cubic FeO and zincblende MnO via topotactic displacement-like pathways.

#Chemicals
Field # Chemicals
Updated 25 January 2021

#238

 

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Description
There used to be a greater diversity of human species, and paleoarchaeologists are still discovering more extinct relatives.

#Environment & Nature;#Theoretical sciences
Field # Environment & Nature
Updated 25 January 2021

#239

 

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The science of why dogs bury bones is explained by the food-caching behavior of their wild, canine ancestors, gray wolves.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#240

 

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The central government told the high court that it was also a matter of concern that Indian users were being "unilaterally" subjected to the change in privacy policy by social networking platform WhatsApp. The submissions were made before Justice Sanjeev Sachdeva by Additional Solicitor General Chetan Sharma during hearing of a petition.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#241

 

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​​Announcing the international coalition during its week-long online Davos Agenda Summit 2021, the World Economic Forum (WEF) said it would work towards improving racial and ethnic justice in the workplace.

#Energy
Field # Energy
Updated 25 January 2021

#242

 

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CAIT has demanded immediate action against e-commerce entities including Amazon, Flipkart, Zomato, Swiggy and others."It is a case of daylight robbery of e-commerce entities in India and therefore demand immediate action against the erring e-commerce portals and online mechanism providers," CAIT said.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#243

 

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Description
During the afternoon trade, the market valuation of Tata Consultancy Services (TCS) was at Rs 12,45,341.44 crore while that of Reliance Industries Ltd (RIL) was at Rs 12,42,593.78 crore on the BSE.

#Social & Corporation affairs;#Economy
Field # Social & Corporation affairs
Updated 25 January 2021

#244

 

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With this update, Samsung Galaxy Tab S7 and S7+ users will be able to easily copy text or images on their smartphone and instantly paste the content onto the Tab S7 or S7+ – and vice versa. Also, the company will rollout auto-sync of Samsung Notes across connected devices as weak as of Samsung Internet tabs.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#245

 

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The Falcon 9 rocket lifted off at 10 a.m. EST from the Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. It flew south along the eastern coast of Florida on its way to space, the company said.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#246

 

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Description
HONGKONG-Makers of Sophia the robot plan mass rollout amid pandemic

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 25 January 2021

#247

 

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Apple is said to unveil iOS 15 update in June this year. Now a new report has revealed that this latest version of the system will not land on some older iPhones.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#248

 

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Google employees from across 13 regions in 10 countries which includes the United Kingdom, Switzerland and the United States have formed an international union. Called Alpha Global, the motive is simple, prevent Google and its parent company from ‘being evil’.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#249

 

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Desi Google Drive alternative DigiBoxx is offering 26GB free storage to new users as part of its Republic Day. Users who sign-up starting January 26, 2021 will be eligible to avail the special offer valid for the Republic Day week.

#Software;#Maps
Field # Software
Updated 25 January 2021

#250

 

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Description
In order to rescue the kidnapped woman, the police used emergency cellular ping to track the location of the victim’s phone.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#251

 

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Description
Certain pacemakers could get deactivated when an iPhone 12 is kept near it.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#252

 

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The feature is said to replace the ‘Active Edge’ squeeze gesture. The double tap gesture on the rear side of Pixel phone is said to provide easy access to Google Assistant among others.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#253

 

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The three new applications came to light after evidence was collected following encounters with terrorists or those who surrendered before the Army gave details about their mode of radicalisation by Pakistan-based terrorist groups, they said. The names of the messaging apps have been withheld for security reasons.

#Medicine & Human body;#Aging
Field # Medicine & Human body
Updated 25 January 2021

#254

 

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The smartwatch is rumoured to come in the first half of 2021. As suggested by online reports, the device may feature a circular design. It is expected that the smartwatch will have two versions -- LTE model and a Wi-Fi version.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#255

 

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Cyber criminals and pirates of the Internet now have a new goldmine in Google Drive where they are freely storing and sharing illegal software licenses, movies, games and porn content -- most of which have allegedly been indexed in Google Search as some Drive users made such links public in their individual accounts.

#Software;#Maps
Field # Software
Updated 25 January 2021

#256

 

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Only the first 50,000 participants will be eligible for the quiz prize.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#257

 

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Result of today’s quiz will be announced on January 26.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#258

 

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As the News Media Bargaining Code triggers a bitter war between Google and the Australian government, the tech giant has detailed eight facts on why reaching a workable Code is important but serious concerns with the current draft remain.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#259

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#260

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#261

 

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Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 25 January 2021

#262

 

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Description
TBD

#Entertainments;#Music
Field # Entertainments
Updated 25 January 2021

#263

 

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Description
TBD

#Hardware & Devices;#Laser
Field # Hardware & Devices
Updated 25 January 2021

#264

 

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Description
TBD

#Archaeology & History
Field # Archaeology & History
Updated 25 January 2021

#265

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#266

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#267

 

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Description
TBD

#Archaeology & History
Field # Archaeology & History
Updated 25 January 2021

#268

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#269

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#270

 

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Today, natural gas and coal combustion supply most demand for industrial process heat (IPH), or the transfer of heat to a material within a production process. With the emergence of low-cost solar photovoltaic (PV) technologies, ...

#Energy
Field # Energy
Updated 25 January 2021

#271

 

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Micro-sized robots could bring a new wave of innovation in the medical field by allowing doctors to access specific regions inside the human body without the need for highly invasive procedures. Among other things, these ...

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#272

 

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Currently, there is a rapid, fundamental transformation of energy systems with new technologies developing at an accelerated pace. It is clear that nuclear energy will be part of the global energy mix for decades to come, ...

#Energy
Field # Energy
Updated 25 January 2021

#273

 

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EPFL engineers teamed up with luxury watchmaker Vacheron Constantin to develop an innovative system that uses lasers to create 3-D sculptures within sapphire watch crystals.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#274

 

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Google said Monday it would make its facilities available for Covid-19 vaccination sites as part of a new initiative to help speed the rollout of inoculations in the United States.

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#275

 

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Right-wing extremists called for open revolt against the U.S. government for months on social media following the election in November. Behind the scenes on private messaging services, many of them recruited new followers, ...

#Medicine & Human body;#Aging
Field # Medicine & Human body
Updated 25 January 2021

#276

 

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High-performance, high-quality Ni-Co-based superalloy powders are promising aircraft engine raw materials. Using machine learning, a NIMS team has succeeded in speedily determining the optimum parameters for manufacturing ...

#Artificial Intelligence
Field # Artificial Intelligence
Updated 25 January 2021

#277

 

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The widespread adoption of battery electric vehicles offers the greatest energy efficiency and potential for CO2 reduction, new analysis by Cambridge engineers has shown.

#Energy
Field # Energy
Updated 25 January 2021

#278

 

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The United States is leading rivals in development and use of artificial intelligence while China is rising quickly and the European Union is lagging, a research report showed Monday.

#Artificial Intelligence
Field # Artificial Intelligence
Updated 25 January 2021

#279

 

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We are still working out what new coronavirus variants will mean for us. As we adapt, there is one thing we know for certain: the only way to stop the virus evolving is to stop it from spreading

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#280

 

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When quantum computers get too complex, they can display hyperchaotic behaviour – like chaos, but more chaotic – and understanding it could help improve computer designs

#Hardware & Devices
Field # Hardware & Devices
Updated 25 January 2021

#281

 

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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

#Medicine & Human body
Field # Medicine & Human body
Updated 25 January 2021

#282

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#283

 

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Description
TBD

#Software;#Security
Field # Software
Updated 25 January 2021

#284

 

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Description
TBD

#Telecommunications
Field # Telecommunications
Updated 25 January 2021

#285

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 25 January 2021

#286

 

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Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 25 January 2021

#287

 

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Description
TBD

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 25 January 2021

#288

 

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Apple's new Fitness+ feature Time to Walk is now available. It attempts to make daily walks more enjoyable through storytelling and music from celebrities.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 25 January 2021

#289

 

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Apple will likely soon launch a new Fitness+ feature called "Time to Walk."

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#290

 

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Workers from Google's parent company Alphabet in 10 countries have banded together to form a union alliance called Alpha Union.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#291

 

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SpaceX launched the Transporter-1 mission on Sunday, Jan. 24 after two delays, sending a record-setting 143 satellites into orbit.

#Astronautics
Field # Astronautics
Updated 25 January 2021

#292

 

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Amazon has finally entered the lucrative TV segment through its own AmazonBasics brand. One of the first TVs to be launched is the 55-inch Fire TV Edition 4K LED TV, officially priced at Rs. 34,999. Is this the best affordable Ultra-HD HDR TV you can buy? Find out in our review.

#Entertainments
Field # Entertainments
Updated 25 January 2021

#293

 

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WhatsApp users in India being treated differently from Europeans over opting out of its new privacy policy is a matter of concern, the central government told the Delhi High Court on Monday.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 25 January 2021

#294

 

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Vivo S7t is expected to launch soon. The phone has been tipped to come with the model number PD2080 and MediaTek Dimensity 820 SoC.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#295

 

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Sony Xperia Compact&rsquo;s new version is tipped to launch this year. The compact phone is expected to feature a 5.5-inch display and measure around 140x68.9x8.9mm. As per a tipster, the new Sony Xperia Compact will have a dual rear camera setup featuring a 13-megapixel primary sensor along with an 8-megapixel camera in the front.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#296

 

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Samsung Galaxy A72 may feature 25W fast charging. A tipster shared that the smartphone received TUV Rheinland certification and supports 9V at 2.77A charging, which is approximately 25W. The device was spotted on the listing carrying the model numbers SM-A725F/DS and SM-A725F.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#297

 

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Redmi Note 10 launch has been teased officially after the rumour mill suggested its existence alongside the Redmi Note 10 5G, Redmi Note 10 Pro, and the Redmi Note 10 Pro 5G.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#298

 

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Realme X7 and Realme X7 Pro launch in India has been teased by Flipkart. While the launch is yet to be announced by the company, a tech blogger seems to have accidentally revealed the India launch date of the two smartphones. Both phones could debut in India as early as February 4. Some variant details of the Indian Realme X7 and Realme X7 Pro models have also surfaced online.

#Gadgets
Field # Gadgets
Updated 25 January 2021

#299

 

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Poco X2 has started getting MIUI 12.1 that brings the anticipated Android 11 update. The new update comes along with the January 2021 Android security patch.

#Software
Field # Software
Updated 25 January 2021

#300

 

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The new Oppo A55 5G is priced in China at CNY 1,599 (roughly Rs. 18,000) for the lone 6GB RAM + 128GB storage option. It is available in Brisk Blue and Rhythm Black colour options. The phone is up for grabs via several online retailers in China including JD, Tmall, and Suning.

#Energy
Field # Energy
Updated 25 January 2021