Please wait. Data is being processed...
Back
Refresh
Bookmark
Signin
Home
Inventions
News of Inventions
Files of Inventions
Groups of Inventors
Subscriptions
Analytics
Reports and analytics
Financial addition
What we are
About
Webinars
Blog
Contacts
News of Inventions:
327666
Files of Inventions:
220
Groups of Inventors:
50
Friend Requests:
Private Messages:
Today's News:
146
Yesterday's News:
267
Today: 26 January 2021, Tuesday.
Discussion with
Friend Requests
Links
What we are
About
Webinars
Blog
Contacts
Subscription
Inventions
News of Inventions
Files of Inventions
Groups of Inventors
Analytics
Reports and analytics
Financial addition
All latest news of Inventions in one place
Listed news of Inventions:
300
from total
327666
Analytics
Reports and analytics
Financial addition
Filters
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
01
02
03
04
05
06
07
08
09
10
11
12
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
01
02
03
04
05
06
07
08
09
10
11
12
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Check all
Uncheck all
3-D printing
Agriculture & Gardening
Archaeology & History
Artificial intelligence
Astronautics
Chemicals
Clothes
Construction
Drones
Energy
Entertainments
Environment & Nature
Food
Gadgets
Genetic engineering
Hardware & Devices
Home furnishings
Household appliances
Household items
Instrument
Internet of things
Materials
Medicine & Human body
Military items
Robotics & Manufacturing
Social & Corporation affairs
Software
Sport & Camping
TBD
Tech lists & Reviews
Telecommunications
Theoretical sciences
Useful trifles
Vehicles & Special machines
Virtual & Augmented reality
Welcome,
Guest
News of Inventions
3-D printing
Agriculture & Gardening
Archaeology & History
Artificial intelligence
Astronautics
Chemicals
Clothes
Construction
Drones
Energy
Entertainments
Environment & Nature
Food
Gadgets
Genetic engineering
Hardware & Devices
Home furnishings
Household appliances
Household items
Instrument
Internet of things
Materials
Medicine & Human body
Military items
Robotics & Manufacturing
Social & Corporation affairs
Software
Sport & Camping
Tech lists & Reviews
Telecommunications
Theoretical sciences
Useful trifles
Vehicles & Special machines
Virtual & Augmented reality
#1
View it
Name
First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAF V600 -mutant advanced melanoma patients: a propensity-matched survival analysis | British Journal of Cancer
Description
Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line anti-PD-1 monotherapy vs. BRAF/MEK inhibitors in advanced BRAFV600-mutant melanoma patients. We selected patients diagnosed between 2014 and 2017 with advanced melanoma and a known BRAFV600-mutation treated with first-line BRAF/MEK inhibitors or anti-PD-1 antibodies, registered in the Dutch Melanoma Treatment Registry. Patients were matched based on their propensity scores using the nearest neighbour and the optimal matching method. Between 2014 and 2017, a total of 330 and 254 advanced melanoma patients received BRAF/MEK inhibitors and anti-PD-1 monotherapy as first-line systemic therapy. In the matched cohort, patients receiving anti-PD-1 antibodies as a first-line treatment had a higher median and 2-year overall survival compared to patients treated with first-line BRAF/MEK inhibitors, 42.3 months (95% CI: 37.3-NE) vs. 19.8 months (95% CI: 16.7–24.3) and 85.4% (95% CI: 58.1–73.6) vs. 41.7% (95% CI: 34.2–51.0). Our data suggest that in the matched BRAFV600-mutant advanced melanoma patients, anti-PD-1 monotherapy is the preferred first-line treatment in patients with relatively favourable patient and tumour characteristics.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#2
View it
Name
Emerging functions of branched ubiquitin chains | Cell Discovery
Description
Ubiquitylation is a critical post-translational modification that controls a wide variety of processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different cellular functions and control the stability, activity, interaction properties, and localization of many different proteins. Recent work has highlighted a role for branched ubiquitin chains in the regulation of cell signaling and protein degradation pathways. Similar to their unbranched counterparts, branched ubiquitin chains are remarkably diverse in terms of their chemical linkages, structures, and the biological information they transmit. In this review, we discuss emerging themes related to the architecture, synthesis, and functions of branched ubiquitin chains. We also describe methodologies that have recently been developed to identify and decode the functions of these branched polymers.
#Theoretical sciences
Field
# Theoretical sciences
Updated
26 January 2021
#3
View it
Name
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers | British Journal of Cancer
Description
Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10–18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10–8). The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#4
View it
Name
Republic Day Parade 2021: How to Watch Live Online and on TV | NDTV Gadgets 360
Description
Republic Day Parade 2021 will be livestreamed at 9.00 am on Tuesday, January 26 on the YouTube channel of the Press Information Bureau (PIB) and DD National. The Republic Day 2021 livestream can also be accessed via the Republic Day Parade 2021 Android app that can be downloaded from the Google Play store. You can also watch the Republic Day Parade live telecast via a DTH connection such as Airtel, Dish TV, and Tata Sky.
#Entertainments
Field
# Entertainments
Updated
26 January 2021
#5
View it
Name
Aerogel Harvests Water From Thin Air
Description
A single kilogram of this new aerogel can generate enough drinking water to meet a household's daily needs
#Materials
Field
# Materials
Updated
26 January 2021
#6
View it
Name
Strong internal resonance in a nonlinear, asymmetric microbeam resonator | Microsystems & Nanoengineering
Description
Exploiting nonlinear characteristics in micro/nanosystems has been a subject of increasing interest in the last decade. Among others, vigorous intermodal coupling through internal resonance (IR) has drawn much attention because it can suggest new strategies to steer energy within a micro/nanomechanical resonator. However, a challenge in utilizing IR in practical applications is imposing the required frequency commensurability between vibrational modes of a nonlinear micro/nanoresonator. Here, we experimentally and analytically investigate the 1:2 and 2:1 IR in a clamped–clamped beam resonator to provide insights into the detailed mechanism of IR. It is demonstrated that the intermodal coupling between the second and third flexural modes in an asymmetric structure (e.g., nonprismatic beam) provides an optimal condition to easily implement a strong IR with high energy transfer to the internally resonated mode. In this case, the quadratic coupling between these flexural modes, originating from the stretching effect, is the dominant nonlinear mechanism over other types of geometric nonlinearity. The design strategies proposed in this paper can be integrated into a typical micro/nanoelectromechanical system (M/NEMS) via a simple modification of the geometric parameters of resonators, and thus, we expect this study to stimulate further research and boost paradigm-shifting applications exploring the various benefits of IR in micro/nanosystems. Achieving strong ‘internal resonance’ within a simple nanoelectromechanical resonator opens doors to further research and practical applications. Hanna Cho, and a team from The Ohio State University and Michigan State University, United States, describe in their new paper how internal resonance (IR) offers a “unique pathway” to steer vibrational energy, with applications in signal detection and simultaneous physical property sensing. Robust achievement of IR has proved challenging, with the property first realized in the early 2010s. The team now describe the robust generation of IR by a “relatively simple” nanoelectromechanical resonator, and the design parameters that can be manipulated to alter resonance behaviors. The team hope that their blueprints can act as a stepping stone for deeper investigation into the exploitation of IR for various applications.
#Environment & Nature
Field
# Environment & Nature
Updated
26 January 2021
#7
View it
Name
16th-century ritual sacrifice, cannibalism and bloody slaughter revealed in Mexican city | Live Science
Description
Conquistadors murdered hundreds of Acolhua people, a sister culture of the Aztecs, after members of a Spanish caravan in Mexico were captured, sacrificed and eaten.
#Archaeology & History
Field
# Archaeology & History
Updated
26 January 2021
#8
View it
Name
Need a lift? SpaceX launches record spacecraft in cosmic rideshare program - Latest News | Gadgets Now
Description
A veteran rocket from billionaire entrepreneur Elon Musk’s SpaceX aerospace company launched 143 spacecraft into space on Sunday, a new record for the most spaceships deployed on a single mission, according to the company.
#Astronautics
Field
# Astronautics
Updated
26 January 2021
#9
View it
Name
Makers of Sophia the robot plan mass rollout amid pandemic - Latest News | Gadgets Now
Description
“Social robots like me can take care of the sick or elderly,” Sophia says as she conducts a tour of her lab in Hong Kong. “I can help communicate, give therapy and provide social stimulation, even in difficult situations.”
#Robotics & Manufacturing
Field
# Robotics & Manufacturing
Updated
26 January 2021
#10
View it
Name
Italy consumer association sues Apple for planned iPhone obsolescence - Latest News | Gadgets Now
Description
Italian consumer association Altroconsumo said it had told Apple it has launched a class action against the US tech giant for the practice of planned obsolescence.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#11
View it
Name
Google Maps is removing one of its biggest problem for users in India - Latest News | Gadgets Now
Description
For non-English users, using Google Maps could be frustrating. For starters, understanding that “एनआईटी from the acronym NIT is pronounced “en-aye-tee”, not as the English word “nit”.
#Software;#Maps
Field
# Software
Updated
26 January 2021
#12
View it
Name
Facebook to provide data on targeted political ads to researchers - Latest News | Gadgets Now
Description
Facebook Inc said it would provide academic researchers information on how political ads were targeted in the lead-up to the presidential election in the United States last year.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
26 January 2021
#13
View it
Name
Nokia smartphones: Dixon to manufacture Nokia branded smartphones in India - Latest News | Gadgets Now
Description
Padget Electronics, a subsidiary of Dixon Technologies, on Monday entered into a partnership to manufacture Nokia smartphones in India for HMD Global.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#14
View it
Name
Budget 2021 Expectations: What Startups Want - Latest News | Gadgets Now
Description
Union Budget 2021 will be like none other, Finance Minister Nirmala Sitharaman has promised. What does that mean for startups? A look at some of their budget expectations.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
26 January 2021
#15
View it
Name
Facebook News launches today as a SECOND 'News Feed' with no posts from friends or family
Description
TBD
#Social & Corporation affairs;#Education
Field
# Social & Corporation affairs
Updated
26 January 2021
#16
View it
Name
PUBG Mobile India may not arrive anytime soon, here is why - Technology News
Description
The Ministry of Electronics and Information Technology has allegedly responded to PUBG Corporation in a notice.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#17
View it
Name
Poco M3 teased for India launch, likely to go official next month - Technology News
Description
The Indian variant of the Poco M3 could come with similar specs and features as the global variant.
#Social & Corporation affairs;#Security
Field
# Social & Corporation affairs
Updated
26 January 2021
#18
View it
Name
Phone numbers of 500 million Facebook users on sale through Telegram bot - Technology News
Description
In a major breach in security, users’ data of over 500 million Facebook users are being sold using a Telegram bot.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#19
View it
Name
OnePlus Nord Android 11-based OxygenOS open beta 2 update released: Here are all the new features - Technology News
Description
Apart from the bug fixes and optimisations, the new update also comes with the latest Google Security patch.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#20
View it
Name
OnePlus 9, OnePlus 9 Pro face major specs leak, tipped to get Snapdragon 888 SoC but no periscope camera - Technology News
Description
The OnePlus 9 Pro is tipped to come with a Snapdragon 888 chipset and a 4,500mAh battery with 65W fast charging.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#21
View it
Name
FAU-G launched in India as rival PUBG Mobile still in jeopardy - Technology News
Description
FAU-G is short for Fearless and United Guards, the storyline of which is based on the Galwan Valley clash between India and China.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#22
View it
Name
Apple likely to equip iPhone 13 with DSLR-like camera stabilisation - Technology News
Description
Apple is likely to equip the new iPhone models with sensor-shift optical image stabilisation which can bring their camera stabilisation very close to DSLRs.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#23
View it
Name
iPhone 12 Mini with Rs 12,000 discount or iPhone 11: Old is gold in this case - Technology News
Description
If you have been planning to buy one of the newer iPhone models, this is probably the best time with Maple Online store offering great deals and discounts on all variants.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#24
View it
Name
Famed Chinese immunologist cleared of plagiarism and fraud
Description
TBD
#Theoretical sciences
Field
# Theoretical sciences
Updated
26 January 2021
#25
View it
Name
BOTW: All Fairy Fountain Locations
Description
Great Fairy Fountains in The Legend of Zelda: Breath of the Wild let you upgrade your armor. Here's where to find every fairy fountain in Breath of the Wild.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#26
View it
Name
BOTW: How to Get the Hylian Shield
Description
You'll have to travel deep into Hyrule Castle to find Link's iconic shield. This guide will walk you through a few ways to find the most durable shield in BOTW.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#27
View it
Name
The Most Famous Video Game Cheat Codes of All Time
Description
For as long as video games have existed, there have been cheat codes. Here are some of the most famous cheat codes from historical games and a few modern ones.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#28
View it
Name
Kingdom Hearts 3 Tips and Tricks
Description
Whether you're a seasoned Keyblade master or a new adventurer, we have some essential tips and tricks to help you on your journey through Kingdom Hearts 3.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#29
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#30
View it
Name
Polk React Soundbar: Wireless, Expandable, With Alexa Smarts
Description
The $249 Polk Audio React soundbar can deliver virtual 5.1 surround sound on its own, or you can expand it with wireless speakers and a wireless subwoofer.
#Hardware & Devices;#Artificial intelligence
Field
# Hardware & Devices
Updated
26 January 2021
#31
View it
Name
Lego Vidiyo sounds like a TikTok-like music video playground for kids - CNET
Description
A new Lego line made with Universal Music scans bricks to create AR music videos in your home.
#Entertainments;#Music
Field
# Entertainments
Updated
26 January 2021
#32
View it
Name
Relationship of back muscle and knee extensors with the compensatory mechanism of sagittal alignment in a community-dwelling elderly population | Scientific Reports
Description
Compensatory mechanisms, such as a decrease in thoracic spine kyphosis and posterior tilting or rotation of the pelvis, aim to achieve optimal alignment of the spine. However, the effect of muscle strength on these compensatory mechanisms has not been elucidated. This study aimed to investigate the impact of back muscle and lower extremity strength on compensatory mechanisms in elderly people. Overall, 409 community-dwelling elderly participants (164 men, 245 women) were included. Age, disc degeneration, and 2 or more vertebral fractures showed a significant increase of risk for sagittal vertical axis (SVA) deterioration. Conversely, stronger back, hip flexor, and knee extensor muscles reduced the risk for SVA deterioration. To investigate the association of each muscle’s strength with compensatory mechanisms, 162 subjects with pelvic incidence-lumbar lordosis > 10° were selected. The linear regression model for thoracic kyphosis demonstrated a negative correlation with back muscle strength and positive correlation with vertebral fracture. The regression analysis for pelvic tilt demonstrated a positive correlation with knee extensor strength. Back, hip flexor, and knee extensor muscle strength were associated with sagittal spinal alignment. Back muscle strength was important for the decrease in thoracic kyphosis, and knee extensor strength was associated with pelvic tilt.
#Social & Corporation affairs;#Security;#Privacy
Field
# Social & Corporation affairs
Updated
26 January 2021
#33
View it
Name
Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort | Scientific Reports
Description
Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#34
View it
Name
Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease | Scientific Reports
Description
Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeutic alternative. However, knowledge about how probiotics influence brain metabolite changes during HE is missing. In the present study, we combined the advantages of ultra-high field in vivo 1H MRS with behavioural tests to analyse whether a long-term treatment with a multistrain probiotic mixture (VIVOMIXX) in a rat model of type C HE had a positive effect on behaviour and neurometabolic changes. We showed that the prophylactic administration of this probiotic formulation led to an increase in gut Bifidobacteria and attenuated changes in locomotor activity and neurometabolic profile in a rat model of type C HE. Both the performance in behavioural tests and the neurometabolic profile of BDL + probiotic rats were improved compared to the BDL group at week 8 post-BDL. They displayed a significantly lesser increase in brain Gln, a milder decrease in brain mIns and a smaller decrease in neurotransmitter Glu than untreated animals. The clinical implications of these findings are potentially far-reaching given that probiotics are generally safe and well-tolerated by patients.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#35
View it
Name
Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model | Scientific Reports
Description
Wolfram syndrome (WS) is a monogenic progressive neurodegenerative disease and is characterized by various neurological symptoms, such as optic nerve atrophy, loss of vision, cognitive decline, memory impairment, and learning difficulties. GLP1 receptor agonist liraglutide and BDNF mimetic 7,8-dihydroxyflavone (7,8-DHF) have had protective effect to visual pathway and to learning and memory in different rat models of neurodegenerative disorders. Although synergistic co-treatment effect has not been reported before and therefore the aim of the current study was to investigate liraglutide, 7,8-DHF and most importantly for the first time their co-treatment effect on degenerative processes in WS rat model. We took 9 months old WS rats and their wild-type (WT) control animals and treated them daily with liraglutide, 7,8-DHF or with the combination of liraglutide and 7,8-DHF up to the age of 12.5 months (n = 47, 5–8 per group). We found that liraglutide, 7,8-DHF and their co-treatment all prevented lateral ventricle enlargement, improved learning in Morris Water maze, reduced neuronal inflammation, delayed the progression of optic nerve atrophy, had remyelinating effect on optic nerve and thereby improved visual acuity in WS rats compared to WT controls. Thus, the use of the liraglutide, 7,8-DHF and their co-treatment could potentially be used as a therapeutic intervention to induce neuroprotection or even neuronal regeneration.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#36
View it
Name
Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients | Scientific Reports
Description
Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p < 0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.2 ± 7.1 vs. 29.4 ± 9.7 units/L, p < 0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by 31phosphorus- and 1proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.
#Energy
Field
# Energy
Updated
26 January 2021
#37
View it
Name
The impact of tinnitus distress on cognition | Scientific Reports
Description
Tinnitus is the chronic perception of a phantom sound with different levels of related distress. Past research has elucidated interactions of tinnitus distress with audiological, affective and further clinical variables. The influence of tinnitus distress on cognition is underinvestigated. Our study aims at investigating specific influences of tinnitus distress and further associated predictors on cognition in a cohort of n = 146 out-ward clinical tinnitus patients. Age, educational level, hearing loss, Tinnitus Questionnaire (TQ) score, tinnitus duration, speech in noise (SIN), stress, anxiety and depression, and psychological well-being were included as predictors of a machine learning regression approach (elastic net) in three models with scores of a multiple choice vocabulary test (MWT-B), or two trail-making tests (TMT-A and TMT-B), as dependent variables. TQ scores predicted lower MWT-B scores and higher TMT-B test completion time. Stress, emotional, and psychological variables were not found to be relevant predictors in all models with the exception of small positive influences of SIN and depression on TMT-B. Effect sizes were small to medium for all models and predictors. Results are indicative of specific influence of tinnitus distress on cognitive performance, especially on general or crystallized intelligence and executive functions. More research is needed at the delicate intersection of tinnitus distress and cognitive skills needed in daily functioning.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#38
View it
Name
Antibodies, epicenter of SARS-CoV-2 immunology | Cell Death & Differentiation
Description
#Theoretical sciences
Field
# Theoretical sciences
Updated
26 January 2021
#39
View it
Name
Algorithms for the selection of fluorescent reporters | Communications Biology
Description
Molecular biologists rely on the use of fluorescent probes to take measurements of their model systems. These fluorophores fall into various classes (e.g. fluorescent dyes, fluorescent proteins, etc.), but they all share some general properties (such as excitation and emission spectra, brightness) and require similar equipment for data acquisition. Selecting an ideal set of fluorophores for a particular measurement technology or vice versa is a multidimensional problem that is difficult to solve with ad hoc methods due to the enormous solution space of possible fluorophore panels. Choosing sub-optimal fluorophore panels can result in unreliable or erroneous measurements of biochemical properties in model systems. Here, we describe a set of algorithms, implemented in an open-source software tool, for solving these problems efficiently to arrive at fluorophore panels optimized for maximal signal and minimal bleed-through. Vaidyanathan et al. present a heuristic algorithm for the selection of fluorescent reporters in the context of single-cell analysis. They present a tool to enable biologists to design multi-colour fluorophore panels based on specific equipment’s configurations. The authors demonstrate the efficacy of their algorithm by comparing computational predictions with experimental observations.
#Hardware & Devices;#Gadgets
Field
# Hardware & Devices
Updated
26 January 2021
#40
View it
Name
Proteome-wide profiling and mapping of post translational modifications in human hearts | Scientific Reports
Description
Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins. PTMs contribute to regulation of protein function and thereby greatly increase the functional diversity of the proteome. In the heart, a few well-studied PTMs, such as phosphorylation and glycosylation, are known to play essential roles for cardiac function. Yet, only a fraction of the ~ 300 known PTMs have been studied in a cardiac context. Here we investigated the proteome-wide map of PTMs present in human hearts by utilizing high-resolution mass spectrometry measurements and a suite of PTM identification algorithms. Our approach led to identification of more than 150 different PTMs across three of the chambers in human hearts. This finding underscores that decoration of cardiac proteins by PTMs is much more diverse than hitherto appreciated and provides insights in cardiac protein PTMs not yet studied. The results presented serve as a catalogue of which PTMs are present in human hearts and outlines the particular protein and the specific amino acid modified, and thereby provides a detail-rich resource for exploring protein modifications in human hearts beyond the most studied PTMs.
#Theoretical sciences
Field
# Theoretical sciences
Updated
26 January 2021
#41
View it
Name
Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips | Scientific Reports
Description
In vitro neuronal models are essential for studying neurological physiology, disease mechanisms and potential treatments. Most in vitro models lack controlled vasculature, despite its necessity in brain physiology and disease. Organ-on-chip models offer microfluidic culture systems with dedicated micro-compartments for neurons and vascular cells. Such multi-cell type organs-on-chips can emulate neurovascular unit (NVU) physiology, however there is a lack of systematic data on how individual cell types are affected by culturing on microfluidic systems versus conventional culture plates. This information can provide perspective on initial findings of studies using organs-on-chip models, and further optimizes these models in terms of cellular maturity and neurovascular physiology. Here, we analysed the transcriptomic profiles of co-cultures of human induced pluripotent stem cell (hiPSC)-derived neurons and rat astrocytes, as well as one-day monocultures of human endothelial cells, cultured on microfluidic chips. For each cell type, large gene expression changes were observed when cultured on microfluidic chips compared to conventional culture plates. Endothelial cells showed decreased cell division, neurons and astrocytes exhibited increased cell adhesion, and neurons showed increased maturity when cultured on a microfluidic chip. Our results demonstrate that culturing NVU cell types on microfluidic chips changes their gene expression profiles, presumably due to distinct surface-to-volume ratios and substrate materials. These findings inform further NVU organ-on-chip model optimization and support their future application in disease studies and drug testing.
#Hardware & Devices
Field
# Hardware & Devices
Updated
26 January 2021
#42
View it
Name
Transmission of Metarhizium anisopliae and Beauveria bassiana to adults of Kuschelorhynchus macadamiae (Coleoptera: Curculionidae) from infected adults and conidiated cadavers | Scientific Reports
Description
Kuschelorhynchus macadamiae is a major pest of macadamias in Australia, causing yield losses of up to 15%. Our previous studies have shown the weevil is susceptible to Beauveria bassiana and Metarhizium anisopliae. The aim of this study was to investigate horizontal transmission of both fungal species to healthy weevils from both infected adults and weevil cadavers. In a confined environment the mortality of healthy adults caused by the transmission of conidia from live fungus-infected adults was < 50%. Under similar experimental conditions, the mortality of healthy adults reached 100% when exposed to conidiated cadavers. However, when conidiated cadavers were used in more spacious environments (insect cages), the mortality of adults was < 80%. Using scanning electron microscopy, it was observed that all healthy adults had conidia attached to all external parts of the body. This suggests that although the conidia were readily transferred to the adults, the lower mortality in the larger insect cages could be the result of an unfavourable environmental factor such as low humidity. The presence of conidia attached to all the adults indicated that they did not show any discriminatory behaviour such as avoidance of conidiated cadavers infected by these two fungal species. The results from this study show that there is potential for enhanced control of adult K. macadamiae via transmission from either fungus-infected adults or conidiated cadavers and this could strengthen sustainable pest management in macadamias.
#Theoretical sciences
Field
# Theoretical sciences
Updated
26 January 2021
#43
View it
Name
Large-scale preparation of Co nanoparticles as an additive in carbon fiber for microwave absorption enhancement in C band | Scientific Reports
Description
Recent studies have found that the core–shell structured metal nanoparticles and porous carbon nanofibers (PCNF) are combined into a microwave absorbing material through electrospinning, which exhibits excellent microwave absorption performance. In this study, the core–shell structure Co nanoparticles prepared by the self-developed HEIBE process (production rate of > 50 g/h) were combined with porous carbon fibers, and their absorbing properties were greatly improved. The morphology of Co/PCNF demonstrated that CoNPs are randomly dispersed in the porous carbon nanofibers and carbon nanofiber form complex conductive network which enhances the dielectric loss of the materials. Meanwhile, the Co/PCNF has a low graphitization and shows a significant improvement in permittivity due to the combination of CoNPs and high conductivity of carbon material. The maximum reflection loss (RL) of Co/PCNF reaches − 63.69 dB at 5.28 GHz with a thickness of 5.21 mm and the absorption bandwidth (RL ≤ − 10.0 dB) is 12.92 GHz. In terms of 5.60 mm and 6.61 mm absorber, there are two absorption peaks of − 47.64 dB and − 48.30 dB appear around 12.50 GHz and 14.10 GHz, respectively. The results presented in this paper may pave a way for promising applications of lightweight and high-efficiency microwave absorbing materials (MAMs).
#Social & Corporation affairs;#Environment & Nature
Field
# Social & Corporation affairs
Updated
26 January 2021
#44
View it
Name
An efficient simulation for quantum secure multiparty computation | Scientific Reports
Description
The quantum secure multiparty computation is one of the important properties of secure quantum communication. In this paper, we propose a quantum secure multiparty summation (QSMS) protocol based on (t, n) threshold approach, which can be used in many complex quantum operations. To make this protocol secure and realistic, we combine both the classical and quantum phenomena. The existing protocols have some security and efficiency issues because they use (n, n) threshold approach, where all the honest players need to perform the quantum multiparty summation protocol. We however use a (t, n) threshold approach, where only t honest players need to compute the quantum summation protocol. Compared to other protocols our proposed protocol is more cost-effective, realistic, and secure. We also simulate it using the IBM corporation’s online quantum computer, or quantum experience.
#Hardware & Devices
Field
# Hardware & Devices
Updated
26 January 2021
#45
View it
Name
Recycling silver nanoparticle debris from laser ablation of silver nanowire in liquid media toward minimum material waste | Scientific Reports
Description
As silver nanowires (Ag NWs) are usually manufactured by chemical synthesis, a patterning process is needed to use them as functional devices. Pulsed laser ablation is a promising Ag NW patterning process because it is a simple and inexpensive procedure. However, this process has a disadvantage in that target materials are wasted owing to the subtractive nature of the process involving the removal of unnecessary materials, and large quantities of raw materials are required. In this study, we report a minimum-waste laser patterning process utilizing silver nanoparticle (Ag NP) debris obtained through laser ablation of Ag NWs in liquid media. Since the generated Ag NPs can be used for several applications, wastage of Ag NWs, which is inevitable in conventional laser patterning processes, is dramatically reduced. In addition, electrophoretic deposition of the recycled Ag NPs onto non-ablated Ag NWs allows easy fabrication of junction-enhanced Ag NWs from the deposited Ag NPs. The unique advantage of this method lies in using recycled Ag NPs as building materials, eliminating the additional cost of junction welding Ag NWs. These fabricated Ag NW substrates could be utilized as transparent heaters and stretchable TCEs, thereby validating the effectiveness of the proposed process.
#Hardware & Devices;#Laser
Field
# Hardware & Devices
Updated
26 January 2021
#46
View it
Name
Simultaneous mapping of EMCD signals and crystal orientations in a transmission electron microscope | Scientific Reports
Description
When magnetic properties are analysed in a transmission electron microscope using the technique of electron magnetic circular dichroism (EMCD), one of the critical parameters is the sample orientation. Since small orientation changes can have a strong impact on the measurement of the EMCD signal and such measurements need two separate measurements of conjugate EELS spectra, it is experimentally non-trivial to measure the EMCD signal as a function of sample orientation. Here, we have developed a methodology to simultaneously map the quantitative EMCD signals and the local orientation of the crystal. We analyse, both experimentally and by simulations, how the measured magnetic signals evolve with a change in the crystal tilt. Based on this analysis, we establish an accurate relationship between the crystal orientations and the EMCD signals. Our results demonstrate that a small variation in crystal tilt can significantly alter the strength of the EMCD signal. From an optimisation of the crystal orientation, we obtain quantitative EMCD measurements.
#Theoretical sciences
Field
# Theoretical sciences
Updated
26 January 2021
#47
View it
Name
Enhanced laser-driven proton acceleration using nanowire targets | Scientific Reports
Description
Laser-driven proton acceleration is a growing field of interest in the high-power laser community. One of the big challenges related to the most routinely used laser-driven ion acceleration mechanism, Target-Normal Sheath Acceleration (TNSA), is to enhance the laser-to-proton energy transfer such as to maximize the proton kinetic energy and number. A way to achieve this is using nanostructured target surfaces in the laser-matter interaction. In this paper, we show that nanowire structures can increase the maximum proton energy by a factor of two, triple the proton temperature and boost the proton numbers, in a campaign performed on the ultra-high contrast 10 TW laser at the Lund Laser Center (LLC). The optimal nanowire length, generating maximum proton energies around 6 MeV, is around 1–2 $$upmu$$ m. This nanowire length is sufficient to form well-defined highly-absorptive NW forests and short enough to minimize the energy loss of hot electrons going through the target bulk. Results are further supported by Particle-In-Cell simulations. Systematically analyzing nanowire length, diameter and gap size, we examine the underlying physical mechanisms that are provoking the enhancement of the longitudinal accelerating electric field. The parameter scan analysis shows that optimizing the spatial gap between the nanowires leads to larger enhancement than by the nanowire diameter and length, through increased electron heating.
#Hardware & Devices;#Laser
Field
# Hardware & Devices
Updated
26 January 2021
#48
View it
Name
Quantum-mechanical exploration of the phase diagram of water | Nature Communications
Description
The set of known stable phases of water may not be complete, and some of the phase boundaries between them are fuzzy. Starting from liquid water and a comprehensive set of 50 ice structures, we compute the phase diagram at three hybrid density-functional-theory levels of approximation, accounting for thermal and nuclear fluctuations as well as proton disorder. Such calculations are only made tractable because we combine machine-learning methods and advanced free-energy techniques. The computed phase diagram is in qualitative agreement with experiment, particularly at pressures ≲ 8000 bar, and the discrepancy in chemical potential is comparable with the subtle uncertainties introduced by proton disorder and the spread between the three hybrid functionals. None of the hypothetical ice phases considered is thermodynamically stable in our calculations, suggesting the completeness of the experimental water phase diagram in the region considered. Our work demonstrates the feasibility of predicting the phase diagram of a polymorphic system from first principles and provides a thermodynamic way of testing the limits of quantum-mechanical calculations. Complex interatomic interactions and diverse structures make computing the phase diagram of water very challenging. Here, a combination of machine learning and advanced free-energy methods at three levels of hybrid DFT enables the prediction of the phase diagram in close agreement with experiment.
#Hardware & Devices
Field
# Hardware & Devices
Updated
26 January 2021
#49
View it
Name
New Research Reignites Debate Around the Behavior of the Giant Dinosaur Spinosaurus
Description
TBD
#Archaeology & History
Field
# Archaeology & History
Updated
26 January 2021
#50
View it
Name
NASA’s Deep Space Network Welcomes a Super Powerful New Dish to the Family
Description
TBD
#Astronautics
Field
# Astronautics
Updated
26 January 2021
#51
View it
Name
How to Quickly and Easily Find Mutated Sperm? Just Go FISH
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#52
View it
Name
Listen-in social network Clubhouse readies for the masses
Description
Invite-only audio social network Clubhouse is readying to let in the masses with the help of a fresh funding round reported to value it at nearly a billion dollars.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
26 January 2021
#53
View it
Name
WATCH LIVE: Samsung announce major mobile phone developments
Description
WATCH LIVE: Samsung announce major mobile phone developments
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#54
View it
Name
Apple warns iPhone 12 could 'interfere' with pacemakers – and to keep it a FOOT away from chest
Description
TBD
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#55
View it
Name
Amazon trolled over new app logo that 'looks like grinning HITLER'
Description
TBD
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
26 January 2021
#56
View it
Name
Amazon has a new iOS app icon design
Description
Amazon's iOS app has a new icon, and it's a bit more colorful than the last one.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
26 January 2021
#57
View it
Name
UK coronavirus variant deadlier but researchers say no need to panic | New Scientist
Description
It appears the UK's B.1.1.7 coronavirus variant is slightly more deadly and more transmissible than other variants, but improved treatments may limit the risk of death if you are infected
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#58
View it
Name
FAU-G ‘Made in India’ Gaming App is Available Now: How to Download on Android | Technology News
Description
The new FAU-G, aka Fearless and United Guards, game is now available on Google Play as a free download. Users can go to the Google Play store on their Android smartphones and download FAU-G. The game is compatible with handsets running Android 8 and above.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#59
View it
Name
Samsung Galaxy S21 is here but you should wait for OnePlus 9 series instead - Technology News
Description
It’s been few days since the Samsung Galaxy S21 series was launched in India. The hype has settled and it’s time to take a closer look at what’s on offer and whether you should spend on it or not.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#60
View it
Name
FAU-G review: An incomplete, lacklustre game that is no PUBG rival - Technology News
Description
FAU-G review: After a lot of ‘halla’, multiple trailers and long wait, FAU-G or Fearless and United Guards is now available for download via Google Play Store.
#Entertainments;#Games
Field
# Entertainments
Updated
26 January 2021
#61
View it
Name
Xiaomi may launch Mi 10 variant with Snapdragon 870 SoC - Technology News
Description
The phone's Snapdragon 870 SoC could be paired with 8GB of LPDDR5 RAM and up to 256GB of UFS 3.1 storage.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#62
View it
Name
Invite-only app Clubhouse come up with Android version - Technology News
Description
There is a strong chance that Clubhouse turns out to be the next big smartphone app. The audio-based social networking platform has seen immense growth in last few months and is becoming increasingly popular among users.
#Software
Field
# Software
Updated
26 January 2021
#63
View it
Name
If you use Facebook, your phone number might be on sale on Telegram: Story in 5 points - Technology News
Description
Facebook landed in a soup recently when a security researcher unearthed that the phone numbers of Facebook users are being sold using a Telegram bot
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#64
View it
Name
Flipkart Mobile Bonanza sale: Offers on iPhone 11, iPhone SE, Moto G 5G and other phones - Technology News
Description
Along with discounts on some of the popular smartphones, Flipkart is offering bank offers and exchange offers to further sweeten the deals.
#Gadgets
Field
# Gadgets
Updated
26 January 2021
#65
View it
Name
After containment zones, Google Maps will now show when and where to get COVID-19 vaccine - Technology News
Description
Google said it's working with authoritative sources including government agencies and retail pharmacies for the information.
#Medicine & Human body
Field
# Medicine & Human body
Updated
26 January 2021
#66
View it
Name
Xiaomi Mi QLED TV 4K: Review in 5 points - Technology News
Description
Priced at an aggressive Rs 54,999, the Mi QLED TV 4K attempts to take on offerings from OnePlus and TCL. But is it worth your money?
#Entertainments
Field
# Entertainments
Updated
26 January 2021
#67
View it
Name
First humans in Americas took their dogs with them - BBC Science Focus Magazine
Description
Researchers think dogs were first domesticated in Siberia, and humans took them along as they migrated.
#Archaeology & History
Field
# Archaeology & History
Updated
26 January 2021
#68
View it
Name
Let’s learn about taste | Science News for Students
Description
TBD
#Social & Corporation affairs;#Education
Field
# Social & Corporation affairs
Updated
26 January 2021
#69
View it
Name
EdgeQ Takes On Intel’s 5G Play With AI-Infused Modem Chip
Description
EdgeQ reveals its new "base-station-on-a-chip" that combines 5G and AI functions to replace multiple hardware components, including Intel CPUs and FPGAs.
#Hardware & Devices
Field
# Hardware & Devices
Updated
26 January 2021
#70
View it
Name
OnePlus 9 Pro, OnePlus 9 Specifications Tipped Ahead of Rumoured March Launch | Technology News
Description
OnePlus 9 Pro and OnePlus 9 could both have 120Hz refresh rate, as per a tipster. OnePlus 9 Pro could feature a 6.8-inch Quad HD+ curved display, while OnePlus 9 may have a 6.55-inch full-HD+ flat display. The phones, rumoured to launch in March, are tipped to weigh less than 200 grams.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#71
View it
Name
iPhone 12, MagSafe Accessories May Interfere With Pacemakers, Medical Implants, Cautions Apple | Technology News
Description
Apple has cautioned users that implanted pacemakers, defibrillators and other medical implants might contain sensors that respond to magnets in iPhones and MagSafe accessories. Users are advised to keep their iPhones and MagSafe accessories a safe distance away (more than 6 inches/ 15 cm apart or more than 12 inches/ 30 cm apart if wirelessly charging). “But consult with your physician and your device manufacturer for specific guidelines,” says the support page.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#72
View it
Name
Google to Open US Offices as COVID-19 Vaccination Centres, Spend $150 Million on Vaccine Awareness: CEO Sundar Pichai | Technology News
Description
Google CEO Sundar Pichai has announced via a blog post that the company’s offices in the US will be used as COVID-19 vaccination centres. Google has also pledged $150 million (roughly Rs. 1,090 crores) for programmes to promote vaccine education.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#73
View it
Name
Google Paying for News is ‘Inevitable’, says Australia | Technology News
Description
Google and other tech behemoths will have to eventually pay for using media content, Australia has said. Responding to the Internet giant’s threat to disable its search engine in the country if it’s forced to pay local publishers for news, Australia’s Treasurer Josh Frydenberg said that paying for new was “inevitable”.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#74
View it
Name
MIUI 12 Disable Ads: How to Remove Ads, and Spam Notifications From Any Xiaomi Smartphone | NDTV Gadgets 360
Description
MIUI 12 boasts a ton of new improvements, but it still features pesky ads in its interface. Here’s how you can remove them.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#75
View it
Name
New Star Wars: Knights of the Old Republic Game in Development: Reports | Technology News
Description
A new Star Wars: Knights of the Old Republic game is reportedly in development, but not at BioWare or Electronic Arts. Reports note that Star Wars fans will “never guess” which studio is behind it.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#76
View it
Name
Razer Naga X Gaming Mouse With 16 Programmable Buttons Launched, Aimed at MMO Gamers | Technology News
Description
Razer’s latest gaming mouse has 16 programmable buttons and a right-handed ergonomic design. The Razer Naga X gaming mouse is designed for massively multiplayer online (MMO) gamers. It is priced at $79.99 (roughly Rs. 5,800) and is available for purchase from Razer’s website. The gaming mouse features the Razer Chroma RGB lighting.
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#77
View it
Name
Netflix Update to Deliver Better Audio on Android With xHE-AAC Codec | Entertainment News
Description
Netflix is rolling out a significant update that promises to improve sound quality on Android devices running version 9 and above. The xHE-AAC codec is said to offer studio-quality audio, better reliability on mobile data, and more.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#78
View it
Name
OnePlus Buds Z Steven Harrington Edition TWS Earbuds With Two-Tone Colour Launched in India | Technology News
Description
OnePlus Buds Z Steven Harrington Edition truly wireless (TWS) earbuds have been launched in India as a limited edition of the regular OnePlus Buds Z. The new earbuds come in a two-tone purple and mint colour option.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#79
View it
Name
YouTube.com Now Available to Be Installed as a Progressive Web App | Technology News
Description
The main YouTube site can now be installed as a Progressive Web App (PWA) for quicker access. Google had recently announced that it was bringing Stadia to iOS as a PWA. After the PWA is installed, the users get a large red play logo in the app launcher to open YouTube in a window that doesn’t have the address bar among other user interface elements.
#Software
Field
# Software
Updated
25 January 2021
#80
View it
Name
Microsoft Is Making It Easier to Transfer Files From Outlook to Teams With Drag and Drop | Technology News
Description
Microsoft has added the capability to drag and drop files from Outlook to Teams. With this feature, users can move attachments between the two apps easily. Until now, users had to first drag the files onto a location like the desktop, and drag them from there to the files tab in Teams.
#Software;#Social & Corporation affairs
Field
# Software
Updated
25 January 2021
#81
View it
Name
SpaceX Launches Falcon 9 Rocket With Record 143 Spacecraft in Cosmic Rideshare Program | Technology News
Description
Elon Musk’s SpaceX set a new record on Sunday for the most spaceships deployed on a single mission with the launch of 143 spacecraft into space via its Falcon 9 reusable rocket.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#82
View it
Name
Tesla Sues Former Employee for Allegedly Stealing 26,000 Confidential Files | Technology News
Description
Tesla has filed a case against a former employee, Alex Khatilov, who the company says stole 26,000 confidential files within three days of being hired, according to a court filing.
#Vehicles & Special machines
Field
# Vehicles & Special machines
Updated
25 January 2021
#83
View it
Name
Redmi Note 10 teased for first time, might launch in India next month - Technology News
Description
Xiaomi might expand its Note line up next month with the launch of the Redmi Note 10 in India. The smartphone has been teased for the very first time by company’s general manager Lu Weibing through a Weibo post.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#84
View it
Name
Redmi K40 retail box leaks, likely to launch without a charger - Technology News
Description
The Redmi K40 series is set for launch next month. Here's what we know about it so far.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#85
View it
Name
Realme C20, company’s first affordable handset of 2021, is almost same as C11 of 2020 - Technology News
Description
Realme C20 comes as the company's first entry-level smartphone of the year 2021.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#86
View it
Name
Realme Buds Q2 design, key specifications spotted ahead of imminent launch - Technology News
Description
Realme is working on the successor of the Buds Q that impressed me last year.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#87
View it
Name
Oppo A55 5G with triple cameras, 5000mAh battery launched: Price, specifications - Technology News
Description
Oppo has launched a new smartphone in China called the A55 5G that is powered by a MediaTek Dimensity 700 processor.
#Energy
Field
# Energy
Updated
25 January 2021
#88
View it
Name
OnePlus Buds Z Steven Harrington Edition launched in India, priced at Rs 3,699 - Technology News
Description
The OnePlus Buds Z Steven Harrington Edition brings the same hardware as the OnePlus Buds Z truly wireless (TWS) earbuds.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#89
View it
Name
Nokia 1.4, 7.4, and 6.4 may now launch as early as Q1 2021 - Technology News
Description
HMD Global may be close to launching the Nokia 1.4, Nokia 6.4, and Nokia 7.4 as early as February this year.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#90
View it
Name
Nikon Z7 mirrorless camera uses Sony sensor: Report - Technology News
Description
It is finally out that Nikon Z7 mirrorless camera uses Sony-made sensor. The code name of the image sensor is Sony IMX309BQJ.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#91
View it
Name
Canon EOS R5 will get improvements through firmware update - Technology News
Description
Canon will soon release a firmware update for Canon EOS R5 with two major improvements including C-Log 3 support and 1080p video capture at up to 120FPS.
#Software;#Security
Field
# Software
Updated
25 January 2021
#92
View it
Name
BSNL extends Rs 699 prepaid plan in more telecom circles, what Airtel and Vi offer at the same price - Technology News
Description
BSNL has extended the availability of its Rs 699 prepaid plan in the Kerala circle as part of its Republic Day offer. The plan is ideal for customers looking for unlimited calling benefits and long validity.
#Social & Corporation affairs;#Environment & Nature
Field
# Social & Corporation affairs
Updated
25 January 2021
#93
View it
Name
OnePlus 9 series rumour roundup: Big displays, Snapdragon 888 SoC and everything else we know so far - Technology News
Description
The core OnePlus 9 series phone are tipped to come with the Snapdragon 888 SoC under the hood.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#94
View it
Name
iPhone 13 series to launch in 2021: Possible specs, India price, features, and everything we know - Technology News
Description
The iPhone 13 lineup is expected to see a couple of major improvements in design, display, cameras, authentication and more. Read this story to find out everything we know so far about the upcoming iPhone 13 lineup.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#95
View it
Name
FAU-G, made in India mobile game, set for Republic Day launch: Gameplay, teaser, and everything we know - Technology News
Description
FAU-G is said to be based on real-world scenarios and has already been confirmed that the game's first level is based on Galwan Valley.
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#96
View it
Name
You may need to vaccinate your pets against COVID-19, scientists warn - BBC Science Focus Magazine
Description
Coronavirus can infect a wide range of species including cats, dogs, mink and other domesticated species, experts said.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#97
View it
Name
Ultra precise lasers remove cancer cells without damaging tissue - BBC Science Focus Magazine
Description
The technology could be used for the treatment of brain, head, and neck cancers.
#Hardware & Devices;#Laser
Field
# Hardware & Devices
Updated
25 January 2021
#98
View it
Name
Dr Michael Mosley on how to keep your blood pressure down - BBC Science Focus Magazine
Description
It’s vital to keep your blood pressure healthy. This is how I keep an eye on mine.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#99
View it
Name
Scientists Say: Body Mass Index | Science News for Students
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#100
View it
Name
Some electric eels coordinate their attacks to zap prey | Science News for Students
Description
TBD
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#101
View it
Name
5 Security Vendors That Have Reported Cyberattacks Since December
Description
Five cybersecurity vendors disclosed in recent weeks that hackers have attacked their internal systems, compromised their certificates, or attempted to access their email accounts. Here’s a rundown of what happened when.
#Software;#Security
Field
# Software
Updated
25 January 2021
#102
View it
Name
IBM Worldwide Ecosystems Chief Bob Lord’s 7 Boldest Statements On IBM’s Red Hat OpenShift Sales Charge
Description
New IBM SVP Bob Lord says the company is upping its partner game as it sharpens its focus on Red Hat OpenShift as the standard for hybrid cloud and AI.
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#103
View it
Name
Robin.io Strengthens Kubernetes, App Management Offering With New Channel Push
Description
Robin.io is beefing up its channel program to better serve Kubernetes and cloud-native application solution providers.
#Social & Corporation affairs;#Vehicles & Special machines
Field
# Social & Corporation affairs
Updated
25 January 2021
#104
View it
Name
SonicWall Partners On High Alert After Hack Exposes Tool Flaw
Description
SonicWall’s 21,000 channel partners had a very long weekend after the company admitted a sophisticated cyberattack against its internal systems had revealed zero-day product vulnerabilities.
#Software;#Security
Field
# Software
Updated
25 January 2021
#105
View it
Name
IBM CEO Arvind Krishna Appoints New Ecosystems Chief To Accelerate Hybrid Cloud-AI Sales Offensive
Description
Here is a look at why IBM CEO Arvind Krishna has named IBM Senior Vice President Bob Lord as the new head of worldwide ecosystems and blockchain.
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#106
View it
Name
HPE Snatches Away HP Channel Veteran To Oversee Worldwide Distribution
Description
Here's a look at why Hewlett Packard Enterprise has snatched away a channel veteran from HP to oversee its worldwide distribution business.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#107
View it
Name
Archaeologists in Turkey Have Discovered a Mysterious Ancient Kingdom Lost in History
Description
It was said that all he touched turned to gold. But destiny eventually caught up with the legendary King Midas, and a long-lost chronicle of his ancient downfall appears to have literally surfaced in Turkey.
#Archaeology & History
Field
# Archaeology & History
Updated
25 January 2021
#108
View it
Name
Proud of vaccine success, Warp Speed’s ex–science head talks politics, presidents, and future pandemics
Description
Moncef Slaoui candidly discusses Trump, the shortcomings of the COVID-19 vaccine rollout, and the joy of getting his first dose
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#109
View it
Name
Ice age Siberian hunters may have domesticated dogs 23,000 years ago
Description
Researchers combine ancient DNA from people and dogs to spell out story of dog domestication
#Archaeology & History
Field
# Archaeology & History
Updated
25 January 2021
#110
View it
Name
SpaceX Launches Record-Setting 143 Satellites in First Rideshare Mission
Description
On Sunday (Jan. 24), SpaceX launched the Transporter-1 mission with an incredible 143 satellites. Not everyone is celebrating, though. ...
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#111
View it
Name
Daily briefing: Retracted COVID papers are still being cited
Description
TBD
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#112
View it
Name
Iran Blames Bitcoin For Massive Electric Grid Blackouts
Description
The Iranian government is shutting down some 1,6000 cryptocurrency mining operations after several major power outages sweeped the country.
#Software;#Finance
Field
# Software
Updated
25 January 2021
#113
View it
Name
Gaming CEO: Brain Interfaces Will Allow Us to Edit Our Feelings
Description
Valve CEO Gabe Newell says his company is working on a brain-computer interface (BCI) headset that can make video games more immersive than ever.
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#114
View it
Name
Amazon Slashes the Apple Watch 6 Price by $60
Description
The Apple Watch series has a new chip for faster processing and even more health and fitness monitoring.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#115
View it
Name
Scientists rediscover adorable rare volcano mouse thought to be extinct - CNET
Description
The mouse species survived a devastating volcano eruption in the Philippines.
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#116
View it
Name
A $10 dip warmer and more tools to tackle your football watch party - CNET
Description
Keep the beer cold and the dips hot with these handy game-day gadgets.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#117
View it
Name
Not just MagSafe: Apple reminds users not to hold iPhones near pacemakers | Ars Technica
Description
In response to iPhone 12 fears, Apple updates support hub with revised guidance.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#118
View it
Name
Apple doubles down on Fitness+ with new “Time to Walk” Apple Watch content | Ars Technica
Description
Dolly Parton, Shawn Mendes, and more lend their voices to the first episodes.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#119
View it
Name
Bad news for land-speed record fans as Bloodhound goes up for sale | Ars Technica
Description
After testing to 628mph in 2019, the car now needs its rocket engine integrated.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#120
View it
Name
AT&T may keep majority ownership of DirecTV as it closes in on final deal | Ars Technica
Description
It's unclear whether AT&T will maintain operational control of DirecTV.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#121
View it
Name
How Final Fantasy VII Remake legitimizes sexuality and gender identity | Ars Technica
Description
Over 20 years later, "Cloud in a dress" isn't just treated as a joke.
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#122
View it
Name
“Single center experience of laparoscopic hysteroannessiectomy and histopathological outcomes in transgender men” | International Journal of Impotence Research
Description
This article presents a retrospective descriptive analysis about female-to-male (FtM) gender-affirmation nongenital surgical procedures involving the gynecological team at the CIDIGeM (Centro Interdipartimentale Disturbi di Identità di Genere Molinette) Center in Turin. From 2004 to 2019, seventy FtM transsexual patients underwent hysteroannessiectomy: the chosen surgical technique involved a Total Laparoscopic Hysterectomy. The patients presented a median age of 30.5 years (range 21–53). No patients presented intraoperative complications, the median of surgery time was 80 min (range 40–150) and the hospital stay median was 5 days (range: 2–25). Histopathological examinations were negative for cancer in all patients except for one unknown case of grade 3 cervical intraepithelial neoplasia. Total Laparoscopic Hysterectomy is confirmed to be the method of choice in the group of FtM transsexuals: this approach has several advantages over abdominal hysterectomy, including more rapid recovery, fewer wound or abdominal wall infections; moreover, it has enabled us to preserve the vital structures needed for reconstruction of external genitalia. Cancer risk is still considered an area of priority in transgender research; thus, we underline the importance of performing a histopathological examination of the surgical specimen.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#123
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#124
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#125
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#126
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#127
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#128
View it
Name
COVID-19 Virus Needs Cholesterol to Invade Cells – What This Means for People Taking Statins
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#129
View it
Name
Airplanes Could Save Fuel, Time and Emissions by Better Surfing the Wind
Description
TBD
#Energy
Field
# Energy
Updated
25 January 2021
#130
View it
Name
With new design, stretchable electronics perform better under strain
Description
Our bodies send out hosts of signals—chemicals, electrical pulses, mechanical shifts—that can provide a wealth of information about our health.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#131
View it
Name
Paleontologists Might Have Discovered the Largest Dinosaur That Ever Lived
Description
Scientists excavating a new species of dinosaur in Argentina have reported that the specimen might be the largest that ever ...
#Archaeology & History
Field
# Archaeology & History
Updated
25 January 2021
#132
View it
Name
Microsoft patent would let us chat with the departed
Description
A chilling episode of the Twilight Zone that first aired 60 years ago focused on a young boy (played by Bill Mumy) who frustrated his parents by insisting he speaks to his grandmother daily on the toy phone she had given ...
#Social & Corporation affairs;#Environment & Nature
Field
# Social & Corporation affairs
Updated
25 January 2021
#133
View it
Name
Meteorites: ‘a story written across light years down the barrel of a microscope’
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#134
View it
Name
Apple warns to keep iPhone 12, MagSafe accessories "safe distance" from medical devices
Description
Apple is warning owners of the iPhone 12 and any MagSafe charging accessories to keep the gadgets at a "safe distance" from medical devices.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#135
View it
Name
A molecular handbook for human development
Description
TBD
#Social & Corporation affairs;#Education
Field
# Social & Corporation affairs
Updated
25 January 2021
#136
View it
Name
Aircraft could cut emissions by better surfing the wind
Description
Airlines could save fuel and reduce emissions on transatlantic flights by hitching a better ride on the jet stream, new research has shown.
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#137
View it
Name
Global absence and targeting of protective immune states in severe COVID-19 | Nature
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#138
View it
Name
Mercury 'at highest point TOMORROW' as tiny planet so shiny you can see it with naked eye
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#139
View it
Name
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis | Nature
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#140
View it
Name
Cyberpunk 2077 update – patch notes as HUGE fix to 'broken' game finally arrives
Description
TBD
#Software;#Security
Field
# Software
Updated
25 January 2021
#141
View it
Name
Seven Facts About the New Head of NASA, Steve Jurczyk
Description
Steve Jurczyk was catapulted from third-in-line to acting leader of NASA when Biden took office. Here's some of what we know about him and his leadership.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#142
View it
Name
Twitter launches crowdsourced fact-checking portal 'Birdwatch'
Description
In Birdwatch, a new pilot program, Twitter users can apply to add contextual notes to tweets that seem misleading.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#143
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#144
View it
Name
How to turn off automatic Time to Walk downloads on your Apple Watch
Description
Apple's new Time to Walk feature on Fitness+ automatically downloads episodes to your Apple Watch. Here's how to turn off the setting.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#145
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#146
View it
Name
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#147
View it
Name
Overprovisioning & Always-On Resources Lead to $26.6 Billion in Public Cloud Waste Expected in 2021 - Business 2 Community
Description
Overprovisioning and leaving cloud resources on are two enormous sources of wasted spend. Wasted spend drags down IT budgets –…...
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#148
View it
Name
Operation Shush: The Rise and Fall of Samsung's Bixby
Description
Once championed as the future of how we would control all kinds of Samsung hardware, the Bixby virtual assistant has steadily been silenced over the past years.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#149
View it
Name
Apple Cautions Against Placing iPhone 12 Near Pacemakers
Description
If you have a pacemaker or some other medical device fitted, and also own an iPhone 12 and/or any MagSafe accessories, then you need to exercise some caution.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#150
View it
Name
Review: 4 Things We Love About Dell’s OptiPlex 7780 All-In-One
Description
Our review of Dell’s OptiPlex 7780 All-In-One finds strong performance and terrific display quality, along with some helpful collaboration features.
#Software
Field
# Software
Updated
25 January 2021
#151
View it
Name
Big Data Analytics Startup Ocient Raises $40M In Early-Round Funding
Description
Big data database and analysis system developer Ocient raises $40 million.
#Software
Field
# Software
Updated
25 January 2021
#152
View it
Name
The best gaming laptop deals right now at Amazon, Best Buy and Newegg - CNET
Description
Notebooks from Alienware, Asus, Dell, HP, MSI and Razer are on sale.
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#153
View it
Name
TCL, Samsung QLED TV Deals for Super Bowl LV -- Upgrade Today
Description
If you're planning to upgrade your TV for Super Bowl LV, Walmart is selling this 65-inch TCL QLED TV at $423 off and this 55-inch Samsung QLED TV at $302 off.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#154
View it
Name
SpaceX Starship SN9 could take flight as soon as Tuesday - CNET
Description
SN9 is on deck to boldly follow in the footsteps of SN8, which bravely sacrificed itself in the name of iteration.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#155
View it
Name
Samsung Galaxy S21 Ultra to sport low-power OLED display - CNET
Description
New displays will consume 16% less power, the electronics giant says.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#156
View it
Name
SpaceX launches record number of spacecraft in cosmic rideshare program
Description
A veteran rocket from billionaire entrepreneur Elon Musk’s SpaceX aerospace company launched 143 spacecraft into space on Sunday, a new record.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#157
View it
Name
One by Wacom pen tablet the first to work with Chromebooks - CNET
Description
Support for other Wacom products is in the works, too.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#158
View it
Name
WHO in Wuhan is probing Covid's origins as politics hangs over mission
Description
WHO scientists are in China to investigate where the coronavirus came from and how it spilled into humans. The trip is the focus of intense political scrutiny.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#159
View it
Name
Militia-related groups kicked out of Amazon Smile charitable giving program - CNET
Description
The five nonprofits share names with either the Oath Keepers and the Three Percent movement.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#160
View it
Name
Moderna announces vaccine upgrades to protect against emerging variants
Description
Moderna is tweaking its coronavirus vaccine to make it more effective against emerging variants of the virus, the company announced Monday.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#161
View it
Name
Former ambassador sues Apple and Alphabet to drop Telegram from app stores - CNET
Description
Like Parler, Telegram is facing allegations of being used to encourage racism and violence.
#Software
Field
# Software
Updated
25 January 2021
#162
View it
Name
'Lost' Indigenous fort to repel Russia rediscovered in Alaska
Description
Archaeologists have discovered traces of a 200-year-old wooden fort in southeastern Alaska built by Indigenous people to resist an invasion by Imperial Russia.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#163
View it
Name
AI helps this Koda social robot dog sense human emotions - CNET
Description
This AI robot dog not only climbs stairs but also interacts socially with its human owners.
#Artificial intelligence
Field
# Artificial intelligence
Updated
25 January 2021
#164
View it
Name
WWE heads to Peacock as NBCUniversal looks to build up its streaming service - CNET
Description
Can you smell what Peacock is cooking?
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#165
View it
Name
NBA streaming: Best ways to watch the 2021 basketball season live online without cable - CNET
Description
Live TV streaming services like AT&T TV, Hulu Live and YouTube TV offer ABC, ESPN, TNT, NBA TV and more. So which one is the best for basketball fans?
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#166
View it
Name
Google workers set up international union alliance - CNET
Description
The move follows employees unionizing in the US.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#167
View it
Name
ADT technician pleads guilty to spying on customer camera feeds for years - CNET
Description
Over four and a half years, a home security technician gave himself access to more than 200 ADT Pulse accounts in order to spy on female customers.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#168
View it
Name
Google Maps will soon show COVID vaccine locations | Ars Technica
Description
Vaccine site listings will show access requirements and appointment info.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#169
View it
Name
“I can’t tell you how much vaccine we have,” new CDC head says | Ars Technica
Description
Biden admin officials work to manage expectations on topsy-turvy vaccine rollout.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#170
View it
Name
Egyptian archaeologists unearth dozens of tombs at Saqqara necropolis | Ars Technica
Description
The graves may belong to people who worshipped the pharaoh Teti, buried nearby.
#Archaeology & History
Field
# Archaeology & History
Updated
25 January 2021
#171
View it
Name
The secret to this $5,000 electric motorcycle is a cast aluminum frame | Ars Technica
Description
The Sondors Metacycle will have a range of 80 miles and a top speed of 85mph.
#Materials
Field
# Materials
Updated
25 January 2021
#172
View it
Name
The history of the connected battlespace, part one: command, control, and conquer | Ars Technica
Description
Since the end of World War II, the US and allies have tried to network-enable war.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#173
View it
Name
Valve’s Gabe Newell imagines “editing” personalities with future headsets | Ars Technica
Description
"Remember when Bob got hacked by Russian malware [and] ran naked through forests?"
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#174
View it
Name
SpaceX set to launch its next Starship prototype on Monday | Ars Technica
Description
It's only been about six weeks since SN8 flew.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#175
View it
Name
Ventilatory response to hypercapnia is increased after 4 h of head down bed rest | Scientific Reports
Description
Head-down bed rest (HDBR) has previously been shown to alter cerebrovascular and autonomic control. Previous work found that sustained HDBR (≥ 20 days) attenuates the hypercapnic ventilatory response (HCVR); however, little is known about shorter-term effects of HDBR nor the influence of HDBR on the hypoxic ventilatory response (HVR). We investigated the effect of 4-h HDBR on HCVR and HVR and hypothesized attenuated ventilatory responses due to greater carotid and brain blood flow. Cardiorespiratory responses of young men (n = 11) and women (n = 3) to 5% CO2 or 10% O2 before and after 4-h HDBR were examined. HDBR resulted in lower HR, lower cardiac output index, lower common carotid artery flow, higher SpO2, and higher pulse wave velocity. After HDBR, tidal volume and ventilation responses to 5% CO2 were enhanced (all P < 0.05), yet no other changes in cardiorespiratory variables were evident. There was no influence of HDBR on the cardiorespiratory responses to hypoxia (all P > 0.05). Short-duration HDBR does not alter the HVR, yet enhances the HCVR, which we hypothesize is a consequence of cephalic CO2 accumulation from cerebral congestion.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#176
View it
Name
Valproic acid influences the expression of genes implicated with hyperglycaemia-induced complement and coagulation pathways | Scientific Reports
Description
Because the liver plays a major role in metabolic homeostasis and secretion of clotting factors and inflammatory innate immune proteins, there is interest in understanding the mechanisms of hepatic cell activation under hyperglycaemia and whether this can be attenuated pharmacologically. We have previously shown that hyperglycaemia stimulates major changes in chromatin organization and metabolism in hepatocytes, and that the histone deacetylase inhibitor valproic acid (VPA) is able to reverse some of these metabolic changes. In this study, we have used RNA-sequencing (RNA-seq) to investigate how VPA influences gene expression in hepatocytes. Interesting, we observed that VPA attenuates hyperglycaemia-induced activation of complement and coagulation cascade genes. We also observe that many of the gene activation events coincide with changes to histone acetylation at the promoter of these genes indicating that epigenetic regulation is involved in VPA action.
#Sport & Camping
Field
# Sport & Camping
Updated
25 January 2021
#177
View it
Name
Urban Greenery Contributes More to Greenhouse Gas Emissions Than Researchers Anticipated
Description
TBD
#Construction;#Agriculture & Gardening;#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#178
View it
Name
Intracellular alpha-fetoprotein interferes with all-trans retinoic acid induced ATG7 expression and autophagy in hepatocellular carcinoma cells | Scientific Reports
Description
Retinoic acid and retinoid acid receptor (RA-RAR) signaling exhibits suppressive functions in the progression of hepatocellular carcinoma (HCC) through multiple mechanisms. However, whether RA-RAR signaling induces autophagy that contributes its anti-tumor activity in HCC remains elusive. In the current study, the effects of RA-RAR pathway on autophagy were investigated in two HCC cell lines: alpha-fetoprotein (AFP) positive PLC/PRF/5 and AFP negative HLE cells. Cell autophagy was analyzed with western blot for detection of LC3 conversion and p62/SQSTM1 degradation while autophagy flux was assayed using the mRFP-GFP-LC3 reporter. Cell apoptosis and viability were analyzed by caspase-3 activity, TdT-mediated dUTP nick end labeling (TUNEL) assay, and Cell Counting Kit (CCK)-8, respectively. Chromatin immunoprecipitation (ChIP) was employed to detect the binding of RAR onto the promoter of autophagy-relevant 7 (ATG7), and co-immunoprecipitation (CoIP) was used to analyze the interaction of AFP and RAR. The results showed that ATRA dosage and time-dependently induced high levels of cell autophagy in both the PLC/PRF/5 and HLE cells, which was accompanied with up-regulation of ATG7. ChIP assay showed that RAR was able to bind to its responsive elements on ATG7 promoter. Impairment of ATG7 induction or blockade of autophagy with chloroquine aggravated ATRA induced apoptosis of HCC cells. Furthermore, intracellular AFP was able to complex with RAR in PLC/PRF/5 cells. Knockdown of AFP in PLC/PRF/5 cells augmented the up-regulation of ATG7 by ATRA while overexpression of AFP in HLE cells attenuated ATRA induced ATG7 expression and autophagy. Thus, ATRA induced ATG7 and autophagy participated in its cytotoxicity on HCC cells and AFP interfere with the induction of ATG7 and autophagy through forming complex with RAR.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#179
View it
Name
Modelling the impact of tailored behavioural interventions on chlamydia transmission | Scientific Reports
Description
Behavioural interventions tailored to psychological characteristics of an individual can effectively achieve risk-reducing behaviour. The impact of tailored interventions on population-level chlamydia prevalence is unknown. We aimed to assess the impact on overall chlamydia prevalence five years after the introduction of an intervention aimed at increasing self-efficacy, social norms, attitudes and intentions towards condom use (i.e., condom intervention), and an intervention aimed at increasing health goals and decreasing impulsiveness (i.e., impulsiveness intervention). A pair model, informed by longitudinal psychological and behavioural data of young heterosexuals visiting sexual health centers, with susceptible-infected-susceptible structure was developed. The intervention effect was defined as an increased proportion of each subgroup moving to the desired subgroup (i.e., lower risk subgroup). Interventions tailored to subgroup-specific characteristics, assuming differential intervention effects in each subgroup, more effectively reduced overall chlamydia prevalence compared to non-tailored interventions. The most effective intervention was the tailored condom intervention, which was assumed to result in a relative reduction in chlamydia prevalence of 18% versus 12% in the non-tailored scenario. Thus, it is important to assess multiple psychological and behavioural characteristics of individuals. Tailored interventions may be more successful in achieving risk-reducing behaviour, and consequently, reduce chlamydia prevalence more effectively.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#180
View it
Name
Novel myostatin-specific antibody enhances muscle strength in muscle disease models | Scientific Reports
Description
Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target for muscle disease therapy because of its role as a negative regulator of muscle growth and strength. Here, we describe a novel antibody therapeutic approach that maximizes the potential of myostatin-targeted therapy. We generated an antibody, GYM329, that specifically binds the latent form of myostatin and inhibits its activation. Additionally, via “sweeping antibody technology”, GYM329 reduces or “sweeps” myostatin in the muscle and plasma. Compared with conventional anti-myostatin agents, GYM329 and its surrogate antibody exhibit superior muscle strength-improvement effects in three different mouse disease models. We also demonstrate that the superior efficacy of GYM329 is due to its myostatin specificity and sweeping capability. Furthermore, we show that a GYM329 surrogate increases muscle mass in normal cynomolgus monkeys without any obvious toxicity. Our findings indicate the potential of GYM329 to improve muscle strength in patients with muscular disorders.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#181
View it
Name
Dysbiosis of gut microbiota in Polish patients with ulcerative colitis: a pilot study | Scientific Reports
Description
Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology is not fully understood and for which no effective treatment is available. Recently, research has focused on the dysbiosis of gut microbiome in UC. However, the results so far remain inconsistent and insufficient to understand the microbial component in UC pathogenesis. In this study, we determine specific changes in the gut microbial profile in Polish UC patients compared to healthy subjects for the first time. Using 16S rRNA gene-based analysis we have described the intestinal microbial community in a group of 20 individuals (10 UC patients and 10 controls). Our results after multiple hypothesis testing correction demonstrated substantially lower gut microbiome diversity in UC cases compared to the controls and considerable differences at the phylum level, as well as among 13 bacterial families and 20 bacterial genera (p < 0.05). UC samples were more abundant in Proteobacteria (8.42%), Actinobacteria (6.89%) and Candidate Division TM7 (2.88%) than those of healthy volunteers (2.57%, 2.29% and 0.012%, respectively). On the other hand, Bacteroidetes and Verrucomicrobia were presented at a lower level in UC relative to the controls (14% and 0% vs 27.97% and 4.47%, respectively). In conclusion, our results show a reduced gut microbial diversity in Polish UC patients, a reduction of taxa with an anti-inflammatory impact and an increased abundance of potentially pathogenic bacteria.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#182
View it
Name
Most Lungs Recover Well After COVID-19 – According to Extensive Health Assessment 3 Months After Recovery
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#183
View it
Name
Altitude and risk of sudden unexpected infant death in the United States | Scientific Reports
Description
The effect of altitude on the risk of sudden infant death syndrome (SIDS) has been reported previously, but with conflicting findings. We aimed to examine whether the risk of sudden unexpected infant death (SUID) varies with altitude in the United States. Data from the Centers for Disease Control and Prevention (CDC)’s Cohort Linked Birth/Infant Death Data Set for births between 2005 and 2010 were examined. County of birth was used to estimate altitude. Logistic regression and Generalized Additive Model (GAM) were used, adjusting for year, mother’s race, Hispanic origin, marital status, age, education and smoking, father’s age and race, number of prenatal visits, plurality, live birth order, and infant’s sex, birthweight and gestation. There were 25,305,778 live births over the 6-year study period. The total number of deaths from SUID in this period were 23,673 (rate = 0.94/1000 live births). In the logistic regression model there was a small, but statistically significant, increased risk of SUID associated with birth at > 8000 feet compared with < 6000 feet (aOR = 1.93; 95% CI 1.00–3.71). The GAM showed a similar increased risk over 8000 feet, but this was not statistically significant. Only 9245 (0.037%) of mothers gave birth at > 8000 feet during the study period and 10 deaths (0.042%) were attributed to SUID. The number of SUID deaths at this altitude in the United States is very small (10 deaths in 6 years).
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#184
View it
Name
Lab-Grown Three-Dimensionally Reconstituted Organoids That Are Just Like Human Organs
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#185
View it
Name
Designing P. aeruginosa synthetic phages with reduced genomes | Scientific Reports
Description
In the era where antibiotic resistance is considered one of the major worldwide concerns, bacteriophages have emerged as a promising therapeutic approach to deal with this problem. Genetically engineered bacteriophages can enable enhanced anti-bacterial functionalities, but require cloning additional genes into the phage genomes, which might be challenging due to the DNA encapsulation capacity of a phage. To tackle this issue, we designed and assembled for the first time synthetic phages with smaller genomes by knocking out up to 48% of the genes encoding hypothetical proteins from the genome of the newly isolated Pseudomonas aeruginosa phage vB_PaeP_PE3. The antibacterial efficacy of the wild-type and the synthetic phages was assessed in vitro as well as in vivo using a Galleria mellonella infection model. Overall, both in vitro and in vivo studies revealed that the knock-outs made in phage genome do not impair the antibacterial properties of the synthetic phages, indicating that this could be a good strategy to clear space from phage genomes in order to enable the introduction of other genes of interest that can potentiate the future treatment of P. aeruginosa infections.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#186
View it
Name
Kraken Mare – a Sea of Liquid Methane on Saturn’s Largest Moon, Titan – Estimated to Be 1,000 Feet Deep
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#187
View it
Name
Micropatterning biomineralization with immobilized mother of pearl proteins | Scientific Reports
Description
In response to the drawbacks of autograft donor-site morbidity and bone morphogenetic protein type 2 (BMP2) carcinogenesis and ectopic bone formation, there has been an increased research focus towards developing alternatives capable of achieving spatial control over bone formation. Here we show for the first time both osteogenic differentiation and mineralization (from solution or mediated by cells) occurring within predetermined microscopic patterns. Our results revealed that both PEGylated BMP2 and nacre proteins induced stem cell osteodifferentiation in microscopic patterns when these proteins were covalently bonded in patterns onto polyethylene glycol diacrylate (PEGDA) hydrogel substrates; however, only nacre proteins induced mineralization localized to the micropatterns. These findings have broad implications on the design and development of orthopedic biomaterials and drug delivery.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#188
View it
Name
Engineering lithoheterotrophy in an obligate chemolithoautotrophic Fe(II) oxidizing bacterium | Scientific Reports
Description
Neutrophilic Fe(II) oxidizing bacteria like Mariprofundus ferrooxydans are obligate chemolithoautotrophic bacteria that play an important role in the biogeochemical cycling of iron and other elements in multiple environments. These bacteria generally exhibit a singular metabolic mode of growth which prohibits comparative “omics” studies. Furthermore, these bacteria are considered non-amenable to classical genetic methods due to low cell densities, the inability to form colonies on solid medium, and production of copious amounts of insoluble iron oxyhydroxides as their metabolic byproduct. Consequently, the molecular and biochemical understanding of these bacteria remains speculative despite the availability of substantial genomic information. Here we develop the first genetic system in neutrophilic Fe(II) oxidizing bacterium and use it to engineer lithoheterotrophy in M. ferrooxydans, a metabolism that has been speculated but not experimentally validated. This synthetic biology approach could be extended to gain physiological understanding and domesticate other bacteria that grow using a single metabolic mode.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#189
View it
Name
Mapping of inhomogeneous quasi-3D electrostatic field in electro-optic materials | Scientific Reports
Description
This paper describes a new method for direct measurement and evaluation of the inhomogeneous electrostatic vector field with translational symmetry in electro-optic materials exhibiting the Pockels effect. It is based on the evaluation of maximum transmittance of low intensity light passing through a sample under a voltage bias. Here, the sample is located between rotating crossed polarizers, and camera images are obtained at each point to determine the electric field. The evaluation procedure is demonstrated using data acquired on a CdZnTeSe quasi-hemispheric semiconductor gamma-ray detector. In addition to CdTe-related compounds, the method can be used for various other materials showing $$overline{4}3m$$ symmetry such as GaAs, CdTe, GaP, 3C-SiC, and ZnS. Furthermore, it can be generalized to other crystalline materials showing the Pockels effect. The method can be used to probe the space charge and the electric field in several kinds of electronic components and devices, as well as provide useful data on the role of defects, contact configurations and other surface and bulk inhomogeneities in the material that can affect the distribution of the internal electric field.
#Materials
Field
# Materials
Updated
25 January 2021
#190
View it
Name
Early warnings of COVID-19 outbreaks across Europe from social media | Scientific Reports
Description
We analyze data from Twitter to uncover early-warning signals of COVID-19 outbreaks in Europe in the winter season 2019–2020, before the first public announcements of local sources of infection were made. We show evidence that unexpected levels of concerns about cases of pneumonia were raised across a number of European countries. Whistleblowing came primarily from the geographical regions that eventually turned out to be the key breeding grounds for infections. These findings point to the urgency of setting up an integrated digital surveillance system in which social media can help geo-localize chains of contagion that would otherwise proliferate almost completely undetected.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#191
View it
Name
Electronic-components less fully textile multiple resonant combiners for body-centric near field communication | Scientific Reports
Description
Smart and e-textiles have nowadays an important increasing place in the garment industry. The rise of embedded telecommunications, especially smartphones in our pocket, enables us to provide a power source and a wireless link for smart textiles. The main issue is to develop garments able to receive power from smartphones and communicate with them without flexibility and comfort constraints bound to embedded solid-state electronic components. Consequently, this article aims to develop a fully textile NFC combiner to transfer data and power between a smartphone and sensors without any electronic components. It precisely describes textile NFC multiple combiners composed of textile NFC antennas linked by two-wire transmission lines. Also, theoretical analysis, simulations, and experiments have been conducted to adapt the resonant frequency of such structures to the NFC technology (13.56 MHz). Finally, our article generalizes textile NFC combiner resonant frequency equations for multiple combiners with any number of antennas.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#192
View it
Name
Examination of permittivity for depolarization field of ferroelectric by ab initio calculation, suggesting hidden mechanisms | Scientific Reports
Description
Electrostatics of depolarization field Ed in relation to the polarization is studied. In particular, the value of permittivity for Ed (εd) in prototypical situations of ferroelectrics, including Mehta formula, is examined by ab initio calculations. By using spontaneous polarization PS corresponding to accurate experiment ones, we show εd = 1, which suggests that the results of εd ≫ 1 indicate hidden mechanisms; εd = 1 suggests that the effect of Ed is significant to induce intriguing important phenomena overlooked by εd ≫ 1. A bridge between εd = 1 and εd ≫ 1, i.e. the consistency of εd = 1 with conventional results is presented. The exact electrostatic equality of head-to-head–tail-to-tail domains to free-standing ferroelectrics is deduced. Hence, most stoichiometric clean freestanding monodomain ferroelectrics and head-to-head–tail-to-tail domains are shown unstable regardless of size, unless partially metallic. This verifies the previous results in a transparent manner. This conclusion is shown consistent with a recent hyperferroelectric LiBeSb and “freestanding” monolayer ferroelectrics, of which origin is suggested to be adsorbates. In addition, this restriction is suggested to break in externally strained ultrathin ferroelectrics. The macroscopic formulas of Ed are found valid down to a several unit-cells, when electronic and atomic-scale surface effects are unimportant and accurate PS is used.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#193
View it
Name
Estimating multiple latencies in the auditory system from auditory steady-state responses on a single EEG channel | Scientific Reports
Description
The latency of the auditory steady-state response (ASSR) may provide valuable information regarding the integrity of the auditory system, as it could potentially reveal the presence of multiple intracerebral sources. To estimate multiple latencies from high-order ASSRs, we propose a novel two-stage procedure that consists of a nonparametric estimation method, called apparent latency from phase coherence (ALPC), followed by a heuristic sequential forward selection algorithm (SFS). Compared with existing methods, ALPC-SFS requires few prior assumptions, and is straightforward to implement for higher-order nonlinear responses to multi-cosine sound complexes with their initial phases set to zero. It systematically evaluates the nonlinear components of the ASSRs by estimating multiple latencies, automatically identifies involved ASSR components, and reports a latency consistency index. To verify the proposed method, we performed simulations for several scenarios: two nonlinear subsystems with different or overlapping outputs. We compared the results from our method with predictions from existing, parametric methods. We also recorded the EEG from ten normal-hearing adults by bilaterally presenting superimposed tones with four frequencies that evoke a unique set of ASSRs. From these ASSRs, two major latencies were found to be stable across subjects on repeated measurement days. The two latencies are dominated by low-frequency (LF) (near 40 Hz, at around 41–52 ms) and high-frequency (HF) (> 80 Hz, at around 21–27 ms) ASSR components. The frontal-central brain region showed longer latencies on LF components, but shorter latencies on HF components, when compared with temporal-lobe regions. In conclusion, the proposed nonparametric ALPC-SFS method, applied to zero-phase, multi-cosine sound complexes is more suitable for evaluating embedded nonlinear systems underlying ASSRs than existing methods. It may therefore be a promising objective measure for hearing performance and auditory cortex (dys)function.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#194
View it
Name
Nutrients exported from upland stream water enlarge perennial biomass crops | Scientific Reports
Description
Rawanbuki, a variety of Japanese butterbur (Petasites japonicus subsp. giganteus), grow naturally along the Rawan River, Hokkaido, northern Japan. Most plants reach 2–3 m in height and 10 cm in diameter in 2 months and are much larger than those grown along other rivers. We examined the hypothesis that nutrients exported from upland streams enhance the growth of the Rawanbuki. Nutrient concentrations, including nitrogen, phosphorus, and base cations, in the Rawan River were much higher than those in rivers of adjacent watersheds. High nutrient concentrations and moisture contents were found in soil along the Rawan River and a significant relationship was found between physicochemical soil conditions and aboveground biomass of butterburs. This indicates that extremely large Rawanbuki plants could be caused by these high nutrient concentrations and moisture contents in the soils. A manipulation experiment showed that fertilization simulated the growth environment along the Rawan River and enhanced the stem height and stem diameter of butterburs. This study concluded that the extremely large butterburs are caused by a large amount of nutrients exported from upland areas. These results are the first demonstration of the role of stream water nutrients in enlarging agricultural crops.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#195
View it
Name
In vitro activity of antimicrobial peptide CDP-B11 alone and in combination with colistin against colistin-resistant and multidrug-resistant Escherichia coli | Scientific Reports
Description
Multidrug-resistant bacteria are a growing global concern, and with increasingly prevalent resistance to last line antibiotics such as colistin, it is imperative that alternative treatment options are identified. Herein we investigated the mechanism of action of a novel antimicrobial peptide (CDP-B11) and its effectiveness against multidrug-resistant bacteria including Escherichia coli #0346, which harbors multiple antibiotic-resistance genes, including mobilized colistin resistance gene (mcr-1). Bacterial membrane potential and membrane integrity assays, measured by flow cytometry, were used to test membrane disruption. Bacterial growth inhibition assays and time to kill assays measured the effectiveness of CDP-B11 alone and in combination with colistin against E. coli #0346 and other bacteria. Hemolysis assays were used to quantify the hemolytic effects of CDP-B11 alone and in combination with colistin. Findings show CDP-B11 disrupts the outer membrane of E. coli #0346. CDP-B11 with colistin inhibits the growth of E. coli #0346 at ≥ 10× lower colistin concentrations compared to colistin alone in Mueller–Hinton media and M9 media. Growth is significantly inhibited in other clinically relevant strains, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. In rich media and minimal media, the drug combination kills bacteria at a lower colistin concentration (1.25 μg/mL) compared to colistin alone (2.5 μg/mL). In minimal media, the combination is bactericidal with killing accelerated by up to 2 h compared to colistin alone. Importantly, no significant red blood hemolysis is evident for CDP-B11 alone or in combination with colistin. The characteristics of CDP-B11 presented here indicate that it can be used as a potential monotherapy or as combination therapy with colistin for the treatment of multidrug-resistant infections, including colistin-resistant infections.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#196
View it
Name
Cysteine: an overlooked energy and carbon source | Scientific Reports
Description
Biohybrids composed of microorganisms and nanoparticles have emerged as potential systems for bioenergy and high-value compound production from CO2 and light energy, yet the cellular and metabolic processes within the biological component of this system are still elusive. Here we dissect the biohybrid composed of the anaerobic acetogenic bacterium Moorella thermoacetica and cadmium sulphide nanoparticles (CdS) in terms of physiology, metabolism, enzymatics and transcriptomic profiling. Our analyses show that while the organism does not grow on l-cysteine, it is metabolized to acetate in the biohybrid system and this metabolism is independent of CdS or light. CdS cells have higher metabolic activity, despite an inhibitory effect of Cd2+ on key enzymes, because of an intracellular storage compound linked to arginine metabolism. We identify different routes how cysteine and its oxidized form can be innately metabolized by the model acetogen and what intracellular mechanisms are triggered by cysteine, cadmium or blue light.
#Energy
Field
# Energy
Updated
25 January 2021
#197
View it
Name
Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes | Scientific Reports
Description
Bloom Syndrome (BS; OMIM #210900; ORPHA #125) is a rare genetic disorder that is associated with growth deficits, compromised immune system, insulin resistance, genome instability and extraordinary predisposition to cancer. Most efforts thus far have focused on understanding the role of the Bloom syndrome DNA helicase BLM as a recombination factor in maintaining genome stability and suppressing cancer. Here, we observed increased levels of reactive oxygen species (ROS) and DNA base damage in BLM-deficient cells, as well as oxidative-stress-dependent reduction in DNA replication speed. BLM-deficient cells exhibited increased mitochondrial mass, upregulation of mitochondrial transcription factor A (TFAM), higher ATP levels and increased respiratory reserve capacity. Cyclin B1, which acts in complex with cyclin-dependent kinase CDK1 to regulate mitotic entry and associated mitochondrial fission by phosphorylating mitochondrial fission protein Drp1, fails to be fully degraded in BLM-deficient cells and shows unscheduled expression in G1 phase cells. This failure to degrade cyclin B1 is accompanied by increased levels and persistent activation of Drp1 throughout mitosis and into G1 phase as well as mitochondrial fragmentation. This study identifies mitochondria-associated abnormalities in Bloom syndrome patient-derived and BLM-knockout cells and we discuss how these abnormalities may contribute to Bloom syndrome.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#198
View it
Name
Configurational diffusion transport of water and oil in dual continuum shales | Scientific Reports
Description
Understanding fluid flow in shale rocks is critical for the recovery of unconventional energy resources. Despite the extensive research conducted on water and oil flow in shales, significant uncertainties and discrepancies remain in reported experimental data. The most noted being that while oil spreads more than water on shale surfaces in an inviscid medium, its uptake by shale pores is much less than water during capillary flow. This leads to misjudgement of wettability and the underlying physical phenomena. In this study, therefore, we performed a combined experimental and digital rock investigation on an organic-rich shale including contact angle and spontaneous imbibition, X-ray and neutron computed tomography, and small angle X-ray scattering tests to study the potential physical processes. We also used non-equilibrium thermodynamics to theoretically derive constitutive equations to support our experimental observations. The results of this study indicate that the pre-existing fractures (first continuum) imbibe more oil than water consistent with contact angle measurements. The overall imbibition is, however, higher for water than oil due to greater water diffusion into the shale matrix (second continuum). It is shown that more water uptake into shale is controlled by pore size and accessibility in addition to capillary or osmotic forces i.e. configurational diffusion of water versus oil molecules. While the inorganic pores seem more oil-wet in an inviscid medium, they easily allow passage of water molecules compared to oil due to the incredibly small size of water molecules that can pass through such micro-pores. Contrarily, these strongly oil-wet pores possessing strong capillarity are restricted to imbibe oil simply due to its large molecular size and physical inaccessibility to the micro-pores. These results provide new insights into the previously unexplained discrepancy regarding water and oil uptake capacity of shales.
#Energy
Field
# Energy
Updated
25 January 2021
#199
View it
Name
The plant AlcR- pAlcA ethanol-inducible system displays gross growth artefacts independently of downstream pAlcA- regulated inducible constructs | Scientific Reports
Description
The AlcR fungal protein responds to ethanol and binds to the fungal pAlcA promoter in its presence. This system was transferred to plants over twenty years ago and was claimed to function in the same manner in plants. However, never has the control experiment with plants containing the AlcR gene alone, with no downstream inducible construct, been made. In this paper, I conduct several experiments with this control, growing p35:AlcR plants in the presence or absence of ethanol. I found that when these plants were grown in the presence of ethanol, growth in several tissues and several stages of growth was retarded. This demonstrates that this system is not suitable for use in the plant sciences, and casts doubt on the conclusions of papers that have published phenotypes using this system.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#200
View it
Name
Quantifying the hydroxyapatite orientation near the ossification front in a piglet femoral condyle using X-ray diffraction tensor tomography | Scientific Reports
Description
While a detailed knowledge of the hierarchical structure and morphology of the extracellular matrix is considered crucial for understanding the physiological and mechanical properties of bone and cartilage, the orientation of collagen fibres and carbonated hydroxyapatite (HA) crystallites remains a debated topic. Conventional microscopy techniques for orientational imaging require destructive sample sectioning, which both precludes further studies of the intact sample and potentially changes the microstructure. In this work, we use X-ray diffraction tensor tomography to image non-destructively in 3D the HA orientation in a medial femoral condyle of a piglet. By exploiting the anisotropic HA diffraction signal, 3D maps showing systematic local variations of the HA crystallite orientation in the growing subchondral bone and in the adjacent mineralized growth cartilage are obtained. Orientation maps of HA crystallites over a large field of view (~ 3 × 3 × 3 mm3) close to the ossification (bone-growth) front are compared with high-resolution X-ray propagation phase-contrast computed tomography images. The HA crystallites are found to predominantly orient with their crystallite c-axis directed towards the ossification front. Distinct patterns of HA preferred orientation are found in the vicinity of cartilage canals protruding from the subchondral bone. The demonstrated ability of retrieving 3D orientation maps of bone-cartilage structures is expected to give a better understanding of the physiological properties of bones, including their propensity for bone-cartilage diseases.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#201
View it
Name
Discovery of a colossal slickhead (Alepocephaliformes: Alepocephalidae): an active-swimming top predator in the deep waters of Suruga Bay, Japan | Scientific Reports
Description
A novel species of the family Alepocephalidae (slickheads), Narcetes shonanmaruae, is described based on four specimens collected at depths greater than 2171 m in Suruga Bay, Japan. Compared to other alepocephalids, this species is colossal (reaching ca. 140 cm in total length and 25 kg in body weight) and possesses a unique combination of morphological characters comprising anal fin entirely behind the dorsal fin, multiserial teeth on jaws, more scale rows than congeners, precaudal vertebrae less than 30, seven branchiostegal rays, two epurals, and head smaller than those of relatives. Mitogenomic analyses also support the novelty of this large deep-sea slickhead. Although most slickheads are benthopelagic or mesopelagic feeders of gelatinous zooplankton, behavioural observations and dietary analyses indicate that the new species is piscivorous. In addition, a stable nitrogen isotope analysis of specific amino acids showed that N. shonanmaruae occupies one of the highest trophic positions reported from marine environments to date. Video footage recorded using a baited camera deployed at a depth of 2572 m in Suruga Bay revealed the active swimming behaviour of this slickhead. The scavenging ability and broad gape of N. shonanmaruae might be correlated with its colossal body size and relatively high trophic position.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#202
View it
Name
Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia | Scientific Reports
Description
Persistent HPV infection associated with immune modulation may result in high-grade squamous intraepithelial lesions (CIN)2/3. Currently, there is little information on the cervicovaginal microbiome, local cytokine levels and HPV infection related to CIN. Follow-up of patients after local surgery provides an opportunity to monitor changes in the cervicovaginal environment. Accordingly, we undertook this longitudinal retrospective study to determine associations between HPV genotypes, cervicovaginal microbiome and local cytokine profiles in 41 Japanese patients with CIN. Cervicovaginal microbiota were identified using universal 16S rRNA gene (rDNA) bacterial primers for the V3/4 region by PCR of genomic DNA, followed by MiSeq sequencing. We found that Atopobium vaginae was significantly decreased (p < 0.047), whereas A. ureaplasma (p < 0.022) increased after surgery. Cytokine levels in cervical mucus were measured by multiplexed bead-based immunoassays, revealing that IL-1β (p < 0.006), TNF-α (p < 0.004), MIP-1α (p < 0.045) and eotaxin (p < 0.003) were significantly decreased after surgery. Notably, the level of eotaxin decreased in parallel with HPV clearance after surgery (p < 0.028). Thus, local surgery affected the cervicovaginal microbiome, status of HPV infection and immune response. Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia may be important for understanding the pathogenesis of CIN in future.
#Medicine & Human body;#Theoretical sciences
Field
# Medicine & Human body
Updated
25 January 2021
#203
View it
Name
Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock | Scientific Reports
Description
Singular blockade of C5a in experimental models of sepsis is known to confer protection by rescuing lethality and decreasing pro-inflammatory responses. However, the role of inhibiting C5a has not been evaluated in the context of sterile systemic inflammatory responses, like polytrauma and hemorrhagic shock (PT + HS). In our presented study, a novel and highly specific C5a L-aptamer, NoxD21, was used to block C5a activity in an experimental murine model of PT + HS. The aim of the study was to assess early modulation of inflammatory responses and lung damage 4 h after PT + HS induction. NoxD21-treated PT + HS mice displayed greater polymorphonuclear cell recruitment in the lung, increased pro-inflammatory cytokine levels in the bronchoalveolar lavage fluids (BALF) and reduced myeloperoxidase levels within the lung tissue. An in vitro model of the alveolar-capillary barrier was established to confirm these in vivo observations. Treatment with a polytrauma cocktail induced barrier damage only after 16 h, and NoxD21 treatment in vitro did not rescue this effect. Furthermore, to test the exact role of both the cognate receptors of C5a (C5aR1 and C5aR2), experimental PT + HS was induced in C5aR1 knockout (C5aR1 KO) and C5aR2 KO mice. Following 4 h of PT + HS, C5aR2 KO mice had significantly reduced IL-6 and IL-17 levels in the BALF without significant lung damage, and both, C5aR1 KO and C5aR2 KO PT + HS animals displayed reduced MPO levels within the lungs. In conclusion, the C5aR2 could be a putative driver of early local inflammatory responses in the lung after PT + HS.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#204
View it
Name
Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children | Scientific Reports
Description
Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates innate immune responses triggered by LPS. Recent studies indicated a positive correlation of circulating LBP level with chronic low-grade inflammation, a condition present in many non-communicable diseases. We determined the association of serum LBP concentration with allergic sensitization in a general pediatric population. Serum LBP was measured in a sample of children (n = 356; mean age = 9.6 ± 0.2 years) in this population-based cross-sectional study. Skin prick tests (SPTs) were performed to assess allergic sensitization to 22 common inhalant and food allergens. One hundred and seven children (30.1%) were nonsensitized, 160 (44.9%) were monosensitized, and 89 (25.0%) were polysensitized. Children who were mono- or polysensitized had a significantly higher median serum LBP level (25.5 ng/mL, inter-quartile range [IQR] 20.3–30.7) than those who were nonsensitized (20.3 ng/mL, IQR = 14.81–25.8, P < 0.0001). Multivariate logistic regression analysis with adjustment for confounders indicated that serum LBP level was positively associated with allergic sensitization overall (adjusted odds ratio [aOR] 1.041; 95% CI 1.007–1.076, P = 0.016), with sensitization to food allergens in particular (aOR 1.080, 95% CI 1.029–1.133, P = 0.002), but not with sensitization to aeroallergens (aOR 1.010, 95% CI 0.982–1.040, P = 0.467). LBP level was not associated with allergic diseases after adjustment. We suggest the possibility of sensitization to food allergens may be related to gut-derived low-grade inflammation, and large sized longitudinal investigations are needed to elucidate the relationship.
#Food
Field
# Food
Updated
25 January 2021
#205
View it
Name
Three Sony WH-1000XM4 Alternatives That Cost Less Than $100
Description
Sony's WH-1000XM4 are widely considered to be the best noise-canceling headphones you can buy. These alternatives are almost as good, but they cost way less.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#206
View it
Name
Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates | Scientific Reports
Description
The coronavirus disease (COVID-19) outbreak has killed over a million people since its emergence in late 2019. However, there has been substantial variability in the policies and intensity of diagnostic efforts between countries. In this paper, we quantitatively evaluate the association between national contact tracing policies and case fatality rates of COVID-19 in 138 countries. Our regression analyses indicate that countries that implement comprehensive contact tracing have significantly lower case fatality rates. This association of contact tracing policy and case fatality rates is robust in our longitudinal regression models, even after controlling for the number of tests conducted and non-pharmaceutical control measures adopted by governments. Our results suggest that comprehensive contact tracing is instrumental not only to curtailing transmission but also to reducing case fatality rates. Contact tracing achieves the early detection and isolation of secondary cases which are particularly important given that the peak in infectiousness occurs during the presymptomatic phase. The early detection achieved by contact tracing accelerates the rate at which infected individuals receive medical care they need to maximize their chance of recovery. In addition, the combination of reduced transmission and more rapid recovery diminishes the burden on the healthcare system which in turn ensures that the resources remain available for individuals who do become infected.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#207
View it
Name
Comparative transcriptomics and host-specific parasite gene expression profiles inform on drivers of proliferative kidney disease | Scientific Reports
Description
The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understanding of T. bryosalmonae-host interactions, we have used a two-host parasite transcriptome sequencing approach in generating two parasite transcriptome assemblies; the first derived from parasite spore sacs isolated from infected bryozoans and the second from infected fish kidney tissues. This approach was adopted to minimize host contamination in the absence of a complete T. bryosalmonae genome. Parasite contigs common to both infected hosts (the intersect transcriptome; 7362 contigs) were typically AT-rich (60–75% AT). 5432 contigs within the intersect were annotated. 1930 unannotated contigs encoded for unknown transcripts. We have focused on transcripts encoding proteins involved in; nutrient acquisition, host–parasite interactions, development, cell-to-cell communication and proteins of unknown function, establishing their potential importance in each host by RT-qPCR. Host-specific expression profiles were evident, particularly in transcripts encoding proteases and proteins involved in lipid metabolism, cell adhesion, and development. We confirm for the first time the presence of homeobox proteins and a frizzled homologue in myxozoan parasites. The novel insights into myxozoan biology that this study reveals will help to focus research in developing future disease control strategies.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#208
View it
Name
Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle | Scientific Reports
Description
The Hippo signaling pathway is a key regulator of tissue development and regeneration. Activation of the Hippo pathway leads to nuclear translocation of the YAP1 transcriptional coactivator, resulting in changes in gene expression and cell cycle entry. Recent studies have demonstrated the nuclear translocation of YAP1 during the development of the sensory organs of the inner ear, but the possible role of YAP1 in sensory regeneration of the inner ear is unclear. The present study characterized the cellular localization of YAP1 in the utricles of mice and chicks, both under normal conditions and after HC injury. During neonatal development, YAP1 expression was observed in the cytoplasm of supporting cells, and was transiently expressed in the cytoplasm of some differentiating hair cells. We also observed temporary nuclear translocation of YAP1 in supporting cells of the mouse utricle after short periods in organotypic culture. However, little or no nuclear translocation of YAP1 was observed in the utricles of neonatal or mature mice after ototoxic injury. In contrast, substantial YAP1 nuclear translocation was observed in the chicken utricle after streptomycin treatment in vitro and in vivo. Together, these data suggest that differences in YAP1 signaling may partially account for the differing regenerative abilities of the avian vs. mammalian inner ear.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#209
View it
Name
Wearable devices for the detection of COVID-19 | Nature Electronics
Description
Wearable electronic devices, which allow physiological signals to be continuously monitored, can be used in the early detection of asymptomatic and pre-symptomatic cases of COVID-19.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#210
View it
Name
A shifty target | Nature Immunology
Description
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#211
View it
Name
Antihypertensives in immunity | Nature Immunology
Description
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#212
View it
Name
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect | Nature Genetics
Description
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are leading causes of sudden death and heart failure in young, otherwise healthy, individuals. We conducted genome-wide association studies and multi-trait analyses in HCM (1,733 cases), DCM (5,521 cases) and nine left ventricular (LV) traits (19,260 UK Biobank participants with structurally normal hearts). We identified 16 loci associated with HCM, 13 with DCM and 23 with LV traits. We show strong genetic correlations between LV traits and cardiomyopathies, with opposing effects in HCM and DCM. Two-sample Mendelian randomization supports a causal association linking increased LV contractility with HCM risk. A polygenic risk score explains a significant portion of phenotypic variability in carriers of HCM-causing rare variants. Our findings thus provide evidence that polygenic risk score may account for variability in Mendelian diseases. More broadly, we provide insights into how genetic pathways may lead to distinct disorders through opposing genetic effects. Genome-wide analyses identify multiple loci associated with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and left ventricular (LV) traits. Cardiomyopathies exhibit strong genetic correlations with LV traits, with opposing effects in HCM and DCM.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#213
View it
Name
Making the cut | Nature Reviews Microbiology
Description
This study reports the development of a CRISPR –Cas9 therapeutic to target herpes simplex virus 1 and treat herpetic stromal keratitis in mice.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#214
View it
Name
Liver metastases siphon T cells and blunt immunotherapy responses | Nature Reviews Gastroenterology & Hepatology
Description
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#215
View it
Name
Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges | Nature Reviews Endocrinology
Description
Therapeutic approaches to the treatment of type 2 diabetes mellitus that are designed to increase insulin secretion either directly target β-cells or indirectly target gastrointestinal enteroendocrine cells (EECs), which release hormones that modulate insulin secretion (for example, incretins). Given that β-cells and EECs both express a large array of G protein-coupled receptors (GPCRs) that modulate insulin secretion, considerable research and development efforts have been undertaken to design therapeutic drugs targeting these GPCRs. Among them are GPCRs specific for free fatty acid ligands (lipid GPCRs), including free fatty acid receptor 1 (FFA1, otherwise known as GPR40), FFA2 (GPR43), FFA3 (GPR41) and FFA4 (GPR120), as well as the lipid metabolite binding glucose-dependent insulinotropic receptor (GPR119). These lipid GPCRs have demonstrated important roles in the control of islet and gut hormone secretion. Advances in lipid GPCR pharmacology have led to the identification of a number of synthetic agonists that exert beneficial effects on glucose homeostasis in preclinical studies. Yet, translation of these promising results to the clinic has so far been disappointing. In this Review, we present the physiological roles, pharmacology and clinical studies of these lipid receptors and discuss the challenges associated with their clinical development for the treatment of type 2 diabetes mellitus. This Review summarizes the physiological functions, pharmacology and clinical studies of G protein-coupled receptors that are specific for lipid metabolite ligands. The challenges associated with the clinical development of therapeutics for type 2 diabetes mellitus that target these G protein-coupled receptors are also discussed.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#216
View it
Name
Reply to ‘Intraoperative radiotherapy for breast cancer: powerful evidence to change practice’ | Nature Reviews Clinical Oncology
Description
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#217
View it
Name
Intraoperative radiotherapy for breast cancer: powerful evidence to change practice | Nature Reviews Clinical Oncology
Description
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#218
View it
Name
The effect of combination therapy with erythropoietin and methylprednisolone in patients with traumatic cervical spinal cord injury: a pilot randomized controlled trial | Spinal Cord
Description
Pilot double-blinded randomized controlled trial. To investigate the additive effect of recombinant human erythropoietin (rhEPO) on functional outcome and disability in patients with traumatic cervical spinal cord injury (TCSCI). University-affiliated hospital in Mashhad, Iran. Patients with acute TCSCI admitted within 8 h after injury were randomly assigned to receive only methylprednisolone (M group) or rhEPO 500 IU/mL plus methylprednisolone (M + E group). All the patients underwent surgery within the next several days. Neurological function was assessed on admission, and at 6th and 12th months after the injury according to the sphincter function and American spinal cord injury association (ASIA) scale. Overall, 54 patients (mean age: 39.7 ± 13.3 years) including 46 (85%) males were studied in two groups of 27. The likelihood of developing adverse neurological outcomes (ASIA impairment score of A compared to D or E) was not significantly different between the groups after 6 (OR = 0.39, 95% CI = 0.03–4.80, P = 0.46) and 12 months (OR = 0.83, 95% CI = 0.11–6.11, P = 0.86). The groups also showed no significant difference in 1-year mortality (OR = 0.83, 95% CI = 0.25–2.74, P = 0.76). It is not clear whether combination therapy with erythropoietin compared to methylprednisolone alone improves neurological functions of patients with TCSCI. Our study provides interim data to guide future larger definitive trials.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#219
View it
Name
Seeking racial and ethnic equity among neonatologists | Journal of Perinatology
Description
Racial and ethnic inequities in leadership achievement, compensation, scholarly productivity, and grant funding exists among physicians. This study explores whether similar inequities exist among neonatologists within the United States. A voluntary anonymous survey was distributed to members of the American Academy of Pediatrics Section on Neonatal–Perinatal Medicine with 560 respondents. Logistic regression and ordinary least squares were used to assess whether racial and ethnic identity is associated with clinical time, leadership, compensation, publication, grant funding, or academic rank. As compared to non-Hispanic White neonatologists, statistical differences were found for underrepresented minorities in medicine in: regions of the country where they worked, total cash compensation received, being awarded an NIH grant, and location of graduate medical education. Fewer differences were found for Asian neonatologists and included location of graduate medicine education. Racial and ethnic identity remains a significant independent factor influencing professional achievement and compensation.
#Social & Corporation affairs;#Security
Field
# Social & Corporation affairs
Updated
25 January 2021
#220
View it
Name
Nuclei isolation of multiple brain cell types for omics interrogation | Nature Protocols
Description
We present a nuclei isolation protocol for genomic and epigenomic interrogation of multiple cell type populations in the human and rodent brain. The nuclei isolation protocol allows cell type-specific profiling of neurons, microglia, oligodendrocytes, and astrocytes, being compatible with fresh and frozen samples obtained from either resected or postmortem brain tissue. This 2-day procedure consists of tissue homogenization with fixation, nuclei extraction, and antibody staining followed by fluorescence-activated nuclei sorting (FANS) and does not require specialized skillsets. Cell type-specific nuclei populations can be used for downstream omic-scale sequencing applications with an emphasis on epigenomic interrogation such as histone modifications, transcription factor binding, chromatin accessibility, and chromosome architecture. The nuclei isolation protocol enables translational examination of archived healthy and diseased brain specimens through utilization of existing medical biorepositories. This protocol describes procedures for isolation of nuclei of multiple cell populations (neurons, microglia, oligodendrocytes, and astrocytes) from resected or postmortem brain tissue that are compatible with downstream epigenomic or transcriptomic profiling.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#221
View it
Name
Isolation and characterization of extracellular vesicle subpopulations from tissues | Nature Protocols
Description
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells. Most EV studies have been performed by using cell lines or body fluids, but the number of studies on tissue-derived EVs is still limited. Here, we present a protocol to isolate up to six different EV subpopulations directly from tissues. The approach includes enzymatic treatment of dissociated tissues followed by differential ultracentrifugation and density separation. The isolated EV subpopulations are characterized by electron microscopy and RNA profiling. In addition, their protein cargo can be determined with mass spectrometry, western blot and ExoView. Tissue-EV isolation can be performed in 22 h, but a simplified version can be completed in 8 h. Most experiments with the protocol have used human melanoma metastases, but the protocol can be applied to other cancer and non-cancer tissues. The procedure can be adopted by researchers experienced with cell culture and EV isolation. This protocol describes how to isolate up to six different subpopulations of extracellular vesicles (EVs) from tissues. The procedure includes detailed instructions for EV characterization using electron microscopy, RNA and protein analysis.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#222
View it
Name
Protecting the CNS | Nature Immunology
Description
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#223
View it
Name
Memory T cells and where to find them | Nature Immunology
Description
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#224
View it
Name
Mitochondria orchestrate T cell fate and function | Nature Immunology
Description
An investigation of the molecular processes of mitochondrial reprogramming and metabolic stress in antigen-experienced T cells within tumor microenvironments reveals mechanisms responsible for T cell exhaustion and dysfunction and facilitates the development of new strategies for tumor immunotherapy.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#225
View it
Name
The root of nutrient stress resistance | Nature Reviews Microbiology
Description
This study shows that plant root barrier function and the root microbiota coordinate to maintain plant nutrient homeostasis.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#226
View it
Name
Getting your foot in the membrane | Nature Reviews Microbiology
Description
This study provides structural insights into how the rotavirus spike protein VP4 undergoes a conformational change to initiate host membrane disruption during infection.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#227
View it
Name
Transition metal nanowires scale up | Nature Electronics
Description
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#228
View it
Name
Digital tech and the pandemic | Nature Electronics
Description
For our 2021 technology of the year, we explore the impact of the coronavirus pandemic on digital technology.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#229
View it
Name
Strain-insensitive intrinsically stretchable transistors and circuits | Nature Electronics
Description
Intrinsically stretchable electronics can form intimate interfaces with the human body, creating devices that could be used to monitor physiological signals without constraining movement. However, mechanical strain invariably leads to the degradation of the electronic properties of the devices. Here we show that strain-insensitive intrinsically stretchable transistor arrays can be created using an all-elastomer strain engineering approach, in which the patterned elastomer layers with tunable stiffnesses are incorporated into the transistor structure. By varying the cross-linking density of the elastomers, areas of increased local stiffness are introduced, reducing strain on the active regions of the devices. This approach can be readily incorporated into existing fabrication processes, and we use it to create arrays with a device density of 340 transistors cm–2 and a strain insensitivity of less than 5% performance variation when stretched to 100% strain. We also show that it can be used to fabricate strain-insensitive circuit elements, including NOR gates, ring oscillators and high-gain amplifiers for the stable monitoring of electrophysiological signals. An all-elastomer strain engineering approach, which uses patterned elastomer layers with tunable stiffnesses, can be used to create intrinsically stretchable transistor arrays with a device density of 340 transistors cm–2 and strain insensitivity of less than 5% performance variation when stretched to 100% strain.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#230
View it
Name
Autophagosomes get wet | Nature Reviews Molecular Cell Biology
Description
Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#231
View it
Name
Got the quantum jitters | Nature Physics
Description
Among the many reasons a signal may deviate from perfect periodicity, quantum-limited jitter is arguably the most fundamental. A clever experiment has now stripped away technical noise to unveil quantum-limited jitter of ultrafast soliton frequency combs.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#232
View it
Name
Extreme-ultraviolet spectral compression by four-wave mixing | Nature Photonics
Description
Extreme-ultraviolet (XUV) sources including high-harmonic generation (HHG), free-electron lasers (FELs), soft-X-ray lasers and laser-driven plasmas are widely used for applications ranging from femtochemistry and attosecond science to coherent diffractive imaging and EUV (or XUV) lithography. The bandwidth of the XUV light emitted by these sources reflects the XUV generation process used. Whereas light from soft-X-ray lasers1 and seeded XUV FELs2 typically has a relatively narrow bandwidth, plasma sources and HHG sources often emit broadband XUV pulses3. Since these characteristic properties of a given source impose limitations on applications, techniques enabling modification of the bandwidth are highly desirable. Here we introduce a concept for efficient spectral compression by four-wave mixing (FWM), exploiting a phase-matching scheme based on closely-spaced resonances. We demonstrate the compression of broadband radiation in the 145–130 nm wavelength range into a narrow-bandwidth XUV pulse at 100.3 nm wavelength in the presence of a broadband near-infrared (NIR) pulse in a krypton gas jet. Our concept provides new possibilities for tailoring the spectral bandwidth of XUV beams. Through a dense krypton gas jet in the presence of a broadband near-infrared pulse, spectral compression of broadband XUV radiation between 145 and 130 nm wavelengths into a narrow-bandwidth XUV pulse at 100.3 nm wavelength by four-wave mixing is demonstrated.
#Theoretical sciences
Field
# Theoretical sciences
Updated
25 January 2021
#233
View it
Name
Room-temperature nonlinear Hall effect and wireless radiofrequency rectification in Weyl semimetal TaIrTe 4 | Nature Nanotechnology
Description
The nonlinear Hall effect (NLHE), the phenomenon in which a transverse voltage can be produced without a magnetic field, provides a potential alternative for rectification or frequency doubling1,2. However, the low-temperature detection of the NLHE limits its applications3,4. Here, we report the room-temperature NLHE in a type-II Weyl semimetal TaIrTe4, which hosts a robust NLHE due to broken inversion symmetry and large band overlapping at the Fermi level. We also observe a temperature-induced sign inversion of the NLHE in TaIrTe4. Our theoretical calculations suggest that the observed sign inversion is a result of a temperature-induced shift in the chemical potential, indicating a direct correlation of the NLHE with the electronic structure at the Fermi surface. Finally, on the basis of the observed room-temperature NLHE in TaIrTe4 we demonstrate the wireless radiofrequency (RF) rectification with zero external bias and magnetic field. This work opens a door to realizing room-temperature applications based on the NLHE in Weyl semimetals. Broken inversion symmetry in a type-II Weyl semimetal TaIrTe4 enables observation of the room-temperature nonlinear Hall effect as well as wireless radiofrequency rectification.
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#234
View it
Name
Ferroelectricity in bulk hafnia | Nature Materials
Description
Ferroelectricity in bulk crystals of hafnium oxide demonstrates that these properties are not limited to films prepared by thin-film deposition techniques.
#Energy
Field
# Energy
Updated
25 January 2021
#235
View it
Name
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes | Nature Chemistry
Description
Closed-loop recycling offers the opportunity to mitigate plastic waste through reversible polymer construction and deconstruction. Although examples of chemical recycling of polymers are known, few have been applied to materials derived from abundant commodity olefinic monomers, which are the building blocks of ubiquitous plastic resins. Here we describe a [2+2] cycloaddition/oligomerization of 1,3-butadiene to yield a previously unrealized telechelic microstructure of (1,n′-divinyl)oligocyclobutane. This material is thermally stable, has stereoregular segments arising from chain-end control, and exhibits high crystallinity even at low molecular weight. Exposure of the oligocyclobutane to vacuum in the presence of the pyridine(diimine) iron precatalyst used to synthesize it resulted in deoligomerization to generate pristine butadiene, demonstrating a rare example of closed-loop chemical recycling of an oligomeric material derived from a commodity hydrocarbon feedstock. Iron-catalysed [2+2] cycloaddition/oligomerization of neat butadiene affords (1,n′-divinyl)oligocyclobutane—a telechelic, crystalline material consisting of 1,3-enchained cyclobutyl units. This oligocyclobutane can be chemically recycled to pure butadiene using the same iron catalyst employed in its synthesis, demonstrating design principles for next-generation plastic materials that can be returned to pristine monomer.
#Chemicals
Field
# Chemicals
Updated
25 January 2021
#236
View it
Name
Anomalous transport due to Weyl fermions in the chiral antiferromagnets Mn 3 X, X = Sn, Ge | Nature Communications
Description
The recent discoveries of strikingly large zero-field Hall and Nernst effects in antiferromagnets Mn3X (X = Sn, Ge) have brought the study of magnetic topological states to the forefront of condensed matter research and technological innovation. These effects are considered fingerprints of Weyl nodes residing near the Fermi energy, promoting Mn3X (X = Sn, Ge) as a fascinating platform to explore the elusive magnetic Weyl fermions. In this review, we provide recent updates on the insights drawn from experimental and theoretical studies of Mn3X (X = Sn, Ge) by combining previous reports with our new, comprehensive set of transport measurements of high-quality Mn3Sn and Mn3Ge single crystals. In particular, we report magnetotransport signatures specific to chiral anomalies in Mn3Ge and planar Hall effect in Mn3Sn, which have not yet been found in earlier studies. The results summarized here indicate the essential role of magnetic Weyl fermions in producing the large transverse responses in the absence of magnetization. The large anomalous Hall (AHE) and anomalous Nernst effects (ANE) in antiferromagnets Mn3Sn/Mn3Ge are considered fingerprints of Weyl nodes residing near the Fermi energy. Here, the authors review the results from previous studies combining with new transport measurements on Mn3Sn/Mn3Ge single crystals, suggesting the essential role of magnetic Weyl fermions in explaining the AHE and ANE.
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#237
View it
Name
Non-equilibrium metal oxides via reconversion chemistry in lithium-ion batteries | Nature Communications
Description
Binary metal oxides are attractive anode materials for lithium-ion batteries. Despite sustained effort into nanomaterials synthesis and understanding the initial discharge mechanism, the fundamental chemistry underpinning the charge and subsequent cycles—thus the reversible capacity—remains poorly understood. Here, we use in operando X-ray pair distribution function analysis combining with our recently developed analytical approach employing Metropolis Monte Carlo simulations and non-negative matrix factorisation to study the charge reaction thermodynamics of a series of Fe- and Mn-oxides. As opposed to the commonly believed conversion chemistry forming rocksalt FeO and MnO, we reveal the two oxide series topotactically transform into non-native body-centred cubic FeO and zincblende MnO via displacement-like reactions whose kinetics are governed by the mobility differences between displaced species. These renewed mechanistic insights suggest avenues for the future design of metal oxide materials as well as new material synthesis routes using electrochemically-assisted methods. The charging of Fe and Mn oxide anodes in lithium-ion batteries are believed to form rocksalt phases via reconstructive conversion reactions. Here, the authors show that MxOy (M = Fe, Mn) transform into non-native body-centred cubic FeO and zincblende MnO via topotactic displacement-like pathways.
#Chemicals
Field
# Chemicals
Updated
25 January 2021
#238
View it
Name
How many early human species existed on Earth? | Live Science
Description
There used to be a greater diversity of human species, and paleoarchaeologists are still discovering more extinct relatives.
#Environment & Nature;#Theoretical sciences
Field
# Environment & Nature
Updated
25 January 2021
#239
View it
Name
Why do dogs bury bones? | Live Science
Description
The science of why dogs bury bones is explained by the food-caching behavior of their wild, canine ancestors, gray wolves.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#240
View it
Name
WhatsApp: WhatsApp treating Indian users differently from Europeans matter of concern: Government tells HC - Latest News | Gadgets Now
Description
The central government told the high court that it was also a matter of concern that Indian users were being "unilaterally" subjected to the change in privacy policy by social networking platform WhatsApp. The submissions were made before Justice Sanjeev Sachdeva by Additional Solicitor General Chetan Sharma during hearing of a petition.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#241
View it
Name
WEF Davos 2021: Infosys, TCS join coalition to tackle workplace racism - Latest News | Gadgets Now
Description
Announcing the international coalition during its week-long online Davos Agenda Summit 2021, the World Economic Forum (WEF) said it would work towards improving racial and ethnic justice in the workplace.
#Energy
Field
# Energy
Updated
25 January 2021
#242
View it
Name
Amazon: Traders body demands action against Amazon, Zomato, Flipkart and Swiggy for breaking rules - Latest News | Gadgets Now
Description
CAIT has demanded immediate action against e-commerce entities including Amazon, Flipkart, Zomato, Swiggy and others."It is a case of daylight robbery of e-commerce entities in India and therefore demand immediate action against the erring e-commerce portals and online mechanism providers," CAIT said.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#243
View it
Name
TCS Market cap: Once again, TCS becomes the most valued domestic firm | Gadgets Now
Description
During the afternoon trade, the market valuation of Tata Consultancy Services (TCS) was at Rs 12,45,341.44 crore while that of Reliance Industries Ltd (RIL) was at Rs 12,42,593.78 crore on the BSE.
#Social & Corporation affairs;#Economy
Field
# Social & Corporation affairs
Updated
25 January 2021
#244
View it
Name
Samsung Galaxy Tab S7 and Tab S7+ get One UI 3 software update - Latest News | Gadgets Now
Description
With this update, Samsung Galaxy Tab S7 and S7+ users will be able to easily copy text or images on their smartphone and instantly paste the content onto the Tab S7 or S7+ – and vice versa. Also, the company will rollout auto-sync of Samsung Notes across connected devices as weak as of Samsung Internet tabs.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#245
View it
Name
spacex: Need a lift? SpaceX launches record spacecraft in cosmic rideshare program - Latest News | Gadgets Now
Description
The Falcon 9 rocket lifted off at 10 a.m. EST from the Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. It flew south along the eastern coast of Florida on its way to space, the company said.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#246
View it
Name
Makers of Sophia the robot plan mass rollout amid pandemic - Latest News | Gadgets Now
Description
HONGKONG-Makers of Sophia the robot plan mass rollout amid pandemic
#Robotics & Manufacturing
Field
# Robotics & Manufacturing
Updated
25 January 2021
#247
View it
Name
iOS 15: iOS 15 may not support these iPhone models - Latest News | Gadgets Now
Description
Apple is said to unveil iOS 15 update in June this year. Now a new report has revealed that this latest version of the system will not land on some older iPhones.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#248
View it
Name
Google employees from 10 countries form global union to prevent Alphabet from ‘being evil’ - Latest News | Gadgets Now
Description
Google employees from across 13 regions in 10 countries which includes the United Kingdom, Switzerland and the United States have formed an international union. Called Alpha Global, the motive is simple, prevent Google and its parent company from ‘being evil’.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#249
View it
Name
Desi Google Drive alternative DigiBoxx offering 26GB free storage - Latest News | Gadgets Now
Description
Desi Google Drive alternative DigiBoxx is offering 26GB free storage to new users as part of its Republic Day. Users who sign-up starting January 26, 2021 will be eligible to avail the special offer valid for the Republic Day week.
#Software;#Maps
Field
# Software
Updated
25 January 2021
#250
View it
Name
Apple Watch helps police save a kidnapped woman - Latest News | Gadgets Now
Description
In order to rescue the kidnapped woman, the police used emergency cellular ping to track the location of the victim’s phone.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#251
View it
Name
Apple has important safety tips for these iPhone users - Latest News | Gadgets Now
Description
Certain pacemakers could get deactivated when an iPhone 12 is kept near it.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#252
View it
Name
Android 12: Android 12 may bring double tap gesture for Pixel phones - Latest News | Gadgets Now
Description
The feature is said to replace the ‘Active Edge’ squeeze gesture. The double tap gesture on the rear side of Pixel phone is said to provide easy access to Google Assistant among others.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#253
View it
Name
Terror groups in Pakistan switch to new messaging applications - Latest News | Gadgets Now
Description
The three new applications came to light after evidence was collected following encounters with terrorists or those who surrendered before the Army gave details about their mode of radicalisation by Pakistan-based terrorist groups, they said. The names of the messaging apps have been withheld for security reasons.
#Medicine & Human body;#Aging
Field
# Medicine & Human body
Updated
25 January 2021
#254
View it
Name
oneplus smartwatch: OnePlus watch reportedly gets certified in India, may launch soon - Latest News | Gadgets Now
Description
The smartwatch is rumoured to come in the first half of 2021. As suggested by online reports, the device may feature a circular design. It is expected that the smartwatch will have two versions -- LTE model and a Wi-Fi version.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#255
View it
Name
google drive: Google Drive becomes a goldmine for pirated, explicit content - Latest News | Gadgets Now
Description
Cyber criminals and pirates of the Internet now have a new goldmine in Google Drive where they are freely storing and sharing illegal software licenses, movies, games and porn content -- most of which have allegedly been indexed in Google Search as some Drive users made such links public in their individual accounts.
#Software;#Maps
Field
# Software
Updated
25 January 2021
#256
View it
Name
Flipkart quiz January 25, 2021: Get answers to these five questions to win gifts, discount coupons and Flipkart Super coins - Latest News | Gadgets Now
Description
Only the first 50,000 participants will be eligible for the quiz prize.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#257
View it
Name
Amazon app quiz January 25, 2021: Get answers to these five questions to win Rs 5,000 in Amazon Pay balance - Latest News | Gadgets Now
Description
Result of today’s quiz will be announced on January 26.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#258
View it
Name
8 facts why News Media Code needs to be tweaked: Google - Latest News | Gadgets Now
Description
As the News Media Bargaining Code triggers a bitter war between Google and the Australian government, the tech giant has detailed eight facts on why reaching a workable Code is important but serious concerns with the current draft remain.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#259
View it
Name
When Galaxies Collide: How Galactic Collisions Can Starve Massive Black Holes
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#260
View it
Name
Puzzling Six-Exoplanet System Discovered With Resonant Rhythmic Movement
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#261
View it
Name
Mysterious Hovering Clouds Spotted Over the Transantarctic Mountains
Description
TBD
#Environment & Nature
Field
# Environment & Nature
Updated
25 January 2021
#262
View it
Name
Musicians Have Brains With Stronger Connections Than Non-musicians
Description
TBD
#Entertainments;#Music
Field
# Entertainments
Updated
25 January 2021
#263
View it
Name
Laser Transformation of Crystal Structures in Super Slow Motion
Description
TBD
#Hardware & Devices;#Laser
Field
# Hardware & Devices
Updated
25 January 2021
#264
View it
Name
Jaw Dropping New Dinosaur Skull Discovery Reveals Evolution of Bizarre Crest
Description
TBD
#Archaeology & History
Field
# Archaeology & History
Updated
25 January 2021
#265
View it
Name
Iodine Thruster Used to Change the Orbit of a Satellite for the First Time Ever
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#266
View it
Name
Ice Is Disappearing Across the Planet at Record Rate
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#267
View it
Name
Dinosaur Embryo Discovery Helps Crack Baby Tyrannosaur Mystery
Description
TBD
#Archaeology & History
Field
# Archaeology & History
Updated
25 January 2021
#268
View it
Name
Depression and Stress Could Dampen Efficacy of COVID-19 Vaccines: Interventions Could Boost Immunity
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#269
View it
Name
COVID-19 Warnings Were on Twitter Well Before the Official Outbreak of the Pandemic
Description
TBD
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#270
View it
Name
Zeroing in on the potential of solar energy to meet industrial process heat demand
Description
Today, natural gas and coal combustion supply most demand for industrial process heat (IPH), or the transfer of heat to a material within a production process. With the emergence of low-cost solar photovoltaic (PV) technologies, ...
#Energy
Field
# Energy
Updated
25 January 2021
#271
View it
Name
Tiny bio-inspired swarm robots for targeted medical interventions
Description
Micro-sized robots could bring a new wave of innovation in the medical field by allowing doctors to access specific regions inside the human body without the need for highly invasive procedures. Among other things, these ...
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#272
View it
Name
Scientists identify the most effective scenario for nuclear energy in Russia through 2100
Description
Currently, there is a rapid, fundamental transformation of energy systems with new technologies developing at an accelerated pace. It is clear that nuclear energy will be part of the global energy mix for decades to come, ...
#Energy
Field
# Energy
Updated
25 January 2021
#273
View it
Name
Lasers and virtual reality to revolutionize watch-crystal engraving
Description
EPFL engineers teamed up with luxury watchmaker Vacheron Constantin to develop an innovative system that uses lasers to create 3-D sculptures within sapphire watch crystals.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#274
View it
Name
Google offers facilities for US vaccination sites
Description
Google said Monday it would make its facilities available for Covid-19 vaccination sites as part of a new initiative to help speed the rollout of inoculations in the United States.
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#275
View it
Name
Far-right groups move to messaging apps as tech companies crack down on extremist social media
Description
Right-wing extremists called for open revolt against the U.S. government for months on social media following the election in November. Behind the scenes on private messaging services, many of them recruited new followers, ...
#Medicine & Human body;#Aging
Field
# Medicine & Human body
Updated
25 January 2021
#276
View it
Name
Achieving cost-efficient superalloy powder manufacturing using machine learning
Description
High-performance, high-quality Ni-Co-based superalloy powders are promising aircraft engine raw materials. Using machine learning, a NIMS team has succeeded in speedily determining the optimum parameters for manufacturing ...
#Artificial Intelligence
Field
# Artificial Intelligence
Updated
25 January 2021
#277
View it
Name
A switch to battery electric vehicles is the best option for cleaner road transport, study finds
Description
The widespread adoption of battery electric vehicles offers the greatest energy efficiency and potential for CO2 reduction, new analysis by Cambridge engineers has shown.
#Energy
Field
# Energy
Updated
25 January 2021
#278
View it
Name
US leading race in artificial intelligence, China rising: survey
Description
The United States is leading rivals in development and use of artificial intelligence while China is rising quickly and the European Union is lagging, a research report showed Monday.
#Artificial Intelligence
Field
# Artificial Intelligence
Updated
25 January 2021
#279
View it
Name
As the coronavirus mutates, we will need to adjust our approach to it | New Scientist
Description
We are still working out what new coronavirus variants will mean for us. As we adapt, there is one thing we know for certain: the only way to stop the virus evolving is to stop it from spreading
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#280
View it
Name
Quantum hyperchaos could help build better quantum computers | New Scientist
Description
When quantum computers get too complex, they can display hyperchaotic behaviour – like chaos, but more chaotic – and understanding it could help improve computer designs
#Hardware & Devices
Field
# Hardware & Devices
Updated
25 January 2021
#281
View it
Name
Covid-19 news: Moderna vaccine appears to work against new variants | New Scientist
Description
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
#Medicine & Human body
Field
# Medicine & Human body
Updated
25 January 2021
#282
View it
Name
Elon Musk is turning oil rigs into floating SPACEPORTS for 'journeys to Moon, Mars and hypersonic trips around Earth'
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#283
View it
Name
Meet Mindful dating site leak as hacker publishes private info of 2.3MILLION users online
Description
TBD
#Software;#Security
Field
# Software
Updated
25 January 2021
#284
View it
Name
Virgin Media finally launches 5G in UK – and it's now live in these 100 towns and cities
Description
TBD
#Telecommunications
Field
# Telecommunications
Updated
25 January 2021
#285
View it
Name
Winter Hexagon: How to see rare space event where SIX constellations combine in the sky this week
Description
TBD
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#286
View it
Name
PS5 restock coming as early as next week at Smyths Toys as desperate gamers scramble to buy sold-out console
Description
TBD
#Entertainments;#Games
Field
# Entertainments
Updated
25 January 2021
#287
View it
Name
PS5 stock checker - PlayStation 5 consoles at Smyths, Argos, Amazon, Game, Currys, Tesco, BT - plus controllers latest
Description
TBD
#Hardware & Devices;#Entertainments
Field
# Hardware & Devices
Updated
25 January 2021
#288
View it
Name
Apple's new 'Time to Walk' feature officially lands on Fitness+
Description
Apple's new Fitness+ feature Time to Walk is now available. It attempts to make daily walks more enjoyable through storytelling and music from celebrities.
#Social & Corporation affairs;#Security
Field
# Social & Corporation affairs
Updated
25 January 2021
#289
View it
Name
Apple's new 'Time to Walk' feature will serve inspiring audio stories while you stroll around
Description
Apple will likely soon launch a new Fitness+ feature called "Time to Walk."
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#290
View it
Name
Google workers in 10 countries form union alliance: 'We will hold Alphabet accountable'
Description
Workers from Google's parent company Alphabet in 10 countries have banded together to form a union alliance called Alpha Union.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#291
View it
Name
SpaceX launched a record-setting 143 satellites into orbit
Description
SpaceX launched the Transporter-1 mission on Sunday, Jan. 24 after two delays, sending a record-setting 143 satellites into orbit.
#Astronautics
Field
# Astronautics
Updated
25 January 2021
#292
View it
Name
AmazonBasics 55-Inch Fire TV Edition Ultra-HD HDR Smart LED TV Review | NDTV Gadgets 360
Description
Amazon has finally entered the lucrative TV segment through its own AmazonBasics brand. One of the first TVs to be launched is the 55-inch Fire TV Edition 4K LED TV, officially priced at Rs. 34,999. Is this the best affordable Ultra-HD HDR TV you can buy? Find out in our review.
#Entertainments
Field
# Entertainments
Updated
25 January 2021
#293
View it
Name
WhatsApp Treating Indian Users Differently from Europeans Matter of Concern: Government Tells Delhi High Court | Technology News
Description
WhatsApp users in India being treated differently from Europeans over opting out of its new privacy policy is a matter of concern, the central government told the Delhi High Court on Monday.
#Social & Corporation affairs
Field
# Social & Corporation affairs
Updated
25 January 2021
#294
View it
Name
Vivo S7t Phone With MediaTek Dimensity 820 SoC Tipped to Launch Soon | Technology News
Description
Vivo S7t is expected to launch soon. The phone has been tipped to come with the model number PD2080 and MediaTek Dimensity 820 SoC.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#295
View it
Name
Sony Xperia Compact Phone Featuring 5.5-Inch Display Tipped to Launch This Year | Technology News
Description
Sony Xperia Compact’s new version is tipped to launch this year. The compact phone is expected to feature a 5.5-inch display and measure around 140x68.9x8.9mm. As per a tipster, the new Sony Xperia Compact will have a dual rear camera setup featuring a 13-megapixel primary sensor along with an 8-megapixel camera in the front.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#296
View it
Name
Samsung Galaxy A72 Receives TUV Rheinland Certification, Tipped to Feature 25W Fast Charging | Technology News
Description
Samsung Galaxy A72 may feature 25W fast charging. A tipster shared that the smartphone received TUV Rheinland certification and supports 9V at 2.77A charging, which is approximately 25W. The device was spotted on the listing carrying the model numbers SM-A725F/DS and SM-A725F.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#297
View it
Name
Redmi Note 10 Launch Teased Officially After Rumours Tipping February Debut in India | Technology News
Description
Redmi Note 10 launch has been teased officially after the rumour mill suggested its existence alongside the Redmi Note 10 5G, Redmi Note 10 Pro, and the Redmi Note 10 Pro 5G.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#298
View it
Name
Realme X7 and Realme X7 Pro India Launch Date Tipped for February 4, Flipkart Availability Teased | Technology News
Description
Realme X7 and Realme X7 Pro launch in India has been teased by Flipkart. While the launch is yet to be announced by the company, a tech blogger seems to have accidentally revealed the India launch date of the two smartphones. Both phones could debut in India as early as February 4. Some variant details of the Indian Realme X7 and Realme X7 Pro models have also surfaced online.
#Gadgets
Field
# Gadgets
Updated
25 January 2021
#299
View it
Name
Poco X2 Starts Getting Android 11 Through MIUI 12.1 Update, Comes With January 2021 Security Patch | Technology News
Description
Poco X2 has started getting MIUI 12.1 that brings the anticipated Android 11 update. The new update comes along with the January 2021 Android security patch.
#Software
Field
# Software
Updated
25 January 2021
#300
View it
Name
Oppo A55 5G With Dimensity 700 SoC, 5,000mAh Battery Launched: Price, Specifications | Technology News
Description
The new Oppo A55 5G is priced in China at CNY 1,599 (roughly Rs. 18,000) for the lone 6GB RAM + 128GB storage option. It is available in Brisk Blue and Rhythm Black colour options. The phone is up for grabs via several online retailers in China including JD, Tmall, and Suning.
#Energy
Field
# Energy
Updated
25 January 2021