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Today: 20 October 2020, Tuesday.

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#1

 

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Description Accurate and continuous monitoring of critically ill patients is frequently achieved using invasive catheters, which is technically complex. Our purpose was to evaluate the validity and accuracy of a photoplethysmography (PPG)-based remote monitoring device compared to invasive methods of arterial line (AL) and Swan-Ganz (SG) catheters in a swine model of controlled hemorrhagic shock. Following a baseline phase, hemorrhagic shock was induced in 11 pigs by bleeding 35% of their blood volume, followed by a post-bleeding follow-up phase. Animals were monitored concomitantly by the PPG device, an AL and a SG catheter, for a median period of 447 min. Heart rate (HR), systolic and diastolic blood pressure (SBP and DBP, respectively), and cardiac output (CO) were recorded continuously. The complete data set consisted of 1312 paired observations. Correlations between the PPG-based technique and the invasive methods were significant (p < 0.001) during baseline, bleeding and follow-up phases for HR (r = 0.90–0.98), SBP (r = 0.90–0.94), DBP (r = 0.89–0.93), and CO (r = 0.76–0.90). Intraclass correlations for all phases combined were 0.96, 0.92, 0.93 and 0.87 for HR, SBP, DBP and CO, respectively. Correlations for changes in CO, SBP and DBP were significant (p < 0.001) and strong (r > 0.88), with concordance rates (determined by quadrant plots) of 86%, 66% and 68%, respectively. The novel PPG-based device was accurate and valid compared to existing invasive techniques and might be used for continuous monitoring in several clinical settings following further studies.

#Food
Field # Food
Updated 19 October 2020

#2

 

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Description Psoriasis is mainly caused because of inappropriate immune responses in the epidermis. Rice (Oryza sativa L.: SRNC05053-6-2) consists of anthocyanin, which exhibits strong antioxidative and anti-inflammatory properties. This study aimed to evaluate the role of this black-coloured rice crude extract in alleviating the symptoms of psoriasis using human psoriatic artificial skin and an imiquimod-induced rat psoriasis model. Psoriasis-related genes, cytokines and chemokines were examined; in addition, the antioxidative and anti-inflammatory properties and the immunohistopathological features of this condition were studied. The results showed that the rice extract reduced the severity of psoriasis by (1) decreasing the epidermal thickness, acanthosis, hyperkeratosis, epidermal inflammation and degree of apoptosis induction via caspase-3, (2) increasing the expression levels of anti-inflammatory cytokines (IL-10 and TGF-β), (3) reducing the levels of pro-inflammatory cytokines (IL-6, IL-8, IL-20, IL-22 and TNF-α), chemokines (CCL-20) and anti-microbial peptides (psoriasin and β-defensin), (4) enhancing the antioxidative property (Nrf-2), (5) downregulating the levels of psoriasis-associated genes (psoriasin, β-defensin, koebnerisin 15L and koebnerisin 15S) and (6) upregulating the levels of psoriasis-improving genes (caspase-14, involucrin and filaggrin). Thus, the extract appears to exert therapeutic effects on psoriasis through its antioxidative and immunomodulatory properties.

#Food
Field # Food
Updated 19 October 2020

#3

 

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Description Feeding infants with formula requires heating water and bottles for sterilization and formula preparation. Plastic infant feeding bottles are commonly used, and now their potential to release microplastics has been explored at a global scale.

#Food
Field # Food
Updated 19 October 2020

#4

 

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Description Raspberry Pi Compute Module 4 has been launched. It 4 will be offered in 32 variants and starts at $25 (roughly Rs. 1,833). Raspberry Pi 4 was introduced more than a year ago.

#Food
Field # Food
Updated 19 October 2020

#5

 

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Description Diarrhoea can be unfortunate but a short-lived side effect of bad takeout food, yet it is also a leading cause of death in children under five globally. Scientists continue to investigate how illness-causing bacteria gain a foothold within the digestive tract when they are usually held in check by t

#Food
Field # Food
Updated 18 October 2020

#6

 

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Description Special guest Brian Bennett joins us for real talk on this eye-opening topic.

#Food
Field # Food
Updated 18 October 2020

#7

 

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Description Cocaine abuse continues to be a serious health problem worldwide. Despite intense research, there is still no FDA-approved medication to treat cocaine use disorder (CUD). In this report, we explored the potential utility of beta-caryophyllene (BCP), an FDA-approved food additive for the treatment of CUD. We found that BCP, when administered intraperitoneally or intragastrically, dose-dependently attenuated cocaine self-administration, cocaine-conditioned place preference, and cocaine-primed reinstatement of drug seeking in rats. In contrast, BCP failed to significantly alter food self-administration or cocaine-induced hyperactivity. It also failed to maintain self-administration in a drug substitution test, suggesting that BCP has no abuse potential. BCP was previously reported to be a selective CB2 receptor agonist. Unexpectedly, pharmacological blockade or genetic deletion of CB1, CB2, or GPR55 receptors in gene-knockout mice failed to alter BCP’s action against cocaine self-administration, suggesting the involvement of non-CB1, non-CB2, and non-GPR55 receptor mechanisms. Furthermore, pharmacological blockade of μ opioid receptor or Toll-like receptors complex failed to alter, while blockade of peroxisome proliferator-activated receptors (PPARα, PPARγ) reversed BCP-induced reduction in cocaine self-administration, suggesting the involvement of PPARα and PPARγ in BCP’s action. Finally, we used electrical and optogenetic intracranial self-stimulation (eICSS, oICSS) paradigms to study the underlying neural substrate mechanisms. We found that BCP is more effective in attenuation of cocaine-enhanced oICSS than eICSS, the former driven by optical activation of midbrain dopamine neurons in DAT-cre mice. These findings indicate that BCP may be useful for the treatment of CUD, likely by stimulation of PPARα and PPARγ in the mesolimbic system.

#Food
Field # Food
Updated 17 October 2020

#8

 

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Description From Oxo, Bodum, Frieling, Veken, Bodum, Kona and others, we took many popular French press models for a spin to find out which are the best.

#Food
Field # Food
Updated 17 October 2020

#9

 

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Description

#Food
Field # Food
Updated 17 October 2020

#10

 

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Description TBD

#Food
Field # Food
Updated 17 October 2020

#11

 

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Description To achieve 30 percent local food production by 2030, Singapore’s most innovative minds are turning to genome editing, artificial intelligence and even microalgae-based proteins.

#Food
Field # Food
Updated 16 October 2020

#12

 

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Description Nutrition expert Professor Christiani Jeyakumar Henry spills the beans on which popular food beliefs are true and which ones should be taken with a grain of salt.

#Food
Field # Food
Updated 16 October 2020

#13

 

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Description To learn which espresso machine is the best we tested many popular models. On the list are from machines from Nespresso, Breville, Mr. Coffee, Cuisinart, DeLonghi and others.

#Food
Field # Food
Updated 16 October 2020

#14

 

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Description We tested many popular brands from Oxo, Filtron, Espro, Takeya and others to find out which cold-brew coffee maker is best.

#Food
Field # Food
Updated 16 October 2020

#15

 

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Description The anti-inflammatory effects of vagus nerve stimulation are well known. It has recently been shown that low-level, transcutaneous stimulation of vagus nerve at the tragus (LLTS) reduces cardiac inflammation in a rat model of heart failure with preserved ejection fraction (HFpEF). The mechanisms by which LLTS affect the central neural circuits within the brain regions that are important for the regulation of cardiac vagal tone are not clear. Female Dahl salt-sensitive rats were initially fed with either low salt (LS) or high salt (HS) diet for a period of 6 weeks, followed by sham or active stimulation (LLTS) for 30 min daily for 4 weeks. To study the central effects of LLTS, four brainstem (SP5, NAb, NTS, and RVLM) and two forebrain sites (PVN and SFO) were examined. HS diet significantly increased the gene expression of proinflammatory cytokines in the SP5 and SFO. LLTS reversed HS diet-induced changes at both these sites. Furthermore, LLTS augmented the levels of antioxidant Nrf2 in the SP5 and SFO. Taken together, these findings suggest that LLTS has central anti-inflammatory and antioxidant properties that could mediate the neuromodulation of cardiac vagal tone in the rat model of HFpEF.

#Food
Field # Food
Updated 16 October 2020

#16

 

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Description

#Food
Field # Food
Updated 16 October 2020

#17

 

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Description A biologist tracking a 4-metre-long python in Australia warned local residents to be on their guard – but one woman woke to find the snake trying to eat her

#Food
Field # Food
Updated 16 October 2020

#18

 

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Description The aim of this study was to investigate the effect of high fat diet and excessive compressive mechanical force on temporomandibular joint. In vivo, a mouse model of temporomandibular joint compressive loading device was used. A high fat diet mouse model and a combined mouse model intraperitoneally treated with or without simvastatin were used in the study. The pathological changes of mandibular condylar cartilage were assessed by Safranin-O staining. The IL-1β, MMP-3, leptin expression changes in the cartilage were detected by immunohistochemistry. In vitro, the mandibular condylar chondrocytes were treated with or without L-1β and simvastatin. The mRNA expression level of matrix MMPs and leptin were assessed. Both excessive compressive mechanical force and high fat diet induced obesity caused TMJ osteoarthritis-like changes and increased expression of IL-1β, MMP-3, and leptin. These pathological changes were much more serious when the two interventions were exerted together, while simvastatin could obviously alleviate these changes. The mRNA expression of MMP-3, MMP-13, and leptin increased in the IL-1β treated chondrocytes treated with IL-1β, and decreased with simvastatin treatment. The development of temporomandibular joint pathological changes could be caused by the excessive compressive mechanical force and high fat diet induced obesity.

#Food
Field # Food
Updated 15 October 2020

#19

 

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Description The diversity of aquaculture production systems in Bangladesh may be calibrated to provide food and nutrition security without negative environmental impact, aligning multiple interests of the United Nations Sustainable Development Goals.

#Food
Field # Food
Updated 14 October 2020

#20

 

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Description Finnish carrier Finnair will start selling business class airplane food in supermarkets in a move to keep its catering staff employed and to offer a taste of the airline experience to those missing flying in the COVID-19 ...

#Food
Field # Food
Updated 14 October 2020

#21

 

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Description COVID-19 pandemic caused a widespread lockdown. You may be one of those people who had to adapt to working from home. Food delivery services enjoyed a nice boost during this time, but scientists from the University of Sydney say that there is a negative in this - food delivery services making junk f

#Food
Field # Food
Updated 14 October 2020

#22

 

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Description We put a group of popular drip machines to the test then picked our favorites. On the list are coffee makers from Bunn, Ninja, Oxo, Technivorm Moccamaster, KitchenAid, Bonavita and others.

#Food
Field # Food
Updated 14 October 2020

#23

 

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Description In 2017, Hyo-Jick Choi and his engineering research team released a study outlining a breathable surgical mask that just doesn’t catch pathogens from entering the respiratory system, it kills them. Choi, a professor in the Faculty of Engineering who runs the Sustainable Engineering and Drug Deliv

#Food
Field # Food
Updated 14 October 2020

#24

 

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Description The Ninja Foodi and Instant Pot Duo Crisp both let you air fry, pressure cook, and more. But, which appliance is better? We compare the two.

#Food
Field # Food
Updated 14 October 2020

#25

 

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Description There may come a time when the next blouse or pair of gym shorts you buy is made of banana peels, rotten tomatoes, coffee grounds or mouldy bread. It’s not as strange as it sounds. In fact, the future of fashion depends on the use of biodegradable and carbon-neutral materials, says Avneet Ghotra,

#Food
Field # Food
Updated 14 October 2020

#26

 

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Description Nom Nom and Canary are partnering for a half-off deal that can save you money on home security and quality dog food.

#Food
Field # Food
Updated 14 October 2020

#27

 

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Description The ability to detect food plays an indispensable role in our survival and wellbeing. Previous psychological studies have revealed that food is detected more rapidly than non-food items. However, whether the detection of food could be modulated by cultural factors remains unknown. We investigated this issue in the present study using a visual search paradigm with Polish and Japanese participants. Photographs of international fast food, domestic Japanese food, or kitchen tools were presented alongside images of non-food distractors (cars). Participants were asked to judge whether the stimuli were all identical or not. The reaction time data showed that participants from both cultures detected food more rapidly than kitchen tools. Japanese participants detected fast food more rapidly than Japanese food, whereas Polish participants did not display such differences between food types. These results suggest that rapid detection of food is universal, but is modulated by cultural experiences.

#Food
Field # Food
Updated 14 October 2020

#28

 

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Description The effects of rice husk flour (RHF), rice husk biochar (RHB), and rice husk-sludge cake biochar (RH-SCB, expresses sludge cake biochar deriving from a sludge that has been previously conditioned with rice husk) used as physical conditioners on sludge dewaterability were compared. The effects of characteristics of physical conditioners on sludge compressibility and zeta potential were analyzed. The optimal rice husk-based powder was RH-SCB, which presented the highest net sludge solid yield (YN, expresses the dry mass flow by filtration) at 20.39 kg/(m2 h) for 70% dry sludge (DS). Characterization analysis indicates that the hardness and surface Fe content of powders which could influence the compressibility coefficient of sludge cake and sludge zeta potential were the major factors influencing sludge dewaterability. The comparison of feasibility and economic analysis showed that adding RH-SCB improves the quality of the sludge filtrate and reduces the pollution potential of conditioned sludge (the ratio of secondary and primary (RSP) of Cu, Zn, Cd reduces from 43.05, 144.00, 7.25 to 7.89, 14.63, 4.27, respectively), and the costs of using RH-SCB were the lowest (at 88.4% lower than that of the raw sludge). Therefore, it is feasible to use RH-SCB to improve sludge dewaterability.

#Food
Field # Food
Updated 14 October 2020

#29

 

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Description The DR5-DQ7/DR7-DQ2 genotype is very frequent among patients affected by celiac disease (CD), in Europe. This genotype, associated to high risk of CD, carries the HLA-DQA1*05 and HLA-DQB1*02 predisposing alleles, in trans configuration. The alleles encode the DQ2.5 heterodimer responsible of gluten peptide presentation on the surface of antigen-presenting cells (APCs), and consequent pathogenic CD4+ T cell activation. We demonstrated that DR5/DR7 APCs induce an anti-gluten CD4+ T cell response, of comparable intensity to that observed with APCs carrying DR1/DR3 genotype, which risk alleles are in cis configuration. In addition, we showed that DR5/DR7 APCs from celiac patients stimulated an effector CD4+ T cell response higher with respect to that induced by DR5/DR7 APCs from healthy subjects. To explain these findings, we assessed the DQ2.5 RNA and protein quantity. We showed that the expression of DQA1*05 and DQB1*02 risk alleles is much higher than the expression of non-CD-associated alleles, in agreement with the previous results obtained with DR1/DR3 genotype. The differential expression of transcripts influences the quantity of DQα1*05 and DQβ1*02 chains and, as consequence, the cell surface density of DQ2.5 heterodimers. Moreover, both RNA and proteins, are more abundant in APCs from celiac patients than controls. Finally, to unravel the mechanism regulating the expression of predisposing DQA1*05 and DQB1*02 alleles, we quantified the new synthetized RNA and found that the differential expression is explained by their transcription rate. Our results confirmed that the strength of antigen-specific CD4+ T cell response is mainly determined by the amount of gluten in the diet and provided a new possible approach for a personalized diagnosis and for risk stratification.

#Food
Field # Food
Updated 14 October 2020

#30

 

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Description The Ninja Foodi and Instant Pot Duo Crisp both let you air fry, pressure cook, and more. But, which appliance is better? We compare the two.

#Food
Field # Food
Updated 14 October 2020

#31

 

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Description Learn how to find the best deals on the best coffee makers and coffee machines during Amazon's Prime Day 2020.

#Food
Field # Food
Updated 13 October 2020