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Today: 22 September 2020, Tuesday.

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#1

 

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The firm, which develops technology that enables financial technology companies to access account data from high street banks, said it will use the funding to continue to grow its business.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 22 September 2020

#2

 

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Spotted wing drosophila, Drosophila suzukii, is a serious invasive pest impacting the production of multiple fruit crops, including soft and stone fruits such as strawberries, raspberries and cherries. Effective control is challenging and reliant on integrated pest management which includes the use of an ever decreasing number of approved insecticides. New means to reduce the impact of this pest that can be integrated into control strategies are urgently required. In many production regions, including the UK, soft fruit are typically grown inside tunnels clad with polyethylene based materials. These can be modified to filter specific wavebands of light. We investigated whether targeted spectral modifications to cladding materials that disrupt insect vision could reduce the incidence of D. suzukii. We present a novel approach that starts from a neuroscientific investigation of insect sensory systems and ends with infield testing of new cladding materials inspired by the biological data. We show D. suzukii are predominantly sensitive to wavelengths below 405 nm (ultraviolet) and above 565 nm (orange & red) and that targeted blocking of lower wavebands (up to 430 nm) using light restricting materials reduces pest populations up to 73% in field trials.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#3

 

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We aimed to explore the effects of type-2 diabetes mellitus (T2DM) and hypoglycemic therapy on the salivary microbiome in periodontitis patients and identify the potential salivary micro-biomarker for the early warning of T2DM. Saliva samples were collected from healthy individuals (Health), periodontitis patients (P), T2DM patients, periodontitis patients with T2DM (DAP), and DAP patients treated with Metformin (Met). Samples were determined by16S rRNA gene sequencing. 29 phyla, 322 genera, and 333 species of salivary microbiome were annotated. Compared to the Health group, the P and DAP group showed a significantly higher diversity of saliva microbiota, while the T2DM and Met group had no significant difference in microbial abundance but showed a trend of increasing diversity. Other than well-known periodontitis-inducing pathogens, the proportion of Prevotella copri, Alloprevotella rava, and Ralstonia pickettii, etc. were also significantly increased in periodontitis patients with or without T2DM. After effective glycemic control, the abundance of Prevotella copri, Alloprevotella rava, Ralstonia pickettii, etc. decreased in periodontitis patients with companion T2DM. The accuracies of the classification models in differentiating Health-vs.-P, DAP-vs.-P, and T2DM-vs.-P were 100%, 96.3%, and 98.1%, respectively. Hypoglycemic therapy could reconstruct the saliva microbiota and hence improve the localized conditions of diabetes patients with periodontitis.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#4

 

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Active meta polarizers based on phase-change materials have recently led to emerging developments in terahertz devices and systems for imaging, security, and high-speed communications. Existing technologies of adaptive control of meta polarizers are limited to the complexity of external stimuli. Here, we introduce an active terahertz polarizer consisting of a single layer of large array patterns of vanadium dioxide material integrated with metallic patch matrix to dynamically reconfigure the polarization of the terahertz waves. The proposed active polarizer is simple in structure and can independently manipulate the polarization of the incident THz waves in two orthogonal directions. In addition, the device can also be performing as a highly efficient reflector at the same frequencies. We demonstrate that efficient and fast polarization changes of THz waves can be achieved over a wide operating bandwidth. Compared with other active polarizers using mechanical, optical and thermal controls, it can be conveniently manipulated with DC bias without any external actuators, intense laser source or heater. Therefore, with the advantages of high efficiency, compact size, low loss, low cost and fast response, the proposed polarizer can be highly integrative and practical to operate within adaptive terahertz circuits and systems.

#Telecommunications
Field # Telecommunications
Updated 21 September 2020

#5

 

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Luke Skywalker and Captain Jean-Luc Picard face off over ... tomatoes?

#Entertainments
Field # Entertainments
Updated 21 September 2020

#6

 

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In an attempt to induce experimental varicosity, reverse perforant vein development was initiated in the rat leg by applying a chronic (14 and 32 weeks) partial stricture on the main branch of the deep femoral vein. At surfacing of the incompetent perforantes, typical reticular vein plaques and spider veins were identified by video-microscopy and quantitative histology. Deep vein blood was channeled by them into the saphenous vein system, the extra flow deforming these vessels, causing local dilations and broken course, even undulations of larger branches.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#7

 

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The company, which this week will hold its third virtual Unpacked event of the past two months, has opted not to have a digital event.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#8

 

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Male aging and obesity have both been shown to contribute to declines in fertility in men. Recent work in aging has shown consistent epigenetic changes to sperm as a man ages. In fact, our lab has built a tool that utilizes DNA methylation signatures from sperm to effectively predict an individual’s age. Herein, we performed this preliminary cohort study to determine if increased BMI accelerates the epigenetic aging in sperm. A total of 96 participants were divided into four age groups (22–24, 30, 40–41, and > 48 years of age) and additionally parsed into two BMI sub-categories (normal and high/obese). We found no statistically significant epigenetic age acceleration. However, it is important to note that within each age category, high BMI individuals were predicted to be older on average than their actual age (~ 1.4 years), which was not observed in the normal BMI group. To further investigate this, we re-trained a model using only the present data with and without BMI as a feature. We found a modest but non-significant improvement in prediction with BMI [r2 = 0.8814, mean absolute error (MAE) = 3.2913] compared to prediction without BMI (r2 = 0.8739, MAE = 3.3567). Future studies with higher numbers of age-matched individuals are needed to definitively understand the impact of BMI on epigenetic aging in sperm.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#9

 

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Donald Trump and Joe Biden will meet in Cleveland for the first of three debates.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#10

 

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The manipulation of polarization state of electromagnetic waves is of great importance in many practical applications. In this paper, the reflection characteristics of a thin and dual-band metasurface are examined in the microwave frequency regime. The metasurface consists of a 22 × 22 element array of periodic unit cells. The geometry of the unit cell consists of three layers, including a 45° inclined dipole shape metal patch on top, which is backed by a 1.6 mm thick FR-4 substrate in the middle, and a fully reflective metallic mirror at the bottom. The proposed surface is exposed to horizontally (x) or vertically (y) polarized plane waves and the co and cross polarization reflection coefficients of the reflected waves are investigated experimentally in the 6–26 GHz frequency range. The metasurface is designed to convert incident waves of known polarization state (horizontal or vertical) to orthogonal polarization state (vertical and horizontal) in two distinct frequency bands, i.e. 7.1–8 GHz and 13.3–25.8 GHz. In these two frequency bands the simulated and experimental results are in good agreement. The polarization conversion ratio (PCR) of the surface is greater than 95% in the targeted frequency bands. A detailed parametric analysis of the metasurface is also discussed in this work and it has been estimated that the surface has the additional ability to convert linearly polarized waves to circularly polarized waves at several distinct frequencies. The proposed metasurface can be utilized in sensor applications, stealth technology, electromagnetic measurements, and antennas design.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#11

 

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Trying to pass the time with a roommate or significant other? Try these board game gems, perfect for our current work-from-home reality.

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#12

 

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The bulk photovoltaic effect (BPVE) is a mechanism of recent focus for novel solar cells that exceed the power conversion efficiency of p–n junction solar cells because of the quantum mechanical effect to generate photocurrent known as shift current. Ferroelectrics are receiving attention again because of their high voltage generation by the BPVE and converse piezoelectric effect to realize high performance optical actuators. We have investigated the BPVE in ferroelectric BiFeO3 (BFO) single crystal thin films, whereby the photovoltage was enhanced by Mn doping, and 852 V generation was demonstrated at 80 K. The enhancement mechanism was also investigated using soft and hard X-ray photoelectron spectroscopy (SXPES, HAXPES), and soft X-ray absorption spectroscopy with synchrotron radiation. This report reveals a way to new voltage source applications employing the BPVE for high impedance devices with ferroelectrics. Important aspects for designing ferroelectric materials by impurity doping are also discussed.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#13

 

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The watch sports a thinner design within a slightly altered frame, according to an iFixit teardown.

#Energy
Field # Energy
Updated 21 September 2020

#14

 

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In recent year, fatty acids (FAs) are heavily studied for heat storage applications and they have shown promising advantages over other organic phase change materials (PCMs). Among the FAs; capric, palmitic and stearic acids are the most studied PCMs. Several researchers have investigated these FAs and tried to improve their thermal properties, mainly by adding different high conducting fillers, such as graphite, metal foams, CNTs, graphene etc. In most cases, these fillers improved the thermal conductivity and heat transfer property but reduce the heat storage capacity considerably. These composites also lose the mixing uniformity during the charging and discharging process. To overcome these issues, selected FAs were grafted on the functionalized CNT surfaces and used as conductive fillers to prepare FA based composite PCMs. This process significantly contributed to prevent the drastic reduction of the overall heat storage capacity and also showed better dispersion in both solid and liquid state. Thermal cycling test showed the variations in the thermal energy storage values of all composite PCMs, however, within the tolerable grade and they had appreciable phase change stability and good chemical stability even after 2,000 cycles.

#Energy
Field # Energy
Updated 21 September 2020

#15

 

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"For our customers, it's a pain to go to Russia, the United States, or India."

#Astronautics
Field # Astronautics
Updated 21 September 2020

#16

 

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The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination and compared findings to stool samples from 16 age-matched infants in the United States (US). In 14 Bangladeshi infants, available post-vaccination serum samples were tested for polio-neutralizing antibodies. The abundance (p = 0.006) and richness (p = 0.013) of the eukaryotic virome increased with age and were higher than seen in age-matched US infants (p < 0.001). In contrast, phage diversity metrics remained stable and were similar to those in US infants. Non-poliovirus eukaryotic virus abundance (3.68 log10 vs. 2.25 log10, p = 0.002), particularly from potential viral pathogens (2.78log10 vs. 0.83log10, p = 0.002), and richness (p = 0.016) were inversely associated with poliovirus shedding. Following vaccination, 28.6% of 14 infants tested developed neutralizing antibodies to all three Sabin types and also exhibited higher rates of poliovirus shedding (p = 0.020). No vaccine-derived poliovirus variants were detected. These results reveal an inverse association between eukaryotic virome abundance and poliovirus shedding. Overall gut virome ecology and concurrent viral infections may impact oral vaccine responsiveness in Bangladeshi infants.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#17

 

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Vitamin E (VitE) deficiency results in embryonic lethality. Knockdown of the gene ttpa encoding for the VitE regulatory protein [α-tocopherol transfer protein (α-TTP)] in zebrafish embryos causes death within 24 h post-fertilization (hpf). To test the hypothesis that VitE, not just α-TTP, is necessary for nervous system development, adult 5D strain zebrafish, fed either VitE sufficient (E+) or deficient (E−) diets, were spawned to obtain E+ and E− embryos, which were subjected to RNA in situ hybridization and RT-qPCR. Ttpa was expressed ubiquitously in embryos up to 12 hpf. Early gastrulation (6 hpf) assessed by goosecoid expression was unaffected by VitE status. By 24 hpf, embryos expressed ttpa in brain ventricle borders, which showed abnormal closure in E− embryos. They also displayed disrupted patterns of paired box 2a (pax2a) and SRY-box transcription factor 10 (sox10) expression in the midbrain-hindbrain boundary, spinal cord and dorsal root ganglia. In E− embryos, the collagen sheath notochord markers (col2a1a and col9a2) appeared bent. Severe developmental errors in E− embryos were characterized by improper nervous system patterning of the usually carefully programmed transcriptional signals. Histological analysis also showed developmental defects in the formation of the fore-, mid- and hindbrain and somites of E− embryos at 24 hpf. Ttpa expression profile was not altered by the VitE status demonstrating that VitE itself, and not ttpa, is required for development of the brain and peripheral nervous system in this vertebrate embryo model.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#18

 

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The association between incidence of diabetes mellitus (DM) and living conditions has not been studied after natural disasters. We compared the incidence of DM between individuals living in temporary housing (TH) and those living in other types of accommodation (non-TH) five years after the 2011 Great East Japan Earthquake. Longitudinal follow-up was conducted from 2011 to 2015 in a cohort of 7,491 residents of coastal communities in Iwate Prefecture directly impacted by the 2011 disaster (mean age, 61.6 years; men, 36.0%). We calculated the odds ratio of new onset of DM in the TH group (n = 2,372) compared with the non-TH group (n = 5,119) using discrete-time logit models stratified by sex and age classes (64 years or younger and older than 65 years). The TH group showed a significantly higher odds ratio (OR) for DM in men aged 64 years or younger (OR [95% confidence interval (CI)], 1.71 [1.03–2.85]; P-value = 0.040). In women, living conditions were not significantly associated DM. Survivors relocated to TH appeared to be at an increased risk of new onset DM.

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#19

 

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T-Mobile rivals say it has too much spectrum, urge FCC to impose limits.

#Telecommunications;#Gadgets
Field # Telecommunications
Updated 21 September 2020

#20

 

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Quaternary alkylammonium compounds (QAACs) are a group of cationic surfactants which are disinfectants with numerous industrial and agricultural applications and frequently released into the environment. One recent hypothesis is that bacteria present in soil will be protected from acute toxic effects of QAACs in the presence of expandable layer silicates due to interlayer sorption. We therefore studied bacterial growth kinetics with high temporal resolution and determined minimal inhibitory concentrations (MICs) of two QAACs, benzyldimethyldodecylammonium chloride (BAC-C12) and didecyldimethylammonium chlorid (DADMAC-C10), for eight strains of different bacterial taxa (Escherichia coli, Acinetobacter, Enterococcus faecium, Enterococcus faecalis, and Pseudomonas fluorescens) in relation to QAAC sorption to smectite and kaolinite. The MICs of BAC-C12 and DADMAC-C10 were in the absence of smectite and kaolinite in the order of 10 to 30 µg mL−1 and 1.0 to 3.5 µg mL−1 for all strains except the more sensitive Acinetobacter strain. For all tested strains and both tested QAACs, the presence of smectite increased apparent MIC values while kaolinite had no effect on MICs. Sorption curves without bacteria showed that smectite sorbed larger amounts of QAACs than kaolinite. Correcting nominal QAAC concentrations employed in toxicity tests for QAAC sorption using the sorption curves explained well the observed shifts in apparent MICs. Transmission electron microscopy (TEM) demonstrated that the interlayer space of smectite expanded from 13.7 ± 1 Å to 19.9 ± 1.5 Å after addition of BAC-C12. This study provides first evidence that low charge 2:1 expandable layer silicates can play an important role for buffering QAAC toxicity in soils.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#21

 

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Agencies that don't update must disconnect all domain controllers from networks.

#Software
Field # Software
Updated 21 September 2020

#22

 

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Two complimentary approaches are widely used to study gene function in zebrafish: induction of genetic mutations, usually using targeted nucleases such as CRISPR/Cas9, and suppression of gene expression, typically using Morpholino oligomers. Neither method is perfect. Morpholinos (MOs) sometimes produce off-target or toxicity-related effects that can be mistaken for true phenotypes. Conversely, genetic mutants can be subject to compensation, or may fail to yield a null phenotype due to leakiness (e.g. use of cryptic splice sites or downstream AUGs). When discrepancy between mutant and morpholino-induced (morphant) phenotypes is observed, experimental validation of such phenotypes becomes very labor intensive. We have developed a simple genetic method to differentiate between genuine morphant phenotypes and those produced due to off-target effects. We speculated that indels within 5′ untranslated regions would be unlikely to have a significant negative effect on gene expression. Mutations induced within a MO target site would result in a Morpholino-refractive allele thus suppressing true MO phenotypes whilst non-specific phenotypes would remain. We tested this hypothesis on one gene with an exclusively zygotic function, tbx5a, and one gene with strong maternal effect, ctnnb2. We found that indels within the Morpholino binding site are indeed able to suppress both zygotic and maternal morphant phenotypes. We also observed that the ability of such indels to suppress morpholino phenotypes does depend on the size and the location of the deletion. Nonetheless, mutating the morpholino binding sites in both maternal and zygotic genes can ascertain the specificity of morphant phenotypes.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#23

 

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It's set after Endgame, will tie in with Doctor Strange in the Multiverse of Madness.

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#24

 

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All natural populations show fluctuations in space or time. This is fundamental for the maintenance of biodiversity, as it allows species to coexist. Long-term ecological studies are rare, mainly due to logistics, but studies like the one presented below recognize the dimensionality of temporal change and the ecological processes that lead to shifts in community composition over time. Here, we used three sampling occasions from a dataset spanning 20 years where dragonflies in central Sweden were monitored. Our aim was to investigate how the prevalence of ecological and biological species traits varied over time measured as Community-level Weighted Means of trait values (CWM). Most CWM values varied significantly between years. Most of the traits changed between the second and the last sampling occasion, but not between the two first ones. These changes could be linked to major changes in species abundance. Our work indicates that fundamental shifts in community structure can occur over a short time, providing environmental drivers act on species turnover. In our case, Climate change and pH levels in lakes are most likely the most important factors.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#25

 

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To determine predictors of rescue treatment among infants treated for retinopathy of prematurity and to evaluate their ocular outcomes at 18–24 months of corrected age. This is a single centre retrospective study of infants who received treatment for type 1 ROP, using laser photocoagulation or anti VEGF agents. Multivariable logistic regression was used to generate a prediction model for rescue treatment of ROP. The primary outcome was an abnormal refractive outcome by 24 months of corrected age, among infants primarily treated with laser therapy. Two hundred and eight infants (including 416 eyes) who received single (n = 151) or rescue (multiple) treatments (n = 57) were included. Ninety three percent of the infants were primarily treated with laser photocoagulation. Lower gestational age, small for gestational age, early packed red blood cell transfusion (within 2 weeks of postnatal age), and presence of Zone 1 retinopathy predicted the need for rescue treatment in treated infants [area under the receiver operating characteristic curve: 0.81 (0.73–0.89)]. The incidence of abnormal refractive outcome, assessed in a total of 174 infants, was found to be significantly higher in the rescue treatment group (67% versus 21%, adjusted odds ratio: 7.56 (3.3–17.2), P < 0.001). Myopia, very high myopia and use of spectacles was significantly higher in the rescue treatment group (P < 0.001 for each). Rescue treatment for ROP was associated with an increased incidence of refractive errors and requirement of spectacles by 2 years of age. Larger prospective multicentre studies are required to confirm the findings from our study.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#26

 

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Many animal and human societies exhibit hierarchical structures with different degrees of steepness. Some of these societies also show cooperative behavior, where cooperation means working together for a common benefit. However, there is an increasing evidence that rigidly enforced hierarchies lead to a decrease of cooperation in both human and non-human primates. In this work, we address this issue by means of an evolutionary agent-based model that incorporates fights as social interactions governing a dynamic ranking, communal work to produce a public good, and norm internalization, i.e. a process where acting according to a norm becomes a goal in itself. Our model also includes the perception of how much the individual is going to retain from her cooperative behavior in future interactions. The predictions of the model resemble the principal characteristics of human societies. When ranking is unconstrained, we observe a high concentration of agents in low scores, while a few ones climb up the social hierarchy and exploit the rest, with no norm internalization. If ranking is constrained, thus leading to bounded score differences between agents, individual positions in the ranking change more, and the typical structure shows a division of the society in upper and lower classes. In this case, we observe that there is a significant degree of norm internalization, supporting large fractions of the population cooperating in spite of the rank differences. Our main results are robust with respect to the model parameters and to the type of rank constraint. We thus provide a mechanism that can explain how hierarchy arises in initially egalitarian societies while keeping a large degree of cooperation.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 21 September 2020

#27

 

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Xiaomi has announced a price drop of its Redmi-branded power bank in India. Launched at Rs 1,599, the Redmi power bank has now become cheaper by Rs 200. The company announced the price cut via Redmi India Twitter account.

#Energy
Field # Energy
Updated 21 September 2020

#28

 

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Optical polarization is an indispensable component in photonic applications, the orthogonality of which extends the degree of freedom of information, and strongly polarized and highly efficient small-size emitters are essential for compact polarization-based devices. We propose a group III-nitride quantum wire for a highly-efficient, strongly-polarized emitter, the polarization anisotropy of which stems solely from its one-dimensionality. We fabricated a site-selective and size-controlled single quantum wire using the geometrical shape of a three-dimensional structure under a self-limited growth mechanism. We present a strong and robust optical polarization anisotropy at room temperature emerging from a group III-nitride single quantum wire. Based on polarization-resolved spectroscopy and strain-included 6-band k·p calculations, the strong anisotropy is mainly attributed to the anisotropic strain distribution caused by the one-dimensionality, and its robustness to temperature is associated with an asymmetric quantum confinement effect.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#29

 

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Currently, we witness the severe spread of the pandemic of the new Corona virus, COVID-19, which causes dangerous symptoms to humans and animals, its complications may lead to death. Although convolutional neural networks (CNNs) is considered the current state-of-the-art image classification technique, it needs massive computational cost for deployment and training. In this paper, we propose an improved hybrid classification approach for COVID-19 images by combining the strengths of CNNs (using a powerful architecture called Inception) to extract features and a swarm-based feature selection algorithm (Marine Predators Algorithm) to select the most relevant features. A combination of fractional-order and marine predators algorithm (FO-MPA) is considered an integration among a robust tool in mathematics named fractional-order calculus (FO). The proposed approach was evaluated on two public COVID-19 X-ray datasets which achieves both high performance and reduction of computational complexity. The two datasets consist of X-ray COVID-19 images by international Cardiothoracic radiologist, researchers and others published on Kaggle. The proposed approach selected successfully 130 and 86 out of 51 K features extracted by inception from dataset 1 and dataset 2, while improving classification accuracy at the same time. The results are the best achieved on these datasets when compared to a set of recent feature selection algorithms. By achieving 98.7%, 98.2% and 99.6%, 99% of classification accuracy and F-Score for dataset 1 and dataset 2, respectively, the proposed approach outperforms several CNNs and all recent works on COVID-19 images.

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#30

 

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TBD

#Entertainments
Field # Entertainments
Updated 21 September 2020

#31

 

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Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quantitative analysis into the locomotor abilities of a stem-archosaur applying 3D modelling techniques. μCT scans of multiple specimens of Euparkeria capensis enabled the reconstruction and three-dimensional articulation of the hindlimb. The joint mobility of the hindlimb was quantified in 3D to address previous qualitative hypotheses regarding the stance of Euparkeria. Our range of motion analysis implies the potential for an erect posture, consistent with the hip morphology, allowing the femur to be fully adducted to position the feet beneath the body. A fully sprawling pose appears unlikely but a wide range of hip abduction remained feasible—the hip appears quite mobile. The oblique mesotarsal ankle joint in Euparkeria implies, however, a more abducted hindlimb. This is consistent with a mosaic of ancestral and derived osteological characters in the hindlimb, and might suggest a moderately adducted posture for Euparkeria. Our results support a single origin of a pillar-erect hip morphology, ancestral to Eucrocopoda that preceded later development of a hinge-like ankle joint and a more erect hindlimb posture.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#32

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#33

 

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#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#34

 

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TBD

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#35

 

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#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#36

 

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Researchers at the University of Helsinki have developed a technique in which a computer models visual perception by monitoring human brain signals. In a way, it is as if the computer tries to imagine what a human is thinking ...

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#37

 

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Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to function in most, if not all, steps of cancer progression. Cancer EVs, including small EVs (sEVs), contain unique biomolecular cargo, consisting of protein, nucleic acid and lipids. Through progress in the identification of this specific cargo, cancer biomarkers have been identified and developed, opening up novel and interesting opportunities for cancer diagnosis and prognosis. Intriguingly, we still lack a comprehensive understanding of the cancer-specific pathways that govern EV biogenesis in cancer cells. Filling this knowledge gap will rapidly improve cancer EV biomarkers, as it will also allow discrimination of the procancer and anticancer actions of those EVs. Even more promising is uncovering therapeutically targetable, tumour-specific EV pathways and content, which will generate novel classes of cancer therapies. This Review highlights the progress the cancer sEV field has made in the areas of biomarker discovery and validation as well as sEV-based therapeutics, highlights the challenges we are facing and identifies gaps in our knowledge, which currently prevent us from developing the full potential of sEVs in cancer diagnostic and therapy. This Review discusses the potential use of cancer-derived extracellular vesicles for cancer biomarkers and novel therapeutics, with a focus on evolving translational applications, and their roles during cancer progression.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#38

 

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Parents are furious over a Facebook rule change: Kids who play the Oculus virtual reality games will soon need to have a Facebook account.

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 21 September 2020

#39

 

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#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#40

 

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Microsoft on Monday announced it will acquire ZeniMax Media for $7.5 billion, adding muscle to its Xbox arm ahead of a fierce battle in the market for new gaming consoles.

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#42

 

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A dose of artificial intelligence can speed the development of 3-D-printed bioscaffolds that help injuries heal, according to researchers at Rice University.

#Artificial Intelligence
Field # Artificial Intelligence
Updated 21 September 2020

#43

 

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Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma, congenital diseases or tumours. However, the reconstruction of bone defects combined with osteoporosis remains a great challenge for clinicians and researchers. Based on our previous study, Ca–Si-based bioceramics (MSCs) showed enhanced bone formation capabilities under normal conditions, and strontium was demonstrated to be therapeutic in promoting bone quality in osteoporosis patients. Therefore, in the present study, we attempted to enlarge the application range of MSCs with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes. In vitro readout suggested that Sr-incorporated MSC scaffolds could enhance the expression level of osteogenic and angiogenic markers of osteoporotic bone mesenchymal stem cells (OVX BMSCs). Animal experiments showed a larger new bone area; in particular, there was a tendency for blood vessel formation to be enhanced in the Sr-MSC scaffold group, showing its positive osteogenic capacity in bone regeneration. This study systematically illustrated the effective delivery of a low-cost therapeutic Sr agent in an osteoporotic model and provided new insight into the treatment of bone defects in osteoporosis patients.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#44

 

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Lou Montulli and the late Ruth Wakefield share a common bond. Sort of. Ruth invented the chocolate chip cookie, which has fueled many programmers through long trying hours into the evening testing code and tracking down bugs. ...

#Gadgets
Field # Gadgets
Updated 21 September 2020

#45

 

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Description
Copy number variants (CNVs), defined as genome sequences of ≥50 bp that differ in copy number from that in a reference genome, are a common form of structural variation. Germline CNVs account for some of the missing heritability that single nucleotide polymorphisms could not account for. Recent technological advances have had a huge impact on CNV research. Microarray technology enables relatively low-cost, high-throughput, genome-wide measurements, and short-read sequencing technology enables the detection of short CNVs that cannot be detected by microarrays. As a result, large-scale genetic studies have been able to identify a variety of common and rare germline CNVs and their associations with diseases. Rare germline CNVs have been reported to be associated with neuropsychiatric disorders. In this review, we focused on germline CNVs and briefly described their functional characteristics, formation mechanisms, detection methods, related databases, and the latest findings. Finally, we introduced recent large-scale genetic studies to assess associations of CNVs with diseases, especially psychiatric disorders, and discussed the use of CNV-based animal models to investigate the molecular and cellular mechanisms underlying these disorders. The development and implementation of improved detection methods, such as long-read single-molecule sequencing, are expected to provide additional insight into the molecular basis of psychiatric disorders and other complex diseases, thus facilitating basic and clinical research on CNVs.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#46

 

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Researchers at EPFL have developed remote-controlled, mechanical microdevices that, when inserted into human tissue, can manipulate the fluid that surrounds them, collect cells or release drugs. This breakthrough offers numerous ...

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#47

 

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Description
This month’s Genome Watch highlights how the search for the origins of SARS-CoV-2 emphasizes the need for integrated phylogenetic methods. This month’s Genome Watch highlights how the search for the origins of SARS-CoV-2 emphasizes the need for integrated phylogenetic methods.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#48

 

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Name
Description
Air pollution is estimated to have caused 30.8 million premature deaths in China and Taiwan since 2000, according to an algorithm that was trained on satellite data

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#49

 

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Name
Description
An article in Physical Review X reports the first experimental measurement of the intra-atomic exchange interaction in rare-earth atoms.

#Energy
Field # Energy
Updated 21 September 2020

#50

 

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Name
Description
Somnox is a robot designed to reduce stress and improve sleep. It does so via features such as customized sounds and breathing regulators.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#51

 

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Description
Janus cylinders are one-dimensional colloids that have two faces with different compositions and functionalities, and are useful as building blocks for advanced functional materials. Such anisotropic objects are difficult to prepare with nanometric dimensions. Here we describe a robust and versatile strategy to form micrometer long Janus nanorods with diameters in the 10-nanometer range, by self-assembly in water of end-functionalized polymers. The Janus topology is not a result of the phase segregation of incompatible polymer arms, but is driven by the interactions between unsymmetrical and complementary hydrogen bonded stickers. Therefore, even compatible polymers can be used to form these Janus objects. In fact, any polymers should qualify, as long as they do not prevent co-assembly of the stickers. To illustrate their applicative potential, we show that these Janus nanorods can efficiently stabilize oil-in-water emulsions. Janus cylinders are useful as building blocks for advanced functional materials but challenging to prepare. Here, the authors describe a robust strategy to form micrometer long Janus nanorods by self-assembly in water of end-functionalized polymers.

#Energy
Field # Energy
Updated 21 September 2020

#52

 

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Description
The facial recognition technology, which the LAPD previously denied using, is tied to at least two wrongful arrests.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 21 September 2020

#53

 

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Name
Description
Local tissue mechanics play a critical role in cell function, but measuring these properties at cellular length scales in living 3D tissues can present considerable challenges. Here we present thermoresponsive, smart material microgels that can be dispersed or injected into tissues and optically assayed to measure residual tissue elasticity after creep over several weeks. We first develop and characterize the sensors, and demonstrate that internal mechanical profiles of live multicellular spheroids can be mapped at high resolutions to reveal broad ranges of rigidity within the tissues, which vary with subtle differences in spheroid aggregation method. We then show that small sites of unexpectedly high rigidity develop in invasive breast cancer spheroids, and in an in vivo mouse model of breast cancer progression. These focal sites of increased intratumoral rigidity suggest new possibilities for how early mechanical cues that drive cancer cells towards invasion might arise within the evolving tumor microenvironment. Local mechanical properties are important to cellular function; but conventional measurement techniques are limited in intact, living, 3D tissues. Here, the authors report on swellable hydrogel microparticles to monitor mechanical properties in situ via a temperature change.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#54

 

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Name
Description
A new capability for iOS 14 plus a timely update from Gmail give users more customization on their iPhones.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#55

 

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Name
Description
The purpose of this work is to develop an active self-cleaning system that removes contaminants from a solar module surface by means of an automatic, water-saving, and labor-free process. The output efficiency of a solar module can be degraded over time by dust accumulation on top of the cover glass, which is often referred to as “soiling”. This paper focuses on creating an active self-cleaning surface system using a combination of microsized features and mechanical vibration. The features, which are termed anisotropic ratchet conveyors (ARCs), consist of hydrophilic curved rungs on a hydrophobic background. Two different ARC systems have been designed and fabricated with self-assembled monolayer (SAM) silane and fluoropolymer thin film (Cytop). Fabrication processes were established to fabricate these two systems, including patterning Cytop without degrading the original Cytop hydrophobicity. Water droplet transport characteristics, including anisotropic driving force, droplet resonance mode, cleaning mechanisms, and system power consumption, were studied with the help of a high-speed camera and custom-made test benches. The droplet can be transported on the ARC surface at a speed of 27 mm/s and can clean a variety of dust particles, either water-soluble or insoluble. Optical transmission was measured to show that Cytop can improve transmittance by 2.5~3.5% across the entire visible wavelength range. Real-time demonstrations of droplet transport and surface cleaning were performed, in which the solar modules achieved a 23 percentage-point gain after cleaning. Micro-patterned, self-cleaning solar panels can maintain their efficiency with little resources or human intervention. The efficiency of solar panels, often built on arid landscapes, can be reduced by up to 40% as dust accumulates on the panels. Di Sun and Karl F. Böhringer, from the United States’ University of Washington, created a micro-patterned solar panel glass that incorporates hydrophilic, curved ‘rungs’ on a hydrophobic surface. When mechanical vibration is applied to the panel surface, water droplets are directionally conveyed along tracks of rungs at speeds of up to 27 mm per second, collecting and removing surface contaminants as they go. The system is simply and inexpensively fabricated and uses minimal amounts of water. In one test, a solar module achieved a 23% gain in power output after cleaning with the system.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#56

 

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Description
One of the best Google Maps alternatives just became way more useful.

#Software;#Maps
Field # Software
Updated 21 September 2020

#57

 

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Name
Description
Potassium-ion batteries are an emerging energy storage technology that could be a promising alternative to lithium-ion batteries due to the abundance and low cost of potassium. Research on potassium-ion batteries has received considerable attention in recent years. With the progress that has been made, it is important yet challenging to discover electrode materials for potassium-ion batteries. Here, we report pyrrhotite Fe1−xS microcubes as a new anode material for this exciting energy storage technology. The anode delivers a reversible capacity of 418 mAh g−1 with an initial coulombic efficiency of ~70% at 50 mA g−1 and a great rate capability of 123 mAh g−1 at 6 A g−1 as well as good cyclability. Our analysis shows the structural stability of the anode after cycling and reveals surface-dominated K storage at high rates. These merits contribute to the obtained electrochemical performance. Our work may lead to a new class of anode materials based on sulfide chemistry for potassium storage and shed light on the development of new electrochemically active materials for ion storage in a wider range of energy applications. Energy storage: Developing electrodes for potassium-based batteries. Microcubes of iron sulfide pyrrhotite constitute a promising electrode material for potassium-ion batteries. Potassium-ion (K+) batteries are being investigated as an alternative to lithium-ion batteries due to potassium’s abundance and low cost, but a challenge lies in discovering suitable materials for the battery’s electrodes. Yang Xu, and a team from University College London, United Kingdom, and Northeast Normal University, China, fabricated microcubes of pyrrhotite to use in K+ battery anodes to store ions. The anodes constructed by the team demonstrated a high capacity, with fast charge/discharge characteristics and stability that withstood repeated K+ insertion/extraction. Employing metal sulfides has cost and sustainability benefits, and the authors hope that their study can fuel further studies to realize the potential of K+ energy storage.

#Energy
Field # Energy
Updated 21 September 2020

#58

 

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Description
The bribes went to at least 10 Amazon employees and contractors.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#59

 

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Description
Optical nanoantennas can convert propagating light to local fields. The local-field responses can be engineered to exhibit nontrivial features in spatial, spectral and temporal domains, where local-field interferences play a key role. Here, we design nearly fully controllable local-field interferences in the nanogap of a nanoantenna, and experimentally demonstrate that in the nanogap, the spectral dispersion of the local-field response can exhibit tuneable Fano lineshapes with nearly vanishing Fano dips. A single quantum dot is precisely positioned in the nanogap to probe the spectral dispersions of the local-field responses. By controlling the excitation polarization, the asymmetry parameter q of the probed Fano lineshapes can be tuned from negative to positive values, and correspondingly, the Fano dips can be tuned across a broad spectral range. Notably, at the Fano dips, the local-field intensity is strongly suppressed by up to ~50-fold, implying that the hot spot in the nanogap can be turned into a cold spot. The results may inspire diverse designs of local-field responses with novel spatial distributions, spectral dispersions and temporal dynamics, and expand the available toolbox for nanoscopy, spectroscopy, nano-optical quantum control and nanolithography. The sharp tip of an atomic force microscope (AFM) has helped researchers develop a new technique for manipulating light-sensitive nanoantennas. Recent studies have shown that engineering tiny gaps between surface-bound gold nanorods is an effective way to focus optical radiation and convert it into locally concentrated energy. Researchers in China have now used an AFM tip to position a semiconductor quantum dot into the gap between two gold nanorods, and controlled and read out the spectrum of the localized energy. When the nanoantenna is exposed to a linearly polarized light, the gap hosts a hot spot with a Lorentz-type spectrum, and the quantum dot is excited. An elliptically polarized light, on the other hand, turns the hot spot into a cold spot with a Fano-type spectrum, and the quantum dot is shielded from light exposure.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#60

 

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Description
The National Snow and Ice Data Center announced that Arctic sea ice fell below a grim benchmark in 2020. It was the second-lowest ice extent on record.

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#61

 

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Description
Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene’s recipe to the cell’s protein-making machinery. As a result, people born w

#Genetic engineering
Field # Genetic engineering
Updated 21 September 2020

#62

 

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Description
A molecule known as ACE2 sits like a doorknob on the outer surfaces of the cells that line the lungs. Since January 2020, researchers have known that SARS-CoV-2, the novel coronavirus that causes COVID-19, primarily uses ACE2 to enter these cells and establish respiratory infections. Finding a way t

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#63

 

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Description
TBD

#Drones
Field # Drones
Updated 21 September 2020

#64

 

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Description
In the past decade, researchers have engineered an array of new tools that control the balance of genetic inheritance. Based on CRISPR technology, such gene drives are poised to move from the laboratory into the wild where they are being engineered to suppress devastating diseases such as mosquito-b

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#65

 

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Description
Smartphone maker OnePlus is all set to launch its latest flagship smartphone OnePlus 8T in India. The company has started teasing the launch of OnePlus 8T 5G smartphone. The company now posted a teaser video with the title “Gear up and Get Ahead with the OnePlus 8T”. The video posted by the company features its brand ambassador Robert Downey Jr.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#66

 

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Description
Aruba COO Vishall Lall sat down with CRN to talk about what he is doing to scale Aruba into a $5 billion company, the importance of Aruba partners, Silver Peak integration plans, and demand for as a service solutions.

#Social & Corporation affairs;#Economy
Field # Social & Corporation affairs
Updated 21 September 2020

#67

 

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Description
In an interaction, Nitin Bansal, head of Ericsson India and head of network solutions, South-East Asia, Oceania & India at Ericsson, gives us an overview of 5G scenario in India. The likely demand, use cases, challenge from Reliance Jio and more ...

#Telecommunications
Field # Telecommunications
Updated 21 September 2020

#68

 

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Here's a look at how Hewlett Packard Enterprise's $925 million acquisition of Silver Peak gives up a "leg up" in the heated enterprise networking battle against rival CIsco.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#69

 

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Paytm has been alleging that its app was removed for launching a UPI cashback campaign on its app called ‘Paytm Cricket League’ and that Google also runs similar schemes on its own apps.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#70

 

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Description
To become eligible for the prize, a participant has to answer all questions of the quiz correctly.

#Entertainments
Field # Entertainments
Updated 21 September 2020

#71

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#72

 

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Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#73

 

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Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#74

 

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Description
The founder and executive chairman of embattled zero-emission truck maker Nikola has resigned, the company announced Sunday, after allegations of fraud which sparked a stock tumble and a regulatory investigation.

#Vehicles & Special machines
Field # Vehicles & Special machines
Updated 21 September 2020

#75

 

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Facebook is launching a new initiative this week to encourage Americans to vote in the upcoming presidential election, the latest effort by the social network to prove it is a responsible player on the internet.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#76

 

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Description
The world is on track to soon exceed a million deaths from covid-19. It is a number we shouldn’t become blasé about

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#77

 

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Description
Christopher Paolini’s epic new novel, To Sleep in a Sea of Stars, is an hallucinatory space opera, perfect reading to help us ride out the current storms

#Entertainments
Field # Entertainments
Updated 21 September 2020

#78

 

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Name
Description
Severe peanut allergies in children jump 85 per cent on Halloween and 60 per cent on Easter, and other nut allergies follow the same trend, possibly due to social gatherings where sweets are shared

#Entertainments
Field # Entertainments
Updated 21 September 2020

#79

 

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Name
Description
TBD

#Hardware & Devices;#Gadgets;#Entertainments;#Games
Field # Hardware & Devices
Updated 21 September 2020

#80

 

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Name
Description
TBD

#Gadgets
Field # Gadgets
Updated 21 September 2020

#81

 

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Name
Description
TBD

#Gadgets
Field # Gadgets
Updated 21 September 2020

#82

 

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Name
Description
lans are to send it to the International Space Station in 2021.

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 21 September 2020

#83

 

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Name
Description
Despite climate change being most obvious to people as unseasonably warm winter days or melting glaciers, as much as 95 percent of the extra heat trapped on Earth by greenhouse gases is held in the world's oceans. For that reason, monitoring the temperature of ocean waters has been a priority for cl

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#84

 

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Description
For any of the 200,000 patients diagnosed with Parkinson’s disease in the United States every year, the diagnosis often occurs only after the appearance of severe symptoms such as tremors or speech difficulties. With the goal of recognizing and treating neurological diseases earlier, researchers are

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#85

 

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Description
For example, the uncontrolled overgrowth of certain oceanic algae species causes toxic red tides that kill fish and other sea life, and sicken humans. On a more individual level, the human gut hosts a large community of different bacteria that is crucial for proper digestion and absorption of nutrie

#Environment & Nature;#Theoretical sciences
Field # Environment & Nature
Updated 21 September 2020

#86

 

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Description
When humans see their children about to eat something they oughtn’t, we can simply tell them, “Don’t eat that. It’ll make you sick.” Those who listen to this advice are spared the painful experience of learning that lesson for themselves. While other animals can’t sit their offspring down for a good

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#87

 

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Back in June of 2020, a large group of physicists had reported flashes of light that match with those expected from a type of dark matter called dark bosons. Now, one of two other teams conducting research into dark matter claims to have also found hints consistent with the elusive particle. The

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#88

 

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No matter how much we try and fight it, aging is a part of life. High cholesterol, diabetes, and fatty liver, the collection of conditions referred to as lifestyle diseases, all become more commonplace as we get older. Interestingly, however, many of these age-related conditions are caused by change

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#89

 

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Optical materials used in electro-optical devices, such as lasers, can be hard to investigate given their transparent nature. Researchers from the Department of Applied Physics have discovered how to study these materials using existing imaging tools in a whole new way. This research could be used b

#Materials
Field # Materials
Updated 21 September 2020

#90

 

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New research by an international team of chemists describes a new type of artificial cell that can communicate with other cells within the body—with potential applications in the field of smart pharmaceuticals. “In the future, artificial cells like this one could be engineered to synthesize and d

#Chemicals
Field # Chemicals
Updated 21 September 2020

#91

 

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Description
Vi (Vodafone Idea) is offering one year Zee5 Premium subscription with five of its prepaid plans at no additional cost. The plans start from Rs. 355 and go up to Rs. 2,595, with the former being the only plan without any talk time.

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 21 September 2020

#92

 

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Twitter and Zoom are found to have racial bias in their algorithms that are impacting the user experience especially for black people. The algorithm that Twitter uses to crop preview images in users&rsquo; timelines seems to be giving preferences to the faces of white people over the ones who have a darker complexion. Zoom, on the other hand, is noticed to remove the head of people with a darker skin pigmentation when they use a virtual background.

#Hardware & Devices;#Gadgets
Field # Hardware & Devices
Updated 21 September 2020

#93

 

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Tencent said its WeChat may not be able to win new users in the United States while the White House challenges a court ruling preventing a ban on the messaging app.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#94

 

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TikTok owner Bytedance said on Sunday that it was the first time it had heard in the news it was setting up a $5 billion (roughly Rs. 36,700 crores) education fund in the United States.

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 21 September 2020

#95

 

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Vivo V20 Pro and Vivo V20 have been launched at an event in Thailand. Both new Vivo V-series phones come with triple rear cameras. In the new series, the Vivo V20 Pro comes with a dual selfie camera setup at the front and is powered by a Qualcomm Snapdragon 765G SoC.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#96

 

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Tecno Spark 6 Air has got a new variant with 3GB RAM + 64GB storage that is priced at Rs. 8,699. That is just Rs. 200 more than the 3GB + 32GB variant that was launched last month. The phone was originally launched in July.

#Drones
Field # Drones
Updated 21 September 2020

#97

 

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Realme XT, Realme X2, and Realme X are receiving their September over-the-air (OTA) updates. This brings the September 2020 Android security patch for the phones, along with a few optimisations such as super night-time standby.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#98

 

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Realme Narzo 20, Narzo 20A, and Narzo 20 Pro have been launched in India as the latest models in the company&rsquo;s Narzo series. While the Narzo 20 and Narzo 20A come with a waterdrop-style display notch, the Narzo 20 Pro in the series comes with a hole-punch design.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#99

 

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Realme C17 has been launched in Bangladesh and it the latest entrant in Realme&rsquo;s budget friendly C-series. The phone is powered by the octa-core Snapdragon 460 processor and you get 6GB of LPDDR4X RAM.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#100

 

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Oppo Reno 4 SE has been launched in China as the latest entry in the Oppo Reno 4 series. It is powered by the MediaTek Dimensity 720 SoC and has 5G support. The phone comes in three colour options.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#101

 

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LG K42 has been launched in Dominican Republic. The mid-range smartphone features MIL-STD-810G certification, dedicated Google Assistant button, side-mounted fingerprint sensor and a quad rear camera setup.

#Hardware & Devices;#Gadgets
Field # Hardware & Devices
Updated 21 September 2020

#102

 

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iPhone 12 will cost more than the iPhone 11, a tipster shared on Chinese micro blogging website Weibo. It was initially believed that the upcoming iPhone 12 may cost between $699 (roughly Rs. 51,200) and $749 (roughly Rs. 54,800) with the latter seeming more likely.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#103

 

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Description
Logitech launched the Logitech MX Anywhere 3 mouse, which has customisable side buttons to control camera and mic settings during video calls. The mouse is priced at $79.99 (roughly Rs. 5,900) and is available in three colours.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#104

 

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Gmail may get a new logo soon, as per a report. The new in-the-works logo features an &lsquo;M,&rsquo; but doesn&rsquo;t explicitly have the traditional envelope to accompany it.

#Software
Field # Software
Updated 21 September 2020

#105

 

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WhatsApp Multiple Device is said to be in final stages and the company wants to soon release the feature to beta testers, a report has said.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#106

 

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Paytm was briefly removed last week from Google Play Store for violating the platform&rsquo;s content rules. While it was restored within a few hours, Paytm published a blog post saying that Google delisted the app as it was offering cashbacks. To this, the tech giant released a statement saying, &ldquo;offering cashbacks and vouchers alone do not constitute a violation.&rdquo;

#Social & Corporation affairs;#Economy;#Finance
Field # Social & Corporation affairs
Updated 21 September 2020

#107

 

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A US judge blocked the Trump administration from requiring Apple and Alphabet&rsquo;s Google to remove Chinese-owned messaging app WeChat for downloads by late Sunday.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#108

 

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Redmi 9 sale will begin at 12pm (noon) via Amazon.in and Mi.com sites. The phone is priced at Rs. 8,999 for the 64GB storage option. There is also a 128GB storage variant that carries a price tag of Rs. 9,999.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#109

 

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Realme Narzo 20 series is all set to debut in India today. This range will include three phones &ndash; the Realme Narzo 20, Realme Narzo 20 Pro, and Realme Narzo 20A.

#Entertainments
Field # Entertainments
Updated 21 September 2020

#110

 

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OnePlus 8T launch in India has been teased through Amazon and OnePlus.in. The new development comes amid the rumours about the OnePlus 8T being churned out by the rumour mill.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#111

 

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Description
Watchmen, Zendaya, and Schitt&rsquo;s Creek are among the &mdash; winners and &mdash; history makers at the 2020 Emmys. Here&rsquo;s the full list of the Emmy winners 2020.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#112

 

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Description
Asus has launched a series of laptops and desktop PCs in India, under the brand umbrella of ExpertBook and ExpertCenter. Designed to meet the needs of business and professional users in the country, the new lineup comprises the ExpertBook B9, ExpertBook P2, and ExpertBook P1 series of laptops, along with AsusPro ExperCenter D3, ExpertCenter D6, and ExpertCenter D8 desktop PCs. Apart from these, Asus also launched two all-in-one PCs in the country.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#113

 

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Description
The US government has now delayed the ban on the Bytedance-owned short video app by a week until September 27.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#114

 

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Description
Realme X50 Pro 5G will be the first smartphone to get the Realme UI 2.0 but more devices will be added to the rollout schedule soon.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#115

 

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Description
Realme Narzo 20 is going to take things forward from the Narzo 10 series but looks like they both will co-exist.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#116

 

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Description
The new range of Narzo smartphones borrows a few things from the Realme 7 series and a few from the rival Redmi Note 9 Pro.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#117

 

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Description
OnePlus Nord brings with itself powerful specs at an aggressive price point. Here's all you need to know about it.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#118

 

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Description
While the company hasn't confirmed the launch date for India, leaks suggest the device could debut on October 14.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#119

 

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Description
Realme Narzo 20 Pro has a lot going on for just Rs 14,999 and it looks promising as far as its specifications and looks go.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#120

 

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Description
Realme on Monday unveiled the Realme Narzo 20, Narzo 20A, Narzo 20 Pro in India.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#121

 

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Description
Organic substance found in everything from mushroom cells to insect shells could help the transform the human race into an interplanetary species.

#Astronautics
Field # Astronautics
Updated 21 September 2020

#122

 

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Description
There’s more to a cup of coffee than just an early morning pick-me-up.

#Food;#Medicine & Human body
Field # Food
Updated 21 September 2020

#123

 

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Description
TBD

#Chemicals
Field # Chemicals
Updated 21 September 2020

#124

 

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Name
Description
TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#125

 

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Name
Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#126

 

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Description
German Aerospace Center (DLR) has come with a fully modular futuristic vehicle concept that looks unlike anything we've seen before.

#Astronautics
Field # Astronautics
Updated 21 September 2020

#127

 

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Name
Description
T?"?؊?sy`?P -~Q{ܜ?Ot????f5?n??Ϭ9?9?z?"??m@

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#128

 

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The first Apple Silicon MacBook is due out by the end of 2020. What should you expect? We have rounded up everything you need to know about Apple’s new laptops.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#129

 

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Following Microsoft's announcement that it is acquiring Bethesda, Microsoft says Deathloop and Ghostwire: Tokyo's will still be PlayStation 5 timed exclusives.

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#130

 

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High-level robot vacuum cleaners have always carried a high price tag, but aggressive pricing from iRobot makes high level performance more affordable.

#Household appliances
Field # Household appliances
Updated 21 September 2020

#131

 

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OnePlus shows no sign of stopping its successive release of great phones. The OnePlus 8T will arrive on October 14 — and we know a lot about it already.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#132

 

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The Samsung Galaxy S21 is truly on the way, and while it probably won't launch until February, we're hearing rumors about it. Here's everything we know.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#133

 

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Issues like the pandemic and the Supreme Court hog the election spotlight, but the tech industry faces massive changes if Trump gets a second term.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#134

 

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Description
The tech company outlined its water positivity initiative on Monday.

#Software;#Social & Corporation affairs
Field # Software
Updated 21 September 2020

#135

 

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Description
The pressure cooker company is expanding into coffee pods. So far, the results are messy. Here are our hands-on first impressions.

#Food
Field # Food
Updated 21 September 2020

#136

 

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Description
People and publishers will be able to manage images across Facebook and Instagram.

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 21 September 2020

#137

 

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Description
Portable Bluetooth speakers continue to improve, with better sound and battery life. These are the best ones you can buy right now.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#138

 

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It has a new notification panel, smart home controls, new emojis, and more!

#Software
Field # Software
Updated 21 September 2020

#139

 

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Description
We take the 2020 Porsche Cayenne Coupé Turbo S E-Hybrid to watch a rocket launch.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#140

 

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Description
Companies could be broken up or forced to sell off European operations.

#Social & Corporation affairs;#Economy
Field # Social & Corporation affairs
Updated 21 September 2020

#141

 

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Description
Doom, Fallout and more will come to other consoles on "case by case basis."

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#142

 

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Description
Cytokines are well-known mediators of the immune response, but, recently, pleiotropic roles in the central nervous system have started to be uncovered. It is now shown that IL-17 directly modulates fear behavior in mice.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#143

 

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Wastewater testing captures the rise and fall of novel coronavirus cases in a mid-sized metropolitan region.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#144

 

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Description
Young-adult cancer survivors report psychosocial distress from infertility. National guidelines recommend pretreatment referrals for sperm cryopreservation, but a study examining use of stored semen among survivors concluded that low uptake might equate to economic unfeasibility. However, examination of sociodemographic factors and psychosocial outcomes suggests that maintaining future opportunities for parenthood might outweigh the ongoing storage costs.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#145

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#146

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#147

 

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Description
Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are of major importance in the clinical management of obesity and type 2 diabetes. DPP-4 is also known as CD26 and represents a membrane bound protease on the surface of several eukaryotic cell types. Of interest, DPP-4, like ACE2, has been shown to serve as a binding partner for corona-like viruses to enter host immune cells. Since metabolic diseases are major risk factors for the present COVID-19 pandemic, we examined circulating soluble DPP-4 serum concentrations in patients suffering from severe COVID-19 infection and in healthy human subjects in a case control design. In this analysis sDPP-4 levels were significantly lower in COVID-19 patients compared to controls (242.70 ± 202.12 ng/mL versus 497.70 ± 188.13 ng/mL, p = 0.02). We also examined sDPP-4 serum concentrations in patients suffering from sepsis not due to corona-like viruses. In these subjects, sDPP-4 levels were not different compared to healthy case controls (p = 0.14), which might suggest the decrease of sDPP-4 to be specific for corona-like virus infections. Currently, most data point towards membrane bound ACE2 in contrast to DPP-4 as the major binding partner for COVID-19 internalization into host immune cells. However, the finding that the circulating soluble form of DPP-4 is reduced in hospitalized patients might suggest a regulatory role for both, ACE and DPP-4, in COVID-19 infections, especially since obesity and type 2 diabetes are major risk factor for a severe course of the disease

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#148

 

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In situ structures of the spirochete flagellar motor by cryo-ET reveal two distinct modes of interactions between the rotor ring and stator units. Together with new cryo-EM structures of the isolated stator units, this work provides insights into the mechanisms of torque generation and directional switch.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#149

 

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Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation1,2, but whether nociceptors also interact with the immune system remains poorly understood. Here we report a neurotechnology for selective epineural optogenetic neuromodulation of nociceptors and demonstrate that nociceptor activation drives both protective pain behavior and inflammation. The wireless optoelectronic system consists of sub-millimeter-scale light-emitting diodes embedded in a soft, circumneural sciatic nerve implant, powered and driven by a miniaturized head-mounted control unit. Photostimulation of axons in freely moving mice that express channelrhodopsin only in nociceptors resulted in behaviors characteristic of pain, reflecting orthodromic input to the spinal cord. It also led to immune reactions in the skin in the absence of inflammation and potentiation of established inflammation, a consequence of the antidromic activation of nociceptor peripheral terminals. These results reveal a link between nociceptors and immune cells, which might have implications for the treatment of inflammation. An optogenetic study shows that activation of pain-triggering sensory neurons induces an immune response.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#150

 

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Physical systems powering motion and creating structure in a fixed amount of time dissipate energy and produce entropy. Whether living, synthetic or engineered, systems performing these dynamic functions must balance dissipation and speed. Here, we show that rates of energy and entropy exchange are subject to a speed limit—a time–information uncertainty relation—imposed by the rates of change in the information content of the system. This uncertainty relation bounds the time that elapses before the change in a thermodynamic quantity has the same magnitude as its s.d. From this general bound, we establish a family of speed limits for heat, dissipated/chemical work and entropy depending on the experimental constraints on the system and its environment. In all of these inequalities, the timescale of transient dynamical fluctuations is universally bounded by the Fisher information. Moreover, they all have a mathematical form that mirrors the Mandelstam–Tamm version of the time–energy uncertainty relation in quantum mechanics. These bounds on the speed of arbitrary observables apply to transient systems away from thermodynamic equilibrium, independent of the physical constraints on the stochastic dynamics or their function. A time–information uncertainty relation in thermodynamics has been derived, analogous to the time–energy uncertainty relation in quantum mechanics, imposing limits on the speed of energy and entropy exchange between a system and external reservoirs.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#151

 

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Many pathogenic fungi depend on the development of specialized infection structures called appressoria to invade their hosts and cause disease. Impairing the function of fungal infection structures therefore provides a potential means by which diseases could be prevented. In spite of this extraordinary potential, however, relatively few anti-penetrant drugs have been developed to control fungal diseases, of either plants or animals. In the present study, we report the identification of compounds that act specifically to prevent fungal infection. We found that the organization of septin GTPases, which are essential for appressorium-mediated infection in the rice blast fungus Magnaporthe oryzae, requires very-long-chain fatty acids (VLCFAs), which act as mediators of septin organization at membrane interfaces. VLCFAs promote septin recruitment to curved plasma membranes and depletion of VLCFAs prevents septin assembly and host penetration by M. oryzae. We observed that VLCFA biosynthesis inhibitors not only prevent rice blast disease, but also show effective, broad-spectrum fungicidal activity against a wide range of fungal pathogens of maize, wheat and locusts, without affecting their respective hosts. Our findings reveal a mechanism underlying septin-mediated infection structure formation in fungi and provide a class of fungicides to control diverse diseases of plants and animals. Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#152

 

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Protein homeostasis preserves stem cell function, but the underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopoietic stem cell function through niche interaction.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#153

 

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#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#154

 

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Description
Ultrasound experiments reveal a multicomponent superconducting order parameter in Sr2RuO4.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#155

 

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Polymeric glasses with significant thermodynamic and kinetic stability have been fabricated using physical vapour deposition, providing a mean to gather insight into the properties of glasses aged for millions of years.

#Materials
Field # Materials
Updated 21 September 2020

#156

 

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Controlling nuclear spins coupled to an electron spin in silicon carbide has enabled development of a ‘quantum register’ interfaced with telecom photons, leading to the possibility of distant transport of quantum information.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#157

 

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Time capsules of fluid, trapped within the oxide minerals from two iron ore deposits reveal an important role for sediment-derived carbonate–sulfate-rich melts in the concentration of iron, a crucial element for humanity’s development.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#158

 

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Some OnePlus Nord users have taken to online forums to highlight a software issue that is causing their phones to do a ‘factory reset’ on its own.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#159

 

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Google Pay on Monday announced the rollout of tokenisation across its platform that will enable users to safely transact with their debit or credit cards.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#160

 

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The Swedish Space Corporation (SSC) has had a contract allowing Beijing access to the satellite antenna at the ground station since at least 2011. It is located next to an SSC satellite station primarily used by the United States and its agencies, including NASA.

#Astronautics
Field # Astronautics
Updated 21 September 2020

#161

 

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Volocopter is one of a fleet of startups developing battery-powered aircraft and, with full certification for its air taxi still a few years away, it wants to put its VoloDrone to work sooner.

#Drones
Field # Drones
Updated 21 September 2020

#162

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#163

 

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Description
TBD

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#164

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#165

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#166

 

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Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#167

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#168

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#169

 

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Experts and r/ChangeMyView subreddit moderators offer 10 tips to debunk conspiracy theories convincingly—and kindly.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#170

 

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TBD

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#171

 

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Description
The World Health Organization endorsed Saturday a protocol for testing African herbal medicines as potential treatments for the coronavirus and other epidemics.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#172

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#173

 

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Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#174

 

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If we make it to Mars, we're not going to be able to bring everything humankind needs to stay for an extended time or even construct colonies on the red planet. New research has come up with a game plan.

#Astronautics
Field # Astronautics
Updated 21 September 2020

#175

 

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A deal to restructure ownership of the popular video app TikTok was thrown into doubt Monday by President Donald Trump, who vowed to block any deal that allows its Chinese parent firm to retain any control.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#176

 

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By studying 488 public airports in the United States, University of Colorado Denver School of Public Affairs researcher Serena Kim, Ph.D., found that 20% of them have adopted solar photovoltaic (PV), commonly known as solar ...

#Energy
Field # Energy
Updated 21 September 2020

#177

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#178

 

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Athletes are always on the lookout for new ways to push the limits of human performance and one needs to first pinpoint their current limits objectively if they seek to overcome them. A team of researchers from the National ...

#Gadgets
Field # Gadgets
Updated 21 September 2020

#179

 

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TBD

#Energy
Field # Energy
Updated 21 September 2020

#180

 

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Self-driving cars, or connected and automated vehicles (CAVs), are closer than ever to becoming a mainstay on our roads. Already, many modern cars have self-driving capabilities—now the next step is full automation.

#Vehicles & Special machines
Field # Vehicles & Special machines
Updated 21 September 2020

#181

 

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Which of the GPS devices used by marathon, half-marathon, long-distance or 10k runners is more accurate? Are sports or mobile phone watches better? Is there a difference between men and women when choosing one device or another? ...

#Gadgets
Field # Gadgets
Updated 21 September 2020

#182

 

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Lufthansa said Monday it will slash more jobs on top of 22,000 previously announced cuts and put more planes out of service with current losses running at some 500 million euros ($590 million) a month.

#Social & Corporation affairs;#Security;#Privacy
Field # Social & Corporation affairs
Updated 21 September 2020

#183

 

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Japanese grocery chain FamilyMart has teamed up with Tokyo startup Telexistence to test the idea of using a remotely controlled shelf stocking robot named the Model-T to restock grocery shelves. On its website, Telexistence ...

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 21 September 2020

#184

 

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Description
??=sF?I?Y?Û?@k??s????ځF?M?S?",9V? #ge?@#?՞??????ʙ???????$???????W???7^?1??^dC,_??9?K?? -q?! Y???d鐸a?k{?N?MguB:?(?b5?@3&v??0??V ??D ?M
#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#185

 

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An international research team has developed "electronic skin" sensors capable of mimicking the dynamic process of human motion. This work could help severely injured people, such as soldiers, regain the ability to control ...

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#186

 

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TBD

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#187

 

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A new paper published today in Nature Energy reveals how a collaborative team of researchers have been able to fully identify the nature of oxidized oxygen in the important battery material—Li-rich NMC—using RIXS (Resonant ...

#Energy
Field # Energy
Updated 21 September 2020

#188

 

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TBD

#Entertainments;#Games
Field # Entertainments
Updated 21 September 2020

#189

 

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Internet-of-Things (IoT) such as smart home locks and medical devices, depend largely on Bluetooth low energy (BLE) technology to function and connect across other devices with reduced energy consumption. As these devices ...

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#190

 

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Imagine having a car accident in a parking lot, your car has some small damage and you have to get it fixed. What if your car could tell you which parts are broken and how much it will cost to fix it? During his Ph.D. at ...

#Hardware & Devices;#Gadgets
Field # Hardware & Devices
Updated 21 September 2020

#191

 

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IIASA researchers have developed a novel measurement framework to track energy poverty that better aligns with the services people lack rather than capturing the mere absence of physical connections to a source of electricity. ...

#Energy
Field # Energy
Updated 21 September 2020

#192

 

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The UK faces a “very difficult problem” of rising covid-19 deaths and cases if it does not change course, chief medical officer for England Chris Whitty has warned

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#193

 

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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#194

 

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TBD

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#195

 

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Description
TBD

#Energy
Field # Energy
Updated 21 September 2020

#196

 

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Description
TBD

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 21 September 2020

#197

 

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Description
TBD

#Gadgets
Field # Gadgets
Updated 21 September 2020

#198

 

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Description
TBD

#Gadgets
Field # Gadgets
Updated 21 September 2020

#199

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 21 September 2020

#200

 

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We know that November brings big mobile offers, across both Android and Apple. So shoppers looking for a Black Friday iPhone deal should keep their eyes peeled

#Gadgets
Field # Gadgets
Updated 21 September 2020

#201

 

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Samsung's new Galaxy S20 Fan Edition smartphone is officially launching on Sept. 23, but we already know a lot about it.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#202

 

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Polaroid has issued a limited edition camera themed around 'The Mandalorian.'

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#203

 

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A leaker claims Apple's upcoming 5.4-inch iPhone will be called iPhone 12 mini.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#204

 

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Micromobility company Bird is partnering with Target to sell its Bird Air e-scooter for $600 online and in stores throughout the U.S.

#Vehicles & Special machines
Field # Vehicles & Special machines
Updated 21 September 2020

#205

 

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Waveguide-based SERS analysis could allow high-throughput, chip-based screening for protease inhibitors For the first time, researchers have detected protease activity with surface-enhanced Raman spectroscopy (SERS) performed using a tiny waveguide. The work paves the way to real-time, label-free l

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#206

 

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Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue have not been undertaken. Using 850K DNA methylation arrays we compared the methylomes of young (27 ± 4.4 years) and aged (83 ± 4 years) human skeletal muscle and that of young/aged heterogenous muscle-derived human primary cells (HDMCs) over several time points of differentiation (0, 72 h, 7, 10 days). Aged muscle tissue was hypermethylated compared with young tissue, enriched for; pathways-in-cancer (including; focal adhesion, MAPK signaling, PI3K-Akt-mTOR signaling, p53 signaling, Jak-STAT signaling, TGF-beta and notch signaling), rap1-signaling, axon-guidance and hippo-signalling. Aged cells also demonstrated a hypermethylated profile in pathways; axon-guidance, adherens-junction and calcium-signaling, particularly at later timepoints of myotube formation, corresponding with reduced morphological differentiation and reductions in MyoD/Myogenin gene expression compared with young cells. While young cells showed little alterations in DNA methylation during differentiation, aged cells demonstrated extensive and significantly altered DNA methylation, particularly at 7 days of differentiation and most notably in focal adhesion and PI3K-AKT signalling pathways. While the methylomes were vastly different between muscle tissue and HDMCs, we identified a small number of CpG sites showing a hypermethylated state with age, in both muscle tissue and cells on genes KIF15, DYRK2, FHL2, MRPS33, ABCA17P. Most notably, differential methylation analysis of chromosomal regions identified three locations containing enrichment of 6–8 CpGs in the HOX family of genes altered with age. With HOXD10, HOXD9, HOXD8, HOXA3, HOXC9, HOXB1, HOXB3, HOXC-AS2 and HOXC10 all hypermethylated in aged tissue. In aged cells the same HOX genes (and additionally HOXC-AS3) displayed the most variable methylation at 7 days of differentiation versus young cells, with HOXD8, HOXC9, HOXB1 and HOXC-AS3 hypermethylated and HOXC10 and HOXC-AS2 hypomethylated. We also determined that there was an inverse relationship between DNA methylation and gene expression for HOXB1, HOXA3 and HOXC-AS3. Finally, increased physical activity in young adults was associated with oppositely regulating HOXB1 and HOXA3 methylation compared with age. Overall, we demonstrate that a considerable number of HOX genes are differentially epigenetically regulated in aged human skeletal muscle and HDMCs and increased physical activity may help prevent age-related epigenetic changes in these HOX genes.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#207

 

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Calorie restriction lowers body temperature in mammals, but most research on how reduced calorie intake produces benefits to long-term health and longevity has focused on nutrient sensing as the primary trigger for the upregulation of stress responses and other helpful changes to cellular metabolism

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#208

 

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Conventional solid lubricants such as MoS2, graphite, or diamond-like carbon films demonstrate excellent tribological performance but only in specific environments due to their inherent materials properties. This limitation prohibits using these solid lubricants in environments that change dynamically. This study presents the results of a novel solid lubricant that was developed using a combination of solution-processed 2D-molybdenum disulfide and graphene-oxide (GO) that can be deposited on to stainless steel substrates using a simple spray-coating technique and show exceptional performance in multifarious environments namely, ambient (humid) atmosphere, dry nitrogen, and vacuum. The tribological performance of the coatings was evaluated using a ball-on-disc sliding test and demonstrated an excellent wear/friction performance in all environments and coating survived even after 44 km of linear sliding. Transmission electron microscopy and Raman spectroscopy analysis of the tribolayers suggested in-operando friction-induced re-orientation of MoS2 layers that were protected by GO layers and, an absence of MoOx peaks indicate a strong resistance to intercalation with moisture and oxygen. The simplicity and robustness of the hybrid MoS2–GO solid lubricant in mitigating wear-friction behavior of steel-on-steel tribopair in a multifarious environment is a game-changing and is promising for various applications.

#Environment & Nature
Field # Environment & Nature
Updated 21 September 2020

#209

 

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Facebook is launching a new initiative this week to encourage Americans to vote in the upcoming presidential election, the latest effort by the social network to prove it is a responsible player on the Internet.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 21 September 2020

#210

 

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Marginal superiority is a common phenomenon in crops, and is caused by the competitiveness of individual plant for resources and crop adaptability to crowded growth conditions. In this study, in order to clarify the response of marginal superiority to maize morphology and plant-density tolerance, field experiments without water and nutrition stress were conducted at Qitai Farm in Xinjiang, China, in 2013–2014 and 2016–2019. The results showed that no more than three border rows of all the cultivars had marginal superiority under high density, about 90% of all the cultivars had no more than two border row that had marginal superiority and a significant negative correlation was observed between marginal superiority and population grain yield (first border row: y = − 2.193x + 213.9, p < 0.05; second border row: y = − 2.076x + 159.2, p < 0.01). Additionally, marginal superiority was found to have a significant positive relationship with plant density (first border row: y = 6.049x + 73.76, p < 0.01; second border row: y = 1.88x + 95.41, p < 0.05) and the average leaf angle above the ear (first border row: y = 2.306x + 103.1, p < 0.01). These results indicated that the smaller the leaf angle above the ear, the weaker the marginal superiority and the higher the grain yield. It suggests that the magnitude of marginal superiority in the border rows can be an indicator for plant-density tolerance under high density. What’s more, cultivars with small leaf angle above the ear can be selected to weaken the marginal superiority and improve grain yield under high plant density. Conversely, cultivars with a large leaf angle above the ear can be selected to achieve higher individual yield in intercropping systems with no more than four rows alternated with other crops.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#211

 

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Ruthenium complexes have been extensively explored as potential molecules for cancer treatment. Considering our previous findings on the remarkable cytotoxic activity exhibited by the ruthenium (II) complex 3-hydroxy-4-methoxybenzoate (hmxbato)-cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6 against Leishmania promastigotes and also the similar metabolic characteristics between trypanosomatids and tumor cells, the present study aimed to analyze the anticancer potential of hmxbato against lung tumor cells, as well as the partial death mechanisms involved. Hmxbato demonstrated selective cytotoxicity against A549 lung tumor cells. In addition, this complex at a concentration of 3.8 µM was able to expressively increase the generation of reactive oxygen species (ROS) in tumor cells, causing an oxidative stress that may culminate in: (1) reduction in cellular proliferation; (2) changes in cell morphology and organization patterns of the actin cytoskeleton; (3) cell arrest in the G2/M phase of the cell cycle; (4) apoptosis; (5) changes in the mitochondrial membrane potential and (6) initial DNA damage. Furthermore, we demonstrated that the induction of programmed cell death can occur by the intrinsic apoptotic pathway through the activation of caspases. It is also worth highlighting that hmxbato exhibited predominant actions on A549 tumor cells in comparison to BEAS-2B normal bronchial epithelium cells, which makes this complex an interesting candidate for the design of new drugs against lung cancer.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#212

 

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Realme unveiled the Android-11-based Realme UI 2.0, which has features such as Dual Mode Music Share, customisable notification bar colours, and dark modes. Realme X50 Pro will be the first phone to receive the update.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#213

 

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Extent of myocardial fibrosis in hemodialysis patients has been associated with poor prognosis. Myocardial extracellular volume (ECV) quantification using contrast enhanced cardiac computed tomography (CT) is a novel method to determine extent of myocardial fibrosis. Cardiac CT-based myocardial ECV in hemodialysis patients with those of propensity-matched non-hemodialysis control subjects were compared. Twenty hemodialysis patients (mean age, 67.4 ± 9.6 years; 80% male) and 20 propensity-matched non-hemodialysis controls (mean age, 66.3 ± 9.1 years; 85% male) who underwent comprehensive cardiac CT consisted of calcium scoring, coronary CT angiography, stress perfusion CT and delayed enhancement CT were evaluated. Myocardial ECV was significantly greater in the hemodialysis group than in the control group (33.8 ± 4.7% versus 26.6 ± 2.9%; P < 0.0001). In the hemodialysis group, modest correlation was evident between myocardial ECV and left atrial volume index (r = 0.54; P = 0.01), while there was no correlation between myocardial ECV and other cardiac parameters including left ventricular mass index and severity of myocardial ischemia. Cardiac CT-based myocardial ECV may offer a potential imaging biomarker for myocardial fibrosis in HD patients.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#214

 

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OnePlus Nord smartphones are getting unwanted factory resets at random, according to multiple user posts on the OnePlus forums. The issue is not restricted to any specific region and appears to take place arbitrarily. This also resulted in the users losing their data following the reset.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#215

 

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The large catalytic subunit of acetohydroxyacid synthase (AHAS, EC 2.2.1.6) of Thermotoga maritima (TmcAHAS) was prepared in this study. It possesses high specific activity and excellent stability. The protein and a whole cell catalyst overexpressing the protein were applied to the preparation of α-hydroxyketones including acetoin (AC), 3-hydroxy-2-pentanone (HP), and (R)-phenylacetylcarbinol (R-PAC). The results show that AC and HP could be produced in high yields (84% and 62%, respectively), while R-PAC could be synthesized in a high yield (about 78%) with an R/S ratio of 9:1. Therefore, TmcAHAS and the whole cell catalyst overexpressing the protein could be practically useful bio-catalysts in the preparation of α-hydroxyketones including AC, HP, and R-PAC. To the best of our knowledge, this is the first time that bacterial AHAS was used as a catalyst to prepare HP with a good yield, and also the first time that TmcAHAS was employed to synthesize AC and R-PAC.

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 21 September 2020

#216

 

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OnePlus 8T launch in India is set for October 14, the Chinese company announced through a press note on Monday. The new development comes just after Amazon suggested the release date of the next-generation OnePlus smartphone through the terms and conditions of its contest.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#217

 

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Graft-versus host disease (GVHD) remains one of the main causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (ASCT). Prophylactic T cell depletion via antithymocyte globulin (ATG) during ASCT conditioning is one of the standards of care for GVHD prophylaxis, although the optimal dosing strategy is still unclear. Recent studies have reported that absolute lymphocyte count at the time of ATG administration could predict survivals in ASCT from unrelated donors. Here this issue was examined in 116 patients receiving peripheral blood stem cells (PBSC) ASCT with purine analog/busulfan-based conditioning regimens between 2009 and 2019 in our department. The impact of lymphopenia at the time of ATG administration was evaluated in terms of overall survival, disease-free survival and GVHD-free/relapse-free survival. After a median follow-up of 4 years, no adverse effect of a profound lymphopenia was observed on patients’ outcome. Notably, a reduced dose of ATG in patients with profound lymphopenia did not translate into better survivals. This study indicates that ATG can be administered whatever the recipient’s lymphocyte counts in patients receiving a PBSC purine analog/busulfan-based conditioning regimen ASCT.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#218

 

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Infinix Hot 10 has been launched in Pakistan. It boasts of impressive specifications such as a quad-core processor, quad rear camera setup, large fullscreen display with a hole-punch design, and a large battery as well.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#219

 

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Shift work, performed by approximately 21 million Americans, is irregular or unusual work schedule hours occurring after 6:00 pm. Shift work has been shown to disrupt circadian rhythms and is associated with several adverse health outcomes and chronic diseases such as cancer, gastrointestinal and psychiatric diseases and disorders. It is unclear if shift work influences the complications associated with certain infectious agents, such as pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility resulting from genital chlamydial infection. We used an Environmental circadian disruption (ECD) model mimicking circadian disruption occurring during shift work, where mice had a 6-h advance in the normal light/dark cycle (LD) every week for a month. Control group mice were housed under normal 12/12 LD cycle. Our hypothesis was that compared to controls, mice that had their circadian rhythms disrupted in this ECD model will have a higher Chlamydia load, more pathology and decreased fertility rate following Chlamydia infection. Results showed that, compared to controls, mice that had their circadian rhythms disrupted (ECD) had higher Chlamydia loads, more tissue alterations or lesions, and lower fertility rate associated with chlamydial infection. Also, infected ECD mice elicited higher proinflammatory cytokines compared to mice under normal 12/12 LD cycle. These results imply that there might be an association between shift work and the increased likelihood of developing more severe disease from Chlamydia infection.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#220

 

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Microsoft said on Monday it would acquire ZeniMax Media for $7.5 billion (Rs. 55,223 crores) in cash, strengthening its Xbox video game offering with the studio behind titles such as Fallout and the Doom reboot.

#Software;#Social & Corporation affairs
Field # Software
Updated 21 September 2020

#221

 

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Attempts at using protein structures to identify disease-causing mutations have been dominated by the idea that most pathogenic mutations are disruptive at a structural level. Therefore, computational stability predictors, which assess whether a mutation is likely to be stabilising or destabilising to protein structure, have been commonly used when evaluating new candidate disease variants, despite not having been developed specifically for this purpose. We therefore tested 13 different stability predictors for their ability to discriminate between pathogenic and putatively benign missense variants. We find that one method, FoldX, significantly outperforms all other predictors in the identification of disease variants. Moreover, we demonstrate that employing predicted absolute energy change scores improves performance of nearly all predictors in distinguishing pathogenic from benign variants. Importantly, however, we observe that the utility of computational stability predictors is highly heterogeneous across different proteins, and that they are all inferior to the best performing variant effect predictors for identifying pathogenic mutations. We suggest that this is largely due to alternate molecular mechanisms other than protein destabilisation underlying many pathogenic mutations. Thus, better ways of incorporating protein structural information and molecular mechanisms into computational variant effect predictors will be required for improved disease variant prioritisation.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#222

 

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OnePlus 8T is finally seeing the light of day next month after a deluge of rumours and leaks that have poured in over some time recently.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#223

 

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The eradication rate of Helicobacter pylori (H. pylori) has been decreasing every year, mainly due to the increase in antibiotic resistance. In fact, many other factors may affect H. pylori eradication. To analyze the clinical factors affecting the initial eradication therapy in Chinese patients with H. pylori infection. We conducted a retrospective study on 264 outpatients who were diagnosed with H. pylori-associated chronic gastritis and peptic ulcer disease between January and December 2015 at a large tertiary hospital in China. The patients were divided into three groups: ECA, RCA, and RCM (R: 20 mg rabeprazole, E: 40 mg esomeprazole, C: 0.5 g clarithromycin, A: 1.0 g amoxicillin and M: 0.4 g metronidazole). The patients were treated for 14 days and followed up for 1 year. The 14C-urea breath test (14C-UBT) was performed 4 weeks after the completion of the eradication therapy. The eradication rate was higher in ≥ 40-year-old patients than in < 40-year-old-patients (85.7% vs. 54.7%, p = 0.002). Multivariate analyses revealed only age ≥ 40 years to be significantly associated with a high H. pylori eradication rate [odds ratio (OR) 4.58, p = 0.003]. The H. pylori eradication rate in patients with duodenal ulcers was significantly higher than that in patients with gastric ulcers (79% vs. 60%, p = 0.012). Age could be a predictor of successful H. pylori eradication. Patients with duodenal ulcers had a higher H. pylori eradication rate than those with other lesions.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#224

 

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The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to inflammation and autoimmune diseases. However, how circulating nucleosomes trigger immune responses has not been fully elucidated. cGAS (cGMP-AMP synthase) is a recently discovered pattern recognition receptor that senses cytoplasmic double-stranded DNA (dsDNA). In this study, we employed in vitro reconstituted nucleosomes to examine whether extracellular nucleosomes can gain access to the cytoplasm of mammalian cells to induce immune responses by activating cGAS. We showed that nucleosomes can be taken up by various mammalian cells. Additionally, we found that in vitro reconstituted mononucleosomes and oligonucleosomes can be recognized by cGAS. Compared to dsDNA, nucleosomes exhibit higher binding affinities to cGAS but considerably lower potency in cGAS activation. Incubation of monocytic cells with reconstituted nucleosomes leads to limited production of type I interferons and proinflammatory cytokines via a cGAS-dependent mechanism. This proof-of-concept study reveals the cGAS-dependent immunogenicity of nucleosomes and highlights the potential roles of circulating nucleosomes in autoimmune diseases, inflammation, and antitumour immunity.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#225

 

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Dell, Nutanix and HPE battled for hyperconverged market share according to IDC’s 2020 global HCI sales data.

#Social & Corporation affairs;#Economy
Field # Social & Corporation affairs
Updated 21 September 2020

#226

 

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Polypyrrole complex nitrogen-doped porous carbon matrix (PPy/N-PCM) was synthesized by a simple two-step method. Firstly, graphene oxide was prepared by the modified Hummers method. Secondly, Polypyrrole was compounded on the graphene oxide substrate, and the carbon matrix with a high specific surface area was obtained through high-temperature carbonization and KOH activation, and polypyrrole was used as a nitrogen source for the final nitrogen-doped composite material. The structure characterization of the carbon matrix and the final composite material shows that the carbon matrix surface has obvious porous structure, and the polypyrrole nanospheres grow uniformly on the porous carbon matrix surface. The electrochemical evaluation show that the prepared PPy/N-PCM has excellent supercapacitor performance, and its specific capacitance can reach 237.5 F g−1. When the current density reaches 10 A g−1, it has good cycle stability (the capacitance retention after 1000 charge and discharge is 88.53% of the initial capacitance value, which is better than pure PPy-60.76% and PPy/rGO-C-71.84%). The excellent capacitance performance, good-looking micro-morphology and simple synthesis method of the PPy/N-PCM provide the possibility for its commercialization.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#227

 

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Anne Rippert talked with CRN about what the new Accenture Cloud First initiative means to the solution provider and its clients.

#Social & Corporation affairs;#Economy
Field # Social & Corporation affairs
Updated 21 September 2020

#228

 

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The ability to express genes ectopically in bacteria is essential for diverse academic and industrial applications. Two major considerations when utilizing regulated promoter systems for ectopic gene expression are (1) the ability to titrate gene expression by addition of an exogenous inducer and (2) the leakiness of the promoter element in the absence of the inducer. Here, we describe a modular chromosomally integrated platform for ectopic gene expression in Vibrio cholerae. We compare the broadly used promoter elements Ptac and PBAD to versions that have an additional theophylline-responsive riboswitch (Ptac-riboswitch and PBAD-riboswitch). These constructs all exhibited unimodal titratable induction of gene expression, however, max induction varied with Ptac > PBAD > PBAD-riboswitch > Ptac-riboswitch. We also developed a sensitive reporter system to quantify promoter leakiness and show that leakiness for Ptac > Ptac-riboswitch > PBAD; while the newly developed PBAD-riboswitch exhibited no detectable leakiness. We demonstrate the utility of the tightly inducible PBAD-riboswitch construct using the dynamic activity of type IV competence pili in V. cholerae as a model system. The modular chromosomally integrated toolkit for ectopic gene expression described here should be valuable for the genetic study of V. cholerae and could be adapted for use in other species.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#229

 

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Brain injury resulting from repeated mild traumatic insult is associated with cognitive dysfunction and other chronic co-morbidities. The current study tested the effects of aberrant neurogenesis in a mouse model of repeated mild traumatic brain injury (rmTBI). Using Barnes Maze analysis, we found a significant reduction in spatial learning and memory at 24 days post-rmTBI compared to repeated sham (rSham) injury. Cell fate analysis showed a greater number of BrdU-labeled cells which co-expressed Prox-1 in the DG of rmTBI-injured mice which coincided with enhanced cFos expression for neuronal activity. We then selectively ablated dividing neural progenitor cells using a 7-day continuous infusion of Ara-C prior to rSham or rmTBI. This resulted in attenuation of cFos and BrdU-labeled cell changes and prevented associated learning and memory deficits. We further showed this phenotype was ameliorated in EphA4f./f/Tie2-Cre knockout compared to EphA4f./f wild type mice, which coincided with altered mRNA transcript levels of MCP-1, Cx43 and TGFβ. These findings demonstrate that cognitive decline is associated with an increased presence of immature neurons and gene expression changes in the DG following rmTBI. Our data also suggests that vascular EphA4-mediated neurogenic remodeling adversely affects learning and memory behavior in response to repeated insult.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#230

 

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Since family history of diabetes is a very strong risk factor for type 2 diabetes, which is one of the most important risk factors for cardiovascular disease (CVD), it might be also useful to assess the risk for CVD. Therefore, we aimed to investigate the relationship between a familial (parents and siblings) history of diabetes and the risk of incident CVD. Data from four prospective German cohort studies were used: EPIC-Potsdam study (n = 26,054), CARLA study (n = 1,079), SHIP study (n = 3,974), and KORA study (n = 15,777). A multivariable-adjusted Cox regression was performed to estimate associations between familial histories of diabetes, myocardial infarction or stroke and the risk of CVD in each cohort; combined hazard ratios (HRMeta) were derived by conducting a meta-analysis. The history of diabetes in first-degree relatives was not related to the development of CVD (HRMeta 0.99; 95% CI 0.88–1.10). Results were similar for the single outcomes myocardial infarction (MI) (HRMeta 1.07; 95% CI 0.92–1.23) and stroke (HRMeta 1.00; 95% CI 0.86–1.16). In contrast, parental history of MI and stroke were associated with an increased CVD risk. Our study indicates that diabetes in the family might not be a relevant risk factor for the incidence of CVD. However, the study confirmed the relationship between a parental history of MI or stroke and the onset of CVD.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#231

 

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Binarization is a critical step in analysis of retinal optical coherence tomography angiography (OCTA) images, but the repeatability of metrics produced from various binarization methods has not been fully assessed. This study set out to examine the repeatability of OCTA quantification metrics produced using different binarization thresholding methods, all of which have been applied in previous studies, across multiple devices and plexuses. Successive 3 × 3 mm foveal OCTA images of 13 healthy eyes were obtained on three different devices. For each image, contrast adjustments, 3 image processing techniques (linear registration, histogram normalization, and contrast-limited adaptive histogram equalization), and 11 binarization thresholding methods were independently applied. Vessel area density (VAD) and vessel length were calculated for retinal vascular images. Choriocapillaris (CC) images were quantified for VAD and flow deficit metrics. Repeatability, measured using the intra-class correlation coefficient, was inconsistent and generally not high (ICC < 0.8) across binarization thresholds, devices, and plexuses. In retinal vascular images, local thresholds tended to incorrectly binarize the foveal avascular zone as white (i.e., wrongly indicating flow). No image processing technique analyzed consistently resulted in highly repeatable metrics. Across contrast changes, retinal vascular images showed the lowest repeatability and CC images showed the highest.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#232

 

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Nations with two-thirds of world’s population have joined, but not United States or China

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#233

 

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Arterial tone is regulated by multiple ligand-receptor interactions, and its dysregulation is involved in ischemic conditions such as acute coronary spasm or syndrome. Understanding the distribution of vasoactive receptors on different arteries may help guide the development of tissue-specific vasoactive treatments against arterial dysfunction. Tissues were harvested from coronary, mesenteric, pulmonary, renal and peripheral human artery (n = 6 samples of each) and examined using a human antibody array to determine the expression of 29 vasoactive receptors and 3 endothelin ligands. Across all types of arteries, outer diameter ranged from 2.24 ± 0.63 to 3.65 ± 0.40 mm, and AVPR1A was the most abundant receptor. The expression level of AVPR1A in pulmonary artery was similar to that in renal artery, 2.2 times that in mesenteric artery, 1.9 times that in peripheral artery, and 2.2 times that in coronary artery. Endothelin-1 was expressed at significantly higher levels in pulmonary artery than peripheral artery (8.8 times), mesenteric artery (5.3 times), renal artery (7.9 times), and coronary artery (2.4 times). Expression of ADRA2B was significantly higher in coronary artery than peripheral artery. Immunohistochemistry revealed abundant ADRA2B in coronary artery, especially vessels with diameters below 50 μm, but not in myocardium. ADRA2C, in contrast, was expressed in both myocardium and blood vessels. The high expression of ADRA2B in coronary artery but not myocardium highlights the need to further characterize its function. Our results help establish the distribution and relative levels of tone-related receptors in different types of arteries, which may guide artery-specific treatments.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#234

 

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Executive chairman Trevor Milton resigns 12 days after GM invests $2 billion, and 10 days after Hindenburg Research burst the ...

#Vehicles & Special machines
Field # Vehicles & Special machines
Updated 21 September 2020

#235

 

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Only a few reports have examined vascular endothelial function before and after educational hospitalization and the factors that affect it in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess vascular endothelial function before and after educational hospitalization and identify factors that affect it. In 65 patients with T2DM who underwent peripheral arterial tonometry (EndoPAT) before and after hospitalization, vascular endothelial function (reactive hyperemia index [RHI]), glucose metabolism, lipid metabolism, and blood pressure were assessed before and after hospitalization. The primary endpoint was hospitalization-induced changes in vascular endothelial function. Educational hospitalization significantly improved the natural logarithmically scaled RHI (L_RHI) from 0.555 ± 0.212 to 0.625 ± 0.245 (p = 0.012). Multivariable logistic regression analysis identified hypoglycemia during hospitalization as the single factor that significantly altered vascular endothelial function (p = 0.019). The odds of achieving normal vascular endothelial function were 0.08 times lower (95% confidence interval, 0.01–0.67) for each episode of hypoglycemia. Furthermore, multivariable analysis identified hypoglycemia during hospitalization as the single factor that worsened L_RHI. Our study showed that educational hospitalization of patients with T2DM improved vascular endothelial function, and that the development of hypoglycemic episodes had a significant negative impact on normalization of vascular endothelial function.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#236

 

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TBD

#Construction
Field # Construction
Updated 21 September 2020

#237

 

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The ability to inhibit host cell apoptosis is important for the intracellular replication of the obligate intracellular pathogen Coxiella burnetii, as it allows the completion of the lengthy bacterial replication cycle. Effector proteins injected into the host cell by the C. burnetii type IVB secretion system (T4BSS) are required for the inhibition of host cell apoptosis. AnkG is one of these anti-apoptotic effector proteins. The inhibitory effect of AnkG requires its nuclear localization, which depends on p32-dependent intracellular trafficking and importin-α1-mediated nuclear entry of AnkG. Here, we compared the sequences of ankG from 37 C. burnetii isolates and classified them in three groups based on the predicted protein size. The comparison of the three different groups allowed us to identify the first 28 amino acids as essential and sufficient for the anti-apoptotic activity of AnkG. Importantly, only the full-length protein from the first group is a bona fide effector protein injected into host cells during infection and has anti-apoptotic activity. Finally, using the Galleria mellonella infection model, we observed that AnkG from the first group has the ability to attenuate pathology during in vivo infection, as it allows survival of the larvae despite bacterial replication.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#238

 

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NASA's OSIRIS-REx spacecraft spotted some strangely light colored rocks on the surface of asteroid Bennu — likely from an entirely different asteroid.

#Astronautics
Field # Astronautics
Updated 21 September 2020

#239

 

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Despite extensive research, little progress has been made in glioblastoma therapy, owing in part to a lack of adequate preclinical in vivo models to study this disease. To mitigate this, primary patient-derived cell lines, which maintain their specific stem-like phenotypes, have replaced established glioblastoma cell lines. However, due to heterogenous tumour growth inherent in glioblastoma, the use of primary cells for orthotopic in vivo studies often requires large experimental group sizes. Therefore, when using intracranial patient-derived xenograft (PDX) approaches, it is advantageous to deploy imaging techniques to monitor tumour growth and allow stratification of mice. Here we show that stable expression of near-infrared fluorescent protein (iRFP) in patient-derived glioblastoma cells enables rapid, direct non-invasive monitoring of tumour development without compromising tumour stemness or tumorigenicity. Moreover, as this approach does not depend on the use of agents like luciferin, which can cause variability due to changing bioavailability, it can be used for quantitative longitudinal monitoring of tumour growth. Notably, we show that this technique also allows quantitative assessment of tumour burden in highly invasive models spreading throughout the brain. Thus, iRFP transduction of primary patient-derived glioblastoma cells is a reliable, cost- and time-effective way to monitor heterogenous orthotopic PDX growth.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#240

 

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We examined whether long-term gamma-glutamyl transferase (GGT) variability can predict cardiovascular disease (CVD) and mortality in individuals with diabetes. We included 698,937 Koreans diabetes patients older than 40 years without histories of CVD, chronic liver disease, or heavy alcoholics who received health exams supported by the Korean government more than once in 2009–2012 (baseline). We used Cox proportional analyses to estimate the risk of stroke, myocardial infarction (MI), and all-cause mortality until December 31, 2016, according to the quartiles of the average successive variability (ASV) of GGT measured during the five years before the baseline. A total 26,119, 15,103, and 39,982 cases of stroke, MI, and death, respectively, were found. GGT ASV quartile 4 had a significantly higher risk of stroke and all-cause mortality than quartile 1, with adjustment for risk factors, such as baseline glucose and GGT level, and comorbidities. Hazard ratios (95% confidence intervals) for GGT ASV quartile 4 were 1.06 (1.03–1.10) and 1.23 (1.20–1.27) for stroke and mortality, respectively. This significant association was shown consistently across the baseline GGT quartiles. GGT variability was related to the risk of stroke and all-cause mortality. The effect was most pronounced in all-cause mortality, irrespective of baseline GGT level.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#241

 

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Photoshop users will soon be able to quickly swap out a sky without complex masking with Adobe Sensei's upcoming Sky Replacement tool.

#Software
Field # Software
Updated 21 September 2020

#242

 

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Postpartum depression (PPD), a main cause of maternal suicide, is an important issue in perinatal mental health. Recently, cerebral diffusion tensor imaging (DTI) studies have shown reduced fractional anisotropy (FA) in major depressive disorder (MDD) patients. There are, however, no reports using diffusion kurtosis imaging (DKI) for evaluation of PPD. This was a Japanese single-institutional prospective study from 2016 to 2019 to examine the pathophysiological changes in the brain of PPD patients using DKI. The DKI data from 3.0 T MRI of patients one month after delivery were analyzed; the patients were examined for PPD by a psychiatrist. The mean kurtosis (MK), FA and mean diffusivity (MD) were calculated from the DKI data and compared between PPD and non-PPD groups using tract-based spatial statistics analysis. Of the 75 patients analyzed, eight patients (10.7%) were diagnosed as having PPD. In the PPD group, FA values in the white matter and thalamus were significantly lower and MD values in the white matter and putamen were significantly higher. The area with significant differences in MD value was more extensive (40.8%) than the area with significant differences in FA value (6.5%). These findings may reflect pathophysiological differences of PPD compared with MDD.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#243

 

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The next-generation Radeon RX 6900 XT GPU is rumored to come with 16GB of VRAM, or 60% more memory than the RTX 3080.

#Hardware & Devices
Field # Hardware & Devices
Updated 21 September 2020

#244

 

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The geometry of an inductor made of a long thin wire and having the highest possible Q-factor is found by numerical optimization. As frequency increases, the Q-factor first grows linearly and then according to a square-root law, while the cross-section of the optimal coil evolves from near-circular to sickle-shaped.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#245

 

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Agrostemma githago L. (corn cockle) is an herbaceous plant mainly growing in Europe. The seeds of the corn cockle are toxic and poisonings were widespread in the past by consuming contaminated flour. The toxic principle of Agrostemma seeds was attributed to triterpenoid secondary metabolites. Indeed, this is in part true. However Agrostemma githago L. is also a producer of ribosome-inactivating proteins (RIPs). RIPs are N-glycosylases that inactivate the ribosomal RNA, a process leading to an irreversible inhibition of protein synthesis and subsequent cell death. A widely known RIP is ricin from Ricinus communis L., which was used as a bioweapon in the past. In this study we isolated agrostin, a 27 kDa RIP from the seeds of Agrostemma githago L., and determined its full sequence. The toxicity of native agrostin was investigated by impedance-based live cell imaging. By RNAseq we identified 7 additional RIPs (agrostins) in the transcriptome of the corn cockle. Agrostin was recombinantly expressed in E. coli and characterized by MALDI-TOF–MS and adenine releasing assay. This study provides for the first time a comprehensive analysis of ribosome-inactivating proteins in the corn cockle and complements the current knowledge about the toxic principles of the plant.

#Medicine & Human body
Field # Medicine & Human body
Updated 21 September 2020

#246

 

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More than 150 ginsenosides have been isolated and identified from Panax plants. Ginsenosides with different glycosylation degrees have demonstrated different chemical properties and bioactivity. In this study, we systematically cloned and characterized 46 UGT94 family UDP-glycosyltransferases (UGT94s) from a mixed Panax ginseng/callus cDNA sample with high amino acid identity. These UGT94s were found to catalyze sugar chain elongation at C3-O-Glc and/or C20-O-Glc of protopanaxadiol (PPD)-type, C20-O-Glc or C6-O-Glc of protopanaxatriol (PPT)-type or both C3-O-Glc of PPD-type and C6-O-Glc of PPT-type or C20-O-Glc of PPD-type and PPT-type ginsenosides with different efficiencies. We also cloned 26 and 51 UGT94s from individual P. ginseng and P. notoginseng plants, respectively; our characterization results suggest that there is a group of UGT94s with high amino acid identity but diverse functions or catalyzing activities even within individual plants. These UGT94s were classified into three clades of the phylogenetic tree and consistent with their catalytic function. Based on these UGT94s, we elucidated the biosynthetic pathway of a group of ginsenosides. Our present results reveal a series of UGTs involved in second sugar chain elongation of saponins in Panax plants, and provide a scientific basis for understanding the diverse evolution mechanisms of UGT94s among plants.

#Software
Field # Software
Updated 21 September 2020

#247

 

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After a fresh round of funding, Dendra Systems is ready to unleash its drone reforestation squad on the world. But is it too little, too late?

#Astronautics
Field # Astronautics
Updated 21 September 2020

#248

 

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In this paper, the rate of heat transfer of the steady MHD stagnation point flow of Casson fluid on the shrinking/stretching surface has been investigated with the effect of thermal radiation and viscous dissipation. The governing partial differential equations are first transformed into the ordinary (similarity) differential equations. The obtained system of equations is converted from boundary value problems (BVPs) to initial value problems (IVPs) with the help of the shooting method which then solved by the RK method with help of maple software. Furthermore, the three-stage Labatto III-A method is applied to perform stability analysis with the help of a bvp4c solver in MATLAB. Current outcomes contradict numerically with published results and found inastounding agreements. The results reveal that there exist dual solutions in both shrinking and stretching surfaces. Furthermore, the temperature increases when thermal radiation, Eckert number, and magnetic number are increased. Signs of the smallest eigenvalue reveal that only the first solution is stable and can be realizable physically.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#249

 

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Fluorescent natural organic matter at tryptophan-like (TLF) and humic-like fluorescence (HLF) peaks is associated with the presence and enumeration of faecal indicator bacteria in groundwater. We hypothesise, however, that it is predominantly extracellular material that fluoresces at these wavelengths, not bacterial cells. We quantified total (unfiltered) and extracellular (filtered at < 0.22 µm) TLF and HLF in 140 groundwater sources across a range of urban population densities in Kenya, Malawi, Senegal, and Uganda. Where changes in fluorescence occurred following filtration they were correlated with potential controlling variables. A significant reduction in TLF following filtration (ΔTLF) was observed across the entire dataset, although the majority of the signal remained and thus considered extracellular (median 96.9%). ΔTLF was only significant in more urbanised study areas where TLF was greatest. Beneath Dakar, Senegal, ΔTLF was significantly correlated to total bacterial cells (ρs 0.51). No significant change in HLF following filtration across all data indicates these fluorophores are extracellular. Our results suggest that TLF and HLF are more mobile than faecal indicator bacteria and larger pathogens in groundwater, as the predominantly extracellular fluorophores are less prone to straining. Consequently, TLF/HLF are more precautionary indicators of microbial risks than faecal indicator bacteria in groundwater-derived drinking water.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#250

 

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Iodothyronine deiodinases (Dios) are important selenoproteins that control the concentration of the active thyroid hormone (TH) triiodothyronine through regioselective deiodination. The X-ray structure of a truncated monomer of Type III Dio (Dio3), which deiodinates TH inner rings through a selenocysteine (Sec) residue, revealed a thioredoxin-fold catalytic domain supplemented with an unstructured Ω-loop. Loop dynamics are driven by interactions of the conserved Trp207 with solvent in multi-microsecond molecular dynamics simulations of the Dio3 thioredoxin(Trx)-fold domain. Hydrogen bonding interactions of Glu200 with residues conserved across the Dio family anchor the loop’s N-terminus to the active site Ser-Cys-Thr-Sec sequence. A key long-lived loop conformation coincides with the opening of a cryptic pocket that accommodates thyroxine (T4) through an I⋯Se halogen bond to Sec170 and the amino acid group with a polar cleft. The Dio3-T4 complex is stabilized by an I⋯O halogen bond between an outer ring iodine and Asp211, consistent with Dio3 selectivity for inner ring deiodination. Non-conservation of residues, such as Asp211, in other Dio types in the flexible portion of the loop sequence suggests a mechanism for regioselectivity through Dio type-specific loop conformations. Cys168 is proposed to attack the selenenyl iodide intermediate to regenerate Dio3 based upon structural comparison with related Trx-fold proteins.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#251

 

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One hotly anticipated new iOS feature is support for picture-in-picture, which lets you view video alongside other apps on your iPhone. Here's how to use it.

#Gadgets
Field # Gadgets
Updated 21 September 2020

#252

 

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Cochlear-implant (CI) users rely on temporal envelope modulations (TEMs) to understand speech, and clinical outcomes depend on the accuracy with which these TEMs are encoded by the electrically-stimulated neural ensembles. Non-invasive EEG measures of this encoding could help clinicians identify and disable electrodes that evoke poor neural responses so as to improve CI outcomes. However, recording EEG during CI stimulation reveals huge stimulation artifacts that are up to orders of magnitude larger than the neural response. Here we used a custom-built EEG system having an exceptionally high sample rate to accurately measure the artefact, which we then removed using linear interpolation so as to reveal the neural response during continuous electrical stimulation. In ten adult CI users, we measured the 40-Hz electrically evoked auditory steady-state response (eASSR) and electrically evoked auditory change complex (eACC) to amplitude-modulated 900-pulses-per-second pulse trains, stimulated in monopolar mode (i.e. the clinical default), and at different modulation depths. We successfully measured artifact-free 40-Hz eASSRs and eACCs. Moreover, we found that the 40-Hz eASSR, in contrast to the eACC, showed substantial responses even at shallow modulation depths. We argue that the 40-Hz eASSR is a clinically feasible objective measure to assess TEM encoding in CI users.

#Medicine & Human body;#Hardware & Devices
Field # Medicine & Human body
Updated 21 September 2020

#253

 

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$$hbox {TiO}_2$$ and $$hbox {SrTiO}_3$$ are well known materials in the field of photocatalysis due to their exceptional electronic structure, high chemical stability, non-toxicity and low cost. However, owing to the wide band gap, these can be utilized only in the UV region. Thus, it’s necessary to expand their optical response in visible region by reducing their band gap through doping with metals, nonmetals or the combination of different elements, while retaining intact the photocatalytic efficiency. We report here, the codoping of a metal and a nonmetal in anatase $$hbox {TiO}_2$$ and $$hbox {SrTiO}_3$$ for efficient photocatalytic water splitting using hybrid density functional theory and ab initio atomistic thermodynamics. The latter ensures to capture the environmental effect to understand thermodynamic stability of the charged defects at a realistic condition. We have observed that the charged defects are stable in addition to neutral defects in anatase $$hbox {TiO}_2$$ and the codopants act as donor as well as acceptor depending on the nature of doping (p-type or n-type). However, the most stable codopants in $$hbox {SrTiO}_3$$ mostly act as donor. Our results reveal that despite the response in visible light region, the codoping in $$hbox {TiO}_2$$ and $$hbox {SrTiO}_3$$ cannot always enhance the photocatalytic activity due to either the formation of recombination centers or the large shift in the conduction band minimum or valence band maximum. Amongst various metal-nonmetal combinations, $$hbox {Mn}_ ext {Ti}hbox {S}_ ext {O}$$ (i.e. Mn is substituted at Ti site and S is substituted at O site), $$hbox {S}_ ext {O}$$ in anatase $$hbox {TiO}_2$$ and $$hbox {Mn}_ ext {Ti}hbox {S}_ ext {O}$$ , $$hbox {Mn}_ ext {Sr}hbox {N}_ ext {O}$$ in $$hbox {SrTiO}_3$$ are the most potent candidates to enhance the photocatalytic efficiency of anatase $$hbox {TiO}_2$$ and $$hbox {SrTiO}_3$$ under visible light irradiation.

#Telecommunications;#Entertainments
Field # Telecommunications
Updated 21 September 2020

#254

 

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In this study, a square cavity is modeled using Computational Fluid Dynamics (CFD) as well as artificial intelligence (AI) approach. In the square cavity, copper (Cu) nanoparticle is the nanofluid and the flow velocity characteristics in the x-direction and y-direction, and the fluid temperature inside the cavity at different times are considered as CFD outputs. CFD outputs have been assessed using one of the artificial intelligence algorithms, such as a combination of neural network and fuzzy logic (ANFIS). As in the ANFIS method, we have a non-dimension procedure in the learning step, and there is no issue in combining other characteristics of the flow and thermal distribution beside the x and y coordinates, we combine two coordinate parameters and one flow parameter. This ability of method can be considered as a meshless learning step that there is no instability of the numerical method or limitation of boundary conditions. The data were classified using the grid partition method and the MF (membership function) type was dsigmf (difference between two sigmoidal membership functions). By achieving the appropriate intelligence in the ANFIS method, output prediction was performed at the points of cavity which were not included in the learning process and were compared to the existing data (the results of the CFD method) and were validated by them. This new combination of CFD and the ANFIS method enables us to learn flow and temperature distribution throughout the domain thoroughly, and eventually predict the flow characteristics in short computational time. The results from AI in the ANFIS method were compared to the ant colony and fuzzy logic methods. The data from CFD results were inserted into the ant colony system for the training process, and we predicted the data in the fuzzy logic system. Then, we compare the data with the ANFIS method. The results indicate that the ANFIS method has a high potentiality compared to the ant colony method because the amount of R in the ANIFS system is higher than R in the ant colony method. In the ANFIS method, R is equal to 0.99, and in the ant colony method, R is equal to 0.91. This shows that the ant colony needs more time for both the prediction and training of the system. Also, comparing the pattern recognition in the two systems, we can obviously see that by using the ANFIS method, the predictions completely match the target points. But the other method cannot match the flow pattern and velocity distribution with the CFD method.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#255

 

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People differ in their willingness to take risks. Recent work found that revealed preference tasks (e.g., laboratory lotteries)—a dominant class of measures—are outperformed by survey-based stated preferences, which are more stable and predict real-world risk taking across different domains. How can stated preferences, often criticised as inconsequential “cheap talk,” be more valid and predictive than controlled, incentivized lotteries? In our multimethod study, over 3,000 respondents from population samples answered a single widely used and predictive risk-preference question. Respondents then explained the reasoning behind their answer. They tended to recount diagnostic behaviours and experiences, focusing on voluntary, consequential acts and experiences from which they seemed to infer their risk preference. We found that third-party readers of respondents’ brief memories and explanations reached similar inferences about respondents’ preferences, indicating the intersubjective validity of this information. Our results help unpack the self perception behind stated risk preferences that permits people to draw upon their own understanding of what constitutes diagnostic behaviours and experiences, as revealed in high-stakes situations in the real world.

#Theoretical sciences
Field # Theoretical sciences
Updated 21 September 2020

#256

 

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New controllers will remain at the $60 starting price.

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 21 September 2020