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Today: 28 February 2020, Friday.

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#1

 

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The characterization of a recently isolated bacteriophage, vB_Eco4M-7, which effectively infects many, though not all, Escherichia coli O157 strains, is presented. The genome of this phage comprises double-stranded DNA, 68,084 bp in length, with a GC content of 46.2%. It contains 96 putative open reading frames (ORFs). Among them, the putative functions of only 35 ORFs were predicted (36.5%), whereas 61 ORFs (63.5%) were classified as hypothetical proteins. The genome of phage vB_Eco4M-7 does not contain genes coding for integrase, recombinase, repressors or excisionase, which are the main markers of temperate viruses. Therefore, we conclude that phage vB_Eco4M-7 should be considered a lytic virus. This was confirmed by monitoring phage lytic development by a one-step growth experiment. Moreover, the phage forms relatively small uniform plaques (1 mm diameter) with no properties of lysogenization. Electron microscopic analyses indicated that vB_Eco4M-7 belongs to the Myoviridae family. Based on mass spectrometric analyses, including the fragmentation pattern of unique peptides, 33 phage vB_Eco4M-7 proteins were assigned to annotated open reading frames. Importantly, genome analysis suggested that this E. coli phage is free of toxins and other virulence factors. In addition, a similar, previously reported but uncharacterized bacteriophage, ECML-117, was also investigated, and this phage exhibited properties similar to vB_Eco4M-7. Our results indicate that both studied phages are potential candidates for phage therapy and/or food protection against Shiga toxin-producing E. coli, as the majority of these strains belong to the O157 serotype.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#2

 

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Fluid states of matter can locally exhibit characteristics of the onset of crystalline order. Traditionally this has been theoretically investigated using multipoint correlation functions. However new measurement techniques now allow multiparticle configurations of cold atomic systems to be observed directly. This has led to a search for new techniques to characterize the configurations that are likely to be observed. One of these techniques is the configuration density (CD), which has been used to argue for the formation of “Pauli crystals” by non-interacting electrons in e.g. a harmonic trap. We show here that such Pauli crystals do not exist, but that other other interesting spatial structures can occur in the form of an “anti-Crystal”, where the fermions preferentially avoid a lattice of positions surrounding any given fermion. Further, we show that configuration densities must be treated with great care as naive application can lead to the identification of crystalline structures which are artifacts of the method and of no physical significance. We analyze the failure of the CD and suggest methods that might be more suitable for characterizing multiparticle correlations which may signal the onset of crystalline order. In particular, we introduce neighbour counting statistics (NCS), which is the full counting statistics of the particle number in a neighborhood of a given particle. We test this on two dimensional systems with emerging triangular and square crystal structures.

#Materials
Field # Materials
Updated 28 February 2020

#3

 

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Cardiovascular (CV) morbidity is the major cause of death in patients with Systemic Lupus Erythematosus (SLE). Previous studies on mannose-binding lectin (MBL) gene polymorphisms in SLE patients suggest that low levels of complement MBL are associated with cardiovascular disease (CVD). However, as large studies on MBL deficiency based on resulting MBL plasma concentrations are lacking, the aim of our study was to analyze the association of MBL concentrations with CVD in SLE patients. Plasma MBL levels SLE patients included in the Swiss SLE Cohort Study were quantified by ELISA. Five different CV organ manifestations were documented. Of 373 included patients (85.5% female) 62 patients had at least one CV manifestation. Patients with MBL deficiency (levels below 500 ng/ml or 1000 ng/ml) had no significantly increased frequency of CVD (19.4% vs. 15.2%, P = 0.3 or 17.7% vs. 15.7%, P = 0.7). After adjustment for traditional CV risk factors, MBL levels and positive antiphospholipid serology (APL+) a significant association of CVD with age, hypertension, disease duration and APL+ was demonstrated. In our study of a large cohort of patients with SLE, we could not confirm previous studies suggesting MBL deficiency to be associated with an increased risk for CVD.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#4

 

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The finding of novel molecular markers for prediction or prognosis of invasiveness in colorectal cancer (CRC) constitutes an appealing challenge. Here we show the up-regulation of EPDR1 in a prospective cohort of 101 CRC patients, in a cDNA array of 43 patients and in in silico analyses. EPDR1 encodes a protein related to ependymins, a family of glycoproteins involved in intercellular contacts. A thorough statistical model allowed us to conclude that the gene is significantly up-regulated in tumour tissues when compared with normal mucosa. These results agree with those obtained by the analysis of three publicly available databases. EPDR1 up-regulation correlates with the TNM staging parameters, especially T and M. Studies with CRC cell lines revealed that the methylation of a CpG island controls EPDR1 expression. siRNA knocking-down and overexpression of the gene following transient plasmid transfection, showed that EPDR1 favours cell proliferation, migration, invasiveness and adhesion to type I collagen fibres, suggesting a role in epithelial to mesenchymal transition. Both statistical and functional analysis correlated EPDR1 overexpression with invasiveness and dissemination of tumour cells, supporting the inclusion of EPDR1 in panels of genes used to improve molecular subtyping of CRC. Eventually, EPDR1 may be an actionable target.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#5

 

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The pro-inflammatory adipokine resistin induces a phenotypic switch of vascular smooth muscle cells (VSMC), a process decisive for atherosclerosis, including morphological changes, increased synthetic activity, proliferation and migration. The guanine-exchange factor ARNO (Cytohesin-2) has been shown to be important for morphological changes and migration of other cell types. In this study we dissected the role of ARNO in resistin induced VSMC phenotypic switching and signalling. Firstly, treatment with the cytohesin inhibitor Secin H3 prevented the resistin mediated induction of morphological changes in VSMC. Secondly, Secin H3 treatment as well as expression of an inactive ARNO (EK) reduced resistin induced VSMC synthetic activity, as assessed by matrix metalloproteinase 2 (MMP-2) expression, as well as the migration into a wound in vitro compared to ARNO WT expression. Thirdly, we found ARNO to influence MMP-2 expression and migration via activation of p38 MAPK and the JNK/AP-1 pathway. Interestingly, these processes were shown to be dependent on the binding of PIP3, as mutation of the ARNO PH-domain inhibited VSMC migration, MMP-2 expression as well as p38 MAPK and JNK signalling. Thus, we demonstrate that ARNO is an important link in resistin dependent cell signalling leading to morphological changes, MMP-2 production and migration of VSMC.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#6

 

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The dog rhinarium (naked and often moist skin on the nose-tip) is prominent and richly innervated, suggesting a sensory function. Compared to nose-tips of herbivorous artio- and perissodactyla, carnivoran rhinaria are considerably colder. We hypothesized that this coldness makes the dog rhinarium particularly sensitive to radiating heat. We trained three dogs to distinguish between two distant objects based on radiating heat; the neutral object was about ambient temperature, the warm object was about the same surface temperature as a furry mammal. In addition, we employed functional magnetic resonance imaging on 13 awake dogs, comparing the responses to heat stimuli of about the same temperatures as in the behavioural experiment. The warm stimulus elicited increased neural response in the left somatosensory association cortex. Our results demonstrate a hitherto undiscovered sensory modality in a carnivoran species.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#7

 

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0.5–1% of ALS (Amyotrophic Lateral Sclerosis) and Parkinson's disease (PD) are associated with mutations in the angiogenin (ANG). These mutations are thought to cause disease through a loss of ANG function, but this hypothesis has not been evaluated statistically. In addition, the potential for ANG to promote disease has not been considered. With the goal of better defining the etiology of ANG-ALS, we assembled all clinical onset and disease duration data and determined if these were correlated with biochemical properties of ANG variants. Loss of ANG stability and ribonuclease activity were found to correlate with early ALS onset, confirming an aspect of the prevailing model of ANG-ALS. Conversely, loss of ANG stability and ribonuclease activity correlated with longer survival following diagnosis, which is inconsistent with the prevailing model. These results indicate that functional ANG appears to decrease the risk of developing ALS but exacerbate ALS once in progress. These findings are rationalized in terms of studies demonstrating that distinct mechanisms contribute to ALS onset and progression and propose that ANG replacement or stabilization would benefit pre-symptomatic ANG-ALS patients. However, this study challenges the prevailing hypothesis that augmenting ANG will benefit symptomatic ANG-ALS patients. Instead, our results suggest that silencing of ANG activity may be beneficial for symptomatic ALS patients. This study will serve as a call-to-arms for neurologists to consistently publish ALS and PD patient's clinical data—if all ANG-ALS patients’ data were available our findings could be tested with considerable statistical power.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#8

 

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A critical limitation of Salmonella typhimurium (S. typhimurium) as an anti-cancer agent is the loss of their invasive or replicative activities, which results in no or less delivery of anti-cancer agents inside cancer cells in cancer therapy. Here we developed an oxytolerant attenuated Salmonella strain (KST0650) from the parental KST0649 (ΔptsIΔcrr) strain using radiation mutation technology (RMT). The oxytolerant KST0650 strain possessed 20-times higher replication activity in CT26 cancer cells and was less virulent than KST0649. Furthermore, KST0650 migrated effectively into tumor tissues in mice. KST0650 was further equipped with a plasmid harboring a spliced form of the intracellular pro-apoptotic protein sATF6, and the expression of sATF6 was controlled by the radiation-inducible recN promoter. The new strain was named as KST0652, in which sATF6 protein expression was induced in response to radiation in a dose-dependent manner. This strain was effectively delivered inside cancer cells and tumor tissues via the Salmonella type III secretion system (T3SS). In addition, combination treatment with KST0652 and radiation showed a synergistic anti-tumor effect in murine tumor model with complete inhibition of tumor growth and protection against death. In conclusion, we showed that RMT can be used to effectively develop an anti-tumor Salmonella strain for delivering anti-cancer agents inside tumors.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#9

 

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To investigate whether automated volumetric radiomic analysis of breast cancer vascularization (VAV) can improve survival prediction in primary breast cancer. 314 consecutive patients with primary invasive breast cancer received standard clinical MRI before the initiation of treatment according to international recommendations. Diagnostic work-up, treatment, and follow-up was done at one tertiary care, academic breast-center (outcome: disease specific survival/DSS vs. disease specific death/DSD). The Nottingham Prognostic Index (NPI) was used as the reference method with which to predict survival of breast cancer. Based on the MRI scans, VAV was accomplished by commercially available, FDA-cleared software. DSD served as endpoint. Integration of VAV into the NPI gave NPIVAV. Prediction of DSD by NPIVAV compared to standard NPI alone was investigated (Cox regression, likelihood-test, predictive accuracy: Harrell’s C, Kaplan Meier statistics and corresponding hazard ratios/HR, confidence intervals/CI). DSD occurred in 35 and DSS in 279 patients. Prognostication of the survival outcome by NPI (Harrell’s C = 75.3%) was enhanced by VAV (NPIVAV: Harrell’s C = 81.0%). Most of all, the NPIVAV identified patients with unfavourable outcome more reliably than NPI alone (hazard ratio/HR = 4.5; confidence interval/CI = 2.14-9.58; P = 0.0001). Automated volumetric radiomic analysis of breast cancer vascularization improved survival prediction in primary breast cancer. Most of all, it optimized the identification of patients at higher risk of an unfavorable outcome. Future studies should integrate MRI as a “gate keeper” in the management of breast cancer patients. Such a “gate keeper” could assist in selecting patients benefitting from more advanced diagnostic procedures (genetic profiling etc.) in order to decide whether are a more aggressive therapy (chemotherapy) is warranted.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#10

 

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Incipient groundwater salinization has been identified in many arid and semi-arid regions where groundwater is increasingly used for irrigation, but the dominant processes at stake in such context are yet uncertain. Groundwater solutes originates from various sources such as atmospheric inputs, rock dissolution and fertilizer residues, and their concentration is controlled by hydrological processes, in particular evapotranspiration. Here, we propose a deconvolution method to identify the sources and processes governing the groundwater Chloride concentration in agricultural catchments, using the relative variations of Sodium and Chloride and using a neighbouring pristine catchment as a reference for the release rate of Na by weathering. We applied the deconvolution method to the case of the Kabini Critical Zone Observatory, South India, where groundwater was sampled in 188 farm tubewells in the semi-arid catchment of Berambadi and in 5 piezometers in the pristine catchment of Mule Hole. In Berambadi, groundwater composition displayed a large spatial variability with Cl contents spanning 3 orders of magnitude. The results showed that the concentration factor due to evapotranspiration was on average about 3 times more than in the natural system, with higher values in the valley bottoms with deep Vertisols. Linked with this process, large concentration of Chloride originating from rain was found only in these areas. At the catchment scale, about 60 percent of the Chloride found in groundwater originates from fertilizer inputs. These results show that Potassium fertilization as KCl is an important source of groundwater salinization in semi-arid context, and stress that identifying dominant drivers is crucial for designing efficient mitigation policies.

#Agriculture & Gardening
Field # Agriculture & Gardening
Updated 28 February 2020

#11

 

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Nature-based tourism (NBT) is vulnerable to a rapid increase in visitors because natural resources are often open access. Market failure caused by over-exploitation of natural resources is an example of social dilemmas in common-pool resource systems. Game theory, which describes people’s decision making under conflicts, has been applied to the analysis of social dilemmas in NBT. However, previous studies use non-cooperative games assuming individualistic players and discuss the emergence of social dilemmas only in a limited situation. Here, we demonstrate, by developing a two-player non-cooperative game of wildlife viewing, that the traditional game-theoretic approach fails to find social dilemmas. By analysing the competition between tour operators (players) with different social value orientations (SVOs), we found that concentration of tours becomes a Pareto-inefficient Nash equilibrium (PINE) when both players are competitive. Whether the wildlife-viewing market is a Prisoner’s dilemma depends on players’ SVOs. Furthermore, we found that fair punishment on competitive players promotes rather than suppresses the emergence of PINE. Our results suggest that the diversity of SVOs is an essential factor in understanding social dilemmas in NBT.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 28 February 2020

#12

 

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Handling of submicron-sized objects is important in many biochemical and biomedical applications, but few methods today can precisely manipulate this range of particles. We present gradient acoustic focusing that enables flow-through particle separation of submicron particles and cells and we apply it for separation of bacteria from blood lysate to facilitate their detection in whole blood for improved diagnostics. To control suspended objects below the classical 2µm size limit for acoustic focusing, we introduce a co-flowing acoustic impedance gradient to generate a stabilizing acoustic volume force that supresses acoustic streaming. The method is validated theoretically and experimentally using polystyrene particles, Staphylococcus aureus, Streptococcus pneumoniae and Escherichia coli. The applicability of the method is demonstrated by the separation of bacteria from selectively chemically lysed blood. Combined with downstream operations, this new approach opens up for novel methods for sepsis diagnostics.

#Hardware & Devices
Field # Hardware & Devices
Updated 28 February 2020

#13

 

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Methylation of lysine residues in histone proteins is catalyzed by S-adenosylmethionine (SAM)-dependent histone lysine methyltransferases (KMTs), a genuinely important class of epigenetic enzymes of biomedical interest. Here we report synthetic, mass spectrometric, NMR spectroscopic and quantum mechanical/molecular mechanical (QM/MM) molecular dynamics studies on KMT-catalyzed methylation of histone peptides that contain lysine and its sterically demanding analogs. Our synergistic experimental and computational work demonstrates that human KMTs have a capacity to catalyze methylation of slightly bulkier lysine analogs, but lack the activity for analogs that possess larger aromatic side chains. Overall, this study provides an important chemical insight into molecular requirements that contribute to efficient KMT catalysis and expands the substrate scope of KMT-catalyzed methylation reactions.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#14

 

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The macroscopic properties of advanced engineering and functional materials are highly dependent on their overall grain orientation distribution, size, and morphology. Here we present Laue 3D neutron diffraction tomography providing reconstructions of the grains constituting a coarse-grained polycrystalline material. Reconstructions of the grain morphology of a highly pure Fe cylinder and a Cu cube sample are presented. A total number of 23 and 9 grains from the Fe and Cu samples, respectively, were indexed and reconstructed. Validation of the grain morphological reconstruction is performed by post-mortem EBSD of the Cu specimen.

#Construction
Field # Construction
Updated 28 February 2020

#15

 

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Campylobacter is the major bacterial agent of human gastroenteritis worldwide and represents a crucial global public health burden. Species differentiation of C. jejuni and C. coli and phylogenetic analysis is challenged by inter-species horizontal gene transfer. Routine real-time PCR on more than 4000 C. jejuni and C. coli field strains identified isolates with ambiguous PCR results for species differentiation, in particular, from the isolation source eggs. K-mer analysis of whole genome sequencing data indicated the presence of C. coli hybrid strains with huge amounts of C. jejuni introgression. Recombination events were distributed over the whole chromosome. MLST typing was impaired, since C. jejuni sequences were also found in six of the seven housekeeping genes. cgMLST suggested that the strains were phylogenetically unrelated. Intriguingly, the strains shared a stress response set of C. jejuni variant genes, with proposed roles in oxidative, osmotic and general stress defence, chromosome maintenance and repair, membrane transport, cell wall and capsular biosynthesis and chemotaxis. The results have practical impact on routine typing and on the understanding of the functional adaption to harsh environments, enabling successful spreading and persistence of Campylobacter.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#16

 

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The presence of a disease continuum in inflammatory arthritis (IA) is a recognised concept, with distinct stages from at-risk stage (presence of anti citrullinated-peptide autoantibody) to diagnosis of rheumatoid arthritis (RA), including therapy-induced remission. Despite T-cell dysregulation being a key feature of RA, there are few reports of T-cell phenotyping along the IA-continuum. We investigated the disturbances of naïve, regulatory and inflammation related cell (IRC) CD4+ T-cell subsets in 705 individuals across the IA-continuum, developing a simple risk-score (summing presence/absence of a risk-associated with a subset) to predict progression from one stage to the next. In 158 at-risk individuals, the 3 subsets had individual association with progression to IA and the risk-score was highly predictive (p < 0.0001). In evolving IA patients, 219/294 developed RA; the risk-score included naïve and/or Treg and predicted progression (p < 0.0001). In 120 untreated RA patients, the risk-score for predicting treatment-induced remission using naïve T-cells had an odds ratio of 15.4 (p < 0.0001). In RA patients in treatment-induced remission, a score using naïve T-cells predicted disease flare (p < 0.0001). Evaluating the risk of progression using naïve CD4+ T-cells was predictive of progression along the whole IA-continuum. This should allow identification of individuals at high-risk of progression, permitting targeted therapy for improved outcomes.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#17

 

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Several patients with thyroid cancer experience symptom distress after diagnosis and surgery. Data on the association between symptomatology and disease recurrence are limited. A retrospective review of a prospectively maintained database was performed, and 57 patients who had recurrence after operation of differentiated thyroid cancer were identified. Controlling for age, sex, surgery, and tumour stage, 114 patients without recurrent disease were selected by case-control matching. Subjective symptoms at follow-up visits were extracted from medical records and classified into three symptom clusters: pharyngolaryngeal, psychoneurological, and gastrointestinal. Compared to the control group, patients with recurrence had higher symptom totals in the pharyngolaryngeal (P < 0.001) and psychoneurological clusters (P = 0.005). Symptom score >3 yielded a sensitivity of 61.4% and a specificity of 80.7% to predict recurrence. Multivariate Cox regression analysis revealed that high symptom score (hazard ratio [HR] = 4.184), family history of thyroid cancer (HR = 2.463), and obesity (HR = 1.981) were independently associated with disease recurrence. Taken together, the likelihood of postoperative recurrence seemed to increase with high self-perceived symptom burden, family history, and obesity in patients with thyroid cancer. The results could be applied to the recurrence surveillance and symptomatic management of thyroid cancer post-operation.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#18

 

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The explosion of network science has permitted an understanding of how the structure of social networks affects the dynamics of social contagion. In community-based interventions with spill-over effects, identifying influential spreaders may be harnessed to increase the spreading efficiency of social contagion, in terms of time needed to spread all the largest connected component of the network. Several strategies have been proved to be efficient using only data and simulation-based models in specific network topologies without a consensus of an overall result. Hence, the purpose of this paper is to benchmark the spreading efficiency of seeding strategies related to network structural properties and sizes. We simulate spreading processes on empirical and simulated social networks within a wide range of densities, clustering coefficients, and sizes. We also propose three new decentralized seeding strategies that are structurally different from well-known strategies: community hubs, ambassadors, and random hubs. We observe that the efficiency ranking of strategies varies with the network structure. In general, for sparse networks with community structure, decentralized influencers are suitable for increasing the spreading efficiency. By contrast, when the networks are denser, centralized influencers outperform. These results provide a framework for selecting efficient strategies according to different contexts in which social networks emerge.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 28 February 2020

#19

 

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The injection of low-salinity brine enhances oil recovery by altering the mineral wettability in carbonate reservoirs. However, the reported effectiveness of low-salinity water varies significantly in the literature, and the underlying mechanism of wettability alteration is controversial. In this work, we investigate the relationships between characteristics of crude oils and the oils’ response to low-salinity water in a spontaneous imbibition test, aiming (1) to identify suitable indicators of the effectiveness of low-salinity water and (2) to evaluate possible mechanisms of low-salinity–induced wettability alteration, including rock/oil charge repulsion and microdispersion formation. Seven oils are tested by spontaneous imbibition and fully characterized in terms of their acidity, zeta potential, interfacial tension, microdispersion propensity, water-soluble organics content and saturate-aromatic-resin-asphaltene fractionation. For the first time, the effectiveness of low-salinity water is found to positively correlate with the oil interfacial tension in low-salinity water. Oils with higher interfacial activity are found to respond more positively to low-salinity water. Moreover, cryogenic transmission electron microscopy images suggest that microdispersion is essentially macroemulsion, and its formation is an effective indicator – but not the root cause – of wettability alteration. The repulsive zeta potential for the rock and the oil in low-salinity water is found to be an insufficient condition for wettability alteration in carbonate minerals.

#Chemicals
Field # Chemicals
Updated 28 February 2020

#20

 

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Chain elongation is a microbial process in which an electron donor, such as ethanol, is used to elongate short chain carboxylic acids, such as acetic acid, to medium chain carboxylic acids. This metabolism has been extensively investigated, but the spread and differentiation of chain elongators in the environment remains unexplored. Here, chain elongating communities were enriched from several inocula (3 anaerobic digesters, 2 animal faeces and 1 caproic acid producing environment) using ethanol and acetic acid as substrates at pH 7 and 5.5. This approach showed that (i) the inoculum’s origin determines the pH where native chain elongators can grow; (ii) pH affects caproic acid production, with average caproic acid concentrations of 6.4 ± 1.6  g·L−1 at pH 7, versus 2.3 ± 1.8  g·L−1 at pH 5.5; however (iii) pH does not affect growth rates significantly; (iv) all communities contained a close relative of the known chain elongator Clostridium kluyveri; and (v) low pH selects for communities more enriched in this Clostridium kluyveri-relative (57.6 ± 23.2% at pH 7, 96.9 ± 1.2% at pH 5.5). These observations show that ethanol-consuming chain elongators can be found in several natural and engineered environments, but are not the same everywhere, emphasising the need for careful inoculum selection during process development.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#21

 

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Neuromuscular impairment requires adherence to a rehabilitation regimen for maximum recovery of motor function. Consumer-grade game controllers have emerged as a viable means to relay supervised physical therapy to patients’ homes, thereby increasing their accessibility to healthcare. These controllers allow patients to perform exercise frequently and improve their rehabilitation outcomes. However, the non-universal design of game controllers targets healthy people and does not always accommodate people with disability. Consequently, many patients experience considerable difficulty assuming certain hand postures and performing the prescribed exercise correctly. Here, we explore the feasibility of improving rehabilitation outcomes through a 3D printing approach that enhances off-the-shelf game controllers in home therapy. Specifically, a custom attachment was 3D printed for a commercial haptic device that mediates fine motor rehabilitation. In an experimental study, 25 healthy subjects performed a navigation task, with the retrofit attachment and without it, while simulating disability of the upper limb. When using the attachment, subjects extended their wrist range of motion, yet maintained their level of compensation. The subjects also showed higher motivation to repeat the exercise with the enhanced device. The results bring forward evidence for the potential of this approach in transforming game controllers toward targeted interventions in home therapy.

#3-D printing
Field # 3-D printing
Updated 28 February 2020

#22

 

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Oxazole has critical roles not only in heterocycle (bio)chemistry research, but also as the backbone of many active natural and medicinal species. These diverse and specialised functions can be attributed to the unique physicochemical properties of oxazole. This contribution investigates the reaction of oxazole and its derivatives with singlet oxygen, employing density functional theory DFT-B3LYP calculations. The absence of allylic hydrogen in oxazole eliminates the ene-mode addition of singlet oxygen to the aromatic ring. Therefore, the primary reaction pathway constitutes the [4 + 2]-cycloaddition of singlet oxygen to oxazole ring, favouring an energetically accessible corridor of 57 kJ/mol to produce imino-anhydride which is postulated to convert to triamide end-product in subsequent steps. The pseudo-first-order reaction rate for substituted oxazole (e.g., 4-methyl-2,5-diphenyloxazole, 1.14 × 106 M−1 s−1) appears slightly higher than that of unsubstituted oxazole (0.94 × 106 M−1 s−1) considering the same initial concentration of the species at 300 K, due to the electronic effect of the functional groups. The global reactivity descriptors have justified the relative influence of the functional groups along with their respective physiochemical properties.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#23

 

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Studies on the expression of cellular glycans are limited by a lack of sensitive tools that can discriminate specific structural features. Here we describe the development of a robust platform using immunized lampreys (Petromyzon marinus), which secrete variable lymphocyte receptors called VLRBs as antibodies, for generating libraries of anti-glycan reagents. We identified a wide variety of glycan-specific VLRBs detectable in lamprey plasma after immunization with whole fixed cells, tissue homogenates, and human milk. The cDNAs from lamprey lymphocytes were cloned into yeast surface display (YSD) libraries for enrichment by multiple methods. We generated VLRB-Ig chimeras, termed smart anti-glycan reagents (SAGRs), whose specificities were defined by microarray analysis and immunohistochemistry. 15 VLRB antibodies were discovered that discriminated between linkages, functional groups and unique presentations of the terminal glycan motif. The development of SAGRs will enhance future studies on glycan expression by providing sequenced, defined antibodies for a variety of research applications. Tanya McKitrick et al. develop a platform for generating libraries of anti-glycan reagents using immunized lampreys. They identify 15 glycan-specific lymphocyte receptor antibodies that can distinguish between different functional groups of the terminal glycan motif.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#24

 

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Storing very large amounts of data and delivering them to researchers in an efficient, verifiable, and compliant manner, is one of the major challenges faced by health care providers and researchers in the life sciences. The electronic health record (EHR) at a hospital or clinic currently functions as a silo, and although EHRs contain rich and abundant information that could be used to understand, improve, and learn from care as part learning health system access to these data is difficult, and the technical, legal, ethical, and social barriers are significant. If we create a microservice ecosystem where data can be accessed through APIs, these challenges become easier to overcome: a service-driven design decouples data from clients. This decoupling provides flexibility: different users can write in their preferred language and use different clients depending on their needs. APIs can be written for iOS apps, web apps, or an R library, and this flexibility highlights the potential ecosystem-building power of APIs. In this article, we use two case studies to illustrate what it means to participate in and contribute to interconnected ecosystems that powers APIs in a healthcare systems.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#25

 

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#Social & Corporation affairs;#Futurism
Field # Social & Corporation affairs
Updated 28 February 2020

#26

 

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Yoshida, Gowers et al. examined somatic mutations in normal lung epithelium to better understand the effects of tobacco smoking, and stopping smoking, on normal tissue biology and how these effects relate to lung cancer development.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#27

 

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Targeted delivery of a nanovaccine loaded with a tumor antigen and adjuvant to the lymph nodes (LNs) is an attractive approach for improving cancer immunotherapy outcomes. However, the application of this technique is restricted by the paucity of suitable tumor-associated antigens (TAAs) and the sophisticated technology required to identify tumor neoantigens. Here, we demonstrate that a self-assembling melittin-lipid nanoparticle (α-melittin-NP) that is not loaded with extra tumor antigens promotes whole tumor antigen release in situ and results in the activation of antigen-presenting cells (APCs) in LNs. Compared with free melittin, α-melittin-NPs markedly enhance LN accumulation and activation of APCs, leading to a 3.6-fold increase in antigen-specific CD8+ T cell responses. Furthermore, in a bilateral flank B16F10 tumor model, primary and distant tumor growth are significantly inhibited by α-melittin-NPs, with an inhibition rate of 95% and 92%, respectively. Thus, α-melittin-NPs induce a systemic anti-tumor response serving as an effective LN-targeted whole-cell nanovaccine. The bee venom melittin has anti-tumor properties but is unsuitable for therapeutic use on its own. Here, the authors generate melittin-nanoparticles and demonstrate that the nanoparticles reduce tumor growth and generate an anti-tumor immune response.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#28

 

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Name
Description
The interaction between immune cells and phosphatidylserine (PS) molecules exposed on the surface of apoptotic-tumor bodies, such as those induced by chemotherapies, contributes to the formation of an immunosuppressive tumor microenvironment (TME). Annexin A5 (AnxA5) binds with high affinity to PS externalized by apoptotic cells, thereby hindering their interaction with immune cells. Here, we show that AnxA5 administration rescue the immunosuppressive state of the TME induced by chemotherapy. Due to the preferential homing of AnxA5 to the TME enriched with PS+ tumor cells, we demonstrate in vivo that fusing tumor-antigen peptide to AnxA5 significantly enhances its immunogenicity and antitumor efficacy when administered after chemotherapy. Also, the therapeutic antitumor effect of an AnxA5-peptide fusion can be further enhanced by administration of other immune checkpoint inhibitors. Our findings support the administration of AnxA5 following chemotherapy as a promising immune checkpoint inhibitor for cancer treatment. AnnexinV has been shown to bind phosphatidylserine expressed by chemotherapy-induced apoptotic cells increasing their immunogeneicity. Here, the authors demonstrate in a preclinical tumor model that fusing tumor-antigen peptide to Annexin V enhances its efficacy when administered after chemotherapy and with other immune checkpoint inhibitors.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#29

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#30

 

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Name
Description
In genome-wide association studies (GWAS), variants showing consistent effect directions across populations are considered as true discoveries. We model this information in an Effect Direction MEta-analysis (EDME) to quantify pleiotropy using GWAS of 34 Cholesky-decorrelated traits in 44,000+ cattle with sequence variants. The effect-direction agreement between independent bull and cow datasets was used to quantify the false discovery rate by effect direction (FDRed) and the number of affected traits for prioritised variants. Variants with multi-trait p < 1e–6 affected 1∼22 traits with an average of 10 traits. EDME assigns pleiotropic variants to each trait which informs the biology behind complex traits. New pleiotropic loci are identified, including signals from the cattle FTO locus mirroring its bystander effects on human obesity. When validated in the 1000-Bull Genome database, the prioritized pleiotropic variants consistently predicted expected phenotypic differences between dairy and beef cattle. EDME provides robust approaches to control GWAS FDR and quantify pleiotropy. Xiang et al. developed an Effect Direction Meta-analysis (EDME) approach to identify true pleiotropy. They used Cholesky-transformation to decorrelate the traits and identified many pleiotropic variants that consistently predicted phenotypic differences in cattle.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#31

 

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Name
Description
Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar ‘Canthatch’ suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-sorted chromosomes, mutagenesis, and map-based cloning. The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryotes that regulates expression of protein-coding genes. Nonsense mutations in Med15b.D result in expression of stem rust resistance. Time-course RNAseq analysis show a significant reduction or complete loss of differential gene expression at 24 h post inoculation in med15b.D mutants, suggesting that transcriptional reprogramming at this time point is not required for immunity to stem rust. Suppression is a common phenomenon and this study provides novel insight into suppression of rust resistance in wheat. Stem rust is an important disease of wheat and resistance present in some cultivars can be suppressed by the SuSr-D1 locus. Here the authors show that SuSr-D1 encodes a subunit of the Mediator Complex and that nonsense mutations are sufficient to abolish suppression and confer stem rust resistance.

#Software
Field # Software
Updated 28 February 2020

#32

 

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Name
Description


#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#33

 

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Name
Description
The coherent light source is one of the most important foundations in both optical physics studies and applied photonic devices. However, the whispering gallery microcavity, as a prime platform for novel light sources, has the intrinsically chiral symmetry and severely rules out access to directional light output, all-optical flip-flops, efficient light extraction, etc. Here, we demonstrate a reconfigurable symmetry-broken microlaser in an ultrahigh-Q whispering gallery microcavity with the symmetric structure, in which a chirality of lasing field is empowered spontaneously by the optical nonlinear effect. Experimentally, the ratio of counter-propagating lasing intensities is found to exceed 160:1, and the chirality can be controlled dynamically and all-optically by the bias in the pump direction. This work not only presents a distinct recipe for coherent light sources with robust and reconfigurable performance, but also opens up an unexplored avenue to symmetry-broken physics in optical micro-structures. The directional lasing emission in whispering gallery microcavities typically resorts to breaking the structure symmetry. Here the authors demonstrate a reconfigurable symmetry-broken microlaser in a symmetric ultrahigh-Q whispering gallery microcavity, in which a chirality of lasing fields is empowered spontaneously by nonlinear effects.

#Hardware & Devices;#Laser
Field # Hardware & Devices
Updated 28 February 2020

#34

 

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Name
Description
Extraterrestrial iron sulfide is a major mineral reservoir of the cosmochemically and astrobiologically important elements iron and sulfur. Sulfur depletion on asteroids is a long-standing, yet unresolved phenomenon that is of fundamental importance for asteroid evolution and sulfur delivery to the Earth. Understanding the chemistry of such environments requires insight into the behavior of iron sulfides exposed to space. Here we show that troilite (FeS) grains recovered from the regolith of asteroid 25143 Itokawa have lost sulfur during long-term space exposure. We report the wide-spread occurrence of metallic iron whiskers as a decomposition product formed through irradiation of the sulfide by energetic ions of the solar wind. Whisker growth by ion irradiation is a novel and unexpected aspect of space weathering. It implies that sulfur loss occurs rapidly and, furthermore, that ion irradiation plays an important role in the redistribution of sulfur between solids and gas of the interstellar medium. The authors here investigate troilite (FeS) grains recovered from the regolith of asteroid Itokawa. Finding wide-spread occurrence of metallic iron whiskers, the authors suggest them to be a decomposition product formed through irradiation of the sulfide by energetic ions of the solar wind.

#Astronautics
Field # Astronautics
Updated 28 February 2020

#35

 

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Description
Mi A3 users, your wait for latest Android 10 update is has gotten longer. In a tweet, Xiaomi India’s brand lead Sumit Sonal announced that the update has been delayed due to Coronavirus outbreak. He also informed that the update — that was scheduled to be rolled out in mid-February — doesn’t have final certification yet and the rollout plan will be communicated “very soon.”

#Gadgets
Field # Gadgets
Updated 28 February 2020

#36

 

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Description
The sudden announcement surprised everyone as Realme X50 Pro runs on Snapdragon 865 SoC which, as per Qualcomm’s website, does not support NavIC.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#37

 

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Name
Description
E-commerce marketplaces including Snapdeal, Amazon and Flipkart have approached the government through industry body Ficci seeking a reversal of the budget proposal.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 28 February 2020

#38

 

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Name
Description
With the crucial meeting of DCC likely to be held on Friday to discuss relief measures for the AGR-hit industry, VIL has made a strong push for setting off Rs 8,000 crore of GST credits and a three-year moratorium on payment of the remaining amount which should be staggered over 15 years at a simple interest rate of 6 per cent.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 28 February 2020

#39

 

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Description
Chinese smartphone manufacturer Vivo on Friday officially unveiled the third generation of its APEX concept smartphone - APEX 2020.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#40

 

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Name
Description
Optimistic that China is slowly bringing the coronavirus outbreak in control, Apple CEO Tim Cook has hinted factories in China that manufacture its devices may open soon.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#41

 

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Name
Description
Google and Microsoft are now deciding to shift the production of their device es from China to Southeast Asia courtesy the outbreak of coronavirus.

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 28 February 2020

#42

 

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Name
Description
It is no surprise that Apple wants you to think that iPad Pro can replace your laptop. Last year the company announced iPadOS, a separate operating system for the tablet.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#43

 

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Name
Description
Amazon Holi Store offers up to 50% discounts on speakers and other mobile accessories.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#44

 

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Description
Amazon has barred more than 1 million products from sale in recent weeks that had inaccurately claimed to cure or defend against the coronavirus, the company said on Thursday.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 28 February 2020

#45

 

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Description
Amazon has emerged as the leader in the global smart speaker market not only in the fourth quarter of the 2019, but also in the entire year, as per the latest report by Canalys. In the fourth quarter, Amazon registered 15.6 million units shipments, capturing a 31.7% market share. Overall, in 2019, Amazon shipped 37.3 million units of smart speakers and garnered a 29.9% market share.

#Hardware & Devices
Field # Hardware & Devices
Updated 28 February 2020

#46

 

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Description
TBD

#Materials
Field # Materials
Updated 28 February 2020

#47

 

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Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 28 February 2020

#48

 

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Name
Description
TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#49

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#50

 

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Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 28 February 2020

#51

 

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Description
Internet search giant Baidu has warned the deadly coronavirus outbreak could drive revenues down in the first quarter, as it reported steady annual revenue growth.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#52

 

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Description
Stress or infection may prompt viruses hidden in our genome to stagger back to life, contributing to some cases of multiple sclerosis, diabetes and schizophrenia

#Archaeology & History
Field # Archaeology & History
Updated 28 February 2020

#53

 

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Description
A huge black hole in a distant galaxy caused the largest explosion we have ever seen, with the energy of 10 billion suns – and it isn't clear why it was so big

#Astronautics
Field # Astronautics
Updated 28 February 2020

#54

 

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Name
Description
A space flight start-up called Astra is about to attempt to launch two small rockets into orbit over a few weeks to win $12 million from the US military

#Astronautics
Field # Astronautics
Updated 28 February 2020

#55

 

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Description
Stranger Things, Black Mirror and Russian Doll are among the best science fiction shows to watch on Netflix at the moment

#Entertainments
Field # Entertainments
Updated 28 February 2020

#56

 

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Description
AN ANCIENT sword mislabelled as "medieval" was actually made around 5,000 years ago, experts claim. The well-aged weapon may be the world's oldest sword, and originates from eastern Turkey.

#Archaeology & History
Field # Archaeology & History
Updated 28 February 2020

#57

 

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Description
IS your iPhone battery life constantly running down? There are loads of ways to keep it alive for longer. We've rounded up some simple tips and hacks to improve your iPhone battery life today.

#Energy
Field # Energy
Updated 28 February 2020

#58

 

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Description
GRAND Theft Auto has always featured high-speed racing – but there's now a proper Formula One mode. Rockstar has added Open Wheel Racing, where players can whizz through a special event called the San Andreas Prix.

#Entertainments;#Games
Field # Entertainments
Updated 28 February 2020

#59

 

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Description
THOUSANDS of raunchy pictures and videos have leaked online from one of the world's biggest porn sites. The files, from adult subscription site OnlyFans, have been dumped into huge databases and shared across the internet by randy cyber crooks.

#Entertainments
Field # Entertainments
Updated 28 February 2020

#60

 

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Description
Vivo Apex 2020 is a new concept smartphone with no side bezels thanks to an extremely curved screen, and a rear camera with 5-7.5x continuous optical zoom.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#61

 

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Description
On Tuesday, the Supreme Court heard the case U.S. v. Sineneng-Smith, which could put the future of online immigration advocacy at risk.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 28 February 2020

#62

 

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Description
Geneva International Motor Show is likely to be cancelled following a ban of large-scale events in Swtizerland.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#63

 

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Description
Most ordinary matter is held together by an invisible subatomic glue known as the strong nuclear force — one of the four fundamental forces in nature, along with gravity, electromagnetism, and the weak force. The strong nuclear force is responsible for the push and pull between protons and neutrons

#Astronautics
Field # Astronautics
Updated 28 February 2020

#64

 

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Description
Ultrasonic waves don’t make a sound, but they can still activate Siri on your cellphone and have it make calls, take images or read the contents of a text to a stranger. All without the phone owner’s knowledge. Attacks on cell phones aren’t new, and researchers have previously shown that ultrason

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 28 February 2020

#65

 

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Description
About 1 million people in the United States have ulcerative colitis, a serious disease of the colon that has no cure and whose cause is obscure. Now, a study by Stanford University School of Medicine investigators has tied the condition to a missing microbe. The microbe makes metabolites that hel

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#66

 

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Description
Scientists around the world are interested in developing new materials to help people live more sustainable and healthy lives, but the quest to produce these materials requires detailed knowledge of the mysterious structures of the molecules they are made from. Designers want to replace wasteful pla

#Materials
Field # Materials
Updated 28 February 2020

#67

 

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Description
Twitter has become an important communication channel in times of emergency. The ubiquitousness of smartphones enables people to announce an emergency they’re observing in real-time. Because of this, more agencies are interested in programmatically monitoring Twitter (i.e. disaster relief organizat

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#68

 

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Description
University of Manchester researchers have made a leap forward in overcoming one of the biggest problems in membrane technology- membrane fouling. Membrane-based separations are essential for various processes, such as water filtration and oil and gas separation. The use of graphene and other 2D m

#Materials
Field # Materials
Updated 28 February 2020

#69

 

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Name
Description
New research from McMaster and McMaster Children’s Hospital shows that two out of three young mothers have at least one mental health problem. Researchers found that teen mothers have a much higher prevalence of mental health challenges than mothers aged 21 and older and teens who aren’t par

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#70

 

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Description
Want to look inside a deep, dark pit on Mars? The scientists and engineers from the NASA’s HiRISE Camera on board the Mars Reconnaissance Orbiter have done just that. From its orbit about 260 km (160 miles) above the surface, HiRISE can this camera can spot something as small as a dinner table, a

#Astronautics
Field # Astronautics
Updated 28 February 2020

#71

 

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Description
Researchers have used cryo-​electron microscopy to elucidate for the first time the structure and function of a very small enzyme embedded in cell membranes. This enzyme builds complex sugar trees that are subsequently attached to other membrane proteins. The findings could accelerate the developmen

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#72

 

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Description
During the life-cycle of FDA regulated products, FDA collects data from a diversity of sources including voluntary reports from healthcare providers and patients. While cause and effect are not always conclusive or relevant in these reports, valuable insights into the impact of regulated products on

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#73

 

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Description
Asthma is the most common chronic childhood disease and is the primary reason why children miss school or end up in hospital. New research from Simon Fraser University and the CHILD Cohort Study shows that frequent exposure to common household cleaning products can increase a child’s risk of

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#74

 

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A team of Northwestern University materials science researchers has developed a new method of viewing the dynamic motion of atoms in atomically thin 2D materials. Funded by the National Science Foundation, the imaging technique reveals the underlying cause behind the performance failure of MoS2,

#Materials
Field # Materials
Updated 28 February 2020

#75

 

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Scientists have devised new analytical tools to break down the enigmatic history of Mars’ atmosphere — and whether life was once possible there. A paper detailing the work was published in the journal Science Advances. It could help astrobiologists understand the alkalinity, pH and nitrogen conte

#Archaeology & History
Field # Archaeology & History
Updated 28 February 2020

#76

 

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SpaceLogistics LLC has achieved a first: it’s docked it’s maintenance satellite, called MEV-1, with another satellite in order to extend the life of the satellite. The docked pair will perform some check-ups, and if all goes well, MEV-1 will boost the client satellite to a higher orbit, extending it

#Astronautics
Field # Astronautics
Updated 28 February 2020

#77

 

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Description
Realme Band, the anticipated smart fitness band by the Chinese brand, will be available for purchase through a &ldquo;Hate-to-wait&rdquo; sale just after its official launch in India on March 5. The fitness band will come in at least three distinct colour options.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#78

 

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Description
Vodafone Idea has sought fixing minimum tariffs for mobile data at Rs. 35 per GB, which is about 7 time the current rate.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 28 February 2020

#79

 

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Data centre do not use so much energy as thought earlier, a new study titled &ldquo;Recalibrating global data center energy-use estimates&rdquo; found out.

#Astronautics
Field # Astronautics
Updated 28 February 2020

#80

 

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Description
Samsung Galaxy Z Flip, the second foldable smartphone from the company, went out of stock within minutes during its second sale in India on Friday.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#81

 

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Description
The Samsung Galaxy S10 Lite 512GB option will go on sale from March 1 i.e. Monday via retail stores, Samsung Opera House, Samsung e-shop and leading online portals. The phone comes in Prism White, Prism Black, and Prism Blue options.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#82

 

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Description
Samsung Galaxy Note 10 update size is said to be 260MB, and the security patch is at February 2020. The translated changelog suggests optimisations in facial recognition and full screen and navigation gestures.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#83

 

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Description
Redmi 8A Dual open sale in India has been announced through the Mi.com, though Amazon is also selling the smartphone.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#84

 

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Description
Realme X and Realme 5 Pro have started receiving Android 10 along with Realme UI in India. The new update brings various software optimisations.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#85

 

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Description
Realme 6 and Realme 6 Pro price in India have been leaked online. Both new Realme phones are said to start at Rs. 9,999.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#86

 

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Description
Red Magic 5G by Nubia will have a unique looking design and will sport a 144Hz display. It is capable of running Real Racing 3 at full 144fps, and others at higher frame rates as well, which is great news for gamers.

#Telecommunications
Field # Telecommunications
Updated 28 February 2020

#87

 

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Description
HTC Wildfire R70, a new smartphone from the Taiwanese company, has been listed on its India website ahead of an official announcement. It is the first new smartphone from the company in 2020.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#88

 

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Telecom companies in India need to implement stringent preventive and punitive measures to counter the menace of online frauds executed through spam SMS or calls, a top Paytm Payments Bank (PPB) executive said on Thursday.

#Social & Corporation affairs;#Finance
Field # Social & Corporation affairs
Updated 28 February 2020

#89

 

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Netflix has silently upgraded the Rs. 199 &ldquo;mobile&rdquo; and the Rs. 499 &ldquo;basic&rdquo; plans to high-definition (HD) video quality in a new test in India. For the geeks out there, that means 720p.

#Entertainments
Field # Entertainments
Updated 28 February 2020

#90

 

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Description
Instagram has released a Progressive Web App (PWA) on the Microsoft Store for Windows 10 users. The app is available as an update and comes with direct messaging features.

#Medicine & Human body;#Aging
Field # Medicine & Human body
Updated 28 February 2020

#91

 

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Description
Vivo has revealed the APEX 2020 concept device and it does bring a few new features for Vivo's future flagship phones. 

#Gadgets
Field # Gadgets
Updated 28 February 2020

#92

 

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Description
The Samsung Galaxy S10 Lite now has a higher memory capacity variant in India.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#93

 

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Description
TikTok is one of the most-downloaded apps in the world and has a humungous fan-following but the Reddit CEO doesn’t seem to be too impressed with the app

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 28 February 2020

#94

 

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The blast came from a supermassive black hole at the centre of a galaxy over 240 million years ago.

#Astronautics
Field # Astronautics
Updated 28 February 2020

#95

 

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Description
The supergiant star has been behaving strangely in recent months. Could it be about to go supernova?

#Astronautics
Field # Astronautics
Updated 28 February 2020

#96

 

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Description
Moose Toys will be introducing some competition for Sony’s Aibo later this year with Squeakee.

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 28 February 2020

#97

 

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Description
Fans of handheld gaming no longer have to rely on Nintendo to get their fix.

#Entertainments;#Games
Field # Entertainments
Updated 28 February 2020

#98

 

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Description
I dare you to say his name.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#99

 

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Description
Taxi drivers ask as one if this applies to cyclists.

#Construction
Field # Construction
Updated 28 February 2020

#100

 

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Name
Description
You still need to commit to a year of Disney+, though.

#Entertainments
Field # Entertainments
Updated 28 February 2020

#101

 

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Description
A wrongful termination lawsuit references a pattern of superior-sanctioned profiling.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 28 February 2020

#102

 

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Description
Lekaneleo roskellyae was discovered back in 1987 but was misidentified until a recent study.

#Archaeology & History
Field # Archaeology & History
Updated 28 February 2020

#103

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#104

 

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Description
So far, BG3 looks like a perfect blend of Bioware's original, Larian's modern touches.

#Entertainments;#Games
Field # Entertainments
Updated 28 February 2020

#105

 

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Description
Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances. In this study, we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells. SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1. Consistent with this, SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α. Notably, these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1. Finally, we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter. These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway. Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy, heart failure, and diabetic cardiomyopathy, our results point to SIRT3 as a potential target for treating these diseases.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#106

 

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Resistive random-access memory (ReRAM) devices based on halide perovskites have recently emerged as a new class of data storage devices, where the switching materials used in these devices have attracted extensive attention in recent years. Thus far, three-dimensional (3D) halide perovskites have been the most investigated materials for resistive switching memory devices. However, 3D-based memory devices display ON/OFF ratios comparable to those of oxide or chalcogenide ReRAM devices. In addition, perovskite materials are susceptible to exposure to air. Herein, we compare the resistive switching characteristics of ReRAM devices based on a quasi-two-dimensional (2D) halide perovskite, (PEA)2Cs3Pb4I13, to those based on 3D CsPbI3. Astonishingly, the ON/OFF ratio of the (PEA)2Cs3Pb4I13-based memory devices (109) is three orders of magnitude higher than that of the CsPbI3 device, which is attributed to a decrease in the high-resistance state (HRS) current of the former. This device also retained a high ON/OFF current ratio for 2 weeks under ambient conditions, whereas the CsPbI3 device degraded rapidly and showed unreliable memory properties after 5 days. These results strongly suggest that quasi-2D halide perovskites have potential in resistive switching memory based on their desirable ON/OFF ratio and long-term stability. A type of computer memory that stores data by changing the resistance of insulating crystals can be made more durable with organic chemical additives. Resistive memory devices constructed from inorganic crystals known as halide perovskites are inexpensive and have minimal power requirements. However, they can degrade quickly in humid conditions. Hyojung Kim from Seoul National University in South Korea and colleagues now report that these stability issues can be improved by sandwiching thin layers of aromatic hydrocarbons between halide perovskite crystals. The water-repelling nature of the organic molecules helps double the lifespan of the new hybrid compared to an unmodified halide perovskite device. In addition, the organic layers augment the differences between ‘ON’ and ‘OFF’ resistive memory states, making device operation more reliable. ReRAM devices based on halide perovskites have recently emerged as a new class of data storage device, where the switching materials used in these devices have attracted huge attention in recent years. In this study, we compare the resistive switching characteristics of ReRAM devices based on a quasi-2D halide perovskite, (PEA)2Cs3Pb4I13, to those based on 3D CsPbI3. Astonishingly, the ON/OFF ratio of the (PEA)2Cs3Pb4I13-based memory devices was much higher than that of the CsPbI3 device. Also this device retained a high ON/OFF current ratio for two weeks under ambient conditions, whereas the CsPbI3 device degraded rapidly and showed unreliable memory properties after five days. We strongly believe that quasi-2D halide perovskites have potential in resistive switching memory based on their high ON/OFF ratio and long-term stability.

#Hardware & Devices
Field # Hardware & Devices
Updated 28 February 2020

#107

 

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Description
The supramolecular self-assembly of a push-pull dye is investigated using scanning tunneling microscopy (STM) at the liquid–solid interface. The molecule has an indandione head, a bithiophene backbone and a triphenylamine–bithiophene moiety functionalized with two carboxylic acid groups as a tail. The STM images show that the molecules adopt an “L” shape on the surface and form chiral Baravelle spiral triangular trimers at low solution concentrations. The assembly of these triangular chiral trimers on the graphite surface results in the formation of two types of chiral Kagomé nanoarchitectures. The Kagomé-α structure is composed of only one trimer enantiomer, whereas the Kagomé-β structure results from the arrangement of two trimer enantiomers in a 1:1 ratio. These Kagomé lattices are stabilized by intermolecular O-H···O hydrogen bonds between carboxylic acid groups. These observations reveal that the complex structure of the push-pull dye molecule leads to the formation of sophisticated two-dimensional chiral Kagomé nanoarchitectures. The subsequent deposition of coronene molecules leads to the disappearance of the Kagomé-β structure, whereas the Kagomé-α structure acts as the host template to trap the coronene molecules. A thin film that spontaneously forms into complex geometric patterns can undergo molecular recognition interactions helpful for sensing small molecules. A team led by Xinrui Miao from the South China University of Technology in Guangzhou and Fabien Silly at the Université Paris-Saclay in Gif sur Yvette, France, used scanning tunneling microscopy to understand how photoactive dyes commonly used in organic solar cells self-organize into assemblies. The team first modified the dyes with carboxylic acids, giving them a spiral structure and enhanced hydrogen bonding capabilities. Atomic-scale imaging of the molecules on graphite revealed that at certain concentrations, groups of dyes could lock together into triangular tiles. In turn, the tiles connected into symmetric lattices containing nanoscale pores. Certain lattices could trap aromatic hydrocarbons within their hexagonal pores. Push-pull dye molecules self-assemble into two 2D Kagomé nanoarchitectures composed of a single or two chiral Baravelle spiral triangular trimer enantiomers. Only one of the two nanoarchitectures is able to trap coronene molecules.

#Materials
Field # Materials
Updated 28 February 2020

#108

 

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A new analysis suggests that 100,000 overdose deaths in the US due to unspecified drugs were actually caused by opioids – bringing the total death count to more than 450,000 people

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#109

 

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Description
A private satellite that’s low on fuel could survive five more years because another satellite has come to its rescue – a technique that could be used by future service spacecraft

#Astronautics
Field # Astronautics
Updated 28 February 2020

#110

 

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The Centres for Disease Control and Prevention has provided information about how the novel coronavirus could affect the US.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#111

 

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Description
TBD

#Entertainments;#Games
Field # Entertainments
Updated 28 February 2020

#112

 

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Description
Major depressive disorder with psychotic features (psychotic depression) is a severe disorder. Compared with other psychotic disorders such as schizophrenia, relatively few studies on the neurobiology of psychotic depression have been pursued. Neuroimaging studies investigating psychotic depression have provided evidence for distributed structural brain abnormalities implicating the insular cortex and limbic system. We examined structural brain networks in participants (N = 245) using magnetic resonance imaging. This sample included healthy controls (n = 159) and the largest cross-sectional sample of patients with remitted psychotic depression (n = 86) collected to date. All patients participated in the Study of Pharmacotherapy of Psychotic Depression II randomized controlled trial. We used a novel, whole-brain, data-driven parcellation technique—non-negative matrix factorization—and applied it to cortical thickness data to derive structural covariance networks. We compared patients with remitted psychotic depression to healthy controls and found that patients had significantly thinner cortex in five structural covariance networks (insular-limbic, occipito-temporal, temporal, parahippocampal-limbic, and inferior fronto-temporal), confirming our hypothesis that affected brain networks would incorporate cortico-limbic regions. We also found that cross-sectional depression and severity scores at the time of scanning were associated with the insular-limbic network. Furthermore, the insular-limbic network predicted future severity scores that were collected at the time of recurrence of psychotic depression or sustained remission. Overall, decreased cortical thickness was found in five structural brain networks in patients with remitted psychotic depression and brain-behavior relationships were observed, particularly between the insular-limbic network and illness severity.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#114

 

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More than 80% of the phones in the world are Android-based smartphones that are made by many big names like Samsung, Xiaomi, Oppo, Vivo, Realme, Google, and the list goes on and on.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#115

 

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Oppo has already confirmed it will launch its mid-range premium smartphone — Reno 3 Pro in India on March 2 in India

#Gadgets
Field # Gadgets
Updated 28 February 2020

#116

 

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Description
Facebook Inc said on Thursday it would cancel its annual developer conference due to fears over the coronavirus, as growing concerns about the economic impact of the global outbreak drove Wall Street to tumble for a sixth straight day.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#117

 

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As per the latest IDC Worldwide Quarterly Wearable Device Tracker, for the fourth quarter of 2019, Apple has again emerged at the top position in the truly wireless category after capturing a 43.1% market share.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#118

 

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To become eligible for the prize, participants must answer all five questions correctly. One wrong answer eliminates you from the quiz.

#Entertainments
Field # Entertainments
Updated 28 February 2020

#119

 

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The biggest explosion seen in the universe has been found. This record-breaking, gargantuan eruption came from a black hole in a distant galaxy cluster hundreds of millions of light years away. "In some ways, this blast is similar to how the eruption of Mt. St. Helens in 1980 ripped off the top o

#Astronautics
Field # Astronautics
Updated 28 February 2020

#120

 

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Researchers at Oak Ridge National Laboratory and the University of Tennessee achieved a rare look at the inner workings of polymer self-assembly at an oil-water interface to advance materials for neuromorphic computing and bio-inspired technologies. Results published in the Journal of the America

#Chemicals
Field # Chemicals
Updated 28 February 2020

#121

 

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Description
Mysterious object could be natural or human-made, more observations needed to tell the full story. Astronomers using the international Gemini Observatory, on Hawaii’s Maunakea, have imaged a very small object in orbit around the Earth, thought to be only a few meters across. According to Grigori

#Astronautics
Field # Astronautics
Updated 28 February 2020

#122

 

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Description
Riding on 4G consumption, the overall mobile data traffic in India increased by 47 percent in 2019 while average monthly data usage per user surpassed 11GB in December last year, a new report said on Thursday.

#Entertainments
Field # Entertainments
Updated 28 February 2020

#123

 

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Apple is set to launch a new version of its Smart Keyboard for the iPad Pro that will feature a built-in trackpad, according to a media report. The new accessory is said to be unveiled later this year.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#124

 

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Facebook on Thursday filed a federal lawsuit against oneAudience data intelligence firm over a tactic it used to gather information about users of social media platforms.

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 28 February 2020

#125

 

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Facebook said on Thursday it would cancel its annual developer conference due to fears over the coronavirus, as growing concerns about the economic impact of the global outbreak drove Wall Street to tumble for a sixth straight day.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#126

 

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Vivo has launched a new 5G phone - the Vivo Z6 5G. The latest Vivo offering packs a quad rear camera setup with a 48-megapixel main shooter, accompanied by dedicated wide-angle and macro cameras.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#127

 

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The Vivo V19 is teased to sport a 48-megapixel main rear camera, and a 32-megapixel front camera. The phone is teased to offer features like Super Night Selfie mode.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#128

 

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The first teaser shared on Weibo shows off Vivo Apex 2020&rsquo;s curved edges, with slightly tapered corners for better protection. The company has already teased that the edges are curved at an angle of 120 degrees. In the post, the company also confirms that the phone will be unveiled at 4pm local time (1.30pm IST).

#Gadgets
Field # Gadgets
Updated 28 February 2020

#129

 

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Responding to issues that several reviewers have discovered on the camera system of the newly launched Galaxy S20 Ultra smartphone, Samsung is readying an update to improve the camera.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#130

 

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The upcoming Realme 6 Pro smartphone seems to have surfaced on Geekbench, tipping key specifications ahead of launch next week. Realme 6 series launch is set for March 5, and the Chinese smartphone maker is hosting an event in New Delhi to unveil the Realme 6 and Realme 6 Pro.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#131

 

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Steven Seagal, the star of action movies including Above the Law and Out for Justice, has agreed to pay $314,000 to resolve charges of &quot;unlawfully touting&quot; a cryptocurrency offering, the US securities regulator said on Thursday.

#Software;#Finance
Field # Software
Updated 28 February 2020

#132

 

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Three more companies have joined the ever growing list of attendees to cancel their presence at GDC 2020. This time, Microsoft, Epic, and Unity have announced that they will withdraw from the event due to coronavirus risks.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#133

 

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Description
The Oppo A31 is powered by a MediaTek Helio P35 SoC and comes with three rear cameras.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#134

 

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Facebook on Thursday confirmed that it has called out its annual F8 developers conference due to the coronavirus outbreak.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#135

 

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Description
We can’t cover all the different ways you can do this, but we will point you towards some of our favourite solutions.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#136

 

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Through its competitive funding schemes and professional support, the Hong Kong Baptist University's Knowledge Transfer Office spurs open innovation in China’s Greater Bay Area.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#137

 

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HPV vaccine hesitancy in Japan could result in 5,000 additional deaths from the disease, a study by Japan and Australia scientists suggests.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#138

 

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Scientists in South Korea have demonstrated that graphene forms a hybrid layer with copper oxide to slow down further corrosion of copper metal.

#Materials
Field # Materials
Updated 28 February 2020

#139

 

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One of Singapore’s robotics pioneers, Professor Marcelo Ang Jr’s research promises to take driverless cars and personal robotic assistants outside the realm of imagination and into the mainstream.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#140

 

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Life on any planet faces numerous existential threats — including the possibility of the planet getting kicked out of its solar system altogether. One team of researchers ran the numbers and found that the Earth is safe from such a catastrophe — almost.

#Astronautics
Field # Astronautics
Updated 28 February 2020

#141

 

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Once upon a time, a small worm mucking about on the Cambrian seafloor did something really, really careless: it lost its legs.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#142

 

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The Vivo Apex 2020 would have been one of the most exciting phones at MWC 2020. It's a concept introducing several new pieces of tech, into a sleek new design.

#Gadgets
Field # Gadgets
Updated 28 February 2020

#143

 

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Invest in the GPU, CPU, display or storage? The trick is knowing exactly what you want to get out of it.

#Entertainments;#Games
Field # Entertainments
Updated 28 February 2020

#144

 

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Description
You may not want to read those terms of service, but you really should.

#Software
Field # Software
Updated 28 February 2020

#145

 

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Description
"It's pretty exhaustive. You gotta do that."

#Astronautics
Field # Astronautics
Updated 28 February 2020

#146

 

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Description
Radiomic features hold potential to improve prediction of disease-free survival (DFS) in triple-negative breast cancer (TNBC) and may show better performance if developed from TNBC patients. We aimed to develop a radiomics score based on MRI features to estimate DFS in patients with TNBC. A total of 228 TNBC patients who underwent preoperative MRI and surgery between April 2012 and December 2016 were included. Patients were temporally divided into the training (n = 169) and validation (n = 59) set. Radiomic features of the tumor were extracted from T2-weighted and contrast-enhanced T1- weighted MRI. Then a radiomics score was constructed with the least absolute shrinkage and selection operator regression in the training set. Univariate and multivariate Cox proportional hazards models were used to determine what associations the radiomics score and clinicopathologic variables had with DFS. A combined clinicopathologic-radiomic (CCR) model was constructed based on multivariate Cox analysis. The incremental values of the radiomics score were evaluated by using the integrated area under the receiver operating characteristic curve (iAUC) and bootstrapping (n = 1000). The radiomics score, which consisted of 5 selected MRI features, was significantly associated with worse DFS in both the training and validation sets (p = 0.002, p = 0.033, respectively). In both the training and validation set, the radiomics score showed comparable performance with the clinicopathologic model. The CCR model demonstrated better performance than the clinicopathologic model in the training set (iAUC, 0.844; difference in iAUC, p < 0.001) and validation set (iAUC, 0.765, difference in iAUC, p < 0.001). In conclusion, MRI-based radiomic features can improve the prediction of DFS when integrated with clinicopathologic data in patients with TNBC.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#147

 

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Sphincter-saving surgery (SSS) is the gold standard for rectal cancer surgery but results in a wide spectrum of bowel dysfunction. This study investigated the impact of colonic dysmotility on the incontinent form of bowel dysfunction. Bowel function of patients who received SSS with loop ileostomy for treating rectal cancer was reviewed retrospectively from June 2013 two August 2015 at a single hospital. Immediately after closure of a diverting stoma, patients were tested for the colonic transit time (CTT) using radiopaque markers. Bowel dysfunction at 6 and 12 months after SSS was measured as the severity of fecal incontinence according to the Cleveland Clinic Incontinence Score (CCIS) and the use of an anti-diarrheal drug. A short CTT for the left colonic segment was significantly associated with the high CCIS and use of an antidiarrheal agent at 6 months after sphincter preservation. However, the CTT didn’t correlate with the CCIS at 12 months after SSS. Rather, age and surgical method demonstrated a significant association. Colonic dysmotility after SSS appears to intensify fecal incontinence for a relatively short period. Its impact abates within a year.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#148

 

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Stevia rebaudiana (Bertoni) is one of a very few plant species that produce zero calorie, sweet compounds known as steviol glycosides (SG). SGs differ in their sweetness and organoleptic properties depending on the number and positioning of sugar groups on the core steviol backbone. There is great interest of modulating the SG profiles of the Stevia plant to enhance the flavor profile for a given application in the food and beverage industries. Here, we report a highly efficient Agrobacterium-mediated stable transformation system using axillary shoots as the initial explant. Using this system, we generated over 200 transgenic Stevia plants overexpressing a specific isoform of UGT76G1. By comparing the SG profiles among independent transgenic events, we demonstrated that altering UGT76G1 expression can change the ratios of specific SG species. Furthermore, using recombinant proteins produced in E. coli, we show that two closely related UGT76G1 isoforms differ in their substrate specificities, providing new insights into mechanisms underlying the diversity of SG profiles that are observed across Stevia germplasm. Finally, we found evidence suggesting that alternative and/or aberrant splicing may serve to influence the ability of the plant to produce functional UGT76G1 transcripts, and possibly produce enzyme variants within the plant.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#149

 

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Histone modifications govern chromatin structures and regulate gene expression to orchestrate cellular functions in the central nervous system, where neuronal cells are postmitotic and developmentally inactive, the functional and age-dependent changes also accumulate in the epigenetic states. Because the brain is composed of several types of cells, such as the neurons, glial cells, and vascular cells, the analysis of histone modifications using bulk brain tissue might obscure alterations specific to neuronal cells. Furthermore, among the various epigenetic traits, analysis of the genome-wide distribution of DNA methylation in the bulk brain is predominantly a reflection of DNA methylation of the non-neuronal cells, which may be a potential caveat of previous studies on neurodegenerative diseases using bulk brains. In this study, we established a method of neuron-specific ChIP-seq assay, which allows for the analysis of genome-wide distribution of histone modifications specifically in the neuronal cells derived from post-mortem brains. We successfully enriched neuronal information with high reproducibility and high signal-to-noise ratio. Our method will further facilitate the understanding of neurodegeneration.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#150

 

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During mung bean post-germination seedling growth, various metabolic and physiological changes occurred, leading to the improvement of its nutritional values. Here, transcriptomic and metabolomic analyses of mung bean samples from 6-hour, 3-day and 6-day after imbibition (6-HAI, 3-DAI, and 6-DAI) were performed to characterize the regulatory mechanism of the primary metabolites during the post-germination seedling growth. From 6-HAI to 3-DAI, rapid changes in transcript level occurred, including starch and sucrose metabolism, glycolysis, citrate cycle, amino acids synthesis, and plant hormones regulation. Later changes in the metabolites, including carbohydrates and amino acids, appeared to be driven by increases in transcript levels. During this process, most amino acids and monosaccharides kept increasing, and accumulated in 6-day germinated sprouts. These processes were also accompanied with changes in hormones including abscisic acid, gibberellin, jasmonic acid, indole-3-acetic acid, etc. Overall, these results will provide insights into molecular mechanisms underlying the primary metabolic regulation in mung bean during post-germination seedling growth.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#151

 

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Brown adipocytes coordinate systemic energy metabolism associated with the pathogenesis of obesity and related metabolic diseases including type 2 diabetes. We have previously reported chemical compound-induced brown adipocytes (ciBAs) converted from human dermal fibroblasts without using transgenes. In this study, to reveal a precise molecular mechanism underlying the direct conversion and human adipocyte browning, we developed serum-free brown adipogenic medium (SFBAM) with an optimized chemical cocktail consisting of Rosiglitazone, Forskolin, and BMP7. During the direct conversion, treatment with BMP7 enhanced Ucp1 expression rather than the conversion efficiency in the absence of BMP signalling inhibitors. Moreover, treatment with a TGF-β signalling pathway inhibitor was no longer required in the serum-free medium, likely because the TGF-β pathway was already suppressed. SFBAM and the chemical cocktail efficiently converted human dermal fibroblasts into ciBAs within four weeks. The ciBAs exhibited increased mitochondrial levels, elevated oxygen consumption rate, and a response to β-adrenergic receptor agonists. Thus the ciBAs converted by the serum-free medium and the chemical cocktail provide a novel model of human brown (beige) adipocytes applicable for basic research, drug screening, and clinical applications.

#Chemicals
Field # Chemicals
Updated 28 February 2020

#152

 

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In this work, the relationship between multiple solvent parameters and charge transfer index was analyzed by multi-factor multi-variate partial least squares regression (PLSR). The charge transfer of the molecule is visualized by the analysis of the excited state wave function. Hydrogen bond basicity and surface tension can significantly affect charge transfer by studying the solvation model parameters and charge transfer index. Finally, a method in which a solvent regulates charge transfer strength and migration length is proposed.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#153

 

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Contact interaction of neuronal cells with extracellular nanometric features can be exploited to investigate and modulate cellular responses. By exploiting nanogratings (NGs) with linewidth from 500 nm down to 100 nm, we here study neurite contact guidance along ultra-small directional topographies. The impact of NG lateral dimension on the neuronal morphotype, neurite alignment, focal adhesion (FA) development and YAP activation is investigated in nerve growth factor (NGF)-differentiating PC12 cells and in primary hippocampal neurons, by confocal and live-cell total internal reflection fluorescence (TIRF) microscopy, and at molecular level. We demonstrate that loss of neurite guidance occurs in NGs with periodicity below 400 nm and correlates with a loss of FA lateral constriction and spatial organization. We found that YAP intracellular localization is modulated by the presence of NGs, but it is not sensitive to their periodicity. Nocodazole, a drug that can increase cell contractility, is finally tested for rescuing neurite alignment showing mild ameliorative effects. Our results provide new indications for a rational design of biocompatible scaffolds for enhancing nerve-regeneration processes.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#154

 

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Hydrogen has the potential to play an important role in decarbonising our energy systems. Crucial to achieving this is the ability to produce clean sources of hydrogen using renewable energy sources. Currently platinum is commonly used as a hydrogen evolution catalyst, however, the scarcity and expense of platinum is driving the need to develop non-platinum-based catalysts. Here we report a protein-based hydrogen evolution catalyst based on a recombinant silk protein from honeybees and a metal macrocycle, cobalt protoporphyrin (CoPPIX). We enhanced the hydrogen evolution activity three fold compared to the unmodified silk protein by varying the coordinating ligands to the metal centre. Finally, to demonstrate the use of our biological catalyst, we built a proton exchange membrane (PEM) water electrolysis cell using CoPPIX-silk as the hydrogen evolution catalyst that is able to produce hydrogen with a 98% Faradaic efficiency. This represents an exciting advance towards allowing protein-based catalysts to be used in electrolysis cells.

#Energy
Field # Energy
Updated 28 February 2020

#155

 

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Waste biomass from γ-polyglutamic acid production was used as an adsorbent to remove Cr(VI) from wastewater. Waste biomass was entrapped in sodium alginate to enhance performance. Orthogonal array design was used to optimize biosorption of Cr(VI) by immobilized waste biomass. The optimal adsorption conditions for immobilized waste biomass were as follows: pH 7.0, initial Cr(VI) concentration of 200 mg/L, 35 °C, waste biomass of 2 g/L, 60 min. Under these conditions, the absorption efficiency of Cr(VI) was 96.38 ± 0.45%. When the waste biomass was treated with 1 mol/L HCl for 1 h, the desorption rate could reach 94.42 ± 0.87%. It was shown that the adsorption kinetics followed the Freundlich adsorption model, indicating that the adsorption of Cr(VI) by bacteria was mainly based on multi-molecular layer adsorption. The absorption conditions of waste biomass were mild (pH 6.0–7.5, 20–35 °C) and easily operated. These investigations lay a foundation for reducing the pollution of γ-polyglutamic acid production, turning the biomass waste into a useful adsorbent for wastewater treatment.

#Software
Field # Software
Updated 28 February 2020

#156

 

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We investigated the impact of acute kidney injury (AKI) in elderly deceased-donors (DDs) vs. AKI in young DDs on post-transplant clinical outcomes. A total of 709 kidney transplant recipients (KTRs) from 602 DDs at four transplant centers were enrolled. KTRs were divided into young-DDKT and elderly-DDKT groups according to the age of DD of 60 years. Both groups were subdivided into non-AKI-KT and AKI-KT subgroups according to AKI in DDs. We investigated short-term and long-term clinical outcomes of non-AKI-DDKT and AKI-DDKT subgroups within young-DDKT and elderly-DDKT groups. The incidence of DGF in the AKI-DDKT subgroup was higher and the allograft function within 12 months after KT in the AKI-DDKT subgroup was lower than those in the non-AKI-DDKT subgroup in both young-DDKT and elderly-DDKT groups. Death-censored allograft survival rate was significantly lower in the AKI-elderly-DDKT subgroup than that in the non-AKI-elderly-DDKT subgroup, but it did not differ between AKI-young-DDKT and non-AKI-young-DDKT subgroup. In multivariable analysis, AKI-elderly-DDKT was an independent risk factor for allograft failure (hazard ratio: 2.648, 95% CI: 1.170–5.994, p = 0.019) and a significant interaction between AKI and old age in DDs on allograft failure was observed (p = 0.001). AKI in elderly DDs, but not in young DDs, can significantly affect long-term allograft outcomes of KTRs.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#157

 

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The aim of this study was to investigate the test-retest reliability of quantitative sensory testing (QST) and mechanical sensitivity mapping of the periauricular skin. Twenty volunteers (10 men, 10 women) participated in two sessions at intervals of one week. Cold and warm detection threshold (CDT&WDT), cold and heat pain threshold (CPT&HPT), mechanical detection and pain threshold (MDT&MPT), pressure pain threshold (PPT) and two-point discrimination (2PD) were measured at five sites: bilateral subauricular and postauricular sites (LA, RA, LB, RB) and the dorsum of left hand (control). Pressure stimulation was applied at each of the four periauricular test sites. The test-retest reliability of the QST data implied fair to excellent agreement as evaluated by the intra-class correlation coefficients (ICC; all >0.4) for different days. There was no difference between each side in the QST parameters and mechanical sensitivity mapping (P ≥ 0.057). Significant differences between subauricular and postauricular sites were shown for WDT and PPT (P ≤ 0.028). NRS scores of mechanical sensitivity mapping showed significant effects of gender, site and point (P ≤ 0.040). QST and mechanical sensitivity mapping can be considered to be a reliable technique to assess somatosensory function of the periauricular skin.

#Hardware & Devices
Field # Hardware & Devices
Updated 28 February 2020

#158

 

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Bats are associated with several important zoonotic viruses from different families. One example includes adeno-associated viruses (AAVs), that are extensively detected in several animals, especially primates. To understand AAVs distribution and genetic diversity in the coastal areas of Southeast China, a total of 415 intestine samples were mostly collected from two provinces of southeast China, i.e., Zhejiang and Fujian province. Intestine samples from five bat species were collected for AAVs detection. The average prevalence rate for AAV detection among these samples was 18.6% (77 positives out of 415 samples) and ranged from 11.8 to 28.9% between the five bat species. This suggests that AAVs are widely distributed in diverse bat populations in southeast coastal areas of China. Based on the genome sequence of bat adeno-associated virus-CXC1(BtAAV-CXC1) from one AAV-positive sample, the genetic diversity of the detected AAVs were assessed and analyzed. Phylogenetic analysis revealed that BtAAV-CXC1 was comparatively distant to other major AAVs from mammals and non-mammals, with only a 52.9~64.7% nucleotide identity. However, they were phylogenetically closer to Rhinolophus sinicus bat adeno-associated virus (Rs-BtAAV1), with a 74.5% nt similarity. Partial analysis of the rep and cap overlapping open reading frame (ORF) sequences from bat AAV samples revealed 48 partial rep sequences and 23 partial cap sequences from positive samples shared 86.9 to 100% and 72.3 to 98.8% nucleotide identities among themselves, respectively. This suggests that the detected AAVs had a distinctly high genetic diversity. These findings led us to conclude that diverse AAVs may be widely distributed in bat populations from the southeast regions of China.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#159

 

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Acute invasive fungal rhinosinusitis (AIFRS) can spread beyond the sinonasal cavity. It is necessary to analyze the association between the specific site involved in the extrasinonasal area and the survival rate to predict patient prognosis. We investigated 50 patients who had extrasinonasal lesions on preoperative gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) scan and underwent wide surgical resection of AIFRS. The specific sites with loss of contrast enhancement (LoCE) on Gd-enhanced MRI were analyzed for AIFRS-specific survival rate. The most common underlying disease was diabetes mellitus followed by hematological malignancy. The most common symptoms were headache and facial pain. Seven patients (14.0%) expired because of AIFRS progression. Poor prognosis was independently associated with LoCE at the skull base on preoperative MRI (HR = 35.846, P = 0.004). In patients with AIFRS extending to the extrasinonasal area, LoCE at the skull base was an independent poor prognostic factor.

#Astronautics
Field # Astronautics
Updated 28 February 2020

#160

 

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Name
Description
The incidence of intervertebral disc (IVD) degeneration disease, caused by changes in the osmotic pressure of nucleus pulposus (NP) cells, increases with age. In general, low back pain is associated with IVD degeneration. However, the mechanism and molecular target of low back pain have not been elucidated, and there are no data suggesting specific biomarkers of low back pain. Therefore, the research aims to identify and verify the significant gene biomarkers of low back pain. The differentially expressed genes (DEGs) were screened in the Gene Expression Omnibus (GEO) database, and the identification and analysis of significant gene biomarkers were also performed with various bioinformatics programs. A total of 120 patients with low back pain were recruited. Before surgery, the degree of pain was measured by the numeric rating scale (NRS), which enables comparison of the pain scores from individuals. After surgery, IVD tissues were obtained, and NP cells were isolated. The NP cells were cultured in two various osmotic media, including iso-osmotic media (293 mOsm/kg H2O) to account for the morbid environment of NP cells in IVD degeneration disease and hyper-osmotic media (450 mOsm/kg H2O) to account for the normal condition of NP cells in healthy individuals. The relative mRNA expression levels of CCL5, OPRL1, CXCL13, and SST were measured by quantitative real-time PCR in the in vitro analysis of the osmotic pressure experiments. Finally, correlation analysis and a neural network module were employed to explore the linkage between significant gene biomarkers and pain. A total of 371 DEGs were identified, including 128 downregulated genes and 243 upregulated genes. Furthermore, the four genes (CCL5, OPRL1, SST, and CXCL13) were identified as significant gene biomarkers of low back pain (P < 0.001) based on univariate linear regression, and CCL5 (odds ratio, 34.667; P = 0.003) and OPRL1 (odds ratio, 19.875; P < 0.001) were significantly related to low back pain through multivariate logistic regression. The expression of CCL5 and OPRL1 might be correlated with low back pain in patients with IVD degeneration disease caused by changes in the osmotic pressure of NP cells.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#161

 

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Description
Encapsulated bioactive agents applied to the Lactuca sativa L. present an innovative approach to stimulate the production of plant secondary metabolites increasing its nutritive value. Calcium and copper ions were encapsulated in biopolymeric microparticles (microspheres and microcapsules) either as single agents or in combination with biocontrol agents, Trichoderma viride spores, a fungal plant growth mediator. Both, calcium and copper ions are directly involved in the synthesis of plant secondary metabolites and alongside, Trichoderma viride can provide indirect stimulation and higher uptake of nutrients. All treatments with microparticles had a positive effect on the enhancement of plant secondary metabolites content in Lactuca sativa L. The highest increase of chlorophylls, antioxidant activity and phenolic was obtained by calcium-based microparticles in both, conventionally and hydroponically grown lettuces. Non-encapsulated fungus Trichoderma viride enhanced the synthesis of plant secondary metabolites only in hydroponics cultivation signifying the importance of its encapsulation. Encapsulation proved to be simple, sustainable and environmentally favorable for the production of lettuce with increased nutritional quality, which is lettuce fortified with important bioactive compounds.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#162

 

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Description
Lipoyl synthases are key enzymes in lipoic acid biosynthesis, a co-factor of several enzyme complexes involved in central metabolism. Plant pyruvate dehydrogenase complex (PDH), located in mitochondria and plastids, catalyses the first step of fatty acid biosynthesis in these organelles. Among their different components, the E2 subunit requires the lipoic acid prosthetic group to be active. De novo lipoic acid biosynthesis is achieved by the successive action of two enzymes on octanoyl-ACP: octanoyltransferase (LIP2) and lipoyl synthase (LIP1). In this study, two plastidial lipoyl synthase genes from sunflower (Helianthus annuus L.) were identified (HaLIP1p1 and HaLIP1p2), sequenced and cloned in a heterologous production system (Escherichia coli). Gene expression studies revealed similar expression patterns for both isoforms, with a slight predominance of HaLIP1p1 in vegetative tissues and mature seeds. Tertiary structural models for these enzymes indicate they both have the same theoretical catalytic sites, using lipoyl-lys and 5-deoxyadenosine as docking substrates. The fatty acid profile of E. coli cells overexpressing HaLIP1p1 and HaLIP1p2 did not present major differences, and the in vivo activity of both proteins was confirmed by complementation of an E. coli JW0623 mutant in which lipoyl synthase is defective. Although no significant differences were detected in the total fatty acid composition of transgenic Arabidopsis thaliana seeds overexpressing any of both proteins, a lipidomic analysis revealed a redistribution of the glycerolipid species, accompanied with increased phosphatidylethanolamine (PE) content and a decrease in diacyglycerols (DAG) and phosphatidylcholine (PC). Depletion of the SAM co-factor caused by HaLIP1p1 and HaLIP1p2 overexpression in transgenic plants could explain this remodelling through its effects on PC synthesis.

#Sport & Camping
Field # Sport & Camping
Updated 28 February 2020

#163

 

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Name
Description
The production of “Laba” garlic is limited to the homemade method with long processing time and non-uniform color quality. Innovative food processing technologies including high hydrostatic pressure (HHP) and high pressure carbon dioxide (HPCD) were applied to the processing of “Laba” garlic. Products prepared at different treatment pressures (200, 350 and 500 MPa of HHP; 4, 7 and 10 MPa of HPCD) were compared by evaluating the texture, color, flavor and sensory qualities. The results indicated that HHP treatment at 200 MPa was optimal for retaining the textural quality of “Laba” garlic, which was mainly attributed to the compacted cells and the increased Ca2+-cross linked cell-cell adhesion. HHP had greater effect on facilitating the formation of the attractive green color of “Laba” garlic than HPCD. The flavor profiles of “Laba” garlic were modified after treatments, with pungent compounds decreased to non-detectable. The results from sensory study confirmed that “Laba” garlic treated by HHP at 200 MPa was most acceptable to consumers. Moreover, considering the treatment capacity and feasibility of commercialization, HHP would be a promising technology in production of “Laba” garlic with improved quality and efficiency.

#Chemicals
Field # Chemicals
Updated 28 February 2020

#164

 

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Name
Description
Primary motor cortex (M1) infarctions sometimes cause sensory impairment. Because sensory signals play a vital role in motor control, sensory impairment compromises the recovery and rehabilitation of motor disability. However, the neural mechanism of the sensory impairment is poorly understood. We show that sensory processing in mouse primary somatosensory cortex (S1) was impaired in the acute phase of M1 infarctions and recovered in a layer-specific manner in the subacute phase. This layer-dependent recovery process and the anatomical connection pattern from M1 to S1 suggested that functional connectivity from M1 to S1 plays a key role in the sensory processing impairment. A simulation study demonstrated that the loss of inhibition from M1 to S1 in the acute phase of M1 infarctions could impair sensory processing in S1, and compensation for the inhibition could recover the temporal coding. Consistently, the optogenetic activation of M1 suppressed the sustained response in S1. Taken together, we revealed how focal stroke in M1 alters the cortical network activity of sensory processing, in which inhibitory input from M1 to S1 may be involved.

#Hardware & Devices
Field # Hardware & Devices
Updated 28 February 2020

#165

 

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Name
Description
Streambeds are critical hydrological interfaces: their physical properties regulate the rate, timing, and location of fluxes between aquifers and streams. Streambed vertical hydraulic conductivity (Kv) is a key parameter in watershed models, so understanding its spatial variability and uncertainty is essential to accurately predicting how stresses and environmental signals propagate through the hydrologic system. Most distributed modeling studies use generalized Kv estimates from column experiments or grain-size distribution, but Kv may include a wide range of orders of magnitude for a given particle size group. Thus, precisely predicting Kv spatially has remained conceptual, experimental, and/or poorly constrained. This usually leads to increased uncertainty in modeling results. There is a need to shift focus from scaling up pore-scale column experiments to watershed dimensions by proposing a new kind of approach that can apply to a whole watershed while incorporating spatial variability of complex hydrological processes. Here we present a new approach, Multi-Stemmed Nested Funnel (MSNF), to develop pedo-transfer functions (PTFs) capable of simulating the effects of complex sediment routing on Kv variability across multiple stream orders in Frenchman Creek watershed, USA. We find that using the product of Kv and drainage area as a response variable reduces the fuzziness in selecting the “best” PTF. We propose that the PTF can be used in predicting the ranges of Kv values across multiple stream orders.

#Entertainments
Field # Entertainments
Updated 28 February 2020

#166

 

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Name
Description
Human cytomegalovirus (CMV) infections comprise a leading cause of newborn impairments worldwide and are pervasive concerns among the immunocompromised. Quantification of CMV viral loads is increasingly used to guide definitions of CMV disease but standardization of CMV quantitation remains problematic, mostly due to differences in qPCR amplicon sizes between clinical laboratories. Here, we used plasma cfDNA sequencing data from 2,208 samples sent for non-invasive prenatal aneuploidy screening to detect CMV and precisely measure the length of CMV fragments in human plasma. CMV reads were identified in 120 (5.4%) samples. Median cfDNA fragment size derived from CMV was significantly shorter than cfDNA derived from human chromosomes (103 vs 172 bp, p < 0.0001), corresponding to the 3rd percentile of human cfDNA. Sequencing of cfDNA from seven plasma samples from transplant patients positive for CMV confirmed the extraordinarily short nature of CMV cfDNA fragment size with a median length of 149 bp. We further show that these high-resolution measurements of CMV DNA fragment size accurately predict measured discrepancies in serum viral load measurements by different qPCR assays. These results highlight the exceptionally fragmented nature of CMV cfDNA and illustrate the promise of plasma cfDNA sequencing for quantitating viral loads through detection of fragments that would be unrecoverable by qPCR.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#167

 

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Name
Description
We study the spin-orbit interaction of two-dimensional electron/hole gas (2DEGs/2DHGs) on quasi-2D potassium niobates (KNs) via first-principles calculations. The strong surface polarity changes the free surface states from 2DEGs to 2DHGs. The in-plane dipole maintained on 2D models leads to giant Zeeman-type spin splitting, as high as 566 meV for the (001)c facet KN and 1.21 eV for the (111)c facet KN. The thickness-dependent Zeeman-type spin splitting shows a linear relation with respect to 1/r, while the corresponding in-plane polarization quantum has a linear relation of 1/(2^0.5)with respect to a decrease in thickness. Interestingly, the 2DHGs with molecular-like orbital character is solely constituted by O 2p states, showing logic switchable behavior at extremely thin samples with enormous Zeeman-type splitting that can switch between insulator and conductor by opposite spin polarization.

#Social & Corporation affairs;#Futurism
Field # Social & Corporation affairs
Updated 28 February 2020

#168

 

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Name
Description
Corpora lutea (CL) are transient endocrine glands supporting pregnancy by progesterone production. They develop at the site of ovulation from the remaining follicle, are highly metabolically active and undergo distinct, transformative processes during their lifetime. In contrast to other species, CL of lynxes do not regress at the end of cycle, but remain functionally active (persist) for years. Reactive oxygen species (ROS) and anti-oxidative enzymes are described to be important for the functionality of CL. We examined ten anti-oxidative enzymes in fresh and persistent CL of lynxes as well as in domestic cat CL of different luteal stages. The gene expression profiles, especially those of SOD1 and SOD2, showed some remarkable differences between CL stages during non-pregnant and pregnant cycles of domestic cats and between fresh and persistent CL of lynxes. Lynx gene expression profiles of SODs were confirmed by western blot analysis, immunohistochemistry and activity assays. SOD2 was characterized by a conspicuous high expression and enzyme activity exclusively in persistent CL. We suggest that SOD2 is required to detoxify potential elevated superoxide anion levels by producing H2O2 in the physiologically persistent CL. This product might also act as a signaling molecule, securing the CL from apoptosis and insuring long-term luteal cell survival.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#169

 

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Name
Description
Th17 cells are critical drivers of autoimmune diseases and immunopathology. There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. Here, we report that anxiolytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vitro and in vivo using the experimental autoimmune encephalomyelitis (EAE) model of Th17 cell-driven pathology. Remarkably, we found that the effects of FGIN-1-27 were independent of translocator protein (TSPO), the reported target for this small molecule, and instead were driven by a metabolic switch in Th17 cells that led to the induction of the amino acid starvation response and altered cellular fatty acid composition. Our findings suggest that the small molecule FGIN-1-27 can be re-purposed to relieve autoimmunity by metabolic reprogramming of pathogenic Th17 cells.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#170

 

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Name
Description
Cowpea, Vigna unguiculata (L.) Walp. is an important grain legume grown in the dry agro-ecologies of the tropics with considerably low yield due to lack of improved varieties, aggravated by prevalent narrow genetic base. Thus, induced mutagenesis was employed using sodium azide and gamma rays to increase genetic variability in cowpea genotypes that resulted in isolation of eleven high yielding mutant lines at the M4 generation from the genetic background of cowpea varieties Gomati VU-89 and Pusa-578. In order to analyze the induced genetic divergence among the mutant lines and parent genotypes, biochemical and molecular characterization was carried out with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), simple sequence repeat (SSR) and CAAT box derived polymorphism (CBDP) markers. Activity of nitrate reductase (NR) and content of chlorophyll, carotenoid, protein and mineral were found to be significantly high in the selected mutant lines compared to their respective parent genotypes. SDS-PAGE profile of seed proteins generated 54 and 28 polymorphic bands and a total polymorphism of 62.06 and 41.17% in Gomati VU-89 and Pusa-578, respectively. SSR primers amplified a total of 16 and 24 polymorphic bands with an average polymorphism of 20.69 and 50.74% in Gomati VU-89 and Pusa-578, respectively. CBDP markers, used for the first time in mutagenized population, generated 175 bands with 77 bands being polymorphic in Gomati VU-89 and 121 bands with 59 bands being polymorphic in Pusa-578. Physiological, biochemical and molecular profiling of the selected promising mutants lines showed that Gomati VU-89-G and Pusa-578-C are genetically most diverged high yielding genotypes with significant increase in protein and micronutrient content, therefore, could be recommended for further research considerations. Thus, the favorable combination of genes induced in the novel cowpea mutants selected through the present study are valuable to correspond farmers requirements for new improved cultivars (direct or hybrids).

#Chemicals
Field # Chemicals
Updated 28 February 2020

#171

 

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Name
Description
Situs inversus (SI), a left-right mirror reversal of the visceral organs, can occur with recessive Primary Ciliary Dyskinesia (PCD). However, most people with SI do not have PCD, and the etiology of their condition remains poorly studied. We sequenced the genomes of 15 people with SI, of which six had PCD, as well as 15 controls. Subjects with non-PCD SI in this sample had an elevated rate of left-handedness (five out of nine), which suggested possible developmental mechanisms linking brain and body laterality. The six SI subjects with PCD all had likely recessive mutations in genes already known to cause PCD. Two non-PCD SI cases also had recessive mutations in known PCD genes, suggesting reduced penetrance for PCD in some SI cases. One non-PCD SI case had recessive mutations in PKD1L1, and another in CFAP52 (also known as WDR16). Both of these genes have previously been linked to SI without PCD. However, five of the nine non-PCD SI cases, including three of the left-handers in this dataset, had no obvious monogenic basis for their condition. Environmental influences, or possible random effects in early development, must be considered.

#Medicine & Human body
Field # Medicine & Human body
Updated 28 February 2020

#172

 

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Name
Description
The response of biological communities to human disturbances depends on factors acting at local and regional scale and on the interaction between them. We compared the response of native forest dung beetle communities to cattle grazing under regional contexts differing on precipitation patterns (Atlantic forest and humid and dry Chaco). Through multivariate and GLMM analyses we contrasted richness and composition across regions and land uses and explored the role of local and regional variables accounting for those changes. We captured a total of 44101 individuals of 109 species. The interaction between local and regional variables influenced the response to livestock management. In the two wet regions (humid Chaco and Atlantic forest) diversity was similar in the native forest regardless of cattle presence but differs strongly in open pastures. In contrast, in the dry Chaco, differences between native forest and land use were not evident. Vegetation structure was a major determinant of species richness, whereas regional climate determined differences in species composition. We concluded that the response of dung beetles to livestock management cannot be generalized for all biomes. In dry ecosystems, dung beetles are probably pre-adapted to environmental conditions imposed by cattle ranching whereas in wet ecosystems the impact of cattle ranching is more significant.

#Theoretical sciences
Field # Theoretical sciences
Updated 28 February 2020

#173

 

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Description
The black and gold howler monkey (Alouatta caraya) is a neotropical primate threatened by habitat loss and capture for illegal trade in Argentina. Using multilocus microsatellite genotypes from 178 A. caraya individuals sampled from 15 localities in Argentina, we built a genotype reference database (GRDB). Bayesian assignment methods applied to the GRDB allowed us to correctly re-assign 73% of individuals to their true location of origin and 93.3% to their cluster of origin. We used the GRDB to assign 22 confiscated individuals (17 of which were reintroduced), and 3 corpses to both localities and clusters of origin. We assigned with a probability >70% the locality of origin of 14 individuals and the cluster of origin of 21. We found that most of the confiscated individuals were assigned to one cluster (F-Ch-C) and two localities included in the GRDB, suggesting that trafficked A. caraya primarily originated in this area. Our results reveal that only 4 of 17 reintroduced individuals were released in sites corresponding to their cluster of origin. Our findings illustrate the applicability of genotype databases for inferring hotspots of illegal capture and for guiding future reintroduction efforts, both of which are essential elements of species protection and recovery programs.

#Environment & Nature
Field # Environment & Nature
Updated 28 February 2020

#174

 

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Name
Description
Google is all set to bring another piece of smart clothing for its users. This time the company has decided to team up with Adidas and Electronic Arts for smart clothing.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#175

 

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Name
Description
Facebook Inc said on Wednesday it would ban advertisements for products offering any cures or prevention around the coronavirus outbreak, and those that create a sense of urgency around the situation.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#176

 

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Name
Description
The justices unanimously upheld a lower court decision that revived the proposed class-action lawsuit filed in 2015 by former Intel engineer Christopher Sulyma against the Santa Clara, California-based chipmaker.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#177

 

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Name
Description
Smartphones from Oppo, Vivo and Xiaomi are listed with up to a discount of 45% as part of Amazon’s Deal of the Day offer.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#178

 

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Name
Description
STL will leverage VMware vCloud NFV to install, manage and maintain the environment for network microservices such as switching, firewall, etc. The solution will enable STL to provide a commercial and stable release to telcos and large enterprise customers who are looking for a commercial rollout in the next few quarters.

#Telecommunications
Field # Telecommunications
Updated 27 February 2020

#179

 

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Name
Description
Result of today’s quiz will be announced on March 31.

#Entertainments
Field # Entertainments
Updated 27 February 2020

#180

 

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Name
Description
In India, smartphone users on an average spend 70 minutes per day watching videosA growing number of smartphone users along with cheap mobile data tariffs and the growth in rural internet penetration, have led to the growing popularity of videos in the country. The video consumption was fueled by the increasing number of Over-the-Top (OTT) platforms with over 30 platforms in India currently.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#181

 

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Name
Description
It appears Samsung is gearing up to launch a toned-down variant of its flagship Android tablet — Galaxy Tab S6 — soon. According to a report by Sammobile, the alleged tablet has been spotted on Bluetooth SIG listing with model number SM-P615 and will be called the Galaxy Tab S6 Lite.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#182

 

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Name
Description
Earlier this week, Huawei confirmed that it is going to host an event in Paris on March 26 to expand its P-series lineup with the launch of P40 and P40 Pro. However, ahead of the official event, the company has launched the P40 Lite — a toned-down variant of the P40 that we will see on the day of the event.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#183

 

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Name
Description
NASA has selected a new space-based instrument as an innovative and cost-effective approach to maintaining the 40-year data record of the balance between the solar radiation entering Earth’s atmosphere and the amount absorbed, reflected, and emitted. This radiation balance is a key factor in determi

#Astronautics
Field # Astronautics
Updated 27 February 2020

#184

 

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Name
Description
New understanding of modeling soot in the atmosphere underscores the importance of reducing carbon emissions. Black carbon particles — more commonly known as soot — absorb heat in the atmosphere. For years, scientists have known that these particles are affecting Earth’s warming climate, but measur

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#185

 

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Name
Description
Google is set to make a tiny change in the search results section for desktop users, the company announced. As per the tweet by the official Google SearchLiaison account, this week onwards, Google Images will show new icons. These icons will represent if the results are from offer pages, videos pages or recipes.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#186

 

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Name
Description
When NASA astronauts blast off for their voyage to the Moon on the Orion spacecraft during Artemis missions, they’ll have protection in the form of the launch abort system (LAS). The LAS is designed to carry crew to safety in the event of an emergency during launch or ascent atop the agency’s Space

#Astronautics
Field # Astronautics
Updated 27 February 2020

#187

 

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Name
Description
The Intellectual Property India site lists the Vivo Watch trademark under the application number 4445715. The listing suggests that the trademark was applied for on February 18.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#188

 

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Name
Description
TBD

#Materials
Field # Materials
Updated 27 February 2020

#189

 

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Name
Description
A study published by Nature Communications said that the Toba supervolcanic eruption did not bring humanity to a near extinction about 74,000 years ago

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#190

 

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Name
Description
A fresh report suggests that the Realme 6 Pro may be powered by the Snapdragon 720G processor, and the render leak hints at a side-mounted fingerprint sensor.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#191

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#192

 

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Name
Description
The LG V60 ThinQ 5G is powered by the Qualcomm Snapdragon 865 SoC, and it runs on the latest Android 10 software.

#Energy
Field # Energy
Updated 27 February 2020

#193

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#194

 

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Name
Description
iPhone XR is making headlines more than a year after its launch. thanks to a report by market research firm Omdia claiming it was the top-selling smartphone globally in 2019. The report says that the iPhone XR sold 9 million units more than the next best-selling device, the iPhone 11.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#195

 

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Name
Description
TBD

#Energy
Field # Energy
Updated 27 February 2020

#196

 

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Name
Description
Huawei has quietly launched a new phone in Spain &ndash; the Huawei P40 Lite &ndash; which packs quad rear cameras and the Kirin 810 SoC.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#197

 

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Name
Description
TBD

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 27 February 2020

#198

 

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Name
Description
Apple CEO Tim Cook while answering questions at the company&rsquo;s annual shareholder meeting on Wednesday said that it would open its online store in India this year, while its first retail stores opening would take place in 2021.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#199

 

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Name
Description
Many children with autism face developmental delays, including communication and behavioral challenges and difficulties with social interaction. This makes learning new skills a major challenge, especially in traditional ...

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#200

 

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Name
Description
The introduction of 5G iPhone model later this year would serve as a catalyst that can accelerate Apple growth in the financial year 2021, a Morgan Stanley report said on Wednesday.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#201

 

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Name
Description
Scientists at Tokyo Institute of Technology have designed a novel processor architecture that can solve combinatorial optimization problems much faster than existing ones. Combinatorial optimizations are complex problems ...

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#202

 

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Name
Description
The US Supreme Court on Wednesday refused to back stricter deadlines for workers to sue retirement plans over alleged mismanagement, ruling Intel cannot avoid a suit accusing it of unlawfully making high-risk investments that cost retirement plan beneficiaries hundreds of millions of dollars.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#203

 

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Name
Description
Microsoft on Wednesday lowered its revenue estimates for the current quarter, saying it will feel the impact of the coronavirus epidemic with lower sales of Windows software and Surface devices.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#204

 

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Name
Description
Now researchers are presenting guidelines for how active matter, such as cells and microorganisms, can best be studied using machine learning techniques. The guidelines can help others navigate the new field, which can significantly ...

#Artificial Intelligence
Field # Artificial Intelligence
Updated 27 February 2020

#205

 

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Name
Description
Indian government is planning to update the around 20-year-old Information Technology (IT) Act to widen its ambit to the changes in technology in the recent years.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#206

 

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Name
Description
Despite all the attention given to phishing attacks, and high profile hacks, email still remains the number one place where victims fall prey to bad guys.

#Software;#Security
Field # Software
Updated 27 February 2020

#207

 

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Name
Description
Australia cricket Ashes docu-series The Test, Zombieland 2: Double Tap, Charlie&rsquo;s Angels, Naveen Richard: Relatively Relatable, Pushpavalli season 2, Blow the Man Down, Making the Cut &mdash; what&rsquo;s coming to Amazon Prime Video India in March 2020.

#Entertainments
Field # Entertainments
Updated 27 February 2020

#208

 

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Name
Description
Apple loves having its products &mdash; the iPhone, the iPad, or the MacBook &mdash; in movies and TV shows, but it won&rsquo;t let villains or bad guys be seen with them, according to Rian Johnson, the writer-director of Star Wars: The Last Jedi and Knives Out.

#Entertainments;#Films
Field # Entertainments
Updated 27 February 2020

#209

 

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Name
Description
Renewable energy has become a mainstream source of power production. The estimated share of renewables in global electricity generation reached 26 % at the end of 2018, while far less growth occurred in heating, cooling and ...

#Energy
Field # Energy
Updated 27 February 2020

#210

 

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Name
Description
Apple&rsquo;s shareholders on Wednesday defeated a proposal critical of its removal of apps at the request of the Chinese government, but the proposal drew a much higher proportion of votes than similar proposals in previous years.

#Social & Corporation affairs;#Economy;#Finance
Field # Social & Corporation affairs
Updated 27 February 2020

#211

 

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Name
Description
If the world is using more and more data, then it must be using more and more energy, right? Not so, says a comprehensive new analysis.

#Energy
Field # Energy
Updated 27 February 2020

#212

 

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Name
Description
Barely two weeks after its launch, the Galaxy S20 Ultra is already facing difficult questions about the performance of its cameras.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#213

 

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Name
Description
Earth’s atmosphere thankfully provides air for us to breathe, but when trying to study interesting objects in space it causes all sorts of problems, writes Chanda Prescod-Weinstein

#Astronautics
Field # Astronautics
Updated 27 February 2020

#214

 

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Name
Description
Vodafone, Reliance Jio and Airtel have a host of exciting prepaid plans offering 2GB data per day. Check them out.

#Telecommunications
Field # Telecommunications
Updated 27 February 2020

#215

 

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Name
Description
A worm-like creature from 518 million years ago evolved to lose its back legs, the earliest known example of an animal losing body parts it no longer needed

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#216

 

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Name
Description
The Oppo Reno 3 Pro is touted to come with four rear cameras and two front-facing cameras.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#217

 

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Name
Description
With the covid-19 virus spreading in a growing number of countries, many of us are wondering if and how we should prepare. Here's what to do

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#218

 

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Name
Description
The LG V60 ThinQ was originally scheduled to launch at the MWC 2020 in Barcelona, which was cancelled over the Coronavirus fears.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#219

 

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Name
Description
One kind of bacteria can cause colon tumours, while lacking another kind of microbe may lead to ulcerative colitis, an inflammatory bowel condition

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#220

 

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Name
Description
The LG Q51 has three cameras at the back and a single camera on the front.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#221

 

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Name
Description
China’s Yutu-2 rover has used radar to peer 40 metres under the surface of the far side of the moon and revealed how past impacts have shaped its geology

#Astronautics
Field # Astronautics
Updated 27 February 2020

#222

 

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Name
Description
The Huawei P40 Lite has been launched quietly in Spain. The phone appears to be a rebranded version of the Huawei Nova 6 SE.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#223

 

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Description
We knew that some fish glowed when placed under certain lights, but researchers have now shown that many amphibians can also shine bright

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#224

 

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Name
Description
Among the MateBook D15's key highlights are its lightweight chassis, FullView Display, and powerful internals. The latest MateBook D15 comes with a range of new features including support for Huawei Share. 

#Gadgets
Field # Gadgets
Updated 27 February 2020

#225

 

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Name
Description
Young girls filming themselves getting changed in school and then publicly sharing the videos might sound like a parent’s worst nightmare — and a predator’s dream.

#Energy
Field # Energy
Updated 27 February 2020

#226

 

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Name
Description
Huawei phones continue to be blocked from using GMS, and instead, now come running Huawei Mobile Services that bring a number of essential apps.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#227

 

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Description
Looking for a payday gaming treat? You can get £30 off the Switch Lite at is cheapest ever price, with Currys PC World.

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 27 February 2020

#228

 

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Description
The Redmi K30 Pro is expected to be launched within a couple of weeks and thanks to a bunch of leaks, we know a lot about Redmi’s upcoming flagship smartphone.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#229

 

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Description
WANT a quick performance boost for your PlayStation 4? There's a little-known feature that'll do the job. Sony's PS5 won't be out until just before Christmas, so upgrade your current console with a cheap and easy trick today.

#Hardware & Devices;#Entertainments;#Games
Field # Hardware & Devices
Updated 27 February 2020

#230

 

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Description
GOT a glowing Amazon Alexa speaker are you're not sure what's happening? We reveal all the Amazon Echo colours you might experience, and explain exactly what they mean.

#Hardware & Devices;#Artificial intelligence
Field # Hardware & Devices
Updated 27 February 2020

#231

 

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Name
Description
On January 22, China shut down all transportation in the city of Wuhan, where the coronavirus outbreak began. The city looks very quiet from space.

#Astronautics
Field # Astronautics
Updated 27 February 2020

#232

 

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Description
BLOOD-RED snow has been spotted in Antarctica as researchers warn this is a sign of climate change. Anyone looking at the spooky images of the "blood snow" would be forgiven for thinking the land was bleeding but it's actually algae that's to blame.

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#233

 

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Description
Called 2020 CD3, the asteroid stumbled into Earth's orbit three years ago, and will be leaving it in just another month or so.

#Astronautics
Field # Astronautics
Updated 27 February 2020

#234

 

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Description
THE NEW Xbox console will come with a handy new feature that makes it easy-peasy to resume games after your console has shut down. The "Quick Resume" feature means players can reboot the console without saving and then almost instantly start the game up again from where they left off.

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 27 February 2020

#235

 

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Description
VENUS and the crescent Moon will come together as a bright celestial phenomenon this evening. According to NASA's calendar, stargazers in the Northern Hemisphere are in for a treat.

#Astronautics
Field # Astronautics
Updated 27 February 2020

#236

 

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Name
Description
Makeway is a DIY course for your marbles.

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#237

 

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Description
Obesity is one of the most important risk factors of knee osteoarthritis (KOA), but its impact on clinical and functional consequences is less clear. The main objective of this cross-sectional study was to describe the relation between body mass index (BMI) and clinical expression of KOA. Participants with BMI ≥ 25 kg/m2 and KOA completed anonymous self-administered questionnaires. They were classified according to BMI in three groups: overweight (BMI 25–30 kg/m2), stage I obesity (BMI 30–35 kg/m2) and stage II/III obesity (BMI ≥ 35 kg/m2). The groups were compared in terms of pain, physical disability, level of physical activity (PA) and fears and beliefs concerning KOA. Among the 391 individuals included, 57.0% were overweight, 28.4% had stage I obesity and 14.6% had stage II/III obesity. Mean pain score on a 10-point visual analog scale was 4.3 (SD 2.4), 5.0 (SD 2.6) and 5.2 (SD 2.3) with overweight, stage I and stage II/III obesity, respectively (p = 0.0367). The mean WOMAC function score (out of 100) was 36.2 (SD 20.1), 39.5 (SD 21.4) and 45.6 (SD 18.4), respectively (p = 0.0409). The Knee Osteoarthritis Fears and Beliefs Questionnaire total score (KOFBEQ), daily activity score and physician score significantly differed among BMI groups (p = 0.0204, p = 0.0389 and p = 0.0413, respectively), and the PA level significantly differed (p = 0.0219). We found a dose–response relation between BMI and the clinical consequences of KOA. Strategies to treat KOA should differ by obesity severity. High PA level was associated with low BMI and contributes to preventing the clinical consequences of KOA.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#238

 

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Description
The HUNU coffee cup is designed for java-lovers on-the-go.

#Food
Field # Food
Updated 27 February 2020

#239

 

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Description
Modern cytometry methods allow collecting complex, multi-dimensional data sets from heterogeneous cell populations at single-cell resolution. While methods exist to describe the progression and order of cellular processes from snapshots of such populations, these descriptions are limited to arbitrary pseudotime scales. Here we describe MAPiT, an universal transformation method that recovers real-time dynamics of cellular processes from pseudotime scales by utilising knowledge of the distributions on the real scales. As use cases, we applied MAPiT to two prominent problems in the flow-cytometric analysis of heterogeneous cell populations: (1) recovering the kinetics of cell cycle progression in unsynchronised and thus unperturbed cell populations, and (2) recovering the spatial arrangement of cells within multi-cellular spheroids prior to spheroid dissociation for cytometric analysis. Since MAPiT provides a theoretic basis for the relation of pseudotime values to real temporal and spatial scales, it can be used broadly in the analysis of cellular processes with snapshot data from heterogeneous cell populations.

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#240

 

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Description
Uber adds a translation feature for in-app messaging between drivers and riders. It also redesigns and adds more details for pick-ups and drop-offs.

#Social & Corporation affairs;#Vehicles & Special machines
Field # Social & Corporation affairs
Updated 27 February 2020

#241

 

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Description
Unpowered exoskeletons with springs in parallel to human plantar flexor muscle-tendons can reduce the metabolic cost of walking. We used ultrasound imaging to look ‘under the skin’ and measure how exoskeleton stiffness alters soleus muscle contractile dynamics and shapes the user’s metabolic rate during walking. Eleven participants (4F, 7M; age: 27.7 ± 3.3 years) walked on a treadmill at 1.25 m s−1 and 0% grade with elastic ankle exoskeletons (rotational stiffness: 0–250 Nm rad−1) in one training and two testing days. Metabolic savings were maximized (4.2%) at a stiffness of 50 Nm rad−1. As exoskeleton stiffness increased, the soleus muscle operated at longer lengths and improved economy (force/activation) during early stance, but this benefit was offset by faster shortening velocity and poorer economy in late stance. Changes in soleus activation rate correlated with changes in users’ metabolic rate (p = 0.038, R2 = 0.44), highlighting a crucial link between muscle neuromechanics and exoskeleton performance; perhaps informing future ‘muscle-in-the loop’ exoskeleton controllers designed to steer contractile dynamics toward more economical force production.

#Hardware & Devices;#Medicine & Human body
Field # Hardware & Devices
Updated 27 February 2020

#242

 

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Description
Immigration and Customs Enforcement has been using facial-recognition tech to locate undocumented immigrants with special Maryland driver's licenses.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 27 February 2020

#243

 

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Description
Bioelectrical impedance spectroscopy (BIS) measures body composition, including fluid status. Acute decompensated heart failure (ADHF) is associated with fluid overload in different body compartments. This investigation aimed to evaluate the feasibility of measuring and monitoring fluid accumulation in patients with ADHF using BIS. The extracellular impedance as a surrogate marker for fluid accumulation was measured in 67 participants (25 healthy reference volunteers and 42 patients admitted with ADHF) using BIS in the “transthoracic”, “foot-to-foot”, “whole-body” and “hand-to-hand” segments. At baseline, BIS showed significantly lower extracellular resistance values for the “whole-body” (P < 0.001), “foot-to-foot” (P = 0.03), “hand-to-hand” (P < 0.001) and “transthoracic” (P = 0.014) segments in patients with ADHF than the reference cohort, revealing a specific pattern for peripheral, central and general fluid accumulation. The “foot-to-foot” (AUC = 0.8, P < 0.001) and “hand-to-hand” (AUC = 0.74, P = 0.04) segments indicated compartments of fluid accumulation with good prediction. During cardiac recompensation, BIS values changed significantly and were in line with routine parameters for monitoring ADHF. Mean bodyweight change per day correlated moderately to good with BIS values in the “whole-body” (r = −0.4), “foot-to-foot” (r = −0.8) and “transthoracic” (r = −0.4) segments. Based on our analysis, we conclude that measuring and monitoring fluid accumulation in ADHF using segmental BIS is feasible and correlates with clinical parameters during recompensation.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#244

 

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Description
UK judges on Thursday blocked the construction of a new runway at London's Heathrow Airport for failing to consider the runway's future climate impacts.

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#245

 

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Name
Description
Peri-implantitis is an inflammatory disease that results in bone destruction around dental implants. A preclinical study using beagle models is frequently performed prior to clinical application in dentistry. Previously, we proposed an immediate peri-implantitis experimental model with a shorter experimental duration and less expense than the conventional experimental model. However, the differences in the regenerative outcomes between the immediate and conventional models were not fully revealed. In this study, we aimed to compare the regenerative outcomes between both models when ex vivo BMP2 gene therapy using autologous periodontal ligament stem cells (B2/PDLSCs) was applied to peri-implantitis defects. The results showed that the defect depths were significantly different between both models. New bone formation occurred in both models, but there were significant differences between the models. More than 70% of the defects were filled with newly formed bone in the conventional model, whereas 30–40% of the defects were filled in the immediate model. However, after adjustment for the differences in the defect depths between the models, the statistically significant differences in the regenerative outcomes between the models were lost. In conclusion, the inferior regenerative outcome of an immediate peri-implantitis model at B2/PDLSCs transplantation resulted from the defect depths, not the model itself.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#246

 

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Name
Description
Listening to songs is a complex task for the brain, so it uses the left hemisphere to process the lyrics while the right hemisphere processes the melody

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#247

 

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The development of a safe and efficacious Zika virus (ZIKV) vaccine remains a global health priority. In our previous work, we developed an Adenovirus vectored ZIKV vaccine using a low-seroprevalent human Adenovirus type 4 (Ad4-prM-E) and compared it to an Ad5 vector (Ad5-prM-E). We found that vaccination with Ad4-prM-E leads to the development of a strong anti-ZIKV T-cell response without eliciting significant anti-ZIKV antibodies, while vaccination with Ad5-prM-E leads to the development of both anti-ZIKV antibody and T-cell responses in C57BL/6 mice. However, both vectors conferred protection against ZIKV infection in a lethal challenge model. Here we continued to characterize the T-cell biased immune response observed in Ad4 immunized mice. Vaccination of BALB/c mice resulted in immune correlates similar to C57BL/6 mice, confirming that this response is not mouse strain-specific. Vaccination with an Ad4 expressing an influenza hemagglutinin (HA) protein resulted in anti-HA T-cell responses without the development of significant anti-HA antibodies, indicating this unique response is specific to the Ad4 serotype rather than the transgene expressed. Co-administration of a UV inactivated Ad4 vector with the Ad5-prM-E vaccine led to a significant reduction in anti-ZIKV antibody development suggesting that this serotype-specific immune profile is capsid-dependent. These results highlight the serotype-specific immune profiles elicited by different Adenovirus vector types and emphasize the importance of continued characterization of these alternative Ad serotypes.

#Environment & Nature;#Theoretical sciences
Field # Environment & Nature
Updated 27 February 2020

#248

 

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Description
Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people wi

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#249

 

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Name
Description
In macaques, the central thalamus modulates cortical feedforward and feedback pathways to control levels of consciousness.

#Hardware & Devices;#Games
Field # Hardware & Devices
Updated 27 February 2020

#250

 

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Name
Description
In Mouse Study, Stem Cells Migrated to Proper Locations in Fetal Brain and Body, Differentiated Into Cells That Produce Crucial Misssing Protein. Administering stem cell or enzyme therapy in utero may be a path to alleviating some congenital diseases that often result in losing a pregnancy, accordi

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#251

 

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Name
Description
Faecal microbiota transplantation (FMT) aims to restore an altered microbiota and has been suggested as a potential treatment option for irritable bowel syndrome (IBS), among other diseases. A new study suggests that the use of a so-called superdonor is necessary to successfully treat patients with IBS using FMT.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#252

 

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Description
An international research team has been able to describe the overall structure of the antibody type IgE, which is the key molecule in allergic diseases. This is a scientific breakthrough that provides important insights into basic mechanisms of allergic reactions and may pave the way for more effect

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#253

 

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Name
Description
In a new study, cryopreserved human hepatocytes retrieved from livers deemed unsuitable for transplantation were thawed and encapsulated into alginate microbeads and then infused into the peritoneal cavity of a group of children with acute liver failure who were awaiting liver transplantation.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#254

 

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Description
Researchers of Sechenov University, a Project 5-100 participant, together with their colleagues from Australia used the microfluidics technology to develop a device able to isolate cancer cells from urine of patients with prostate cancer. The study showed high sensitivity and specificity of the new

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#255

 

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Name
Description


#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#256

 

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Name
Description
Ever since K2-18b, a planet outside our solar system was discovered, scientists across the world have taken a keen interest on the planet. But after two different teams last year reported the detection of water vapour in its hydrogen-rich atmosphere, researchers are now edging to find signs of life.

#Astronautics
Field # Astronautics
Updated 27 February 2020

#258

 

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Name
Description
Samsung Galaxy S20 smartphone in India will cost Rs. 66,999, while the S20+ is priced at Rs. 73,999, and the Galaxy S20 Ultra at Rs. 92,999.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#259

 

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Name
Description
The assembly of the seed microbiota involves some early microbial seed colonizers that are transmitted from the maternal plant through the vascular system, while other microbes enter through the stigma. Thus, the seed microbiota consists of microbes not only recruited from the plant vascular tissues, but also from the flower. Flowers are known to be a hub for microbial transmission between plants and insects. This floral-insect exchange opens the possibility for insect-transmitted bacteria to colonize the ovule and, subsequently, the seed to pass then into the next plant generation. In this study, we evaluated the contribution of insect pollination to the seed microbiota through high-throughput sequencing. Oilseed rape (OSR) flowers were exposed to visits and pollination by honey bees (Apis mellifera), red mason bees (Osmia bicornis), hand pollinated or left for autonomous self-pollination (ASP). Sequence analyses revealed that honey bee visitation reduced bacterial richness and diversity in seeds, but increased the variability of seed microbial structure, and introduced bee-associated taxa. In contrast, mason bee pollination had minor effects on the seed microbiota. Our study provides the first evidence that insect pollination is an ecological process involved in the transmission of bacteria from flowers to seeds.

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#260

 

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Name
Description
Nubia Red Magic 5G has capacitive shoulder buttons on the right side along with two vents for ventilation on either side of the phone.

#Telecommunications
Field # Telecommunications
Updated 27 February 2020

#261

 

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Name
Description
Blood serum is enriched in lipids and has provided a platform to understand the pathogenesis of a number of human diseases with improved diagnosis and development of biomarkers. Understanding lipid changes in neurodegenerative diseases is particularly important because of the fact that lipids make up >50% of brain tissues. Frontotemporal dementia (FTD) is a common cause of early onset dementia, characterized by brain atrophy in the frontal and temporal regions, concomitant loss of lipids and dyslipidemia. However, little is known about the link between dyslipidemia and FTD pathophysiology. Here, we utilized an innovative approach – lipidomics based on mass spectrometry – to investigate three key aspects of FTD pathophysiology – mitochondrial dysfunction, inflammation, and oxidative stress. We analyzed the lipids that are intrinsically linked to neurodegeneration in serum collected from FTD patients and controls. We found that cardiolipin, acylcarnitine, lysophosphatidylcholine, platelet-activating factor, o-acyl-ω-hydroxy fatty acid and acrolein were specifically altered in FTD with strong correlation between the lipids, signifying pathophysiological changes in FTD. The lipid changes were verified by measurement of the common disease markers (e.g. ATP, cytokine, calcium) using conventional assays. When put together, these results support the use of lipidomics technology to detect pathophysiological changes in FTD.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#262

 

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Description
Interaction with biological material can alter physicochemical parameters of magnetic nanoparticles and might thereby change their magnetic behavior with potentially important implications for various nanoparticle applications. Little is known about changes of the magnetic behavior that occur during the initial phase of cell binding and uptake. We investigate the magnetic behavior of very small superparamagnetic iron-oxide nanoparticles (VSOP) during initial contact with THP-1 monocytes. We combine real-time magnetic particle spectroscopy (MPS), a fast and sensitive method for specific detection of magnetic nanoparticles in biological specimen with high-pressure-freezing/freeze-substitution transmission electron microscopy (HPF/FS-TEM), enabling us to generate snapshots of the interaction of VSOP with the cellular glycocalyx. MPS reveals significant changes of the dynamic magnetic behavior within seconds after VSOP injection into monocyte suspensions that correlate with the formation of nanoparticle clusters in the glycocalyx. The combination of real-time MPS and HPF/FS-TEM provides an ideal platform to analyze magnetic behaviors of nanoparticles upon interaction with cells and tissues.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#263

 

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Description
Most studies on ungulate reproduction have focused on the covariates of male reproductive success, while there is much less information on female tactics of mate choice. The aim of this work is to fill this gap and to assess condition-dependent variations in female tactics in a lekking fallow deer (Dama dama) population. In particular, we investigated three indirect selection mechanisms: i) aggregation: when females join an already formed female group; ii) copying: when females copy the mate choice of other females and iii) territory choice: when females select a territory where many copulations had previously occurred. Our results show that female fallow deer, which are less experienced (younger) and/or incur higher travel costs (home range far from the lek), adopt indirect forms of mate selection more often than older females or females residing near the lek, respectively. Compared to adults, younger females remained longer in the lek (almost three times) and in male territories, returning to the lek after copulation. However, despite the time spent at the lek, younger females were not able to select the highest-rank males, and relied on territory choice more often than older females. Farther does visited the lek less frequently (farthest females only once) and arrived on average 5 days later than closer females (which performed up to 7 visits), but they were seen more often within female groups (aggregation). We did not find a different amount of copying in younger or in farther females. Our results contribute to advance our understanding of female behaviours in ungulate leks.

#Theoretical sciences
Field # Theoretical sciences
Updated 27 February 2020

#264

 

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Description
WhatsApp beta for Android has been updated to version 2.20.60 with additional solid colour options for the Dark theme. The new update is available for download through the Google Play Beta programme.

#Software
Field # Software
Updated 27 February 2020

#265

 

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Description
We discuss the design of the thermal analog of logic gates in systems made of a collection of nanoparticles. We demonstrate the possibility to perform NOT, OR, NOR, AND and NAND logical operations at submicrometric scale by controlling the near-field radiative heat exchanges between their components. We also address the important point of the role played by the inherent non-additivity of radiative heat transfer in the combination of logic gates. These results pave the way to the development of compact thermal circuits for information processing and thermal management.

#Theoretical sciences
Field # Theoretical sciences
Updated 27 February 2020

#266

 

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Description
Microsoft has began rolling out the much-awaited Chromium based Edge browser with the latest Windows 10 system update

#Software
Field # Software
Updated 27 February 2020

#267

 

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Description
This study presents the removal of phosphate from aqueous solution using a new silver nanoparticles-loaded tea activated carbon (AgNPs-TAC) material. In order to reduce costs, the tea activated carbon was produced from tea residue. Batch adsorption experiments were conducted to evaluate the effects of impregnation ratio of AgNPs and TAC, pH solution, contact time, initial phosphate concentration and dose of AgNPs-AC on removing phosphate from aqueous solution. Results show that the best conditions for phosphate adsorption occurred at the impregnation ratio AgNPs/TAC of 3% w/w, pH 3, and contact time lasting 150 min. The maximum adsorption capacity of phosphate on AgNPs-TAC determined by the Langmuir model was 13.62 mg/g at an initial phosphate concentration of 30 mg/L. The adsorption isotherm of phosphate on AgNPs-TAC fits well with both the Langmuir and Sips models. The adsorption kinetics data were also described well by the pseudo-first-order and pseudo-second-order models with high correlation coefficients of 0.978 and 0.966, respectively. The adsorption process was controlled by chemisorption through complexes and ligand exchange mechanisms. This study suggests that AgNPs-TAC is a promising, low cost adsorbent for phosphate removal from aqueous solution.

#Theoretical sciences
Field # Theoretical sciences
Updated 27 February 2020

#268

 

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Description
Google says that these new languages support both text and website translations, with Kinyarwanda, Tatar, and Uyghur specifically supporting virtual keyboard input.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#269

 

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Description
Gene expression is a biological process regulated at different molecular levels, including chromatin accessibility, transcription, and RNA maturation and transport. In addition, these regulatory mechanisms have strong links with cellular metabolism. Here we present a multi-omics dataset that captures different aspects of this multi-layered process in yeast. We obtained RNA-seq, metabolomics, and H4K12ac ChIP-seq data for wild-type and mip6Δ strains during a heat-shock time course. Mip6 is an RNA-binding protein that contributes to RNA export during environmental stress and is informative of the contribution of post-transcriptional regulation to control cellular adaptations to environmental changes. The experiment was performed in quadruplicate, and the different omics measurements were obtained from the same biological samples, which facilitates the integration and analysis of data using covariance-based methods. We validate our dataset by showing that ChIP-seq, RNA-seq and metabolomics signals recapitulate existing knowledge about the response of ribosomal genes and the contribution of trehalose metabolism to heat stress. Raw data, processed data and preprocessing scripts are made available. Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.11836743

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#270

 

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Description
Samsung Mobile has been named as the most desired phone according to a report by TRA Research. Previously the brand topped the list in 2013, 2015 and 2018.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#271

 

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Description
Chip maker MediaTek has launched a new processor — Helio P95 — that is expected to power budget and mid-range smartphones. The processor supports either a dual camera setup of 24MP+16MP or a single 64MP sensor and offers facial recognition for mobile payments and screen unlock. As for storage, the chipset supports 8GB memory size of UFS 2.1 type and for display, it can support a maximum display resolution of 2520 x 1080 pixels.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#272

 

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Description
Xiaomi may soon launch the Redmi Note 9 series in India as its next offering in the affordable smartphone space. While leaks are yet to come out, here's a bunch of features we can expect from the next Redmi Note device.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#273

 

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Description
Earphones and fitness bands are the two most-popular categories in the Indian wearables market, according to the Worldwide Quarterly Wearable Device Tracker, 4Q19 report by IDC. The earwear category recorded a dominant market share of 57% at the end of 2019. Whereas, the wristband category has registered an annual growth of 52.6% with 5.3 million units shipped.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#274

 

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Description
Asked by: Glyn Leaney, Ashford

#Materials
Field # Materials
Updated 27 February 2020

#275

 

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Name
Description
TBD

#Gadgets
Field # Gadgets
Updated 27 February 2020

#276

 

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Description
In the fourth of six MIT symposia on climate change this year, panels of researchers described ways of achieving economy-wide deep decarbonization to head off the most catastrophic effects of global climate change.

#Construction;#Agriculture & Gardening;#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#277

 

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Description
TBD

#Software;#Social & Corporation affairs
Field # Software
Updated 27 February 2020

#278

 

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Description
“We’ve learned a lot from this about what the microbiome should be."

#Environment & Nature;#Theoretical sciences
Field # Environment & Nature
Updated 27 February 2020

#279

 

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Description
Google translate help users by giving them perfect translations in different languages. The company has rolled out the latest update for the app which will make it useful for more people. Google has announced that it is adding five new languages to the Google translate app.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#280

 

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Description
The internet is full of bad words, and that can stop you from thinking about God properly. Apparently.

#Telecommunications
Field # Telecommunications
Updated 27 February 2020

#281

 

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Description
Although the coronavirus outbreak has slowed down the global supply-chain for industries across the spectrum, the need of the hour is to not only have a diverse portfolio of products but also a diverse portfolio of factories so that such unpredictable situations can be tackled in an efficient way in the future, a top HP Inc executive has said.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#282

 

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Description
The new Timex Smart line aims to “disrupt the wearables category” at an affordable price.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#283

 

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Name
Description
The cloud gaming service Shadow has revealed that its iOS app has been removed from the App Store.

#Entertainments;#Games
Field # Entertainments
Updated 27 February 2020

#284

 

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Name
Description
The first half of Doctor Who’s season finale brought dread and wants to answer it with hope.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#285

 

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Description
VENUS and the crescent Moon will come together as a bright celestial phenomenon this evening. According to Nasa's calendar, stargazers in the Northern Hemisphere are in for a treat.

#Astronautics
Field # Astronautics
Updated 27 February 2020

#286

 

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Description
A report by Wired suggests that some sellers on Amazon have been overcharging for masks on the e-commerce platform. Amazon has issued a stern warning to sellers and told them not to do so. Sellers have been retailing masks at four times their actual prices. If a product is suddenly priced higher than the recent prices offered on Amazon, then the e-commerce giant can take certain action.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#287

 

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Description
An atmosphere of distrust is certainly something we don’t need during this critical time.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#288

 

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Description
TBD

#Astronautics
Field # Astronautics
Updated 27 February 2020

#289

 

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Description
“We’re effectively operating now on the basis that there is a pandemic.”

#Astronautics
Field # Astronautics
Updated 27 February 2020

#290

 

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Name
Description
CRN asks security CEOs, channel chiefs and technical leaders attending RSA 2020 which cybersecurity startups they believe are best defending emerging technologies or simplifying long-standing protection issues.

#Software;#Security
Field # Software
Updated 27 February 2020

#291

 

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TBD

#Chemicals
Field # Chemicals
Updated 27 February 2020

#292

 

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Here are 15 of the best IT jobs that made Glassdoor's Best Jobs In America 2020 list.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#293

 

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TBD

#Astronautics
Field # Astronautics
Updated 27 February 2020

#294

 

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CRN rounded up five 5G news announcements that were slated to be rolled out during the now-cancelled Mobile World Congress (MWC 2020) due to Coronavirus.

#Telecommunications
Field # Telecommunications
Updated 27 February 2020

#295

 

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Foreign firms in virus-hit China are expecting large drops in revenue, especially for the first half of the year, with some planning to lower their business targets, said trade associations on Thursday.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#296

 

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Facebook said Wednesday that it is banning ads that make false claims about products tied to the new coronavirus.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#297

 

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Air France is taking new cost-cutting measures, including a partial hiring freeze, to offset the impact of the coronavirus outbreak on the travel sector, according to an internal letter obtained by AFP.

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#298

 

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The global PC market will drop 9 percent in 2020 due in part to the spread of the coronavirus, IDC said.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#299

 

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International Cricket Council (ICC), in partnership with Facebook has unveiled a new video series, #BreakingBoundaries in which sporting stars from around the world are set to feature.

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 27 February 2020

#300

 

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Encouraging the growth of benign bacteria is a tasty way to preserve vegetables, such as with this easy kimchi recipe, says Sam Wong

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#301

 

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Intel announced at RSA 2020 plans to expand Software Guard Extensions support for Xeon processors and introduce new hardware security capabilities like full memory encryption.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#302

 

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Lose your bearings in an unfamiliar landscape and fear shreds your navigational brain. But studies are now revealing the common mistakes lost people make, helping rescue teams to find them before it’s too late

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#303

 

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The UK government’s approval for a third runway to be built at Heathrow is illegal because it doesn't consider the Paris climate deal, the Court of Appeal has ruled

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#304

 

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Solar Blinds can reduce your electricity bill by 30%. They can generate 100W per 1 sqm, which is enough to power a TV or charge a laptop. They can also prevent 100 gms of carbon emissions.

#Energy
Field # Energy
Updated 27 February 2020

#305

 

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Tech firms are making record profits but paying little tax. Now global leaders are discussing ways to make them pay their fair share

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#306

 

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MICROSOFT has hidden a fun game in the latest version of its internet browser, Edge. Dubbed "Let's Surf", the mini-game has you take control of a surfer on a trip through perilous waters.

#Software
Field # Software
Updated 27 February 2020

#307

 

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SONY is handing out two free games to PS4 owners – if you have a PlayStation Plus membership. Many PS4 owners already have subscriptions, so read on to find out which PS Plus March 2020 freebies you can claim.

#Hardware & Devices;#Entertainments;#Games
Field # Hardware & Devices
Updated 27 February 2020

#308

 

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A POPULAR baby monitor has been blasted by experts for having vulnerabilities that could allow hackers to access the device and view images and videos. The camera in question reportedly comes with an increased risk of third parties being able to spy on children, without parents even knowing.

#Hardware & Devices
Field # Hardware & Devices
Updated 27 February 2020

#309

 

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Researchers hope serological testing will help them better understand the epidemic

#Medicine & Human body
Field # Medicine & Human body
Updated 27 February 2020

#310

 

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DESIGNS for a folding iPhone that bends in half like a retro flip phone have been unveiled by an Apple super-fan. The concept device, displayed in a clever fake video, is first shown in its palm-sized folded form, boasting a small touch display on the front.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#311

 

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Critics argue goal is to “sideline science” and aid industry

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 27 February 2020

#312

 

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TIKTOK presents itself as an all-American social media app – but its links to the Chinese surveillance state run deep. It's owned by one of China's most elusive billionaires, and is linked to a heavily censored app called Douyin.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 27 February 2020

#313

 

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TBD

#Environment & Nature
Field # Environment & Nature
Updated 27 February 2020

#314

 

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Archaeologists puzzle out a clash of Mesoamerican cultures

#Archaeology & History
Field # Archaeology & History
Updated 27 February 2020

#315

 

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The camera on Samsung's Galaxy S20 Ultra will be improved via a software update, Samsung said.

#Gadgets
Field # Gadgets
Updated 27 February 2020

#316

 

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