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Today: 24 November 2020, Tuesday.

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#1

 

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Treatment with CD19 or CD22-targeted chimeric antigen receptor-engineered T (CD19/CD22 CAR-T) cells achieve complete responses in 60–90% of adults and children with refractory or relapsed (R/R) acute lymphoblastic leukemia (ALL). This led to the approval of tisagenlecleucel (Kymriah) by the FDA and several European regulatory agencies in ALL patients up to 25 years of age. Although CAR T-cell therapy is likely to transform the ALL therapeutic landscape, its development and wide dissemination have been impacted by the occurrence of significant toxicities; namely, cytokine release syndrome (CRS) and Immune effector cell-Associated Neurotoxicity Syndrome (ICANS) have been reported at higher rates in ALL patients compared to other B cell malignancies, particularly in the adult population. Here, we review recent data suggesting a significant proportion of ALL patients are at risk of developing severe, sometimes life-threatening, CRS, and ICANS after CD19 and CD22 CAR T-cell therapy. After describing the key clinical and laboratory features of severe CRS and ICANS, we explore the disease and treatment-related factors that may predict the severity of these toxicities. Last, we review strategies under investigation in the prophylactic and therapeutic settings to improve the safety of CAR T-cells for ALL.

#Medicine & Human body
Field # Medicine & Human body
Updated 24 November 2020

#2

 

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The function of the origin recognition complex (ORC) in DNA replication is highly conserved in recognizing and marking the initiation sites. The detailed molecular mechanisms by which human ORC is reconfigured into a state competent for origin association remain largely unknown. Here, we present structural characterizations of human ORC1–5 and ORC2–5 assemblies. ORC2–5 exhibits a tightly autoinhibited conformation with the winged-helix domain of ORC2 completely blocking the central DNA-binding channel. The binding of ORC1 partially relieves the autoinhibitory effect of ORC2–5 through remodeling ORC2-WHD, which makes ORC2-WHD away from the central channel creating a still autoinhibited but more dynamic structure. In particular, the AAA+ domain of ORC1 is highly flexible to sample a variety of conformations from inactive to potentially active states. These results provide insights into the detailed mechanisms regulating the autoinhibition of human ORC and its subsequent activation for DNA binding.

#Software
Field # Software
Updated 24 November 2020

#3

 

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Macrophages are mainly divided into two populations, which play a different role in physiological and pathological conditions. The differentiation of these cells may be regulated by transcription factors. However, it is unclear how to modulate these transcription factors to affect differentiation of these cells. Here, we found that lncLy6C, a novel ultraconserved lncRNA, promotes differentiation of Ly6Chigh inflammatory monocytes into Ly6Clow/neg resident macrophages. We demonstrate that gut microbiota metabolites butyrate upregulates the expression of lncLy6C. LncLy6C deficient mice had markedly increased Ly6Chigh pro-inflammatory monocytes and reduced Ly6Cneg resident macrophages. LncLy6C not only bound with transcription factor C/EBPβ but also bound with multiple lysine methyltransferases of H3K4me3 to specifically promote the enrichment of C/EBPβ and H3K4me3 marks on the promoter region of Nr4A1, which can promote Ly6Chigh into Ly6Cneg macrophages. As a result, lncLy6C causes the upregulation of Nr4A1 to promote Ly6Chigh inflammatory monocytes to differentiate into Ly6Cint/neg resident macrophages.

#Medicine & Human body;#Theoretical sciences
Field # Medicine & Human body
Updated 24 November 2020

#4

 

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As policy makers aim to plant more trees to increase shade on warming city streets globally, Google has launched Tree Canopy Lab that combines Artificial Intelligence (AI) and aerial imagery.

#Artificial intelligence
Field # Artificial intelligence
Updated 24 November 2020

#5

 

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The robotic Chang'e 5 mission will land on the moon, gather rock samples and then blast off back to Earth - the first such mission in over 40 years. It could be a rehearsal for landing humans on the moon

#Astronautics
Field # Astronautics
Updated 24 November 2020

#6

 

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Bees tasked with flying through a narrow gap will turn sideways to avoid touching the edges, showing that they are aware of how big they are

#Environment & Nature
Field # Environment & Nature
Updated 24 November 2020

#7

 

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Microsoft and LG have entered into an exclusive agreement that promotes Xbox Series X gaming on the OLED televisions.

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#8

 

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The government has secured 100 million doses of the AstraZeneca/Oxford University vaccine.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#9

 

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TBD

#Sport & Camping
Field # Sport & Camping
Updated 23 November 2020

#10

 

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TBD

#Social & Corporation affairs;#Vehicles & Special machines
Field # Social & Corporation affairs
Updated 23 November 2020

#11

 

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Here’s what to watch for in Dell’s earnings results, as Dell Technologies looks to grow PC, storage and server sales.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#12

 

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Intel CEO Bob Swan urged President-elect Joe Biden to invest in U.S. manufacturing and digital infrastructure in an open letter published to Intel's website Monday.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#13

 

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Manufacturing Software Developer AVEVA Opens Entire Application Portfolio To Industrial Distribution Partners with AVEVA Select program.

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 23 November 2020

#14

 

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Native American rock art appears to depict the psychoactive flower, rather than the experience of getting high

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#15

 

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Finds from the Saqqara necropolis suggest a society trying to revive the past

#Archaeology & History
Field # Archaeology & History
Updated 23 November 2020

#16

 

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That makes it the most expensive video game ever sold at auction, surpassing a copy of the original Super Mario ...

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#17

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#18

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#19

 

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TBD

#Astronautics
Field # Astronautics
Updated 23 November 2020

#20

 

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Neurohacker Collective's Qualia Immune is a nutritional formula designed to provide comprehensive support for your immune system.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#21

 

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Gamers can now take advantage of discounts, as Black Friday deals have started for gaming laptops from Acer, Alienware, MSI, and more from various retailers.

#Astronautics
Field # Astronautics
Updated 23 November 2020

#22

 

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Upgrade your work-from-home setup this Black Friday. Get the Logitech M325 Wireless Mouse for just $10 from Staples for Black Friday.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#23

 

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Consumers flocked to Walmart and other retailers early in the pandemic when Amazon was at times slow to deliver essentials including toilet paper. Now, Amazon competitors see another opportunity to seize market share.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#24

 

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TBD

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#25

 

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There won't be many exclusives on Microsoft's new console for awhile, but with our list of the best Xbox Series X exclusives, you'll know which to download.

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#26

 

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Assassin's Creed Valhalla is full of Norse and British lore. If you're looking for Excalibur, a lady in a lake won't toss it to you. Here's how to find it.

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#27

 

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TBD

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#28

 

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Protect your home from porch pirates this season. Shop Black Friday sales now and get the Ring Video Doorbell 3 with Ring Assist+ for just $140 at QVC.

#Hardware & Devices;#Security
Field # Hardware & Devices
Updated 23 November 2020

#29

 

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Want to cook more often? Get the Instant Pot Duo Crisp with Air Fryer Lid for just $79 as part of Walmart's Black Friday sales.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#30

 

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These Roborock S-series combination robotic vacuums and floor mops have jaw-dropping Black Friday discounts.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#31

 

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The brand new Microsoft Surface Duo is now $200 off at Amazon as one of its Friday deals.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#32

 

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This 50-inch 4K TV from TCL is $120 off, available for just $230 at Best Buy.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#33

 

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Astronomers spotted a minimoon orbiting Earth in February and have confirmed it was there for nearly three years before drifting away. We should be able to find many more like it in the future

#Astronautics
Field # Astronautics
Updated 23 November 2020

#34

 

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The General Services Administration on Monday ascertained President-elect Joe Biden as the apparent winner of the 2020 presidential race, clearing the way for a new administration amid Trump's meritless legal fight.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#35

 

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China launches mission to bring back material from moon

#Astronautics
Field # Astronautics
Updated 23 November 2020

#36

 

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The data shows tyrannosaur and herbivores were still dominating the globe.

#Archaeology & History
Field # Archaeology & History
Updated 23 November 2020

#37

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#38

 

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AMD's flagship Zen 2 laptop CPUs save power by delaying their full performance.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#39

 

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What happened to the airport workers next is unclear.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#40

 

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OneWeb plans satellite launches in December and throughout 2021 and 2022.

#Astronautics
Field # Astronautics
Updated 23 November 2020

#41

 

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It's totally zany, fully lamp-shady, An-i-mani-acs! (Those are the facts!)

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#42

 

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The aim of this study was to explore the relative prevalence and clinical differences between age-related macular degeneration (AMD) and pachychoroid disease in patients older than 50 years with newly diagnosed exudative neovascular maculopathy, and also assess the rate of misdiagnosis between these two disorders. In this retrospective observational study, we reviewed data from patients 50 years of age and older with newly diagnosed treatment-naïve exudative macular neovascularization (MNV) secondary to AMD or pachychoroid disease. Of the 139 patients (139 eyes) who fulfilled the inclusion criteria, 35 patients were graded as being affected by pachychoroid disease complicated by exudative MNV and 104 subjects had neovascular AMD. Therefore, prevalence of pachychoroid disease complicated by exudative MNV was 25.2% (confidence interval—CI 18.2–33.2%). Mean ± SD age was 67.0 ± 8.8 years in the pachychoroid disease group and 80.6 ± 6.6 years in the neovascular AMD group (P < 0.0001). At baseline, BCVA was better in patients with pachychoroid disease complicated by exudative MNV (0.4 ± 0.3 LogMAR vs. 0.7 ± 0.5 LogMAR, P = 0.003). At the 1-year follow-up visit, BCVA was still better in patients with pachychoroid-associated MNV (0.34 ± 0.32 LogMAR vs. 0.59 ± 0.52 LogMAR; P = 0.005). In our study cohort, 19 patients were graded to be affected by pachychoroid disease complicated by exudative MNV even though a diagnosis of neovascular AMD was erroneously reported in their medical records at baseline. In conclusion, pachychoroid disease is a frequent cause of exudative MNV in aged patients with a high rate of misdiagnosis. A correct diagnosis may be important as these two disorders differ in terms of clinical characteristics and prognosis.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#43

 

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There have been few reports on fixation of Rommens classification Type IIIA fragility fractures of the pelvis (FFPs). Here, we present our less invasive surgical technique, called iliac intramedullary stabilization (ILIS), for the internal fixation of Type IIIA FFPs. The technique involves a closed reduction, termed the femur internal rotation reduction method (FIRM), whereby the fracture fragments are repositioned using lateral rotators by internally rotating the femur while the patient is in the prone position. Two iliac screws are inserted on the ilium bilaterally via the supra-acetabular bone canal during FIRM and connected with two transverse rods and two cross connectors. We refer to this internal fixation procedure as ILIS. We retrospectively recruited patients with Type IIIA fractures, treated using this procedure, at our institute between October 2017 and October 2019. We evaluated operative and post-operative outcomes. We enrolled 10 patients (9 women and 1 man; mean age, 85.2 years) who were followed up for over 6 months. All patients suffered FFPs after falling from a standing position. The mean operative time was 145.1 (range, 94–217) minutes, and the mean blood loss was 258.5 (range, 100–684) ml. All patients were allowed full weight bearing from post-operative day 1. All patients achieved bone union and regained their pre-injury walking ability at 6 months after surgery without evident secondary displacement. In conclusion, our ILIS technique allows less invasive internal fixation of Type IIIA FFPs with adequate stability for full weight bearing from post-operative day 1.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#44

 

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SMARCA4 and EZH2 are two functional key players of their respective antagonizing chromatin remodeling complexes SWI/SNF and PRC2. EZH2 inhibitory drugs may abrogate pro-oncogenic features of PRC2 and turn the balance to cell differentiation via SWI/SNF activity in cancers. SMARCA4 and EZH2 expression was assessed by RT-PCR in 238 epithelial ovarian cancers (OCs) and put in relation to clinico-pathological parameters and patients’ outcome. Optimal thresholds for high and low expression of both variables were calculated by the Youden’s index based on receiver operating characteristic (ROC) curves. High SMARCA4 mRNA expression was independently associated with favorable progression-free survival (PFS) (P = 0.03) and overall survival (OS) (P = 0.018). As Youden’s threshold determination for EZH2 yielded a S-shaped ROC-curve, two cut-off points (29th and 94th percentile) predicting opposite features were defined. Whereas EZH2 mRNA levels beyond the 29th percentile independently predicted poor PFS (P = 0.034), Cox-regression in EZH2 transcripts above the 94th percentile revealed a conversion from unfavorable to favorable PFS and OS (P = 0.009 and P = 0.032, respectively). High SMARCA4 expression associates with improved survival, whereas moderate/high EZH2 expression predicts poor outcome, which converts to favorable survival in ultra-high expressing OCs. This small OC subgroup could be characterized by REV7-abrogated platinum hypersensitivity but concomitant PARP-inhibitor resistance.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#45

 

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Phase distribution of emerging organic contaminants is highly influential in their presence, fate and transport in surface water. Therefore, it is crucial to determine their state, partitioning behaviour and tendencies in water environments. In this study, Bisphenol A was investigated in both colloidal and soluble phases in water. BPA concentrations ranged between 1.13 and 5.52 ng L−1 in the soluble phase and n.d-2.06 ng L−1 in the colloidal phase, respectively. BPA was dominant in the soluble phase, however, the colloidal contribution ranged between 0 and 24% which implied that colloids can play a significant role in controlling BPA’s transportation in water. Urban and industrial areas were the main sources of BPA while forest areas displayed lower levels outside the populated domains. pH levels were between 6.3 and 7.4 which might have affected BPA’s solubility in water to some extent. The particle size distribution showed that the majority of the particles in river samples were smaller than 1.8 µm in diameter with a small presence of nanoparticles. Zeta potential varied between − 25 and − 18 mV, and these negative values suggested instability of particles. Furthermore, BPA was positively correlated with BOD, COD and NH3–N which might indicate that these organic compounds were released concurrently with BPA. RQ assessment showed low levels of risk towards algae and fish in the study area.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#46

 

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There is an ongoing debate on whether encircling scleral buckling (SB) procedure for the treatment of rhegmatogenous retinal detachment (RRD) may cause an impairment in choroidal blood flow. The aim of this study was to compare choroidal vascularity index (CVI) and subfoveal choroidal thickness (CT) between eyes that had undergone encircling SB with unoperated fellow eyes (FEs). Thirty patients treated with encircling SB for unilateral RRD were included. Demographic and clinical characteristics as well as enhanced depth imaging—optical coherence tomography scans were retrospectively collected. Images were binarised using ImageJ software, total choroidal area along with luminal and stromal area (respectively, TCA, LA and SA) were segmented and the CVI was computed as the ratio of LA/TCA. In addition, CT was evaluated. The mean follow-up interval between surgery and examination was 25.5 ± 16.8 months. Choroidal thickness, TCA, LA and SA were significantly increased in the operated eyes compared to FEs (respectively, 271.7 ± 78.0 µm vs. 238.5 ± 83.4, P = 0.001; 1.804 ± 0.491 mm2 vs. 1.616 ± 0.496, P = 0.001; 1.199 ± 0.333 mm2 vs. 1.067 ± 0.337, P < 0.001 and 0.605 ± 0.171 mm2 vs. 0.550 ± 0.171, P = 0.001). Conversely, CVI did not significantly differ between the two groups (66.4 ± 3.6 vs. 65.9 ± 3.2, P = 0.490). In conclusion, eyes treated with encircling SB for RRD presented increased LA, SA and CT compared with FEs, but showed no difference in CVI.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#47

 

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The use of microorganisms that allows the recovery of critical high-tech elements such as gallium (Ga) and indium (In) has been considered an excellent eco-strategy. In this perspective, it is relevant to understand the strategies of Ga and In resistant strains to cope with these critical metals. This study aimed to explore the effect of these metals on two Ga/In resistant strains and to scrutinize the biological processes behind the oxidative stress in response to exposure to these critical metals. Two strains of Serratia fonticola, A3242 and B2A1Ga1, with high resistance to Ga and In, were submitted to metal stress and their protein profiles showed an overexpressed Superoxide Dismutase (SOD) in presence of In. Results of inhibitor-protein native gel incubations identified the overexpressed enzyme as a Fe-SOD. Both strains exhibited a huge increase of oxidative stress when exposed to indium, visible by an extreme high amount of reactive oxygen species (ROS) production. The toxicity induced by indium triggered biological mechanisms of stress control namely, the decrease in reduced glutathione/total glutathione levels and an increase in the SOD activity. The effect of gallium in cells was not so boisterous, visible only by the decrease of reduced glutathione levels. Analysis of the cellular metabolic viability revealed that each strain was affected differently by the critical metals, which could be related to the distinct metal uptakes. Strain A3242 accumulated more Ga and In in comparison to strain B2A1Ga1, and showed lower metabolic activity. Understanding the biological response of the two metal resistant strains of S. fonticola to stress induced by Ga and In will tackle the current gap of information related with bacteria-critical metals interactions.

#Materials
Field # Materials
Updated 23 November 2020

#48

 

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Upon completion of this activity, participants will be able to: In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Springer Nature. Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Medscape, LLC designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 75% minimum passing score and complete the evaluation at www.medscape.org/journal/eye; (4) view/print certificate. 1.0 Release date: Expiration date: November 23rd 2021 Post-test link: https://medscape.org/eye/posttest938103 S.S. has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Allergan, Inc.; Apellis; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Heidelberg Pharma GmbH; Novartis; Oculis; Optos; Oxurion; Roche. Served as a speaker or a member of a speakers bureau for: Allergan, Inc.; Bayer AG; Novartis Pharmaceuticals Corporation; Optos. Received grants for clinical research from: Allergan, Inc.; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Novartis Pharmaceuticals Corporation; Optos. T.E.d.C. and W.F.M. have disclosed no relevant financial relationships. Charles P. Vega, MD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: GlaxoSmithKline. To determine if commercial OCTA measurements can provide quantitative biomarkers for detection of radiation retinopathy (RR) s/p I-125 plaque brachytherapy in patients with uveal melanoma. Retrospective review of 6 × 6 mm OCTA images of nonirradiated fellow eyes (group 1, 28 eyes), eyes without RR (group 2, 22 eyes), eyes with RR (group 3, 13 eyes). We used automated AngioVue AngioAnalytics OCTA software determinations of FAZ size, perimeter size, and 27 capillary density measurements (nine regions of each segmentation: full-thickness retina, superficial plexus, deep plexus). Average time since irradiation was 1.9 years in group 2, and 3.7 years in group 3. FAZ size was 1.2 mm in group 3 compared with 0.2 mm in group 1 and 0.3 mm in group 2 (both p < 0.001). Capillary density was statistically significantly reduced in group 3 compared with group 1 in all 27 regions. Group 2 had significantly decreased superficial plexus capillary density compared with group 1 in three regions. Group 3 had significantly reduced capillary density compared with group 2 in 6/27 (22%) regions. Linear regression showed a change in whole-scan density of −1.5 per year after irradiation in the full-thickness retina segmentation (p = 0.008). Quantitative OCTA may aid in early detection of RR.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#49

 

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Lithocholic bile acid (LCA) has been reported to selectively kill cancer cells within many tumor cell lines including neuroblastoma or glioblastoma. Wilms’ tumor shares similarities with neuro- and glioblastoma. Hence, the aim of the study was to evaluate the effects of LCA on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used. SK NEP1 was tested as well. It was originally classified as a nephroblastoma cell line but was meanwhile reclassified as an ewing sarcoma cell line. As control cell lines HEK 293 from embryonic kidney and RC 124 from adult kidney tissue as well as podocytes were used. The effects were evaluated using proliferation assay, caspase activity assay, FACS and Western blot. LCA showed a dose and time-dependent selective effect inducing apoptosis in nephroblastoma cells. However, these effects were not limited to the nephroblastoma cell line but also affected control kidney cell lines and the sarcoma cells; only podocytes are significantly less affected by LCA (at dosages < 200 µm). There were no significant differences regarding the TGR5 receptor expression. The study showed that LCA has a strong, yet unselective effect on all used in vitro cell-lines, sparing the highly differentiated podocytes in lower concentrations. Further studies are needed to verify our results before dismissing LCA as an anti-cancer drug.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#50

 

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The Glasgow Microenvironment Score (GMS) combines peritumoural inflammation and tumour stroma percentage to assess interactions between tumour and microenvironment. This was previously demonstrated to associate with colorectal cancer (CRC) prognosis, and now requires validation and assessment of interactions with adjuvant therapy. Two cohorts were utilised; 862 TNM I–III CRC validation cohort, and 2912 TNM II–III CRC adjuvant chemotherapy cohort (TransSCOT). Primary endpoints were disease-free survival (DFS) and relapse-free survival (RFS). Exploratory endpoint was adjuvant chemotherapy interaction. GMS independently associated with DFS (p = 0.001) and RFS (p < 0.001). GMS significantly stratified RFS for both low risk (GMS 0 v GMS 2: HR 3.24 95% CI 1.85–5.68, p < 0.001) and high-risk disease (GMS 0 v GMS 2: HR 2.18 95% CI 1.39–3.41, p = 0.001). In TransSCOT, chemotherapy type (pinteraction = 0.013), but not duration (p = 0.64) was dependent on GMS. Furthermore, GMS 0 significantly associated with improved DFS in patients receiving FOLFOX compared with CAPOX (HR 2.23 95% CI 1.19–4.16, p = 0.012). This study validates the GMS as a prognostic tool for patients with stage I–III colorectal cancer, independent of TNM, with the ability to stratify both low- and high-risk disease. Furthermore, GMS 0 could be employed to identify a subset of patients that benefit from FOLFOX over CAPOX.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#51

 

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Dysphagia is frequent in many neurological diseases and gives rise to severe complications such as malnutrition, dehydration and aspiration pneumonia. Therefore, early detection and management of dysphagia is essential and can reduce mortality. This study investigated the effect of cognitive and motor dual-task interference on swallowing in healthy participants, as dual-task effects are reported for other motor tasks such as gait and speech. 27 participants (17 females; 29.2 ± 4.1 years) were included in this prospective study and examined using flexible endoscopic evaluation of swallowing (FEES). Using a previously established FEES-based score, the paradigms “baseline swallowing”, “cognitive dual-task” and “motor dual-task” were assessed. Scores of the three paradigms were compared using a repetitive measures ANOVA and post-hoc analysis. Mean baseline swallowing score in single task was 5 ± 3. It worsened to 6 ± 5 in the cognitive (p = 0.118), and to 8 ± 5 in the motor dual-task condition (p < 0.001). This change was driven by subclinical worsening of premature bolus spillage and pharyngeal residue. Oropharyngeal swallowing is not exclusively reflexive in nature but requires attention, which leads to motor dual-task interference. This has potential diagnostic and therapeutic implications, e.g. in the early screening for dysphagia or in avoiding dual-task situations while eating.

#Medicine & Human body;#Software
Field # Medicine & Human body
Updated 23 November 2020

#52

 

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T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we observe that human memory T cells are more sensitive to CD28 costimulation than naive T cells. To deconvolute how the T-cell receptor (TCR) and CD28 orchestrate activation of human T cells, we stimulate cells using varying intensities of TCR and CD28 and profiled gene expression. We show that genes involved in cell cycle progression and division are CD28-driven in memory cells, but under TCR control in naive cells. We further demonstrate that T-helper differentiation and cytokine expression are controlled by CD28. Using chromatin accessibility profiling, we observe that AP1 transcriptional regulation is enriched when both TCR and CD28 are engaged, whereas open chromatin near CD28-sensitive genes is enriched for NF-kB motifs. Lastly, we show that CD28-sensitive genes are enriched in GWAS regions associated with immune diseases, implicating a role for CD28 in disease development. Our study provides important insights into the differential role of costimulation in naive and memory T-cell responses and disease susceptibility.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#53

 

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Energy dissipation rates are an important characteristic of turbulence; however, their magnitude in observational profiles can be incorrectly determined owing to their irregular appearance during vertical evolution. By analysing the data obtained from oceanic turbulence measurements, we demonstrate that the vertical sequences of energy dissipation rates exhibit a scaling property. Utilising this property, we propose a method to estimate the population mean for a profile. For scaling in the observed profiles, we demonstrate that our data exhibit a statistical property consistent with that exhibited by the universal multifractal model. Meanwhile, the population mean and its uncertainty can be estimated by inverting the probability distribution obtained by Monte Carlo simulations of a cascade model; to this end, observational constraints from several moments are imposed over each vertical sequence. This approach enables us to determine, to some extent, whether a profile shows an occasionally large mean or whether the population mean itself is large. Thus, it will contribute to the refinement of the regional estimation of the ocean energy budget, where only a small amount of turbulence observation data is available.

#Energy
Field # Energy
Updated 23 November 2020

#54

 

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Over the past 30 years since the implementation of the National Health Service Breast Screening Programme, improvements in diagnostic techniques and treatments have led to the need for an up-to-date evaluation of its benefit on risk of death from breast cancer. An initial pilot case-control study in London indicated that attending mammography screening led to a mortality reduction of 39%. Based on the same study protocol, an England-wide study was set up. Women aged 47–89 years who died of primary breast cancer in 2010 or 2011 were selected as cases (8288 cases). When possible, two controls were selected per case (15,202 controls) and were matched by date of birth and screening area. Conditional logistic regressions showed a 38% reduction in breast cancer mortality after correcting for self-selection bias (OR 0.62, 95% CI 0.56–0.69) for women being screened at least once. Secondary analyses by age group, and time between last screen and breast cancer diagnosis were also performed. According to this England-wide case-control study, mammography screening still plays an important role in lowering the risk of dying from breast cancer. Women aged 65 or over see a stronger and longer lasting benefit of screening compared to younger women.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#55

 

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Fibulin-3 is an extracellular matrix glycoprotein widely expressed in various tissues. Tissue fibulin-3 expression have never been reported in association with prognosis of mesothelioma. Hence, we sought to determine the association between fibulin-3 expression and mesothelioma survival. We made a tissue microarray, which was comprised of cancer and normal tissue from mesothelioma patients (n = 82) during the period 1998–2017 in China. Fibulin-3 and HGMB1 expression were analyzed by immunohistochemistry method. Kaplan–Meier method and Cox proportional hazard models were used for analyzing survival data. Overall, 61 cases (74.4%) were female; 90.2% were of epithelioid type; the median overall survival time was 12.5 months. Fibulin-3 and HMGB1 were highly expressed in tumor tissue rather than adjacent tissue. The expression of fibulin-3 in tissue was correlated with that of HMGB1 (r = 0.32, P = 0.003). High expression of fibulin-3 in tumor tissue could predict poor survival in patients with mesothelioma (P = 0.02). This remained true in a multivariate model, with a significant hazard ratio of 1.91. We demonstrated that fibulin-3 in tumor tissue was a novel biomarker of poor survival of mesothelioma, suggesting it may be a relevant target for therapeutic intervention.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#56

 

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To enable survival in adverse conditions, cancer cells undergo global metabolic adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling on three different levels: first, in its free form, in redox control, as a component of the antioxidant glutathione or its involvement in protein s-cysteinylation, a reversible post-translational modification; second, as a substrate for the production of hydrogen sulphide (H2S), which feeds the mitochondrial electron transfer chain and mediates per-sulphidation of ATPase and glycolytic enzymes, thereby stimulating cellular bioenergetics; and, finally, as a carbon source for epigenetic regulation, biomass production and energy production. This review will provide a systematic portrayal of the role of cysteine in cancer biology as a source of carbon and sulphur atoms, the pivotal role of cysteine in different metabolic pathways and the importance of H2S as an energetic substrate and signalling molecule. The different pools of cysteine in the cell and within the body, and their putative use as prognostic cancer markers will be also addressed. Finally, we will discuss the pharmacological means and potential of targeting cysteine metabolism for the treatment of cancer.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#57

 

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Catalpol has gained increasing attention for its potential contributions in controlling glycolipid metabolism and diabetic complications, which makes used as a very promising scaffold for seeking new anti-diabetic drug candidates. Acylation derivatives of catalpol crotonate (CCs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surfex-Docking method. Catalpol hexacrotonate (CC-6) was synthesized using microwave assisted method and characterized by FT-IR, NMR, HPLC and HRMS. The MD results indicate that with the increasing of esterification degree of hydroxyl, the C log P of CCs increased significantly, and the calculated total scores (Total_score) of CCs are all higher than that of catalpol. It shows that CCs maybe served as potential lead compounds for neuroprotective agents. It was found that the maximum Total_score of isomers in one group CCs is often not that the molecule with minimum energy. MD calculations show that there are five hydrogen bonds formed between CC-6 and the surrounding amino acid residues. Molecular dynamics simulation results show that the binding of CC-6 with GSH-Px is stable. CC-6 was screened for SH-SY5Y cells viability by MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay, the result indicates CC-6 can effectively reverse SZT induced cells apoptosis with dose-dependent manner, which can indirectly show that CC-6 is a potential neuroprotective agent.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#58

 

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Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling. Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling, its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated. In the present study, we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism. Absorbable collagen sponges containing 3 μg of recombinant human BMP2 (rhBMP2) were implanted in the dorsal muscle pouches of wild type (WT) and Smurf2−/− mice. The rhBMP2-induced ectopic bone in Smurf2−/− mice showed greater bone mass, higher mineral apposition and bone formation rates, and greater osteoblast numbers than the ectopic bone in WT mice. In WT mice, the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone. In contrast, in Smurf2−/− mice, the induced bone consisted of a thick, continuous outer cortical shell and abundant inner trabecular bone. Additionally, rhBMP2-stimulated bone marrow stromal cells (BMSCs) from Smurf2−/− mice showed increased osteogenic differentiation. Smurf2 induced the ubiquitination of Smad1/5. BMP/Smad signaling was enhanced in Smurf2−/− BMSCs stimulated with rhBMP2, and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs. These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling, thereby identifying a new regulatory mechanism in bone metabolism.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#59

 

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Intestinal fibrosis is a common complication of inflammatory bowel disease but remains difficult to detect. Matrix metalloproteases (MMPs) have key roles in fibrosis and are therefore potential targets for fibrosis detection. We determined whether immunoPET of F(ab′)2 antibody fragments targeting MMPs detects colitis induced colonic fibrosis. Mice were administered 2% dextran sulfate sodium treated water for 1 cycle (inflamed) or 3 cycles (fibrotic), or were untreated (control). Colonic and kidney collagen, innate cytokine, MMPs and fecal MPO concentrations were analyzed by multiplex/ELISA. α-pro-MMP-9 F(ab′)2 fragments were engineered and conjugated to 89Zr for PET imaging, ex-vivo Cherenkov analysis and bio-distribution. Colonic innate cytokine concentrations and fecal myeloperoxidase were increased in inflamed mice but not fibrotic mice, while collagen concentrations were increased in fibrotic mice. MMPs were increased in inflamed mice, but only pro-MMP-9 remained increased in fibrotic mice. 89Zr-pro-MMP-9 F(ab′)2 uptake was increased in the intestine but also in the kidney of fibrotic mice, where collagen and pro-MMP-9 concentrations were increased. 89Zr-pro-MMP-9 F(ab′)2 detects colitis induced intestinal fibrosis and associated kidney fibrosis.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#60

 

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Experiencing pain with a familiar individual can enhance one’s own pain sensitivity, a process known as pain contagion. When experiencing pain with an unfamiliar individual, pain contagion is suppressed in males by activating the endocrine stress response. Here, we coupled a histological investigation with pharmacological and behavioral experiments to identify enhanced glucocorticoid receptor activity in the prelimbic subdivision of the medial prefrontal cortex as a candidate mechanism for suppressing pain contagion in stranger mice. Acute inhibition of glucocorticoid receptors in the prelimbic cortex was sufficient to elicit pain contagion in strangers, while their activation prevented pain contagion in cagemate dyads. Slice physiology recordings revealed enhanced excitatory transmission in stranger mice, an effect that was reversed by pre-treating mice with the corticosterone synthesis inhibitor metyrapone. Following removal from dyadic testing, stranger mice displayed enhanced affective-motivational pain behaviors when placed on an inescapable thermal stimulus, which were reversed by metyrapone. Together, our data suggest that the prelimbic cortex may play an integral role in modulating pain behavior within a social context and provide novel evidence towards the neural mechanism underlying the prevention of pain contagion.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#61

 

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Differentiating pseudoprogression from true tumor progression has become a significant challenge in follow-up of diffuse infiltrating gliomas, particularly high grade, which leads to a potential treatment delay for patients with early glioma recurrence. In this study, we proposed to use a multiparametric MRI data as a sequence input for the convolutional neural network with the recurrent neural network based deep learning structure to discriminate between pseudoprogression and true tumor progression. In this study, 43 biopsy-proven patient data identified as diffuse infiltrating glioma patients whose disease progressed/recurred were used. The dataset consists of five original MRI sequences; pre-contrast T1-weighted, post-contrast T1-weighted, T2-weighted, FLAIR, and ADC images as well as two engineered sequences; T1post–T1pre and T2–FLAIR. Next, we used three CNN-LSTM models with a different set of sequences as input sequences to pass through CNN-LSTM layers. We performed threefold cross-validation in the training dataset and generated the boxplot, accuracy, and ROC curve, AUC from each trained model with the test dataset to evaluate models. The mean accuracy for VGG16 models ranged from 0.44 to 0.60 and the mean AUC ranged from 0.47 to 0.59. For CNN-LSTM model, the mean accuracy ranged from 0.62 to 0.75 and the mean AUC ranged from 0.64 to 0.81. The performance of the proposed CNN-LSTM with multiparametric sequence data was found to outperform the popular convolutional CNN with a single MRI sequence. In conclusion, incorporating all available MRI sequences into a sequence input for a CNN-LSTM model improved diagnostic performance for discriminating between pseudoprogression and true tumor progression.

#Artificial Intelligence
Field # Artificial Intelligence
Updated 23 November 2020

#62

 

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Due to strong Coulomb interactions, two-dimensional (2D) semiconductors can support excitons with large binding energies and complex many-particle states. Their strong light-matter coupling and emerging excitonic phenomena make them potential candidates for next-generation optoelectronic and valleytronic devices. The relaxation dynamics of optically excited states are a key ingredient of excitonic physics and directly impact the quantum efficiency and operating bandwidth of most photonic devices. Here, we summarize recent efforts in probing and modulating the photocarrier relaxation dynamics in 2D semiconductors. We classify these results according to the relaxation pathways or mechanisms they are associated with. The approaches discussed include both tailoring sample properties, such as the defect distribution and band structure, and applying external stimuli such as electric fields and mechanical strain. Particular emphasis is placed on discussing how the unique features of 2D semiconductors, including enhanced Coulomb interactions, sensitivity to the surrounding environment, flexible van der Waals (vdW) heterostructure construction, and non-degenerate valley/spin index of 2D transition metal dichalcogenides (TMDs), manifest themselves during photocarrier relaxation and how they can be manipulated. The extensive physical mechanisms that can be used to modulate photocarrier relaxation dynamics are instrumental for understanding and utilizing excitonic states in 2D semiconductors. Electrons and positively charged regions in semiconductors known as holes can form tightly bound states called excitons, offering new opportunities in optoelectronics and in ‘valleytronics,’ which exploits the effects of valleys and peaks in an energy landscape. The excitons display particle-like properties, so are described as quasiparticles. Fengqiu Wang and colleagues at Nanjing University, in China, review many technical aspects of the creation and control of excitons in single layer (2D) semiconductor sheets. The restrictions of 2D materials promote unique exciton behavior and strong light-matter interactions. The authors focus on the ability of excitons to act as photocarriers of absorbed light energy, and on the relaxation processes that can release the energy. Learning how to control exciton formation, interactions and relaxation will be crucial for using them to develop novel optoelectronic and photonic devices.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#63

 

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The plastic zone range is an important parameter in the analysis of damage characteristics and the degree of damage to the rock surrounding a roadway. Based on the establishment of a plastic zone calculation model considering the creep effect, this paper obtains the characteristics of the change in the plastic zone damage range with time by solving the model. Additionally, the validity of the model is verified by field experiments. The research results can provide guidance for gas pressure measurement and gas drainage in coal mines.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#64

 

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Magnetic resonances not only play crucial roles in artificial magnetic materials but also offer a promising way for light control and interaction with matter. Recently, magnetic resonance effects have attracted special attention in plasmonic systems for overcoming magnetic response saturation at high frequencies and realizing high-performance optical functionalities. As novel states of matter, topological insulators (TIs) present topologically protected conducting surfaces and insulating bulks in a broad optical range, providing new building blocks for plasmonics. However, until now, high-frequency (e.g. visible range) magnetic resonances and related applications have not been demonstrated in TI systems. Herein, we report for the first time, to our knowledge, a kind of visible range magnetic plasmon resonances (MPRs) in TI structures composed of nanofabricated Sb2Te3 nanogrooves. The experimental results show that the MPR response can be tailored by adjusting the nanogroove height, width, and pitch, which agrees well with the simulations and theoretical calculations. Moreover, we innovatively integrated monolayer MoS2 onto a TI nanostructure and observed strongly reinforced light–MoS2 interactions induced by a significant MPR-induced electric field enhancement, remarkable compared with TI-based electric plasmon resonances (EPRs). The MoS2 photoluminescence can be flexibly tuned by controlling the incident light polarization. These results enrich TI optical physics and applications in highly efficient optical functionalities as well as artificial magnetic materials at high frequencies. Nanostructured antimony telluride (Sb2Te3) can support visible range magnetic resonances and dramatically enhance the weak interactions of light with 2D materials. Hua Lu and workers from China and Australia used focused ion beam milling to write a grating of periodic nanogrooves into single-crystalline Sb2Te3, a well-known topological insulator. They then placed a flake of the 2D material MoS2 on top. Characterization showed the existence of a kind of magnetic plasmon resonances (MPRs) with a resonant wavelength that redshifts with increasing nanogroove height and pitch and blueshifts with increasing nanogroove width. Visible photoluminescence experiments showed that the MPRs can dramatically increase the emission from the MoS2, which could be tuned by changing the polarization angle of the incident excitation light. The findings are expected to aid the development of nanoscale optical devices made from layered nanomaterials.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#65

 

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Mitochondrial response to inflammation is crucial in the metabolic adaptation to infection. This study aimed to explore the mitochondrial response under inflammatory and anti-inflammatory environments, with a focus on the tricarboxylic acid (TCA) cycle. Expression levels of key TCA cycle enzymes and the autophagy-related protein light chain 3b (LC3b) were determined in raw 264.7 cells treated with lipopolysaccharide (LPS) and metformin (Met). Additionally, reactive oxygen species (ROS) levels and mitochondrial membrane potential were assessed using flow cytometry. Moreover, 8-week-old C57BL/6J mice were intraperitoneally injected with LPS and Met to assess the mitochondrial response in vivo. Upon LPS stimulation, the expression of key TCA enzymes, including citrate synthase, α-ketoglutarate dehydrogenase, and isocitrate dehydrogenase 2, and the mitochondrial membrane potential decreased, whereas the levels of LC3b and ROS increased. However, treatment with Met inhibited the reduction of LPS-induced enzyme levels as well as the elevation of LC3b and ROS levels. In conclusion, the mitochondrial TCA cycle is affected by the inflammatory environment, and the LPS-induced effects can be reversed by Met treatment.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#66

 

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Two-dimensional (2D) transition metal dichalcogenides (TMDCs) and graphene compose a new family of crystalline materials with atomic thicknesses and exotic mechanical, electronic, and optical properties. Due to their inherent exceptional mechanical flexibility and strength, these 2D materials provide an ideal platform for strain engineering, enabling versatile modulation and significant enhancement of their optical properties. For instance, recent theoretical and experimental investigations have demonstrated flexible control over their electronic states via application of external strains, such as uniaxial strain and biaxial strain. Meanwhile, many nondestructive optical measurement methods, typically including absorption, reflectance, photoluminescence, and Raman spectroscopies, can be readily exploited to quantitatively determine strain-engineered optical properties. This review begins with an introduction to the macroscopic theory of crystal elasticity and microscopic effective low-energy Hamiltonians coupled with strain fields, and then summarizes recent advances in strain-induced optical responses of 2D TMDCs and graphene, followed by the strain engineering techniques. It concludes with exciting applications associated with strained 2D materials, discussions on existing open questions, and an outlook on this intriguing emerging field. A review of recent advances in strain-induced new optical responses of two-dimensional (2D) materials concludes with various applications associated with strain-engineered 2D materials. The review, conducted by Dangyuan Lei and colleagues at The City University of Hong Kong, in collaboration with a researcher from The Hong Kong Polytechnic University, first provides a brief introduction to the macroscopic theory of crystal elasticity and how external strain affects the physical and optical properties of 2D materials. It then summarizes how recent advances in the application of external strains in 2D materials, including TMDCs and graphene, can be used to modify their unique physical and optical properties, followed by a summary of strain engineering techniques. The review concludes by highlighting some of the peculiar applications associated with strained 2D materials, such as high-sensitivity optical resonators and flexible electronic devices.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#67

 

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Brown adipose tissue (BAT) is the primary non-shivering thermogenesis organ in mammals, which plays essential roles in maintaining the body temperature of infants. Although the development of BAT during embryogenesis has been well addressed in rodents, how BAT grows after birth remains unknown. Using mouse interscapular BAT (iBAT) as an example, we studied the cellular and molecular mechanisms that regulate postnatal BAT growth. By analyzing the developmental dynamics of brown adipocytes (BAs), we found that BAs size enlargement partially accounts for iBAT growth. By investigating the BAs cell cycle activities, we confirmed the presence of proliferative BAs in the neonatal mice. Two weeks after birth, most of the BAs exit cell cycle, and the further expansion of the BAT was mainly due to lipogenesis-mediated BAs volume increase. Microscopy and fluorescence-activated cell sorting analyses suggest that most BAs are mononuclear and diploid. Based on the developmental dynamics of brown adipocytes, we propose that the murine iBAT has two different growth phases between birth and weaning: increase of BAs size and number in the first two weeks, and BAs size enlargement thereafter. In summary, our data demonstrate that both lipogenesis and proliferation of BAs contribute to postnatal iBAT growth in mice.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#68

 

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Mobile carrier SK Telecom said on Sunday it has developed a next-generation cloud native core network system with Samsung Electronics that can provide better 5G services.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#69

 

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Nesting birds can act as thermal ecosystem engineers by providing warm habitats that may attract arthropods to colonise the nest structure. This cohabitation of birds and nest-dwelling invertebrates may foster symbiotic relationships between them, but evidence is lacking. We investigated whether ants are attracted to bird nests by the heat generated by the hosts, and/or the nests’ structural insulation properties, to raise their broods (larvae and/or pupae) in advantageous thermal conditions. We found that the endothermic activity of birds within their nests created ‘heat islands’, with thermal conditions potentially promoting the survival and development of ant larvae in cool environments. We experimentally confirmed that the presence of heat within bird nests, and not the structure itself, attracted the ants to colonise the nests. As ants might benefit from exploiting warm bird nests, this may be a previously overlooked commensal, mutualistic or parasitic relationship which may be ecologically significant and globally widespread among various nesting birds and reproducing ants. Similar interspecific interactions may exist with other arthropods that reproduce in avian and mammalian nests. Further research is needed to reveal the nature of these relationships between such taxa, and to understand the role of warm-blooded animals as thermal ecosystem engineers.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#70

 

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The app called Task Mate is in early access and is being tested with a select few users through a referral code system.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#71

 

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High-producing ruminants need high-concentrate diets to satisfy their nutrient requirements and meet performance objectives. However, such diets induce sub-acute ruminal acidosis (SARA), which will adversely affect dry matter intake and lead to lower production performance. This work develops a novel modelling approach to quantify the capacity of dairy goats to adapt to a high-concentrate diet challenge at the individual level. The animal model used was dairy goats (from Saanen or Alpine breed), and rumen pH was used as the indicator of the response. A three-step modelling procedure was developed to quantify daily scores and produce a single global index for animals’ adaptive response to the new diet. The first step summarizes the post-prandial kinetics of rumen acid status using three synthetic variables. In the second step, the effect of time on the response of goats is described, in the short and long terms. In the last step, a metric based on phase trajectories ranks goats for their resilience capacity. This modelling procedure showed a high variability among the goats in response to the new diet, highlighting in particular their daily and general strategies to buffer the effect of the diet change. Two main categories of adaptive strategies were observed: (i) acid status increased, but the goats tried to minimize its variations, and (ii) acid status oscillated between increases and decreases. Such phenotyping, alongside other behavioral, digestive, and metabolic measures, can help to determine biomarkers of goats’ capacity to adapt to diets of higher nutritive value and to increase production performance without compromising their health status. Quantifying the capacity of goats to buffer the effect of highly fermentable diets helps to better adapt feed to animals in precision livestock farming. This procedure is generic and can be adapted to any indicator of animal health and performance. In particular, several indicators can be combined to assess multi-performance, which is of major interest in the context of selection for robust animals.

#Food
Field # Food
Updated 23 November 2020

#72

 

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Flipkart daily trivia comprises of five questions based on general knowledge.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#73

 

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Deficiency of selenium (Se) will lead to malnutrition and decreased immune function of the body. There is a common phenomenon of Se deficiency in foods. In this study, different concentrations of sodium selenite (Na2SeO3) were applied to Moringa oleifera grownin soil. The purpose was to explore the feasibility of Se biofortification of M. oleifera root. The effect of exogenous Se on the accumulation of Se and cadmium (Cd) in the roots of M. oleifera was studied by inductively coupled plasma mass spectrometry, and the mechanism of exogenous Se on the accumulation of Se and Cd in the roots was studied by Fourier transform infrared spectroscopy (FTIR) combined with principal component analysis and partial least squares regression analysis. The results showed that Na2SeO3 significantly affected the accumulation of Se and Cd in the roots (p < 0.05). The increase in Se was highest when Na2SeO3 was around 4.0 mg/kg, which increased by 315% compared with the control. The decrease in Cd was the lowest when Na2SeO3 was around 2.0 mg/kg, which decreased by 80% compared with the control. The results of FTIR analysis showed that Na2SeO3 treatment changed the carboxylate, phosphate radical, hemicellulose and protein in roots of M. oleifera, while the increase of Se was related to hemicellulose, protein, polysaccharide and lignin, and the decrease of Cd was related to hemicellulose and protein. The results showed that exogenous Se increased the accumulation of Se and inhibited the absorption of Cd. Therefore, the roots of M. oleifera can be used in Se biofortified products.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#74

 

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The study comes at a time when companies around the world are turning to automation to boost business productivity and employee satisfaction.

#Artificial intelligence
Field # Artificial intelligence
Updated 23 November 2020

#75

 

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The dissemination of tattooing into mainstream culture has raised concerns pertaining to the medical implications of these practices. This paper reports on the coating of tattoo needles with metallic-glass (MG) to reduce trauma to the skin. Extensive experimentation using pork samples and live pigs demonstrated the beneficial effects of non-stick MG coatings. Following 30 insertions into pork skin, significantly less tissue adhered to the MG-coated needles than to uncoated needles. MG-coated needles were also shown to reduce the spread of pigment to the surface of surrounding skin by up to 57%. This resulted in narrower tattoo lines of higher density, indicating that MG-coated needles could be useful in high-resolution tattooing. Histopathological analysis on live pigs revealed severe trauma induced by bare needles, as indicated by the secretion of fluids immediately after tattooing. The wounds formed by coated needles closed within 2 h after tattooing; however, those formed by bare needles remained open for at least 2 h and inflammation was still observed after 3 days. At 5 days after tattooing, skin punctured by the coated needle was entirely healed, whereas skin punctured by the bare needle was still covered with scabs. In addition to the medical benefits, it appears that MG-coated needles could improve the quality of tattoos, based on the fact that the amount of pigment retained in the skin is inversely proportional to the trauma caused by needles.

#Medicine & Human body;#Entertainments
Field # Medicine & Human body
Updated 23 November 2020

#76

 

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Name of the winner is chosen via lucky draw.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#77

 

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Topologically distinct magnetic structures like skyrmions, domain walls, and the uniformly magnetized state have multiple applications in logic devices, sensors, and as bits of information. One of the most promising concepts for applying these bits is the racetrack architecture controlled by electric currents or magnetic driving fields. In state-of-the-art racetracks, these fields or currents are applied to the whole circuit. Here, we employ micromagnetic and atomistic simulations to establish a concept for racetrack memories free of global driving forces. Surprisingly, we realize that mixed sequences of topologically distinct objects can be created and propagated over far distances exclusively by local rotation of magnetization at the sample boundaries. We reveal the dependence between chirality of the rotation and the direction of propagation and define the phase space where the proposed procedure can be realized. The advantages of this approach are the exclusion of high current and field densities as well as its compatibility with an energy-efficient three-dimensional design.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#78

 

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Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#79

 

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Pancreatic cancer is one of the most lethal and chemo-resistant cancers worldwide. Growing evidence supports the theory that the gut microbiota plays an essential role in modulating the host response to anti-cancer therapy. The present study aimed to explore the effect of probiotics as an adjuvant during chemotherapy for pancreatic cancer. An LSL-KrasG12D/−-Pdx-1-Cre mouse model of pancreatic ductal adenocarcinoma (PDAC) was created to study the effects of using four-week multi-strain probiotics (Lactobacillus paracasei GMNL-133 and Lactobacillus reuteri GMNL-89) as an adjuvant therapy for controlling cancer progression. At 12 weeks of age, pancreatitis was induced in the mice by two intraperitoneal injection with caerulein (25 μg/kg 2 days apart). Over the next 4 weeks the mice were treated with intraperitoneal injections of gemcitabine in combination with the oral administration of probiotics. The pancreas was then harvested for analysis. Following caerulein treatment, the pancreases of the LSL-KrasG12D/−-Pdx-1-Cre transgenic mice exhibited more extensive pancreatic intraepithelial neoplasia (PanIN) formation. Combined treatment with gemcitabine and probiotics revealed a lower grade of PanIN formation and a decrease in the expression of vimentin and Ki-67. Mice that received gemcitabine in combination with probiotics had lower aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Notably, the use of high-dose probiotics alone without gemcitabine also had an inhibitory effect on PanIN changes and serum liver enzyme elevation. These findings suggest that probiotics are able to make standard chemotherapy more effective and could help improve the patient’s tolerance of chemotherapy.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#80

 

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The role of minimally invasive surgery (MIS) to treat clinically T4 (cT4) colorectal cancer (CRC) remains uncertain and deserves further investigation. A retrospective cohort study was conducted between September 2006 and March 2019 recruiting patients diagnosed as cT4 CRC and undergoing MIS at a university hospital and its branch. Patients’ demography, clinicopathology, surgical and oncological outcomes, and radicality were analyzed. A total of 128 patients were recruited with an average follow-up period of 33.8 months. The median time to soft diet was 6 days, and the median postoperative hospitalization periods was 11 days. The conversion and complication (Clavien–Dindo classification ≥ II) rates were 7.8% and 27.3%, respectively. The 30-day mortality was 0.78%. R0 resection rate was 92.2% for cT4M0 and 88.6% for pT4M0 patients. For cT4 CRC patients, the disease-free survival and 3-year overall survival were 86.1% and 86.8% for stage II, 54.1% and 57.9% for stage III, and 10.8% and 17.8% for stage IV. With acceptable conversion, complication and mortality rate, MIS may achieve satisfactory R0 resection rate and thus lead to good oncological outcomes for selected patients with cT4 CRC.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#81

 

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Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.

#Astronautics
Field # Astronautics
Updated 23 November 2020

#82

 

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Several studies have shown that the benefits of working memory (WM) training can be attributed to functional and structural neural changes in the underlying neural substrate. In the current study, we investigated whether the functional connectivity of the brain at rest in the default mode network (DMN) changes with WM training. We varied the complexity of the training intervention so, that half of the participants attended dual n-back training whereas the other half attended single n-back training. This way we could assess the effects of different training task parameters on possible connectivity changes. After 16 training sessions, the dual n-back training group showed improved performance accompanied by increased functional connectivity of the ventral DMN in the right inferior frontal gyrus, which correlated with improvements in WM. We also observed decreased functional connectivity in the left superior parietal cortex in this group. The single n-back training group did not show significant training-related changes. These results show that a demanding short-term WM training intervention can alter the default state of the brain.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#83

 

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Soil physical properties and soil organic carbon (SOC) are considered as important factors of soil quality. Arable land, grassland, and forest land coexist in the saline-alkali reclamation area of the Yellow River Delta (YRD), China. Such different land uses strongly influence the services of ecosystem to induce soil degradation and carbon loss. The objective of this study is to evaluate the variation of soil texture, aggregates stability, and soil carbon affected by land uses. For each land use unit, we collected soil samples from five replicated plots from “S” shape soil profiles to the depth of 50 cm (0–5, 5–10, 10–20, 20–30, and 30–50 cm). The results showed that the grassland had the lowest overall sand content of 39.98–59.34% in the top 50 cm soil profile. The content of soil aggregates > 0.25 mm (R0.25), mean weight diameter and geometric mean diameter were significantly higher in grassland than those of the arable and forest land. R0.25, aggregate stability in arable land in the top 30 cm were higher than that of forest land, but lower in the soil profile below 20 cm, likely due to different root distribution and agricultural practices. The carbon management index (CMI) was considered as the most effective indicator of soil quality. The overall SOC content and CMI in arable land were almost the lowest among three land use types. In combination with SOC, CMI and soil physical properties, we argued that alfalfa grassland had the advantage to promote soil quality compared with arable land and forest land. This result shed light on the variations of soil properties influenced by land uses and the importance to conduct proper land use for the long-term sustainability of the saline-alkali reclamation region.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#84

 

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Vegetarians, vegans and pescetarians are more likely to break their hips than those who eat meat, possibly due to lack of calcium and protein in their diet

#Food
Field # Food
Updated 23 November 2020

#85

 

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Human decision-making is often swayed by irrecoverable investments even though it should only be based on future—and not past—costs and benefits. Although this sunk cost effect is widely documented and can lead to devastating losses, the underlying psychological mechanisms are unclear. To tease apart possible explanations through a comparative approach, we assessed capuchin and rhesus monkeys’ susceptibility to sunk costs in a psychomotor task. Monkeys needed to track a moving target with a joystick-controlled cursor for variable durations. They could stop at any time, ending the trial without reward. To minimize the work required for a reward, monkeys should have always persisted for at least 1 s, but should have abandoned the trial if that did not yield a reward. Capuchin monkeys and especially rhesus macaques persisted to trial completion even when it was suboptimal, and were more likely to complete the trial the longer they had already tracked the target. These effects were less pronounced, although still present, when the change in expected tracking duration was signalled visually. These results show that sunk cost effects can arise in the absence of human-unique factors and may emerge, in part, because persisting can resolve uncertainty.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#86

 

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New report outlines future research pathways to airline decarbonization Global air travel consumes more than 100 billion gallons of jet fuel annually. That’s expected to more than double by 2025 to 230 billion gallons. Despite the current pandemic, these projections reflect future anticipated pas

#Energy
Field # Energy
Updated 23 November 2020

#87

 

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Brain embryonic periventricular endothelial cells (PVEC) crosstalk with neural progenitor cells (NPC) promoting mutual proliferation, formation of tubular-like structures in the former and maintenance of stemness in the latter. To better characterize this interaction, we conducted a comparative transcriptome analysis of mouse PVEC vs. adult brain endothelial cells (ABEC) in mono-culture or NPC co-culture. We identified > 6000 differentially expressed genes (DEG), regardless of culture condition. PVEC exhibited a 30-fold greater response to NPC than ABEC (411 vs. 13 DEG). Gene Ontology (GO) analysis of DEG that were higher or lower in PVEC vs. ABEC identified “Nervous system development” and “Response to Stress” as the top significantly different biological process, respectively. Enrichment in canonical pathways included HIF1A, FGF/stemness, WNT signaling, interferon signaling and complement. Solute carriers (SLC) and ABC transporters represented an important subset of DEG, underscoring PVEC’s implication in blood–brain barrier formation and maintenance of nutrient-rich/non-toxic environment. Our work characterizes the gene signature of PVEC and their important partnership with NPC, underpinning their unique role in maintaining a healthy neurovascular niche, and in supporting brain development. This information may pave the way for additional studies to explore their therapeutic potential in neuro-degenerative diseases, such as Alzheimer’s and Parkinson’s disease.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#88

 

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The incorporation of the biologically vital element phosphorus into material found in living species may have formed during impact from astrophysical bodies on early Earth. NASA’s Exobiology Program has awarded Lawrence Livermore National Laboratory (LLNL) senior scientist Nir Goldman a three-yea

#Astronautics
Field # Astronautics
Updated 23 November 2020

#89

 

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We combine COVID-19 case data with mobility data to estimate a modified susceptible-infected-recovered (SIR) model in the United States. In contrast to a standard SIR model, we find that the incidence of COVID-19 spread is concave in the number of infectious individuals, as would be expected if people have inter-related social networks. This concave shape has a significant impact on forecasted COVID-19 cases. In particular, our model forecasts that the number of COVID-19 cases would only have an exponential growth for a brief period at the beginning of the contagion event or right after a reopening, but would quickly settle into a prolonged period of time with stable, slightly declining levels of disease spread. This pattern is consistent with observed levels of COVID-19 cases in the US, but inconsistent with standard SIR modeling. We forecast rates of new cases for COVID-19 under different social distancing norms and find that if social distancing is eliminated there will be a massive increase in the cases of COVID-19.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#90

 

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Samsung Galaxy Z Fold 3 (not the official name) is said to launch in June 2021 and the company may discontinue the Galaxy Note series as it is bringing S Pen support to the Galaxy S lineup and its future foldable phones.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#91

 

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The Asbestos Injury Relief Act in Korea requires that asbestos exposure be assessed through clinical examination and chest computed tomography (CT). However, a more specific measurement of asbestos characteristics in the lung tissue may be appropriate. We aimed to investigate the asbestos burden and characterize asbestos fibers in patients with lung cancer and ultimately assess the relationship between occupational and environmental asbestos exposure and lung cancer in Korea. We evaluated 37 lung cancer patients (LCPs) from Busan. The factors affecting asbestos burden in LCPs were analyzed using a multiple regression analysis. History of asbestos exposure (environmental/occupational), male sex, and old age were the main factors affecting asbestos burden in lung tissues of LCPs. These factors had an approximate 37% adjusted coefficient of determination. There was a significant difference in the length of asbestos fibers (4.06–37.6 µm vs. 4.26–91.7 µm) and aspect ratio (4.5–151.9 vs. 5.6–735.6) between those who were occupationally exposed to asbestos and those who were environmentally exposed (P < 0.01). Therefore, both environmental/occupational exposure to asbestos should be strongly managed to reduce the risk of lung cancer, and exposure should be assessed according to the characteristics of asbestos fibers in the lung tissue.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#92

 

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Activate DND on Airtel quickly by following these steps and reduce the number of spam calls and messages you get.

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 23 November 2020

#93

 

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Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut microbiota, in facilitating weight loss and resolving associated comorbidities. VSG in humans is a complex procedure and includes peri-operative antibiotics and caloric restriction in addition to the altered anatomy. The impact of each of these factors on the intestinal microbiota have not been evaluated. The aim of this study was to determine the relative contributions of each of these factors on intestinal microbiota composition following VSG prior to substantial weight loss. Thirty-two obese patients underwent one of three treatments: (1) VSG plus routine intravenous peri-operative antibiotics (n = 12), (2) VSG with intravenous vancomycin chosen for its low intestinal penetrance (n = 12), and (3) caloric restriction (n = 8). Fecal samples were evaluated for bacterial composition prior to and 7 days following each intervention. Only patients undergoing VSG with routine peri-operative antibiotics showed a significant shift in community composition. Our data support the single dose of routine peri-operative antibiotics as the most influential factor of intestinal microbial composition acutely following VSG.

#Medicine & Human body;#Theoretical sciences
Field # Medicine & Human body
Updated 23 November 2020

#94

 

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FIFA 21, Watch Dogs: Legion, Ghost of Tsushima, The Last of Us Part II, Star Wars: Squadrons, NBA 2K21, Persona 5 Royal, Assassin&rsquo;s Creed Odyssey, GTA 5, God of War, PUBG &mdash; these are the best PlayStation Black Friday deals on PS4 and PS5 games.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#95

 

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Luneburg lenses and Maxwell fisheye lenses possess distinct properties of focusing, well beyond conventional lenses made of uniform materials. In this paper, a planar broadband bifunctional Luneburg-fisheye lens synthesized by gradient anisotropic metasurface is proposed. The proposed anisotropic metasurface is formed by non-resonant anisotropic cells, so that it can independently realize the equivalent gradient refractive indexes of Luneburg lens and Maxwell fisheye lens along orthogonal directions in a broad band, respectively. To verify the performance of the bifunctional lens, a prototype associated with a feeding log-periodic dipole antenna has been fabricated. Experimental results show that the proposed lens functions well over a wide frequency range with high efficiency and low profile, which coincides well with theoretical predictions and simulated results. It is expected that the proposed design will facilitate the applications of multifunctional metadevices in microwave and optical ranges.

#Telecommunications
Field # Telecommunications
Updated 23 November 2020

#96

 

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IIT alumnus Pradeep Poonia released a series of tweets earlier this month, sharing internal slack chats from WhiteHat Jr among other things. Poonia alleges that the teachers aren&rsquo;t trained enough, and lack sufficient knowledge to teach the students who sign up for the program about coding. WhiteHat Jr has dismissed these claims and asked for $2.6 million (roughly Rs. 192,836,700) in damages.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#97

 

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A widespread belief is that large groups engaged in joint actions that require a high level of flexibility are unable to coordinate without the introduction of additional resources such as shared plans or hierarchical organizations. Here, we put this belief to a test, by empirically investigating coordination within a large group of 16 musicians performing collective free improvisation—a genre in which improvisers aim at creating music that is as complex and unprecedented as possible without relying on shared plans or on an external conductor. We show that musicians freely improvising within a large ensemble can achieve significant levels of coordination, both at the level of their musical actions (i.e., their individual decisions to play or to stop playing) and at the level of their directional intentions (i.e., their intentions to change or to support the music produced by the group). Taken together, these results invite us to reconsider the range and scope of actions achievable by large groups, and to explore alternative organizational models that emphasize decentralized and unscripted forms of collective behavior.

#Entertainments;#Music
Field # Entertainments
Updated 23 November 2020

#98

 

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Google is testing Task Mate, an app that will let users earn money by doing &lsquo;simple&rsquo; tasks on their phones. There will be a variety of tasks users can perform, such as clicking a picture of a restaurant or translating a sentence from English to a local language. The app is currently in beta and is limited to selected testers through a referral code system.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#99

 

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Glioblastoma (GBM) is the most common and malignant cancer of the central nervous system, and radiotherapy is widely applied in GBM treatment; however, the sensitivity to radiotherapy varies in different patients. To solve this clinical dilemma, a radiosensitivity prediction signature was constructed in the present study based on genomic methylation. In total, 1044 primary GBM samples with clinical and methylation microarray data were involved in this study. LASSO-COX, GSVA, Kaplan–Meier survival curve analysis, and COX regression were performed for the construction and verification of predictive models. The R programming language was used as the main tool for statistical analysis and graphical work. Via the integration analysis of methylation and the survival data of primary GBM, a novel prognostic and radiosensitivity prediction signature was constructed. This signature was found to be stable in prognosis prediction in the TCGA and CGGA databases. The possible mechanism was also explored, and it was found that this signature is closely related to DNA repair functions. Most importantly, this signature could predict whether GBM patients could benefit from radiotherapy. In summary, a radiosensitivity prediction signature for GBM patients based on five methylated probes was constructed, and presents great potential for clinical application.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#100

 

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Are you tired of entering the PDF password every time you want to open the file? Here&rsquo;s how to remove password from PDF files.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#101

 

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Cryptosporidiosis, caused by protozoan parasites of the genus Cryptosporidium, is estimated to rank as a leading cause in the global burden of neglected zoonotic parasitic diseases. This diarrheal disease is the second leading cause of death in children under 5 years of age. Based on the C. parvum transcriptome data, glutathione transferase (GST) has been suggested as a drug target against this pathogen. GSTs are diverse multifunctional proteins involved in cellular defense and detoxification in organisms and help pathogens to alleviate chemical and environmental stress. In this study, we performed genome-wide data mining, identification, classification and in silico structural analysis of GSTs in fifteen Cryptosporidium species. The study revealed the presence three GSTs in each of the Cryptosporidium species analyzed in the study. Based on the percentage identity and comprehensive comparative phylogenetic analysis, we assigned Cryptosporidium species GSTs to three new GST classes, named Vega (ϑ), Gamma (γ) and Psi (ψ). The study also revealed an atypical thioredoxin-like fold in the C. parvum GST1 of the Vega class, whereas C. parvum GST2 of the Gamma class and C. melagridis GST3 of the Psi class has a typical thioredoxin-like fold in the N-terminal region. This study reports the first comparative analysis of GSTs in Cryptosporidium species.

#Environment & Nature;#Theoretical sciences
Field # Environment & Nature
Updated 23 November 2020

#102

 

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Vivo V20 Pro pre-order offers are tipped to include 10 percent cashback on ICICI credit and debit cards, Bank of Baroda credit cards, and ZestMoney Finance. Bajaj Finance may offer an EMI scheme that allows for an upfront fee of just Rs. 101, and there will be several other EMI schemes from IDFC First Bank and Home Credit. Pre-order users may also get Vivo upgrade rewards and V-shield complete mobile protection.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#103

 

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We have derived an expression of the Dzyaloshinskii–Moriya interaction (DMI), where all the three components of the DMI vector can be calculated independently, for a general, non-collinear magnetic configuration. The formalism is implemented in a real space—linear muffin-tin orbital—atomic sphere approximation (RS-LMTO-ASA) method. We have chosen the Cr triangular trimer on Au(111) and Mn triangular trimers on Ag(111) and Au(111) surfaces as numerical examples. The results show that the DMI (module and direction) is drastically different between collinear and non-collinear states. Based on the relation between the spin and charge currents flowing in the system and their coupling to the non-collinear magnetic configuration of the triangular trimer, we demonstrate that the DMI interaction can be significant, even in the absence of spin-orbit coupling. This is shown to emanate from the non-collinear magnetic structure, that can induce significant spin and charge currents even with spin-orbit coupling is ignored.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#104

 

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Days after WhatsApp made the Disappearing Messages official, the feature has now been rolled out in India.

#Software;#Social & Corporation affairs
Field # Software
Updated 23 November 2020

#105

 

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The capillary network of the kidney glomerulus filters small molecules from the blood. The glomerular 3D structure should help to understand its function, but it is poorly characterized. We therefore devised a new approach in which an automated tape collecting microtome (ATUM) was used to collect 0.5 μm thick serial sections from fixed mouse kidneys. The sections were imaged by scanning electron microscopy at ~ 50 nm/pixel resolution. With this approach, 12 glomeruli were reconstructed at an x–y–z resolution ~ 10 × higher than that of paraffin sections. We found a previously undescribed no-cross zone between afferent and efferent branches on the vascular pole side; connections here would allow blood to exit without being adequately filtered. The capillary diameters throughout the glomerulus appeared to correspond with the amount of blood flow within them. The shortest path (minimum number of branches to travel from afferent to efferent arterioles) is relatively independent of glomerular size and is present primarily on the vascular pole size. This suggests that new branches and longer paths form on the urinary pole side. Network analysis indicates that the glomerular network does not form by repetitive longitudinal splitting of capillaries. Thus the 3D structure of the glomerular capillary network provides useful information with which to understand glomerular function. Other tissue structures in the body may benefit from this new three dimensional approach.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#106

 

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The Vivo V20 Pro will be priced in India at Rs 29,990, and the phone is said to be already up for pre-booking.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#107

 

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Breeding has substantially increased the genetic yield potential, but fungal pathogens are still major constraints for wheat production. Therefore, breeding success for resistance and its impact on yield were analyzed on a large panel of winter wheat cultivars, representing breeding progress in Germany during the last decades, in large scale field trials under different fungicide and nitrogen treatments. Results revealed a highly significant effect of genotype (G) and year (Y) on resistances and G × Y interactions were significant for all pathogens tested, i.e. leaf rust, strip rust, powdery mildew and Fusarium head blight. N-fertilization significantly increased the susceptibility to biotrophic and hemibiotrophic pathogens. Resistance was significantly improved over time but at different rates for the pathogens. Although the average progress of resistance against each pathogen was higher at the elevated N level in absolute terms, it was very similar at both N levels on a relative basis. Grain yield was increased significantly over time under all treatments but was considerably higher without fungicides particularly at high N-input. Our results strongly indicate that wheat breeding resulted in a substantial increase of grain yield along with a constant improvement of resistance to fungal pathogens, thereby contributing to an environment-friendly and sustainable wheat production.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#108

 

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The Redmi Note 9 Pro 5G has appeared on Geekbench ahead of its rumoured November 26 launch.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#109

 

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One of the potential antibiofilm strategies is to use lytic phages and phage-derived polysaccharide depolymerases. The idea is to uncover bacteria embedded in the biofilm matrix making them accessible and vulnerable to antibacterials and the immune system. Here we present the antibiofilm efficiency of lytic phage KP34 equipped with virion-associated capsule degrading enzyme (depolymerase) and its recombinant depolymerase KP34p57, depolymerase-non-bearing phage KP15, and ciprofloxacin, separately and in combination, using a multidrug-resistant K. pneumoniae biofilm model. The most effective antibiofilm agents were (1) phage KP34 alone or in combination with ciprofloxacin/phage KP15, and (2) depolymerase KP34p57 with phage KP15 and ciprofloxacin. Secondly, applying the commonly used biofilm microtiter assays: (1) colony count, (2) LIVE/DEAD BacLight Bacterial Viability Kit, and (3) crystal violet (CV) biofilm staining, we unravelled the main advantages and limitations of the above methods in antibiofilm testing. The diverse mode of action of selected antimicrobials strongly influenced obtained results, including a false positive enlargement of biofilm mass (CV staining) while applying polysaccharide degrading agents. We suggest that to get a proper picture of antimicrobials’ effectiveness, multiple examination methods should be used and the results must be read considering the principle of each technique and the antibacterial mechanism.

#Materials
Field # Materials
Updated 23 November 2020

#110

 

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OnePlus 9 Pro has already seen its specifications leak online on Geekbench. Here's all we know about it.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#111

 

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Environmental DNA (eDNA) metabarcoding of marine sediments has revealed large amounts of sequences assigned to planktonic taxa. How this planktonic eDNA is delivered on the seafloor and preserved in the sediment is not well understood. We address these questions by comparing metabarcoding and microfossil foraminifera assemblages in sediment cores taken off Newfoundland across a strong ecological gradient. We detected planktonic foraminifera eDNA down to 30 cm and observed that the planktonic/benthic amplicon ratio changed with depth. The relative proportion of planktonic foraminiferal amplicons remained low from the surface down to 10 cm, likely due to the presence of DNA from living benthic foraminifera. Below 10 cm, the relative proportion of planktonic foraminifera amplicons rocketed, likely reflecting the higher proportion of planktonic eDNA in the DNA burial flux. In addition, the microfossil and metabarcoding assemblages showed a congruent pattern indicating that planktonic foraminifera eDNA is deposited without substantial lateral advection and preserves regional biogeographical patterns, indicating deposition by a similar mechanism as the foraminiferal shells. Our study shows that the planktonic eDNA preserved in marine sediments has the potential to record climatic and biotic changes in the pelagic community with the same spatial and temporal resolution as microfossils.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#112

 

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Apple is reported to stop supporting the iPhone 6s, iPhone 6s Plus, and iPhone SE next year with iOS 15.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#113

 

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Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha-N-acetylglucosaminidase activity, leading to increased levels of nondegraded heparan sulfate (HS). A mouse model has been useful to evaluate novel treatments for MPS IIIB, but has limitations. In this study, we evaluated the naturally occurring canine model of MPS IIIB for the onset and progression of biochemical and neuropathological changes during the preclinical stages (onset approximately 24–30 months of age) of canine MPS IIIB disease. Even by 1 month of age, MPS IIIB dogs had elevated HS levels in brain and cerebrospinal fluid. Analysis of histopathology of several disease-relevant regions of the forebrain demonstrated progressive lysosomal storage and microglial activation despite a lack of cerebrocortical atrophy in the oldest animals studied. More pronounced histopathology changes were detected in the cerebellum, where progressive lysosomal storage, astrocytosis and microglial activation were observed. Microglial activation was particularly prominent in cerebellar white matter and within the deep cerebellar nuclei, where neuron loss also occurred. The findings in this study will form the basis of future assessments of therapeutic efficacy in this large animal disease model.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#114

 

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These prepaid plans from Airtel offer data, calling, streaming benefits and are priced between Rs 219 to Rs 448. Some plans give streaming benefits to Disney+ Hotstar, Zee5 Premium and Amazon Prime.

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 23 November 2020

#115

 

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Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS). Our aims were: (1) to compare the efficiency of KFLC through different interpretation approaches in diagnosing MS. (2) to evaluate the prognostic value of KFLC in radiologically and clinically isolated syndromes (RIS-CIS). We enrolled 133 MS patients and 240 with other neurological diseases (93 inflammatory including 18 RIS-CIS, 147 non-inflammatory). Albumin, lambda free light chain (LFLC) and KFLC were measured in the CSF and serum by nephelometry. We included two groups of markers: (a) corrected for blood-CSF barrier permeability: immunoglobulin G (IgG), KFLC and LFLC indexes. (b) CSF ratios (not including albumin and serum-correction): CSF KFLC/LFLC, CSF KFLC/IgG, CSF LFLC/IgG. KFLC were significantly higher in MS patients compared to those with other diseases (both inflammatory or not). KFLC index and CSF KFLC/IgG ratio showed high sensitivity (93% and 86.5%) and moderate specificity (85% and 88%) in diagnosing MS. RIS-CIS patients who converted to MS showed greater KFLC index and CSF KFLC/IgG. Despite OB are confirmed to be the gold-standard to detect intrathecal IgG synthesis, the KFLC confirmed their accuracy in MS diagnosis. A “kappa-oriented” response characterizes MS and has a prognostic impact in the RIS-CIS population.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#116

 

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If you order a PlayStation 5, you want to receive a PlayStation 5. Not a bag of rice.

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#117

 

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Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (species richness), phylogenetic and functional diversity of birds to forest fragmentation. We hypothesised that with increasing forest patch isolation and/or decreasing patch size the diversity of birds decreases but only if certain thresholds of fragmentation metrics are reached. Specifically, we hypothesized that out of the three diversity components the taxonomic diversity is the most sensitive to forest fragmentation, which means that it starts declining at larger patch size and higher connectivity values than phylogenetic and functional diversity do. We compared the three biodiversity metrics of central European bird species in a large set of forest patches located in an agricultural landscape. General additive modeling and segmented regression were used in analyses. Habitat fragmentation differentially affected studied biodiversity metrics. Bird taxonomic diversity was the most responsive towards changes in fragmentation. We observed an increase in taxonomic diversity with increasing patch area, which then stabilized after reaching certain patch size. Functional diversity turned out to be the least responsive to the fragmentation metrics and forest stand characteristics. It decreased linearly with the decreasing isolation of forest patches. Apart from the habitat fragmentation, bird taxonomic diversity but not phylogenetic diversity was positively associated with forest stand age. The lower share of dominant tree species, the highest taxonomic diversity was. While preserving a whole spectrum of forests (in terms of age, fragmentation and size) is important from the biodiversity perspective, forest bird species might need large, intact, old-growth forests. Since the large and intact forest becomes scarcer, our study underscore their importance for the preservation of forest specialist species.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#118

 

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Pharmaceutical company AstraZeneca said Monday late-stage trials of its Covid-19 vaccine were “highly effective” in preventing disease.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#119

 

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One current goal in native mass spectrometry is the assignment of binding affinities to noncovalent complexes. Here we introduce a novel implementation of the existing laser-induced liquid bead ion desorption (LILBID) mass spectrometry method: this new method, LILBID laser dissociation curves, assesses binding strengths quantitatively. In all LILBID applications, aqueous sample droplets are irradiated by 3 µm laser pulses. Variation of the laser energy transferred to the droplet during desorption affects the degree of complex dissociation. In LILBID laser dissociation curves, laser energy transfer is purposely varied, and a binding affinity is calculated from the resulting complex dissociation. A series of dsDNAs with different binding affinities was assessed using LILBID laser dissociation curves. The binding affinity results from the LILBID laser dissociation curves strongly correlated with the melting temperatures from UV melting curves and with dissociation constants from isothermal titration calorimetry, standard solution phase methods. LILBID laser dissociation curve data also showed good reproducibility and successfully predicted the melting temperatures and dissociation constants of three DNA sequences. LILBID laser dissociation curves are a promising native mass spectrometry binding affinity method, with reduced time and sample consumption compared to melting curves or titrations.

#Hardware & Devices;#Laser
Field # Hardware & Devices
Updated 23 November 2020

#120

 

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Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activation of CD8+ T cells by targeting CD4+ T cells. When autologous OCs were used to expand patient NK cells much lower percentages of expanded CD8+ T cells, decreased numbers of expanded NK cells and decreased functions of NK cells could be observed, and the addition of allogeneic healthy OCs increased the patients’ NK function. Mechanistically, OC-expanded NK cells were found to lyse CD4+ T cells but not CD8+ T cells suggesting potential selection of CD8+ T cells before their expansion by OC activated NK cells. In agreement, Increased IFN-γ secretion, and NK cell-mediated cytotoxicity and higher percentages of CD8+ T cells, in various tissue compartments of oral tumor-bearing hu-BLT mice in response to immunotherapy by OC-expanded NK cells were observed. Thus, our results indicate an important relationship between NK and CD8+ T cells.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#121

 

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Name
Description
Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#122

 

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Description
Selective serotonin reuptake inhibitors (SSRIs) are standard of care for major depressive disorder (MDD) pharmacotherapy, but only approximately half of these patients remit on SSRI therapy. Our previous genome-wide association study identified a single-nucleotide polymorphism (SNP) signal across the glutamate-rich 3 (ERICH3) gene that was nearly genome-wide significantly associated with plasma serotonin (5-HT) concentrations, which were themselves associated with SSRI response for MDD patients enrolled in the Mayo Clinic PGRN-AMPS SSRI trial. In this study, we performed a meta-analysis which demonstrated that those SNPs were significantly associated with SSRI treatment outcomes in four independent MDD trials. However, the function of ERICH3 and molecular mechanism(s) by which it might be associated with plasma 5-HT concentrations and SSRI clinical response remained unclear. Therefore, we characterized the human ERICH3 gene functionally and identified ERICH3 mRNA transcripts and protein isoforms that are highly expressed in central nervous system cells. Coimmunoprecipitation identified a series of ERICH3 interacting proteins including clathrin heavy chain which are known to play a role in vesicular function. Immunofluorescence showed ERICH3 colocalization with 5-HT in vesicle-like structures, and ERICH3 knock-out dramatically decreased 5-HT staining in SK-N-SH cells as well as 5-HT concentrations in the culture media and cell lysates without changing the expression of 5-HT synthesizing or metabolizing enzymes. Finally, immunofluorescence also showed ERICH3 colocalization with dopamine in human iPSC-derived neurons. These results suggest that ERICH3 may play a significant role in vesicular function in serotonergic and other neuronal cell types, which might help explain its association with antidepressant treatment response.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#123

 

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Description
A novel microwave-assisted sol–gel-hydrothermal method was employed to rapidly synthesize Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT) powders. The effects of reaction time on the structure, crystallinity, purity and morphology of the products were investigated. The results of XRD, FTIR, SEM and TEM indicated that BCZT powders could be obtained in even 60 min at a low synthesis temperature of 180 °C, which were well-crystallized with stoichiometric composition and uniform grain size (~ 85 nm). BCZT ceramic derived from the rapidly-synthesized powders had a dense microstructure and good electrical properties (εm = 9579, d33 = 496 pC/N, 2Pr = 25.22 µC/cm2, 2Ec = 7.52 kV/cm). The significant electrical properties were closely related to the high activity of the BCZT powders, resulting from the rapid microwave-assisted sol–gel-hydrothermal process.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#124

 

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Description
Recently, Twitter started rolling out its version of Instagram Stories called Twitter Fleets globally. With Twitter Fleets, users can post content which will disappear in 24 hours. However, because of some bug, the fleets are not disappearing after 24 hours.

#Software;#Social & Corporation affairs
Field # Software
Updated 23 November 2020

#125

 

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Description
The police have busted a racket of fake Xiaomi products worth Rs 33.3 lakh in Bengaluru and Chennai. Seven people were arrested selling ‘unauthorised’ Xiaomi products. These fake products were seized from four suppliers in Chennai and three suppliers in Bengaluru. The shop owners from both the cities were selling fake Mi India products worth Rs 24.9 lakh and 8.4 lakh respectively.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#126

 

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Description
The board of Pegatron, Apple’s second largest contract manufacturer, has approved an initial investment of $150 million (Rs 1100 crore) for building manufacturing facilities in India, its top executive has said.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#127

 

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Description
Five years ago, a Yale-led partnership launched a landmark study to identify the biomarkers, or biological indicators, of autism that could help diagnose, track, and assess treatments in patients. Since then, the Autism Biomarkers Consortium for Clinical Trials has discovered the first two biomar

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#128

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#129

 

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Description
When someone struggles to open a lock with a key that doesn’t quite seem to work, sometimes jiggling the key a bit will help. Now, new research from MIT suggests that coronaviruses, including the one that causes Covid-19, may use a similar method to trick cells into letting the viruses inside. The f

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#130

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#131

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#132

 

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Description
With chemical rockets approaching their theoretical limits, engineers have been looking at nuclear energy in attempts to build an engine suitable for covering large distances in space. If such engines are to be used for crewed missions outside the Earth’s atmosphere, they would have to be light and

#Astronautics
Field # Astronautics
Updated 23 November 2020

#133

 

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Description
A possibility to perform health diagnostics without contact is crucial during the current pandemic. A recent study suggests using thermal video recording of the human face to estimate a physiological metrics called ISTI (Initial Systolic Time Interval). It is further used to classify whether a perso

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#134

 

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Description
When robots and humans interact in a shared environment, it is important for them to move in ways that prevent collisions or accidents. To reduce the risk of collisions, roboticists have developed numerous of techniques that ...

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#135

 

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Name
Description
Prostate cancer growth is often driven by male sex hormones called androgens. Hormone therapy is commonly administered to lower the level of androgens in the body, but relapse is common when the cancer cells develop resistance to these therapies. A multidisciplinary team of cancer researchers led

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#136

 

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Name
Description
Engineering a spaceship is as difficult as it sounds. Modeling plays a large role in the time and effort it takes to create spaceships and other complex engineering systems. It requires extensive physics calculations, sifting ...

#Artificial Intelligence
Field # Artificial Intelligence
Updated 23 November 2020

#137

 

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Description
As many as 75 percent of the women in North American experience hot flashes, and many of these women still look to hormone therapy to relieve the surge of hormones, otherwise known as vasomotor symptoms, or VMS. But new research, shared recently at the Annual North American Menopause Society Conf

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#138

 

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Name
Description
Apple said Monday it would extend through June 30 a waiver on app fees for paid events such as tutoring and fitness classes, citing the coronavirus pandemic.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#139

 

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Description
Multilayer plastic materials are ubiquitous in food and medical supply packaging, particularly since the specific properties of layered polymers can keep moisture from fouling sterile syringes or light and oxygen from making potato chips stale. But despite their utility, those ever-present plastics

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#140

 

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Description
Lancaster University is involved in a major research project which aims to control the spread of an invasive malaria mosquito in Sudan and Ethiopia. According to the World Health Organisation, there were 228 million cases of malaria in 2018. The four year £3.5m project funded by the Wellco

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#141

 

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Description
Lush vegetation is not the first picture that comes to mind when thinking about a desert. And yet, a new study utilising detailed satellite imagery and deep learning has found that the West African Sahara and Sahel deserts are actually home to approximately 1.8 billion trees, all told. The resear

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#142

 

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Description
University of Virginia Cancer Center researchers have identified a gene responsible for the spread of so-called “triple-negative” breast cancer to other parts of the body – a process called metastasis – and developed a potential way to stop it. Triple-negative breast cancer is an aggressive form of

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#143

 

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Description
The coronavirus pandemic has shown that human grocery workers are essential, but it's made it clear that Marty the grocery store robot is non-essential.

#Robotics & Manufacturing
Field # Robotics & Manufacturing
Updated 23 November 2020

#144

 

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Description
Increasingly, artificial intelligence systems known as deep learning neural networks are used to inform decisions vital to human health and safety, such as in autonomous driving or medical diagnosis. These networks are good at recognizing patterns in large, complex datasets to aid in decision-making

#Artificial intelligence
Field # Artificial intelligence
Updated 23 November 2020

#145

 

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Description
Cybersecurity researchers claim a discount router has a dangerous backdoor.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#146

 

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Description
Samsung Galaxy A12 has been spotted on a Bluetooth certification site. The smartphone has been subject to several leaks of late, indicating that it could be launched soon. Samsung Galaxy A12 is expected to be backed by a Helio P35 SoC, run Android 10 out of the box, and have 3GB RAM on board.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#147

 

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Description
Know your customers (KYC) is the process by which businesses identify and verify diverse customers and evaluate the probable risks…...

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#148

 

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Description
A leaked poster claims that the Redmi Note 9 Pro may have an LCD display with 120Hz refresh rate. It is expected to be powered by the Snapdragon 750G SoC and have an 108-megapixel primary sensor. The phone is reported to pack 4,820mAh battery with 33W fast charging support. The poster also claims that there will be 3.5mm audio jack support and offer NFC. It is also leaked to support Hi-Res Audio.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#149

 

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Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#150

 

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Description
FIFA 21, Forza Horizon 4, Watch Dogs: Legion, Sea of Thieves, Halo: The Master Chief Collection, Gears 5, Ori and the Will of the Wisps, No Man&rsquo;s Sky, Age of Empires II: Definitive Edition, Red Dead Redemption 2: Ultimate Edition, Star Wars: Squadrons, Marvel&rsquo;s Avengers &mdash; these are the best Xbox Black Friday deals on Xbox One, Xbox Series S/X, and PC games.

#Entertainments;#Games
Field # Entertainments
Updated 23 November 2020

#151

 

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Description
CRN looks at the 10 hottest semiconductor startups of 2020, which are making everything from AI chips and new CPU architectures to storage accelerators and data processing units.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#152

 

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Name
Description
ShopDisney.in, Disney&rsquo;s online store, is now open for orders in India, and will serve more than 500 cities at launch. Free shipping is only offered on ShopDisney.in orders that cross Rs. 999.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#153

 

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Description
Dheeraj Pandey talks about Nutanix’s ideal new CEO during the cloud software company’s financial earnings report.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#154

 

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Description
Twitter Fleets are accessible even after their 24-hour expiration period due to a bug, claims a report. The company is working on a fix and will be releasing it soon.

#Software;#Social & Corporation affairs
Field # Software
Updated 23 November 2020

#155

 

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Description
Google Chrome extensions will have to show more detail on user data they collect starting from January 2021. The tools for this have been provided to developers and they are required to implement the changes by January 18 next year.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#156

 

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Description
Google Call could be the new name for Google&rsquo;s phone app as it was spotted in a YouTube ad. The app icon comes with the four Google colours that fall in line with the Workspace rebrand.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#157

 

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Description
Researchers at the University of Tokyo have identified how the architecture of the cell nucleus can change gene activity in plants. This discovery reveals fundamental knowledge about genome regulation and points towards future methods for potentially manipulating the expression of many genes simulta

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#158

 

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Name
Description
Oppo is making the Find X3 and Find X3 Pro the devices that can take on the likes of Samsung and Apple phones.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#159

 

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Name
Description
A major nexus involved in the counterfeiting of Xiaomi devices has been busted. Here's how you can be safe and spot fake Xiaomi products.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#160

 

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Description
In a letter to a coalition of privacy groups, Apple’s director of global privacy, Jane Horvath said that Facebook’s intent is to collect as much data as possible across both first and third-party products to develop and monetise detailed profiles of their users.

#Social & Corporation affairs;#Education
Field # Social & Corporation affairs
Updated 23 November 2020

#161

 

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Description
Geneticist Sir Paul Nurse explains why cells are the building blocks of life on Earth in part one of our biology podcast series.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#162

 

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Name
Description
Want a good National Geographic documentary on (extremely cute) dog evolution? Or natural history? Stream now on Disney Plus.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#163

 

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Name
Description
After a decade, National Ignition Facility nears a self-heated, sustained reaction, though net energy gain is still elusive

#Energy
Field # Energy
Updated 23 November 2020

#164

 

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Name
Description
AstraZeneca/University of Oxford vaccine uses a chimpanzee virus to deliver coronavirus gene and had better efficacy, 90%, when given as a half dose followed by a full dose

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#165

 

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Name
Description
Fitbit update: Sense and Versa to get audible replies to get Google Assistant, Alexa and Bluetooth calling features

#Gadgets
Field # Gadgets
Updated 23 November 2020

#166

 

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Name
Description
TBD

#Artificial intelligence
Field # Artificial intelligence
Updated 23 November 2020

#167

 

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Name
Description
TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#168

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#169

 

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Name
Description
TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#170

 

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Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#171

 

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Name
Description
TBD

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#172

 

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Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 23 November 2020

#173

 

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Name
Description
TBD

#Energy
Field # Energy
Updated 23 November 2020

#174

 

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Description
UK's Oxford University and AstraZeneca have announced their COVID-19 vaccine is up to 90 percent effective according to preliminary study results.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#175

 

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Name
Description
This Black Friday, save big on the best headphones on the market, available at Amazon right now.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#176

 

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Name
Description
Looking for a new laptop? You can save $300 on the Dell XPS 13 and pay just $650 for a great system as part of the Black Friday Dell XPS deals going on now.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#177

 

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Name
Description
You just bought a new next-gen gaming console like the PS5 or Xbox Series X and you want to make sure they perform their best? These TV settings are the key.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#178

 

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Name
Description
California's new pandemic-related stay-at-home order allows Tesla's Alameda County factory to stay open, preventing the kind of showdown we saw in the spring.

#Social & Corporation affairs;#Security
Field # Social & Corporation affairs
Updated 23 November 2020

#179

 

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Name
Description
The Star Wars tie-in is also playable on other 5G Android phones.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#180

 

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Name
Description
We go hands on with the Cyberpunk 2077 phone from OnePlus.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#181

 

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Name
Description
All around me are familiar faces.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#182

 

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Name
Description
You can get gifts delivered to Amazon Books stores or Amazon 4-star locations.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#183

 

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Name
Description
Two more victims of the 79 CE eruption of Mount Vesuvius are accounted for.

#Archaeology & History
Field # Archaeology & History
Updated 23 November 2020

#184

 

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Name
Description
The EPA says the extended-range Mustang Mach-E can go 300 miles on a charge.

#Social & Corporation affairs;#Environment & Nature
Field # Social & Corporation affairs
Updated 23 November 2020

#185

 

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Name
Description
Data cap comes to 12 more US states over four years after everyone else got it.

#Telecommunications;#Gadgets
Field # Telecommunications
Updated 23 November 2020

#186

 

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Name
Description
AstraZeneca used two dosages: One 62% effective, the other 90%, for 70% average.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#187

 

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Name
Description
The quick sequential organ failure assessment (qSOFA) score has been proposed as a means to rapidly identify adult patients with suspected infection, in pre-hospital, Emergency Department (ED), or general hospital ward locations, who are in a high-risk category with increased likelihood of “poor outcomes:” a greater than 10% chance of dying or an increased likelihood of spending 3 or more days in the ICU. This score is intended to replace the use of systemic inflammatory response syndrome (SIRS) criteria as a screening tool; however, its role in ED screening and identification has yet to be fully elucidated. In this retrospective observational study, we explored the performance of triage qSOFA (tqSOFA), maximum qSOFA, and first initial serum lactate (> 3 mmol/L) at predicting in-hospital mortality and compared these results to those for the initial SIRS criteria obtained in triage. A total of 2859 sepsis cases were included and the in-hospital mortality rate was 14.4%. The sensitivity of tqSOFA ≥ 2 and maximum qSOFA ≥ 2 to predict in-hospital mortality were 33% and 69%, respectively. For comparison, the triage SIRS criteria and the initial lactate > 3 mmol/L had sensitivities of 82% and 65%, respectively. These results demonstrate that in a large ED sepsis database the earliest measurement of end organ impairment, tqSOFA, performed poorly at identifying patients at increased risk of mortality and maximum qSOFA did not significantly outperform initial serum lactate levels.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#188

 

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Description
Inappropriate gestational weight gain (GWG), either above or below the recommended values, has been associated with an increased risk of adverse obstetric outcomes. To evaluate the risks of GWG for foetal acidosis according to pre-pregnancy body mass index (BMI) and mode of delivery, we analysed women with singleton pregnancies between 2011 and 2014 in the Japan Environment and Children’s Study. Participants (n = 71,799) were categorised according to pre-pregnancy BMI. GWG was categorised into insufficient, appropriate, or excessive. Foetal acidosis was defined as umbilical artery pH (UmA-pH) < 7.20 or < 7.10. Multiple logistic regressions were performed for each BMI category to identify the risks of GWG for foetal acidosis, accounting for the mode of delivery. Excessive GWG was significantly associated with increased foetal acidosis in overweight women and in women whose pre-pregnancy BMI was 23.0–25.0 kg/m2 especially in those with vaginal deliveries. Conversely, excessive GWG was not significantly associated with increased foetal acidosis in obese women and in women whose pre-pregnancy BMI was  ≥ 25.0 kg/m2.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#189

 

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Description
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#190

 

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Description
Here, we describe an extension of our silicon fluoride acceptor (SiFA) protocol for 18F-labeling of peptides that addresses challenges associated with preparing a clinical-grade (Tyr3)-octreotate (TATE) tracer for diagnosis of neuroendocrine tumors (NETs). After several iterations of protocol optimization (e.g., finding the optimal pH at which the isotopic exchange (IE) reaction produces high radiochemical yields (RCYs)), the SiFA technology achieved clinical applicability, as showcased by radiosynthesis of [18F]SiFAlin-TATE ([18F]SiTATE), the first SiFA peptide used in the clinical diagnosis of NETs. The TATE peptide binds to somatostatin receptors associated with NETs. Radiolabeled TATE derivatives are routinely applied in clinical oncological PET imaging. The (SiFA) 18F-labeling technology is based on the IE of a 19F atom for a radioactive 18F atom, a highly efficient labeling reaction under mild conditions. The 19F is part of a biomolecule bearing the SiFA building block, composed of a central silicon (Si) atom, a 19F atom connected to the Si atom, and two Si-bound tert-butyl groups. The IE proceeds through a penta-coordinate bipyramidal intermediate, followed by elimination of non-radioactive 19F, yielding the labeled compound in high RCYs at room temperature (22 °C). The simplicity and lack of side-product formation of this approach enable a one-step, kit-like preparation of structurally complex and unprotected radiopharmaceuticals. Compounds such as peptides used for tumor imaging in nuclear medicine can be 18F-labeled without the need for complex purification protocols. [18F]SiTATE can be synthesized within 30 min in preparative RCYs of 42%, radiochemical purity of >97% and high molar activity of 60 GBq/µmol. This extension of the original silicon fluoride acceptor (SiFA) protocol for 18F-labeling of peptides describes modifications required for the preparation of clinical-grade [18F]SiFAlin-TATE for diagnosis of neuroendocrine tumors via PET imaging.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#191

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#192

 

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Description
Plasmodium falciparum parasites survive the dry season by accepting increased clearance rates through the host spleen, which leads to a persistent lower-level infection.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#193

 

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Description


#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#194

 

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Description
Maintaining ignorance to self-nucleic acids can prevent inflammatory diseases such as Aicardi–Goutières syndrome (AGS). A new study finds that mutations in LSM11 and RNU7-1, which encode components of the histone messenger RNA–preprocessing complex, cause AGS by loosening the binding of cyclic GMP–AMP synthase (cGAS) to nucleosomes, thus enabling cGAS activation and induction of type I interferons.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#195

 

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Description
A new study reports the seroprevalence of SARS-CoV-2 antibodies among a cross-section of patients on haemodialysis and uses these data to estimate seroprevalence in the general US population. Although this study demonstrates the potential of monitoring infectious disease prevalence in dialysis populations, the findings should be interpreted with caution.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#196

 

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Description
Nanoparticles enable wireless neural stimulation without the need for genetic manipulation. However, challenges remain for their potential application in the cure of human neurodegenerative diseases. A careful analysis of the different nanomaterials and energy sources that proved effective in animal models will direct their clinical translatability.

#Materials
Field # Materials
Updated 23 November 2020

#197

 

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Description
Although most patients with metastatic castration-resistant prostate cancer (mCRPC) initially benefit from treatment with androgen receptor signaling inhibitors (ARSi), resistance inevitably occurs. Hence, we investigated the prognostic value of automated circulating tumor cell (CTC) and tumor-derived extracellular vesicle (tdEV) enumeration and their dynamics, in patients with mCRPC in the context of the initiation of treatment with ARSi. Furthermore, we hypothesize that CTC phenotypic heterogeneity might serve as a measurable biomarker under these circumstances. Using an image analysis tool, we reanalyzed all CellSearch images previously acquired in the context of a prospective, multicenter clinical study for patients with mCRPC (n = 170) starting a new line of ARSi, for CTC and tdEV detection and enumeration. CTC (n = 19 129) phenotypic diversity was quantified by the Shannon index (SI). Progression-free survival (PFS) and overall survival (OS) were compared between groups of patients stratified according to CTC, tdEV, and SI levels. Automated CTC enumeration provided similar clinical prognostication compared with operator-based counts. Patients demonstrating high CTC phenotypic heterogeneity before therapy had a shorter median PFS (4.82 vs. 8.49 months, HR 1.79; P = 0.03) and OS (12.6 months vs. not reached, HR 2.32; P = 0.03), compared to patients with low diversity, irrespective of CTC level. Multivariable analysis showed how the prognostic value of the baseline SI was lost by pretreatment chemotherapy status, CTC counts, and PSA levels. Automated CTC counts are a reliable substitute for reviewer-based enumeration, as they are equally informative for prognosis assessment in patients with mCRPC. Beyond enumeration, we demonstrated the added value of studying CTC phenotypic diversity for patient prognostication, warranting future investigation.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#198

 

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Description
Copy-number variants (CNVs) are an important part of human genetic variation. They can be benign or can play a role in human disease by creating dosage imbalances and disrupting genes and regulatory elements. Accurate identification and clinical annotation of CNVs is essential, however, manual evaluation of individual CNVs by clinicians is challenging on a large scale. Here, we present ClassifyCNV, an easy-to-use tool that implements the 2019 ACMG classification guidelines to assess CNV pathogenicity. ClassifyCNV uses genomic coordinates and CNV type as input and reports a clinical classification for each variant, a classification score breakdown, and a list of genes of potential importance for variant interpretation. We validate ClassifyCNV’s performance using a set of known clinical CNVs and a set of manually evaluated variants. ClassifyCNV matches the pathogenicity category for 81% of manually evaluated variants with the significance of the remaining pathogenic and benign variants automatically determined as uncertain, requiring a further evaluation by a clinician. ClassifyCNV facilitates the implementation of the latest ACMG guidelines in high-throughput CNV analysis, is suitable for integration into NGS analysis pipelines, and can decrease time to diagnosis. The tool is available at https://github.com/Genotek/ClassifyCNV .

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#199

 

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Name
Description
Schmallenberg virus (SBV), an arthropod-transmitted pathogenic bunyavirus, continues to be a threat to the European livestock industry, causing morbidity and mortality among young ruminant livestock. Here, we describe a novel SBV subunit vaccine, based on bacterially expressed SBV nucleoprotein (SBV-N) administered with a veterinary-grade Saponin adjuvant. When assayed in an IFNAR-/- mouse model, SBV-N with Saponin induced strong non-neutralizing broadly virus-reactive antibodies, decreased clinical signs, as well as significantly reduced viremia. Vaccination assays also suggest that this level of immune protection is cell mediated, as evidenced by the lack of neutralizing antibodies, as well as interferon-γ secretion observed in vitro. Therefore, based on these results, bacterially expressed SBV-N, co-administered with veterinary-grade Saponin adjuvant may serve as a promising economical alternative to current SBV vaccines, and warrant further evaluation in large ruminant animal models. Moreover, we propose that this strategy may be applicable to other bunyaviruses.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#200

 

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Name
Description
Replication timing (RT) domains are stable units of chromosome structure that are regulated in the context of development and disease. Conventional genome-wide RT mapping methods require many S-phase cells for either the effective enrichment of replicating DNA through bromodeoxyuridine (BrdU) immunoprecipitation or the determination of copy-number differences during S-phase, which precludes their application to non-abundant cell types and single cells. Here, we provide a simple, cost-effective, and robust protocol for single-cell DNA replication sequencing (scRepli-seq). The scRepli-seq methodology relies on whole-genome amplification (WGA) of genomic DNA (gDNA) from single S-phase cells and next-generation sequencing (NGS)-based determination of copy-number differences that arise between replicated and unreplicated DNA. Haplotype-resolved scRepli-seq, which distinguishes pairs of homologous chromosomes within a single cell, is feasible by using single-nucleotide polymorphism (SNP)/indel information. We also provide computational pipelines for quality control, normalization, and binarization of the scRepli-seq data. The experimental portion of this protocol (before sequencing) takes 3 d. This protocol describes experimental and computational procedures for obtaining genome-wide DNA replication timing maps based on copy-number differences derived from whole-genome amplification and next-generation sequencing of genomic DNA from single S-phase cells.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#201

 

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Name
Description
Studies demonstrate the efficacy of screening by liquid biopsy for enrollment in clinical trials of precision cancer therapy.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#202

 

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Name
Description
Single-cell analysis provides novel insights into elements of CAR T cell toxicities and response.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#203

 

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Name
Description
This study shows that a distinct gut microbiome composition as well as specific bacterial metabolites provide radioprotection in mice.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#204

 

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Name
Description
A class of biological matter including elongated cells and filaments can be understood in the framework of active nematic liquid crystals. Within these systems, topological defects emerge and give rise to remarkable collective behaviours.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#205

 

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Name
Description
Individuals who have lost the use of their hands because of amputation or spinal cord injury can use prosthetic hands to restore their independence. A dexterous prosthesis requires the acquisition of control signals that drive the movements of the robotic hand, and the transmission of sensory signals to convey information to the user about the consequences of these movements. In this Review, we describe non-invasive and invasive technologies for conveying artificial sensory feedback through bionic hands, and evaluate the technologies’ long-term prospects. This Review discusses non-invasive and invasive technologies for conveying artificial sensory feedback through bionic hands.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#206

 

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Name
Description
Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex. Here we critically assess the current knowledge regarding H2Aub deposition and removal, its crosstalk with PcG repressive complex 2 (PRC2)-mediated histone H3K27 methylation, and the recent attempts toward discovering its readers and solving its enigmatic functions. We also discuss mounting evidence of the involvement of H2A ubiquitination in human pathologies including cancer, while highlighting some knowledge gaps that remain to be addressed. Histone H2A monoubiquitination on lysine 119 in vertebrate and lysine 118 in Drosophila (H2Aub) is an epigenomic mark usually associated with gene repression by Polycomb group factors. Here the authors review the current knowledge on the deposition and removal of H2Aub, its function in transcription and other DNA-associated processes as well as its relevance to human disease.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#207

 

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Name
Description
Sensory substitution is a promising therapeutic approach for replacing a missing or diseased sensory organ by translating inaccessible information into another sensory modality. However, many substitution systems are not well accepted by subjects. To explore the effect of sensory substitution on voluntary action repertoires and their associated affective valence, we study deaf songbirds to which we provide visual feedback as a substitute of auditory feedback. Surprisingly, deaf birds respond appetitively to song-contingent binary visual stimuli. They skillfully adapt their songs to increase the rate of visual stimuli, showing that auditory feedback is not required for making targeted changes to vocal repertoires. We find that visually instructed song learning is basal-ganglia dependent. Because hearing birds respond aversively to the same visual stimuli, sensory substitution reveals a preference for actions that elicit sensory feedback over actions that do not, suggesting that substitution systems should be designed to exploit the drive to manipulate. The challenge of sensory substitution as a therapeutic approach is to design systems that are well accepted by subjects. Here, in deaf songbirds, the authors substitute hearing with vision, suggesting substitution devices could provide sensory feedback for the key actions that are deprived.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#208

 

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Name
Description
The chemistry of carbon monoxide (CO) as a ligand has evolved significantly and transition-metal carbonyl complexes have been widely used as catalysts in many important catalytic processes. Here the authors comment on the recent progress of main-group element carbonyl complexes along with their future prospects.

#Chemicals
Field # Chemicals
Updated 23 November 2020

#209

 

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Name
Description
Organolead halide perovskites, primarily regarded as a high-performance semiconducting component in photovoltaics, have excellent optical and charge-transport characteristics that are advantageous for photocatalysis. However, their moisture-sensitive nature largely hinders their application to water splitting. Here we report a semiconductive organolead iodide layered crystalline material ([Pb8I8(H2O)3]8+[–O2C(CH2)4CO2–]4) with a bandgap of ~2.74 eV that demonstrates a high robustness over a wide pH range as well as under aqueous boiling conditions. The Earth-abundant material maintains excellent optical characteristics similar to those of perovskites, and includes suitable band positions, excellent carrier diffusion lengths (up to 1.4 μm) and long carrier lifetimes (up to 1.2 μs). When illuminated by sunlight and combined with trace amounts of a Rh co-catalyst, the hybrid iodoplumbate steadily and efficiently produces stoichiometric amounts of hydrogen and oxygen in a recyclable manner. Our findings extend the excellent optoelectronic properties of organolead halide materials from photovoltaics to photocatalytic water splitting. Despite their promising optical properties, organolead halide perovskites are not frequently used in photocatalysis due to their low stability in water. Here, a long-lasting semiconductive organolead iodide layered crystalline material with the ability to perform overall water splitting is introduced.

#Materials
Field # Materials
Updated 23 November 2020

#210

 

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Name
Description
Chiral α-aryl glycines play a key role in the preparation of some bioactive products, however, their catalytic asymmetric synthesis is far from being satisfactory. Herein, we report an efficient nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters, affording chiral α-aryl glycines in high yields and enantioselectivities (up to 98% ee). The hydrogenation can be conducted on a gram scale with a substrate/catalyst ratio of up to 2000. The obtained chiral N-p-methoxyphenyl α-aryl glycine derivatives are not only directly useful chiral secondary amino acid esters but can also be easily deprotected by treatment with cerium ammonium nitrate for further transformations to several widely used molecules including drug intermediates and chiral ligands. Formation of a chiral Ni-H species in hydrogenation is detected by 1H NMR. Computational results indicate that the stereo selection is determined during the approach of the substrate to the catalyst. Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.

#Energy
Field # Energy
Updated 23 November 2020

#211

 

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Name
Description
Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their size and aspect ratio. Here we show that the limitations imposed by fluid instabilities with thermally drawn nanowires can be alleviated by adding tungsten carbide nanoparticles to the metal core to arrive at wire lengths more than 30 cm with diameters as low as 170 nm. The nanoparticles support thermal drawing in two ways, by increasing the viscosity of the metal and lowering the interfacial energy between the boron silicate and zinc phase. This mechanism of suppressing fluid instability by nanoparticles not only enables a scalable production of ultralong metal nanowires, but also serves for widespread applications in other fluid-related fields. Thermal drawing of glass-cladded metal nanowires is limited by fluid instabilities. Hwang et al. show how admixing tungsten carbide nanoparticles to the zinc core of a borosilicate-cladded wire leads to intact fibres over lengths significantly exceeding those of metals with high melting points.

#Materials
Field # Materials
Updated 23 November 2020

#212

 

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Name
Description
Magnetic and spintronic media have offered fundamental scientific subjects and technological applications. Magneto-optic Kerr effect (MOKE) microscopy provides the most accessible platform to study the dynamics of spins, magnetic quasi-particles, and domain walls. However, in the research of nanoscale spin textures and state-of-the-art spintronic devices, optical techniques are generally restricted by the extremely weak magneto-optical activity and diffraction limit. Highly sophisticated, expensive electron microscopy and scanning probe methods thus have come to the forefront. Here, we show that extreme anti-reflection (EAR) dramatically improves the performance and functionality of MOKE microscopy. For 1-nm-thin Co film, we demonstrate a Kerr amplitude as large as 20° and magnetic domain imaging visibility of 0.47. Especially, EAR-enhanced MOKE microscopy enables real-time detection and statistical analysis of sub-wavelength magnetic domain reversals. Furthermore, we exploit enhanced magneto-optic birefringence and demonstrate analyser-free MOKE microscopy. The EAR technique is promising for optical investigations and applications of nanomagnetic systems. Magneto-optic Kerr effect microscopy is useful for dynamic magnetic studies, but is limited by the weak magneto-optical activity. Here, the authors show that extreme anti-reflection result in a Kerr amplitude as large as 20° and enables real-time detection of sub-wavelength magnetic domain reversals.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#213

 

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Name
Description
Carboranes are a class of carbon-boron molecular clusters with three-dimensional aromaticity, and inherent robustness. These endowments enable carboranes as valuable building blocks for applications ranging from functional materials to pharmaceuticals. Thus, the chemistry of carboranes has received tremendous research interest, and significant progress has been made in the past decades. However, many attempts to the synthesis of carboranes with more than 14 vertices had been unsuccessful since the report of a 14-vertex carborane in 2005. The question arises as to whether these long sought-after molecules exist. We describe in this article the synthesis and structural characterization of 15- and 16-vertex closo-carboranes as well as 16-vertex ruthenacarborane. Such a success relies on the introduction of silyl groups to both cage carbons, stabilizing the corresponding nido-carborane dianions and promoting the capitation reaction with HBBr2·SMe2. This work would shed some light on the preparation of carboranes with 17 vertices or more, and open the door for studying supercarborane chemistry. The synthesis of closo-carboranes with more than 14 vertexes is challenging, and no examples have been reported to date. Herein, the authors present the long-sought 15- and 16-vertex closo-carboranes, in which the introduction of silyl groups to the two cage carbons is crucial; this finding might enable the synthesis of even larger carborane analogs in the future.

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#214

 

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Name
Description
In this perspective, I discuss a few basic concepts in fundamental mechanistic studies of electrochemical carbon dioxide reduction. Electrochemical carbon dioxide (CO2) reduction has the potential to sustainably produce carbon-based fuels and chemicals while mitigating the increasing levels of CO2 in the atmosphere. In this comment, the author discusses a few basic concepts in the fundamental mechanistic studies of electrochemical CO2 reduction.

#Chemicals
Field # Chemicals
Updated 23 November 2020

#215

 

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Name
Description
How can humans slow climate change? By harnessing natural and human-made carbon removal opportunities.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#216

 

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Name
Description
The skeleton of an ancient Egyptian woman who wore a complex hairstyle with 70 hair extensions has been unearthed at Amarna.

#Archaeology & History
Field # Archaeology & History
Updated 23 November 2020

#217

 

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Name
Description
Google has announced that Google Chrome extensions will have to reveal all personal data that is being collected from January 2021.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#218

 

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Name
Description
It seems that consumer electronics giant Samsung is planning to launch a new Galaxy A-series smartphone soon. Samsung Galaxy A12 has received Bluetooth certification which hints that the company might soon launch the smartphone.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#219

 

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Name
Description
Realme recently confirmed that it will launch its all-new Realme X7 series of smartphones in India next year. Now, the Realme X7 with codename RMX2176 has received certification from the Bureau of Indian Standards. This further confirms that the smartphone will launch in India soon. It is also expected that the company might launch the smartphone in January 2021.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#220

 

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Name
Description
Digital financial services provider Paytm has introduced a new mode of payment for its postpaid users. The company has announced that the users of its postpaid service can now convert their spends into Equated Monthly Installments (EMIs).

#Software;#Finance
Field # Software
Updated 23 November 2020

#221

 

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Name
Description
Lava International is in advanced talks with one of the top Indian telcos to make co-branded smartphones, which will be subsidized by the operator, pulling the cost sharply down for the 4G device.

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#222

 

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Name
Description
The international version of the UMANG app was launched on Monday for select countries, including the US, UK, Canada, Australia, UAE, Netherlands, Singapore, Australia and New Zealand, an official statement said. This will help Indian international students, NRIs and Indian tourists abroad to avail Government of India services anytime, it added.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#223

 

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Name
Description
Internet search giant Google has rolled out the support to schedule actions of smart home devices using Google Assistant. Till now, users could operate their smart home gadgets through Google Assistant but only for an immediate action. Now, however, it comes with the support to specify what time of the day they want them to perform those actions.

#Gadgets;#Internet of things
Field # Gadgets
Updated 23 November 2020

#224

 

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Name
Description
Artificial intelligence (AI), machine learning, 5G and Internet of Things (IoT) would be the most important technologies in 2021, according to a new study by the Institute of Electrical and Electronics Engineers (IEEE).

#Artificial Intelligence
Field # Artificial Intelligence
Updated 23 November 2020

#225

 

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Name
Description
Airtel Digital TV, the DTH arm of telco Bharti Airtel, on Monday partnered with online learning platform Vedantu to offer Maths and Science lectures to class 6-12 students.

#Entertainments
Field # Entertainments
Updated 23 November 2020

#226

 

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Name
Description
TBD

#Food
Field # Food
Updated 23 November 2020

#227

 

View it
Name
Description
TBD

#Artificial Intelligence
Field # Artificial Intelligence
Updated 23 November 2020

#228

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#229

 

View it
Name
Description
TBD

#Theoretical sciences
Field # Theoretical sciences
Updated 23 November 2020

#230

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#231

 

View it
Name
Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#232

 

View it
Name
Description
TBD

#Materials
Field # Materials
Updated 23 November 2020

#233

 

View it
Name
Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#234

 

View it
Name
Description
TBD

#3-D printing
Field # 3-D printing
Updated 23 November 2020

#235

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 23 November 2020

#236

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 23 November 2020

#237

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 23 November 2020

#238

 

View it
Name
Description
TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#239

 

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Name
Description
Snapchat on Monday unveiled a new curated short-form video feed in a stepped up challenge to social media rivals like TikTok.

#Software
Field # Software
Updated 23 November 2020

#240

 

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Name
Description
Deep neural networks, multilayered systems built to process images and other data through the use of mathematical modeling, are a cornerstone of artificial intelligence.

#Artificial Intelligence
Field # Artificial Intelligence
Updated 23 November 2020

#241

 

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Name
Description
The current global supply of crude oil is expected to meet demand through 2050, but there may be a few more drops to squeeze out. By making use of a previously undesired side effect in oil recovery, researchers have developed ...

#Energy
Field # Energy
Updated 23 November 2020

#242

 

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Name
Description
Harnessing the power of deep learning leads to better predictions of patient admissions and flow in emergency departments.

#Artificial Intelligence
Field # Artificial Intelligence
Updated 23 November 2020

#243

 

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Name
Description
A convolutional neural network is a type of artificial neural network in which the neurons are organized into receptive fields in a very similar way to neurons in the visual cortex of a biological brain. Today, convolutional ...

#Artificial intelligence
Field # Artificial intelligence
Updated 23 November 2020

#244

 

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Name
Description
Promising early results from vaccine trials offer hope of defeating covid-19, but vaccines may be less effective in the real world and people's safety concerns could hamper take-up

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#245

 

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Name
Description
The nematode worm Caenorhabditis elegans has been used by biologists for decades, but it has been hiding a secret the whole time: it makes milk

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#246

 

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Description
A covid-19 vaccine developed by AstraZeneca and the University of Oxford may be up to 90 per cent effective when given first as a half dose and then a full dose, and it doesn't need to be kept at a very low temperature

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#247

 

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Description
The robotic Chang'e 5 mission will land on the moon, gather rock samples and then blast off back to Earth - the first such mission in over 40 years. It could be a rehearsal for landing humans on the moon

#Astronautics
Field # Astronautics
Updated 23 November 2020

#248

 

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Name
Description
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#249

 

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Name
Description
TBD

#Hardware & Devices;#Artificial intelligence
Field # Hardware & Devices
Updated 23 November 2020

#250

 

View it
Name
Description
TBD

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 23 November 2020

#251

 

View it
Name
Description
TBD

#Software
Field # Software
Updated 23 November 2020

#252

 

View it
Name
Description
TBD

#Astronautics
Field # Astronautics
Updated 23 November 2020

#253

 

View it
Name
Description
TBD

#Environment & Nature
Field # Environment & Nature
Updated 23 November 2020

#254

 

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Name
Description
EASILY turning any room into a home cinema, the incredible deal is not to be sniffed at.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#255

 

View it
Name
Description
TBD

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#256

 

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Name
Description
TBD

#Hardware & Devices;#Gadgets;#Entertainments;#Games
Field # Hardware & Devices
Updated 23 November 2020

#257

 

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Name
Description
TBD

#Entertainments
Field # Entertainments
Updated 23 November 2020

#258

 

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Name
Description
This smart cutting board, called Nutrio, can detect and weigh whatever you put on it for all of your food tracking needs.

#Food
Field # Food
Updated 23 November 2020

#259

 

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Name
Description
Apple's new iPhone 12 Pro Max has been fully disassembled.

#Energy
Field # Energy
Updated 23 November 2020

#260

 

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Name
Description
The CDC released an updated scientific brief saying the coronavirus is spread mostly by people who are asymptomatic or presymptomatic.

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#261

 

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Name
Description
All the cells of the body come from the same tiny clump of stem cells and share the same set of genes. But by following different patterns of activating those genes, they quickly embark towards different destinies, becoming tissues as diverse as liver, blood and brain.Tracking this process in humans

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#262

 

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Name
Description
Amateur astronomy is a very broad and fuzzy term. Because of how rapidly astronomy, optics and imaging develops, modern day “amateur” telescopes and astrophotography systems can be more advanced than professional systems 50-100 years ago. At first sight, small amateur telescopes stand no chance ag

#Astronautics
Field # Astronautics
Updated 23 November 2020

#263

 

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Name
Description
Let’s create new senses for ourselves! Leverage Neosensory’s Buzz haptic wristband and Edge Impulse’s machine learning platform to create powerful new sensory perceptions. Build applications on any BLE-enabled platform, whether it’s a mobile phone or an Arduino to stream and encode sensory informat

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#264

 

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Name
Description
The BMW Group is looking for innovative approaches to improve the customer experience when charging an Electric Vehicle (EV). BMW Group is seeking a versatile EV charging cable that is easy to handle and can be packed into a small volume. Globally electric vehicles (EVs) are witnessing increa

#Vehicles & Special machines
Field # Vehicles & Special machines
Updated 23 November 2020

#265

 

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Name
Description
Inspired by nature, researchers at The City College of New York (CCNY) can demonstrate a synthetic strategy to stabilize bio-inspired solar energy harvesting materials. Their findings, published in the latest issue of  “Nature Chemistry,” could be a significant breakthrough in functionalizing molecu

#Energy
Field # Energy
Updated 23 November 2020

#266

 

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Name
Description
An international team of researchers from Bristol and China has prepared biocompatible protocells that generate nitric oxide gas – a known reagent for blood vessel dilation - that when placed inside blood vessels expand the biological tissue. In a new study published in Nature Chemistry, Prof

#Medicine & Human body
Field # Medicine & Human body
Updated 23 November 2020

#267

 

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Name
Description
NineSigma, representing Titan Advanced Energy Solutions, seeks developments and approaches to enable production of transducer components and/or assemblies at high volume. Current transducer assemblies are hand-built. Titan seeks technologies, materials, manufacturing methods, and other expertise to

#Theoretical sciences;#Hardware & Devices
Field # Theoretical sciences
Updated 23 November 2020

#268

 

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Name
Description
Excell Broadband is revising its Internet plans with higher speeds and reduced rates. A 150Mbps broadband plan, referred to as the preferred plan, is being offered at Rs. 1,199. Its &lsquo;Smart&rsquo; plan, meanwhile, starts at Rs. 499 and offers users 60Mbps speed with 400GB data limit and 1Mbps speed post FUP.

#Telecommunications
Field # Telecommunications
Updated 23 November 2020

#269

 

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Name
Description
Wireless Power Consortium has certified a new Timex alarm clock with wireless charging (TW300) device. The listing has an image attached alongside that shows a cylindrical table-top design with a flat surface on top for wireless charging support. There&rsquo;s a display screen up front that shows the time in red LED light. This product lets you charge your phone wirelessly with a bedside device that also offers alarm clock functionality.

#Hardware & Devices
Field # Hardware & Devices
Updated 23 November 2020

#270

 

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Name
Description
Google Assistant&rsquo;s Scheduled Actions feature will let users set a smart home command to trigger at a later time. Users can schedule the command to be triggered at a pre-set time and for a fixed duration. Google says that commands can be scheduled for any day within a seven-day period.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 23 November 2020

#271

 

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Description
Counterfeit Mi India products worth Rs. 33.3 Lakh were seized from four suppliers in Chennai and three in Bengaluru, as per Xiaomi. The company said in a statement that seven people are currently held in custody for selling the allegedly unauthorised products. Over 3,000 products were found in raids conducted in October and November.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#272

 

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Name
Description
Onleaks aka Steve Hemmerstoffer has published renders of the OnePlus 9 Pro on Voice. He has additionally tipped key specifications of the OnePlus 9 Pro, including a 6.7-inch display size. The tipster claims that the OnePlus 9 Pro may launch in March 2021.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#273

 

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Name
Description
India smartphone exports are estimated to cross $1.5 billion in 2020. India exports smartphones to 24 countries with total of 12.9 million mobiles phones shipped between January and September.

#Gadgets
Field # Gadgets
Updated 23 November 2020

#274

 

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Description
PlayStation 5 does not seem to be getting updates for older generation games to run at 120fps like the Xbox Series X does and this is because of the way Sony has implemented backward compatibility.

#Hardware & Devices;#Entertainments
Field # Hardware & Devices
Updated 23 November 2020

#275

 

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Name
Description
The changelog for the Flipboard Android app version 4.2.59 confirms that dark mode has arrived. It reads, &ldquo;Now with dark mode: We know you have been asking for it, and now the wait is over. To turn on dark mode, go to Settings under your Profile, then tap on Theme. Here, you can choose Light, Dark, or Use System Setting, which will adjust dark mode based on your phone&rsquo;s system settings&rdquo;.

#Software
Field # Software
Updated 23 November 2020

#276

 

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Name
Description
Instagram has an option to restrict users, that is to limit what they can post and who can see what they can post on your account.

#Software;#Social & Corporation affairs
Field # Software
Updated 23 November 2020

#277

 

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Name
Description
India’s leading payment services Paytm has announced a new EMI option for its postpaid users.

#Software;#Finance
Field # Software
Updated 23 November 2020

#278

 

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Name
Description
HMD Global, the licensee of Nokia smartphones, has got as many as eight new devices listed on the Wi-Fi Alliance website.

#Gadgets
Field # Gadgets
Updated 23 November 2020