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Today: 06 July 2020, Monday.

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#1

 

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Prophylactic donor lymphocyte infusions (DLI) are used to augment post-transplant immune recovery to reduce both infectious complications and disease recurrence. Preclinical studies implicate the naive T-cell subset as the primary driver of graft-versus-host disease (GvHD). In this phase I dose escalation study, we assessed the safety of a DLI that was depleted of CD45RA+ naive T cells. Sixteen adult patients received a prophylactic DLI at a median of 113 days (range 76–280 days) following an HLA-identical, non-myeloablative allogeneic hematopoietic stem cell transplantation. Three patients each received the naive T-cell depleted DLI with a CD3+ dose of 1 × 105/kg, 1 × 106/kg, and 5 × 106/kg. The maximum dose of 1 × 107/kg was expanded to 7 patients. No dose-limiting grade III/IV acute GvHD or adverse events attributable to the DLI were observed at any dose level. One patient developed grade 2 acute GvHD of skin and upper intestines, and another developed moderate chronic GvHD of the lungs following the DLI. With a median follow-up of 2.8 years, 2-year progression-free and overall survival is 50.0% and 68.8%, respectively. In conclusion, these data suggest that a DLI that has been depleted of CD45RA+ naive T cells is feasible and carries a low risk of acute or chronic GvHD.

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#2

 

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Allogeneic peripheral blood stem cell transplantation (PBSCT) is associated with an increased risk of severe acute and chronic graft-versus-host disease (GVHD) compared to bone marrow transplantation. Anti-thymocyte globulin (ATG) can reduce severe acute and chronic GVHD in PBSCT; however, an optimal dose of ATG remains undefined. We conducted a multicenter phase II study to investigate safety and efficacy of low-dose ATG (a total of 2 mg/kg Thymoglobulin) in patients undergoing HLA-matched PBSCT after myeloablative conditioning. The primary endpoint was grades III–IV GVHD at 100 days. Seventy-seven patients were enrolled and 72 patients with a median age of 46.5 years were eligible for analysis. The primary endpoint, cumulative incidence of grades III–IV acute GVHD at 100 days was 1.4% (95% CI, 0.1–6.7%), which was greatly less than our pre-defined statistical threshold value (18.0%). The incidence of chronic GVHD at 1 year was also low (all-grade; 15.3%, moderate to severe; 5.6%). Non-relapse mortality, relapse, overall survival, disease-free survival, and GVHD-free, relapse-free survival at 1 year were 4.2%, 20.8%, 84.7%, 75.0%, and 69.4%, respectively. Low dose thymoglobulin is promising to reduce severe acute and chronic GVHD in HLA-matched PBSCT following myeloablative conditioning.

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#3

 

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Altered dopamine transmission is thought to influence the formation of persecutory delusions. However, despite extensive evidence from clinical studies there is little experimental evidence on how modulating the dopamine system changes social attributions related to paranoia, and the salience of beliefs more generally. Twenty seven healthy male participants received 150mg L-DOPA, 3 mg haloperidol, or placebo in a double-blind, randomised, placebo-controlled study, over three within-subject sessions. Participants completed a multi-round Dictator Game modified to measure social attributions, and a measure of belief salience spanning themes of politics, religion, science, morality, and the paranormal. We preregistered predictions that altering dopamine function would affect (i) attributions of harmful intent and (ii) salience of paranormal beliefs. As predicted, haloperidol reduced attributions of harmful intent across all conditions compared to placebo. L-DOPA reduced attributions of harmful intent in fair conditions compared to placebo. Unexpectedly, haloperidol increased attributions of self-interest about opponents’ decisions. There was no change in belief salience within any theme. These results could not be explained by scepticism or subjective mood. Our findings demonstrate the selective involvement of dopamine in social inferences related to paranoia in healthy individuals.

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#4

 

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Autism spectrum disorders (ASD) are highly heritable and are characterized by deficits in social communication and restricted and repetitive behaviors. Twin studies on phenotypic subdomains suggest a differing underlying genetic etiology. Studying genetic variation explaining phenotypic variance will help to identify specific underlying pathomechanisms. We investigated the effect of common variation on ASD subdomains in two cohorts including >2500 individuals. Based on the Autism Diagnostic Interview-Revised (ADI-R), we identified and confirmed six subdomains with a SNP-based genetic heritability h2SNP = 0.2–0.4. The subdomains nonverbal communication (NVC), social interaction (SI), and peer interaction (PI) shared genetic risk factors, while the subdomains of repetitive sensory-motor behavior (RB) and restricted interests (RI) were genetically independent of each other. The polygenic risk score (PRS) for ASD as categorical diagnosis explained 2.3–3.3% of the variance of SI, joint attention (JA), and PI, 4.5% for RI, 1.2% of RB, but only 0.7% of NVC. We report eight genome-wide significant hits—partially replicating previous findings—and 292 known and novel candidate genes. The underlying biological mechanisms were related to neuronal transmission and development. At the SNP and gene level, all subdomains showed overlap, with the exception of RB. However, no overlap was observed at the functional level. In summary, the ADI-R algorithm-derived subdomains related to social communication show a shared genetic etiology in contrast to restricted and repetitive behaviors. The ASD-specific PRS overlapped only partially, suggesting an additional role of specific common variation in shaping the phenotypic expression of ASD subdomains.

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#5

 

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In the biggest news of the week, the government blocked 59 China-linked apps. The week also saw some launches from Vivo, Panasonic, OnePlus, Logitech and Fossil. Reliance Jio launched its video-conferencing app JioMeet. All this and other top tech news of the week.

#Entertainments
Field # Entertainments
Updated 05 July 2020

#6

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#7

 

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A wave of protests over law enforcement abuses has highlighted concerns over artificial intelligence programs like facial recognition which critics say may reinforce racial bias.

#Hardware & Devices;#Gadgets
Field # Hardware & Devices
Updated 05 July 2020

#8

 

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New Scientist's weekly round-up of the best books, films, TV series, games and more that you shouldn’t miss

#Medicine & Human body;#Psychology
Field # Medicine & Human body
Updated 05 July 2020

#9

 

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Picture a Scientist shines a light on gender discrimination in science – and also finds reasons to be hopeful, says Simon Ings

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 05 July 2020

#10

 

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We once thought Mars had canals built by an advanced society. We've come a long way since then, but there is still much to discover, finds Leah Crane

#Astronautics
Field # Astronautics
Updated 05 July 2020

#11

 

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How much easier life would be after a storm if insurance companies stopped haggling over wind versus water damage! Wind damage, which is covered by insurance, can be identified by combining wind-field models and terrain information. While not something the average homeowner can figure out, this kind

#Environment & Nature
Field # Environment & Nature
Updated 05 July 2020

#12

 

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OnePlus TV 32Y1 model in the newly announced Y series will be going on sale today at 12pm (noon) via Amazon. This will be the first sale of the TV model.

#Entertainments
Field # Entertainments
Updated 05 July 2020

#13

 

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Mi TV 4X price in India is quite low but is that the only reason Xiaomi TVs have succeeded in India?

#Gadgets
Field # Gadgets
Updated 05 July 2020

#14

 

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IIT Bombay Heritage Foundation on Friday announced a grant of Rs. 2.35 crores to IIT Bombay in order to fulfill the needs of students in wake of the COVID-19 pandemic.

#Hardware & Devices
Field # Hardware & Devices
Updated 05 July 2020

#15

 

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The lenses, made of spider dragline silk, could be used to create high resolution images of human tissue.

#Medicine & Human body;#Aging
Field # Medicine & Human body
Updated 05 July 2020

#16

 

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Wear your masks and you can have an edit button, Twitter says

#Software;#Social & Corporation affairs
Field # Software
Updated 05 July 2020

#17

 

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This London-based watchmaker is turning firefighting materials into unique watches

#Gadgets
Field # Gadgets
Updated 05 July 2020

#18

 

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v class="pf-content">

A meter-class telescope with a coronagraph to block solar light, placed in the strong interference region of the solar gravitational lens (SGL), is capable of imaging an exoplanet at a distance of up to 30 parsecs with a few 10 km-scale resolution on its surface. The picture shows results of a simulation of the effects of the SGL on an Earth-like exoplanet image. Earth diameter is 12724 kilometers. Ten-kilometer resolution would be better than a one-megapixel image....

#Theoretical sciences

Field # Theoretical sciences
Updated 05 July 2020

#19

 

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“This building is not a monument.”

#Astronautics
Field # Astronautics
Updated 05 July 2020

#20

 

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The virus has sometimes moved from pigs to humans, but not between humans.

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#21

 

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ThiefQuest or EvilQuest can grab passwords and credit card numbers.

#Software;#Security
Field # Software
Updated 05 July 2020

#22

 

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On the 25th anniversary of the SNES game's US release, it feels more relevant than ever.

#Entertainments;#Games
Field # Entertainments
Updated 05 July 2020

#23

 

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The transport of proteins across the nuclear membrane is a highly regulated process, essential for the cell function. This transport is actively mediated by members of the karyopherin family, termed importins, or exportins, depending on the direction of transport. These proteins play an active part in tumorigenesis, through aberrant localization of their cargoes, which include oncogenes, tumor-suppressor genes and mediators of key signal transduction pathways. Overexpression of importins and exportins is reported in many malignancies, with implications in cell growth and viability, differentiation, drug resistance, and tumor microenvironment. Given their broad significance across tumors and pathways, much effort is being put to develop specific inhibitors as a novel anticancer therapeutics. Already, selinexor, a specific inhibitor of exportin-1 (XPO1), is approved for clinical use. This review will focus on the role of importins and exportins in hematological malignancies. We will discuss current preclinical and clinical data on importins and exportins, and demonstrate how our growing understanding of their functions has identified new therapeutic targets.

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#24

 

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TBD

#Astronautics
Field # Astronautics
Updated 05 July 2020

#25

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#26

 

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TBD

#Chemicals
Field # Chemicals
Updated 05 July 2020

#27

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#28

 

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TBD

#Medicine & Human body
Field # Medicine & Human body
Updated 05 July 2020

#29

 

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Uber kicked off rideshare operations in Japan's capital city on Friday. Thanks to a partnership with three local taxi services, Tokyo riders can summon one of the 600 cars plugg...

#Social & Corporation affairs;#Vehicles & Special machines
Field # Social & Corporation affairs
Updated 05 July 2020

#30

 

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TwoSeven's group streaming service offers users a wide range of compatibility with Netflix, Hulu, YouTube, HBO, and more. But it's still a work in progress.

#Entertainments
Field # Entertainments
Updated 05 July 2020

#31

 

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A new image from the ESA/NASA Hubble Space Telescope shows an incredibly detailed look at a fluffy-looking spiral galaxy.

#Astronautics
Field # Astronautics
Updated 05 July 2020

#32

 

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In a mobile-first world, it’s easy to think anything related to your brand’s mobile presence should be a top priority.…...

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 05 July 2020

#33

 

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It’s nice to know that, even in these tumultuous times, some amount of normality will return somewhere.

#Entertainments
Field # Entertainments
Updated 05 July 2020

#34

 

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Researchers have published a list of more than 50 iOS apps that do the same thing.

#Social & Corporation affairs
Field # Social & Corporation affairs
Updated 05 July 2020

#35

 

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Imagine being completely blind but still being able to see. Does that sound impossible? Well, it happens.

#Hardware & Devices;#Games
Field # Hardware & Devices
Updated 05 July 2020

#36

 

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TBD

#Entertainments;#Games
Field # Entertainments
Updated 05 July 2020